EP1353857B1 - Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms - Google Patents
Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms Download PDFInfo
- Publication number
- EP1353857B1 EP1353857B1 EP02702263A EP02702263A EP1353857B1 EP 1353857 B1 EP1353857 B1 EP 1353857B1 EP 02702263 A EP02702263 A EP 02702263A EP 02702263 A EP02702263 A EP 02702263A EP 1353857 B1 EP1353857 B1 EP 1353857B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compartments
- package unit
- administration forms
- primary package
- sealed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
- B65D75/5855—Peelable seals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/527—Tear-lines for separating a package into individual packages
Definitions
- the invention relates to a primary packaging unit for several separated film platelets as dosage forms, the in this in trained in several rows subjects are arranged, in particular for circular dosage forms.
- Medicaments in solid form are usually singulated into dosage units (dosage forms) and packaged individually in primary packaging in a predetermined number and dispensed as a so-called card to the patient or consumer containing the dosage forms between at least two layers sealed together.
- dosage forms for drugs, such as tablets or dragees
- the dosage form of the "wafer” is a film plate of, for example, a polymeric component and an active ingredient having a predetermined amount of active ingredient, which is tuned in its thickness and its dimensions to the amount of active ingredient to be dispensed.
- DE 198 00 682 a primary packaging for such film platelets is described.
- This has an underlayer and a top layer, between which wafer-shaped film platelets are enclosed as dosage forms in compartments (compartments).
- Upper layer and lower layer are connected to each other by sealing seams or areas in which perforations are introduced as predetermined breaking lines in the areas between the compartments, which allow as required separation of the individual compartments of the primary packaging unit.
- an unsealed edge may be disposed adjacent each compartment on at least one side outside the sealing area, or the top and bottom layers may be mutually offset and interconnected so that a protruding edge of one of the two layers is formed.
- the post-published WO-A-01/62621 relates to a primary packaging unit with a lower layer and an upper layer. In this, the two layers are not connected to each other in predetermined areas and thereby form a tear-open.
- the invention is that in a Primärverpakkungsech for several isolated dosage forms in Form of film platelets consisting of a lower layer and a formed with this sealed upper class, between those surrounded by seal areas individual subjects are designed for the dosage forms in their area the upper and lower layers are unsealed, at least two rows of subjects are formed, and the Subjects and dosage forms of the adjacent rows to each other staggered or, alternatively, that the compartments are arranged annularly.
- the multi-row Positioning with an offset of the compartments or even the annular positioning of the dosage forms leads to a denser packing per unit area and thus too smaller primary packaging units.
- the primary packaging unit for round wafer-shaped Film plate provided as a dosage form, in which the compartments are arranged so that the offset of the in these enclosed dosage forms half Distance between the centers of two adjacent administration forms corresponds to one row, and that all neighboring ones Dosage forms have the same distance from each other.
- the connecting lines form the midpoints of the dosage forms isosceles triangles.
- the offset may be be chosen differently.
- the distance between the edges of two adjacent ones Dosage forms between 3 mm and 50 mm, preferably between 6 mm and 20 mm.
- the dosage forms are it preferably with circular dosage forms with a diameter between 0.5 and 3 cm and with a thickness between 50 and 700 ⁇ m.
- the primary packing points the subjects associated tear tabs formed thereby are that in their area the upper class not with the lower class is connected and the upper class in the the subjects facing away from the area with the lower layer sealed upper layer is separated.
- the tear tabs borders on predetermined tear lines, which are in the sealed Upper layer of the compartments surrounding areas arranged are. With the help of a pull tab, the upper class becomes along the a trainees surrounding tear line of the lower layer separated, and the respective compartment is opened. The dosage form is accessible.
- the pull tabs are Advantageously arranged so that they are in between the compartments protrude intermediate spaces given a neighboring row.
- annularly arranged compartments In annularly arranged compartments, they are in trained in the area enclosed by the subjects and aligned to the center of the round primary packaging unit and can be easily grabbed there. The neighboring ones Trays remain unaffected when a tray is torn open and closed.
- the two layers are particularly suitable Polyethylene (PE), polyethylene terephthalate (PET), Polypropylene (PP) and ethylene-vinyl acetate copolymer (EVA), but also paper, aluminum or composites of these materials.
- PE Polyethylene
- PET polyethylene terephthalate
- PP Polypropylene
- EVA ethylene-vinyl acetate copolymer
- the upper layer and the lower layer consist of different materials. It can be advantageous too, for one of the two layers or just for the Upper layer to use a transparent material.
- the primary packaging unit is made by a Striped drug form withdrawn from a supply roll and one also pulled from such a train is supplied from the material of the underlayer and out the drug delivery forms, in particular circular dosage forms, according to the predetermined Arrangement in primary packing, punched out or be cut out and the residual material is separated, by passing the residual material web over a separating edge the dosage forms dissolved from the dressing remain on the web of the material of the lower layer and be advanced with this. Following the separation is positioned on the lower course and on this Dosage forms a web of the material of Upper layer fed and with the material of the lower layer sealed in predetermined areas. After that, the Upper web for the formation of tear tabs and tear lines through and punched. Finally, the sealed Composite with the dosage forms positioned according to the sample separated from the following lanes.
- Fig. 1 shows in conjunction with Fig. 1a a Primärverpakkungsech arranged with five in two rows I and II circular film platelets as dosage forms 1 with a Diameter of 1.9 cm and a thickness of 200 microns.
- each one is three adjacent dosage forms 1 positioned so that these form an isosceles triangle, so that the adjacent dosage forms 1 of both rows I and II have a distance S from each other. The distance its edges is 1.7 cm.
- the primary packaging unit is made of a sub-layer 2 of a composite of Paper, aluminum and polyethylene with a thickness of 500 microns and a sealed with this upper layer 3 of a Composite of polyethylene terephthalate, polypropylene and Polyethylene formed with a thickness of 70 microns, between which subjects 4 are formed for the dosage forms 1 are in their area the two layers 2 and 3 are not are sealed together.
- the diameter of the compartments 4 is 2.2 cm and is thus larger than that of the dosage forms 1, so that around this annular Airspace 5 is given.
- the subjects 4 are tongue-shaped Areas 6 of the upper class 3 assigned, not with the Underlayer 2 are sealed and those in the area respective tray 4 facing away from the rest of the upper class 3 are separated and as gripping and tear tabs serve.
- Fig. 2 shows a primary packaging unit with only four compartments 8 and dosage forms 1, in which they have a greater distance from each other than in the above-described embodiment.
- Fig. 3 is a primary packaging of a lower layer 11 of a composite of paper, aluminum and polyethylene having a thickness of 500 microns and sealed with this top layer 12 of a composite of polyethylene terephthalate, polypropylene and polyethylene having a thickness of 70 microns and shown seven between these annularly arranged compartments 13 and seven housed in these dosage forms 1.
- This primary packaging represents a weekly package from which a dosage form 1 is to be taken every day.
- the arrangement of the compartments 13 is made so that they lie with their centers on a circle of a diameter of 9.5 cm and a regular distance S 3 of 3.5 cm from each other.
- the upper layer 12 is recessed in the region of a gap 14 given by the predetermined number of dosage forms and the dimensioning and sealed in the hatched areas 15 with the lower layer 11.
- This primary packaging is also provided with tongue-shaped tear-open tabs (16) formed by unsealed areas 16 of the upper layer 12, which are separated from one another and point all toward the center. Between the compartments 13, tear lines 17 are formed in the sealed area.
- Fig. 4 the procedure for producing a Primary packaging unit shown.
- the drug web 20 is a punching station 21 in a predetermined cycle intermittently fed and before this with the web-shaped material the lower layer 2, in which (21) circular dosage forms 1, according to the predetermined Packaging pattern of the primary packaging unit according to Fig. 1, Fig. 2 or Fig. 3, on the web of the Under layer 2 are punched out.
- the material web of the lower layer 2 is a not further shown Transport mechanism 22 moved forward in time. Carry out the residual material web 23 about a separation edge 24 with a small diameter, the dosage forms 1 are separated and are in the predetermined packaging position on the web of the lower class 2.
- the material web of the upper class. 3 supplied as a cover layer and with the material web of the lower layer 2 in a sealing station 25 after a predetermined Sealed pattern, with both the areas to Training of subjects 4 (13) as well as the areas in which the tear tabs 6 (16) are formed, unsealed stay.
- the upper-layer web is in one Punching station 26 according to a predetermined pattern for training punctured by predetermined tear lines 7 (10, 17) and for separation the tear tabs (16) punched.
- a subsequent Cutting station 27 will be the so designed Primary packaging unit P separated from the following.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Plastic Fillers For Packaging (AREA)
- Buffer Packaging (AREA)
- Packaging Of Machine Parts And Wound Products (AREA)
- Bending Of Plates, Rods, And Pipes (AREA)
Abstract
Description
Die Erfindung betrifft eine Primärverpackungseinheit für mehrere vereinzelte Filmplättchen als Darreichungsformen, die in dieser in in mehreren Reihen ausgebildeten Fächern angeordnet sind, insbesondere für kreisrunde Darreichungsformen.The invention relates to a primary packaging unit for several separated film platelets as dosage forms, the in this in trained in several rows subjects are arranged, in particular for circular dosage forms.
Arzneimittel in fester Form werden in der Regel zu Dosiseinheiten
(Darreichungsformen) vereinzelt und in Primärverpackungen
in vorbestimmter Anzahl einzeln verpackt und als
sog. Karte an den Patienten oder Verbraucher abgegeben, die
die Darreichungsformen zwischen wenigstens zwei miteinander
versiegelten Schichten enthält. Neben den bekannten festen
Darreichungsformen für Arzneimittel, wie Tabletten oder
Dragees, gibt es auch die Darreichungsform des "Wafer". Bei
diesem handelt es sich um ein Filmplättchen aus beispielsweise
einem polymeren Bestandteil und einem Wirkstoff mit
einer vorbestimmten Wirkstoffmenge, das in seiner Dicke und
seinen Abmessungen auf die abzugebende Wirkstoffmenge abgestimmt
ist. In der DE 198 00 682 wird eine Primärverpackung
für derartige Filmplättchen beschrieben. Diese weist eine
Unterschicht und eine Oberschicht auf, zwischen denen oblatenförmige
Filmplättchen als Darreichungsformen in Kompartimenten
(Fächern) eingeschlossen sind. Oberschicht und Unterschicht
sind durch Siegelnähte bzw. -bereiche miteinander
verbunden, in die in die Bereiche zwischen den Fächern
Perforationen als Sollbruchlinien eingebracht sind, die eine
bedarfsweise Abtrennung der einzelnen Fächer von der
Primärverpackungseinheit ermöglichen. Zur Erleichterung des
Anfassens und des Aufreißens kann neben jedem Fach auf mindestens
einer Seite außerhalb des Siegelbereiches ein unversiegelter
Rand angeordnet sein, oder Ober- und Unterschicht
können gegeneinander verschoben angeordnet und miteinander
verbunden sein, so daß ein überstehender Rand einer
der beiden Schichten gebildet ist.
Des weiteren hat die nachreröffentlichte WO-A-01/62621 eine Primärverpackungseinheit
mit einer Unterschicht und einer Oberschicht zum
Gegenstand. Bei dieser sind die beiden Schichten in vorbestimmten
Bereichen nicht miteinander verbunden sind und
bilden dadurch eine Aufreißhilfe.Medicaments in solid form are usually singulated into dosage units (dosage forms) and packaged individually in primary packaging in a predetermined number and dispensed as a so-called card to the patient or consumer containing the dosage forms between at least two layers sealed together. In addition to the known solid dosage forms for drugs, such as tablets or dragees, there is also the dosage form of the "wafer". This is a film plate of, for example, a polymeric component and an active ingredient having a predetermined amount of active ingredient, which is tuned in its thickness and its dimensions to the amount of active ingredient to be dispensed. In DE 198 00 682 a primary packaging for such film platelets is described. This has an underlayer and a top layer, between which wafer-shaped film platelets are enclosed as dosage forms in compartments (compartments). Upper layer and lower layer are connected to each other by sealing seams or areas in which perforations are introduced as predetermined breaking lines in the areas between the compartments, which allow as required separation of the individual compartments of the primary packaging unit. To facilitate grasping and tearing, an unsealed edge may be disposed adjacent each compartment on at least one side outside the sealing area, or the top and bottom layers may be mutually offset and interconnected so that a protruding edge of one of the two layers is formed.
Furthermore, the post-published WO-A-01/62621 relates to a primary packaging unit with a lower layer and an upper layer. In this, the two layers are not connected to each other in predetermined areas and thereby form a tear-open.
Aufgrund der flächigen Ausdehnung der Arzneiform, der Ausdehnung eines Freiraumes um die Darreichungsform herum und der Breite des Siegelbereichs erreichen Primärverpackungseinheiten nach der DE 198 00 682 eine Ausdehnung, die deren Handhabung beeinträchtigt. So weist z.B. eine Karte (Primärverpackungseinheit) mit fünf oblatenförmigen Darreichungsformen mit je einer Fläche von 2 cm2 eine Gesamtbreite von 11 cm und eine Breite von 6 cm auf. Diese Karte läßt sich beispielsweise in einem Portemonnaie schlecht unterbringen. Eine Wochenpackung mit mindestens sieben Darreichungsformen wäre daher noch ungünstiger. Der Grund liegt in der Größe der oblatenförmigen Darreichungsformen, die im wesentlichen einen Durchmesser von 1, 5 cm aufweisen, was mit einer geringeren Packungsdichte in der Primärverpackungseinheit verbunden ist, zumal die Darreichungsformen in dieser dicht abgeschlossen sein müssen. Eine gute Handhabbarkeit, eingeschlossen eine problemlose Unterbringung beim Mitführen, ist aber gerade ein erklärtes Ziel dieser neuen Darreichungsform, die insbesondere rund (oblatenförmig) angeboten wird und zur Darreichung gelangt, um auch eine gewisse Nähe zu anderen Darreichungsformen zu suggerieren und ihre Etablierung zu erleichtern.Due to the two-dimensional extent of the drug form, the expansion of a free space around the dosage form and the width of the seal area reach primary packaging units according to DE 198 00 682 an extent that affects their handling. Thus, for example, a card (primary packaging unit) with five wafer-shaped administration forms, each with an area of 2 cm 2, has a total width of 11 cm and a width of 6 cm. This card can be badly accommodated, for example, in a wallet. A weekly package with at least seven dosage forms would therefore be even less favorable. The reason lies in the size of the wafer-shaped dosage forms, which have a diameter of 1, 5 cm, which is associated with a lower packing density in the primary packaging unit, especially since the dosage forms must be sealed in this. However, good handling, including problem-free accommodation when carrying along, is precisely a stated goal of this new dosage form, which is offered in particular round (wafer-shaped) and administered, in order to suggest a certain proximity to other forms of administration and to facilitate their establishment.
Es ist daher Aufgabe der Erfindung, eine Primärverpackungseinheit
nach dem Oberbegriff des Anspruchs 1 oder 6 so zu
gestalten, daß diese eine dichtere Packung für insbesondere
runde Darreichungsformen ermöglicht.It is therefore an object of the invention to provide a primary packaging unit
according to the preamble of
Diese Aufgabe wird bei einer Verpackungseinheit nach dem
Oberbegriff des Anspruchs 1 oder 6 durch deren kennzeichnende
Merkmale gelöst. Vorteilhafte Ausgestaltungen sind
jeweils in den Unteransprüchen aufgeführt.This task is performed on a packaging unit after
The preamble of
Die Erfindung besteht darin, daß bei einer Primärverpakkungseinheit für mehrere vereinzelte Darreichungsformen in Form von Filmplättchen, die aus einer Unterschicht und einer mit dieser versiegelten Oberschicht gebildet ist, zwischen denen von Siegelbereichen umgebene einzelne Fächer für die Darreichungsformen ausgebildet sind, in deren Bereich die Ober- und die Unterschicht unversiegelt sind, mindestens zwei Reihen von Fächern gebildet sind, und die Fächer und Darreichungsformen der benachbarter Reihen zueinander versetzt angeordnet sind, oder, alternativ dazu, daß die Fächer ringförmig angeordnet sind. Die mehrreihige Positionierung mit einem Versatz der Fächer oder auch die ringförmige Positionierung der Darreichungsformen, führt zu einer dichteren Packung je Flächeneinheit und damit auch zu kleineren Primärverpackungseinheiten.The invention is that in a Primärverpakkungseinheit for several isolated dosage forms in Form of film platelets consisting of a lower layer and a formed with this sealed upper class, between those surrounded by seal areas individual subjects are designed for the dosage forms in their area the upper and lower layers are unsealed, at least two rows of subjects are formed, and the Subjects and dosage forms of the adjacent rows to each other staggered or, alternatively, that the compartments are arranged annularly. The multi-row Positioning with an offset of the compartments or even the annular positioning of the dosage forms leads to a denser packing per unit area and thus too smaller primary packaging units.
Bevorzugt ist die Primärverpackungseinheit für runde oblatenförmige Filmplättchen als Darreichungsform vorgesehen, bei der die Fächer so angeordnet sind, daß der Versatz der in diesen eingeschlossenen Darreichungsformen dem halben Abstand der Mittelpunkte zweier benachbarter Darreichungsformen einer Reihe entspricht, und daß alle benachbarten Darreichungsformen den gleichen Abstand voneinander haben. Das bedeutet bei einem Abstand A zwischen zwei benachbarten Darreichungsformen einer Reihe, daß eine Darreichungsform der benachbarten Reihe um 0, 5 A zu diesen versetzt angeordnet ist. Zudem bilden die Verbindungslinien der Mittelpunkte der Darreichungsformen gleichschenklige Dreiecke. Je nach Ausführungsform der Erfindung kann der Versatz jedoch auch anders gewählt werden. Bei der bevorzugten Ausführungsform beträgt der Abstand der Ränder zweier benachbarter Darreichungsformen zwischen 3 mm und 50 mm, vorzugsweise zwischen 6 mm und 20 mm. Bei den Darreichungsformen handelt es sich bevorzugt um kreisrunde Darreichungsformen mit einem Durchmesser zwischen 0,5 und 3 cm und mit einer Dicke zwischen 50 und 700 µm.Preferably, the primary packaging unit for round wafer-shaped Film plate provided as a dosage form, in which the compartments are arranged so that the offset of the in these enclosed dosage forms half Distance between the centers of two adjacent administration forms corresponds to one row, and that all neighboring ones Dosage forms have the same distance from each other. This means at a distance A between two adjacent Dosage forms of a series that a dosage form the adjacent row offset by 0, 5 A to these is. In addition, the connecting lines form the midpoints of the dosage forms isosceles triangles. ever however, according to an embodiment of the invention, the offset may be be chosen differently. In the preferred embodiment is the distance between the edges of two adjacent ones Dosage forms between 3 mm and 50 mm, preferably between 6 mm and 20 mm. When the dosage forms are it preferably with circular dosage forms with a diameter between 0.5 and 3 cm and with a thickness between 50 and 700 μm.
Zur Verbesserung der Handhabung weist die Primärverpackung den Fächern zugeordnete Aufreißlaschen auf, die dadurch gebildet sind, daß in deren Bereich die Oberschicht nicht mit der Unterschicht verbunden ist und die Oberschicht in dem den Fächern abgewandten Bereich von der mit der Unterschicht versiegelten Oberschicht separiert ist. Die Aufreißlaschen grenzen an Sollreißlinien, die in der versiegelten Oberschicht der die Fächer umgebenden Bereiche angeordnet sind. Mit Hilfe einer Aufreißlasche wird die Oberschicht entlang der ein Fach umgebenden Sollreißlinie von der Unterschicht getrennt, und das jeweilige Fach wird geöffnet. Die darinliegende Darreichungsform ist zugänglich. Bei in Reihen angeordneten Fächern sind die Aufreißlaschen vorteilhaft so angeordnet, daß sie in die zwischen den Fächern einer benachbarten Reihe gegebenen Zwischenräume hineinragen. Bei ringförmig angeordneten Fächern sind sie in dem von den Fächern umschlossenen Bereich ausgebildet und zum Zentrum der runden Primärverpackungseinheit ausgerichtet und können dort leicht gegriffen werden. Die benachbarten Fächer bleiben beim Aufreißen eines Faches unbeeinträchtigt und geschlossen.To improve handling, the primary packing points the subjects associated tear tabs formed thereby are that in their area the upper class not with the lower class is connected and the upper class in the the subjects facing away from the area with the lower layer sealed upper layer is separated. The tear tabs borders on predetermined tear lines, which are in the sealed Upper layer of the compartments surrounding areas arranged are. With the help of a pull tab, the upper class becomes along the a trainees surrounding tear line of the lower layer separated, and the respective compartment is opened. The dosage form is accessible. For racks arranged in rows, the pull tabs are Advantageously arranged so that they are in between the compartments protrude intermediate spaces given a neighboring row. In annularly arranged compartments, they are in trained in the area enclosed by the subjects and aligned to the center of the round primary packaging unit and can be easily grabbed there. The neighboring ones Trays remain unaffected when a tray is torn open and closed.
Als Materialien für die beiden Schichten eignen sich insbesondere Polyethylen (PE), Polyethylenterephthalat (PET), Polypropylen (PP) und Ethylen-vinylacetat-Copolymer (EVA), aber auch Papier, Aluminium oder Verbunde dieser Materialien. Dabei können die Oberschicht und die Unterschicht aus verschiedenen Materialien bestehen. Vorteilhaft kann es auch sein, für eine der beiden Schichten oder nur für die Oberschicht ein transparentes Material einzusetzen.As materials for the two layers are particularly suitable Polyethylene (PE), polyethylene terephthalate (PET), Polypropylene (PP) and ethylene-vinyl acetate copolymer (EVA), but also paper, aluminum or composites of these materials. Here, the upper layer and the lower layer of consist of different materials. It can be advantageous too, for one of the two layers or just for the Upper layer to use a transparent material.
Die Primärverpackungseinheit wird hergestellt, indem eine bahnförmige Arzneimittelform von einer Vorratsrolle abgezogen und einer ebenfalls von einer solchen abgezogenen Bahn aus dem Material der Unterschicht zugeführt wird und aus der Arzneimittelbahn die Darreichungsformen, insbesondere kreisrunde Darreichungsformen, entsprechend der vorbestimmten Anordnung in der Primärverpackung, ausgestanzt oder ausgeschnitten werden und das Restmaterial separiert wird, indem die Restmaterialbahn über eine Separierkante geführt wird, an der die aus dem Verband gelösten Darreichungsformen auf der Bahn des Materials der Unterschicht verbleiben und mit dieser vorgeschoben werden. Im Anschluß an das Separieren wird auf die Unterbahn und die auf dieser positionierten Darreichungsformen eine Bahn aus dem Material der Oberschicht zugeführt und mit dem Material der Unterschicht in vorbestimmten Bereichen versiegelt. Danach wird die Oberbahn zur Ausbildung von Aufreißlaschen und Sollreißlinien durch- und angestanzt. Schließlich wird der versiegelte Verbund mit den nach dem Muster positionierten Darreichungsformen von den nachfolgenden Bahnen abgetrennt.The primary packaging unit is made by a Striped drug form withdrawn from a supply roll and one also pulled from such a train is supplied from the material of the underlayer and out the drug delivery forms, in particular circular dosage forms, according to the predetermined Arrangement in primary packing, punched out or be cut out and the residual material is separated, by passing the residual material web over a separating edge the dosage forms dissolved from the dressing remain on the web of the material of the lower layer and be advanced with this. Following the separation is positioned on the lower course and on this Dosage forms a web of the material of Upper layer fed and with the material of the lower layer sealed in predetermined areas. After that, the Upper web for the formation of tear tabs and tear lines through and punched. Finally, the sealed Composite with the dosage forms positioned according to the sample separated from the following lanes.
Die Erfindung wird nachstehend an Ausführungsbeispielen erläutert.
In den zugehörigen Zeichnungen zeigen:
Fig. 1 zeigt in Verbindung mit Fig. 1a eine Primärverpakkungseinheit
mit fünf in zwei Reihen I und II angeordneten
kreisrunden Filmplättchen als Darreichungsformen 1 mit einem
Durchmesser von 1,9 cm und einer Dicke von 200 µm. Die
Darreichungsformen 1 der beiden Reihen I und II sind versetzt
zueinander positioniert, wobei der Versatz dem halben
Abstand S (S = 3,6 cm) der Mittelpunkte zweier benachbarter
Darreichungsformen 1 einer Reihe I oder II entspricht und
somit 0,5 S = 1,8 cm beträgt. Darüber hinaus sind jeweils
drei benachbarte Darreichungsformen 1 so positioniert, daß
diese ein gleichschenkliges Dreieck bilden, so daß auch die
benachbarten Darreichungsformen 1 beider Reihen I und II
untereinander einen Abstand S voneinander haben. Der Abstand
ihrer Ränder beträgt 1,7 cm. Die Primärverpackungseinheit
ist aus einer Unterschicht 2 aus einem Verbund von
Papier, Aluminium und Polyethylen mit einer Dicke von 500
µm und einer mit dieser versiegelten Oberschicht 3 aus einem
Verbund von Polyethylenterephthalat, Polypropylen und
Polyethylen mit einer Dicke von 70 µm gebildet, zwischen
denen Fächer 4 für die Darreichungsformen 1 ausgebildet
sind, in deren Bereich die beiden Schichten 2 und 3 nicht
miteinander versiegelt sind. Der Durchmesser der Fächer 4
beträgt 2,2 cm und ist somit größer als der der Darreichungsformen
1, so daß um diese herum ein ringförmiger
Luftraum 5 gegeben ist. Den Fächern 4 sind zungenförmige
Bereiche 6 der Oberschicht 3 zugeordnet, die nicht mit der
Unterschicht 2 versiegelt sind und die im Bereich.ihrer dem
jeweiligen Fach 4 abgewandten Spitze von der übrigen Oberschicht
3 separiert sind und als Anfaß- und Aufreißlaschen
dienen. Überdies grenzen diese auf ihrer dem jeweiligen
Fach 4 zugewandten Seite an Sollreißlinien 7, die beidseits
eines Faches 4 in der mit der Unterschicht 2 versiegelten
Oberschicht 3 ausgebildet sind. Die zungenförmigen Aufreißlaschen
(6) ragen jeweils in die zwischen den Fächern 4 gegebenen
Räume der jeweils anderen Reihe I oder II hinein.Fig. 1 shows in conjunction with Fig. 1a a Primärverpakkungseinheit
arranged with five in two rows I and II
circular film platelets as dosage forms 1 with a
Diameter of 1.9 cm and a thickness of 200 microns. The
Dosage forms 1 of the two rows I and II are offset
positioned to each other, wherein the offset of half
Distance S (S = 3.6 cm) of the centers of two adjacent
Forms of
Fig. 2 zeigt eine Primärverpackungseinheit mit nur vier Fächern
8 und Darreichungsformen 1, bei der diese einen größeren
Abstand voneinander haben als in der vorbeschriebenen
Ausführungsform. Der Abstand zwischen den in den Fächern 8
untergebrachten Darreichungsformen 1 einer Reihe I oder II
beträgt S1 = 4,5 cm und zwischen den Darreichungsformen 1
der beiden Reihen I und II S2 = 4 cm. Die ebenso wie in der
Ausführung nach Fig. 1 gebildeten Aufreißlaschen 9 grenzen
im Unterschied zu diesen (6) jeweils an separate Sollreißlinien
10.Fig. 2 shows a primary packaging unit with only four
In Fig. 3 ist eine Primärverpackung aus einer Unterschicht
11 aus einem Verbund von Papier, Aluminium und Polyethylen
mit einer Dicke von 500 µm und einer mit dieser versiegelten
Oberschicht 12 aus einem Verbund von Polyethylenterephthalat,
Polypropylen und Polyethylen mit einer Dicke von
70 µm und mit sieben zwischen diesen ringförmig angeordneten
Fächern 13 sowie sieben in diesen untergebrachten Darreichungsformen
1 dargestellt. Diese Primärverpackung
stellt eine Wochenpackung dar, aus der jeden Tag eine Darreichungsform
1 entnommen werden soll. Die Anordnung der
Fächer 13 ist so getroffen, daß diese mit ihren Mittelpunkten
auf einem Kreis eines Durchmessers von 9,5 cm liegen
und einen regelmäßigen Abstand S3 von 3,5 cm voneinander
haben. Die Oberschicht 12 ist im Bereich einer durch die
vorbestimmte Anzahl der Darreichungsformen und die Dimensionierung
gegebenen Lücke 14 ausgespart und in den schraffierten
Bereichen 15 mit der Unterschicht 11 versiegelt.
Auch diese Primärverpackung ist mit durch unversiegelte Bereiche
16 der Oberschicht 12 gebildeten zungenförmigen Aufreißlaschen
(16) versehen, die voneinander getrennt sind
und alle nach der Mitte weisen. Zwischen den Fächern 13
sind in dem versiegelten Bereich Sollreißlinien 17 ausgebildet.In Fig. 3 is a primary packaging of a
In Fig. 4 ist der Verfahrensablauf zur Herstellung einer
Primärverpackungseinheit dargestellt. Zur Herstellung wird
auf Rollen bevorratetes bahnförmiges Material des Arzneimittels,
zur Bildung der Unterschicht 2 (11) und der Oberschicht
3 (12) bereitgestellt. Die Arzneimittelbahn 20 wird
einer Stanzstation 21 in einem vorbestimmten Takt intermittierend
zugeführt und vor dieser mit dem bahnförmigen Material
der Unterschicht 2 zusammengeführt, in der (21)
kreisrunde Darreichungsformen 1, entsprechend dem vorbestimmten
Verpackungsmuster der Primärverpackungseinheit gemäß
Fig. 1, Fig. 2 oder Fig. 3, auf der Materialbahn der
Unterschicht 2 ausgestanzt werden. Die Materialbahn der Unterschicht
2 wird durch einen nicht weiter dargestellten
Transportmechanismus 22 im Takt vorwärtsbewegt. Durch Führen
der Restmaterialbahn 23 um eine Ablösekante 24 mit einem
kleinem Durchmesser werden die Darreichungsformen 1 separiert
und liegen in der vorbestimmten Verpackungsposition
auf der Materialbahn der Unterschicht 2. Danach wird, ebenfalls
im Takt, auf diese die Materialbahn der Oberschicht 3
als Deckschicht zugeführt und mit dem Materialbahn der Unterschicht
2 in einer Siegelstation 25 nach einem vorbestimmten
Muster versiegelt, wobei sowohl die Bereiche zur
Ausbildung der Fächer 4 (13) als auch die Bereiche, in denen
die Aufreißlaschen 6 (16) ausgebildet werden, unversiegelt
bleiben. Danach wird die Oberschichtbahn in einer
Stanzstation 26 nach einem vorgegebenen Muster zur Ausbildung
von Sollreißlinien 7 (10, 17) angestanzt und zur Trennung
der Aufreißlaschen (16) durchgestanzt. In einer nachfolgenden
Schneidstation 27 wird die derart gestaltete
Primärverpackungseinheit P von der nachfolgenden getrennt.In Fig. 4, the procedure for producing a
Primary packaging unit shown. For the production becomes
stocked on rolls of sheet material of the drug,
for forming the underlayer 2 (11) and the topsheet
3 (12). The
- II
- Reiheline
- IIII
- Reiheline
- SS
- Abstanddistance
- 11
- DarreichungsformDosage Form
- 22
- Unterschichtunderclass
- 33
- Oberschichttop layer
- 44
- Fachsubject
- 55
- Luftraumairspace
- 66
- Aufreißlaschepull tab
- 77
- SollreißlinieIntended tear line
- 88th
- Fachsubject
- 99
- Aufreißlaschepull tab
- 1010
- SollreißlinieIntended tear line
- 1111
- Unterschichtunderclass
- 1212
- Oberschichttop layer
- 1313
- Fachsubject
- 1414
- Lückegap
- 1515
- BereichArea
- 1616
- Aufreißlaschepull tab
- 1717
- SollreißlinieIntended tear line
- 2020
- Arzneimittelbahnmedicines train
- 2121
- Stanzstationpunching station
- 2222
- Transportmechanismustransport mechanism
- 2323
- RestmaterialbahnResidual material web
- 2424
- Ablösekante removal edge
- 2525
- Siegelstationsealing station
- 2626
- Stanzstationpunching station
- 2727
- Schneidstationcutting station
- PP
- PrimärverpackungseinheitPrimary packaging unit
Claims (11)
- Primary package unit for a plurality of separated film laminas as administration forms, having a bottom layer and a top layer sealed thereto, between which layers individual compartments, surrounded by sealed regions, are formed for the administration forms in the region of which the top and bottom layers are unsealed, characterized in that said primary package unit is provided with at least two rows (I, II) of compartments (4, 8), and that the compartments (4, 8) and administration forms (1) of neighbouring rows (I, II) are offset from one another.
- Primary package unit according to claim 1, characterized in that the compartments (4) are arranged such that the offset of the administration form (1) corresponds to half the distance (S) between the centre points of two neighbouring administration forms (1) of a row (I, II), and that all neighbouring administration forms (1) are arranged at equal distance (S) from one another.
- Primary package unit according to claim 1 or 2, characterized in that the administration forms (1) are arranged such that the distance between the borders of two neighbouring administration forms (1) is between 3 mm and 50 mm, preferably between 6 mm and 20 mm.
- Primary package unit according to any one of the preceding claims, characterized in that it has top layer sections associated with the compartments (4, 8) and not connected with the bottom layer (2) and which in the region facing away from the compartments (4, 8) are separated from the top layer (3) and serve as tear tabs (6, 9), and in that the tear tabs (6, 9) border on predetermined tear lines (7, 10) which are arranged in the sealed top layer (3) of the regions surrounding the compartments (4, 8).
- Primary package unit according to claim 4, characterized in that the tear tabs (6, 9) each project into the spaces, existing between the compartments (4, 8), of a neighbouring row (I, II).
- Primary package unit for a plurality of separated film-shaped administration forms, having a bottom layer and a top layer sealed thereto, between which layers individual compartments surrounded by sealed regions are formed for the administration forms, in the region of which the top and bottom layers are unsealed, characterized in that the compartments (13) are arranged in ring-shape.
- Primary package unit according to claim 7, characterized in that it has sections of the top layer (12), associated with the compartments (13), which sections are not connected with the bottom layer (11) and which are separated in the region facing away from the compartments (13) from the top layer (12) and serve as tear tabs (16), and in that the said tear tabs (16) verge on predetermined tear lines (17) which are arranged in the sealed upper layer (12) of the regions surrounding the compartments (13).
- Primary package unit according to claim 7, characterized in that the tear tabs (16) are formed in the region enclosed by the compartments (13).
- Primary package unit according to any one of the preceding claims, characterized in that the bottom layer and/or the top layer are made of polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), ethylene vinyl acetate copolymer (EVA), paper, aluminium, or composites of these materials.
- Primary packaging according to any one of the preceding claims, characterized in that the upper layer (3, 12) and/or the bottom layer (2, 11) are configured so as to be transparent.
- Process for the production of a primary package unit according to claims 1 to 5 or 6 to 8, characterized in that a web-shaped medicament form (20) is fed to a web of the material of the bottom layer (2, 11), and that, in particular circular, administration forms (1) are punched or cut out of the web-shaped medicament form (20) according to the predetermined packaging pattern, and that the remaining material is separated, and that subsequently a web of the material of the top layer (3, 12) is fed as a cover for the administration form (1) and is sealed with the material of the former web (2, 11) in predetermined regions, and that thereafter the top web (3, 12) is punched through and partially punched to produce tear tabs (6, 9, 16) and predetermined tear lines (7, 10, 17), and that subsequently the advanced packaging unit is separated from the following one.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10102818 | 2001-01-23 | ||
DE10102818A DE10102818A1 (en) | 2001-01-23 | 2001-01-23 | Primary packaging unit for several isolated film platelets as dosage forms |
PCT/EP2002/000287 WO2002059012A1 (en) | 2001-01-23 | 2002-01-14 | Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1353857A1 EP1353857A1 (en) | 2003-10-22 |
EP1353857B1 true EP1353857B1 (en) | 2004-08-18 |
Family
ID=7671412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02702263A Expired - Lifetime EP1353857B1 (en) | 2001-01-23 | 2002-01-14 | Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms |
Country Status (10)
Country | Link |
---|---|
US (1) | US7293653B2 (en) |
EP (1) | EP1353857B1 (en) |
JP (1) | JP2004517011A (en) |
KR (1) | KR100808612B1 (en) |
AT (1) | ATE273869T1 (en) |
DE (2) | DE10102818A1 (en) |
DK (1) | DK1353857T3 (en) |
ES (1) | ES2227425T3 (en) |
PT (1) | PT1353857E (en) |
WO (1) | WO2002059012A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6960486B2 (en) * | 2001-09-20 | 2005-11-01 | University Of Alabama At Brimingham Research Foundation | Mid-IR microchip laser: ZnS:Cr2+ laser with saturable absorber material |
AU2003268909A1 (en) | 2002-10-04 | 2004-04-23 | Elan Pharma International Limited | Improved blister packaging |
US20060169601A1 (en) * | 2003-12-23 | 2006-08-03 | Lyon Stephen C | Medicinal container |
DE102004017030A1 (en) * | 2004-04-02 | 2005-10-20 | Schering Ag | Flat system for use in the oral cavity, e.g. for transmucosal drug delivery, comprises an intermediate, active agent-containing layer sealed between two covering layers of higher surface area |
US20060207911A1 (en) * | 2005-03-15 | 2006-09-21 | Bullock John D | Emergency medical treatment system |
US20060254949A1 (en) * | 2005-05-12 | 2006-11-16 | Staggs William B Jr | Credit card-shaped drug delivery system |
US7758484B2 (en) * | 2005-12-30 | 2010-07-20 | 3M Innovative Properties Company | Packaging and method for making the same |
DE102006041921A1 (en) | 2006-09-07 | 2008-03-27 | Lts Lohmann Therapie-Systeme Ag | Packaging for active substance-containing films and process for their preparation |
DK2248519T3 (en) | 2006-10-02 | 2018-01-02 | Applied Pharma Res | Non-mucoadhesive film dosage forms |
JP5184925B2 (en) * | 2007-03-15 | 2013-04-17 | 株式会社シード | Contact lens shipping container and connection structure thereof |
ATE543743T1 (en) * | 2008-08-11 | 2012-02-15 | Boehringer Ingelheim Int | BLISTER PACKAGING |
DE102010028351A1 (en) | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | wafer pocket |
US20120305584A1 (en) * | 2011-06-06 | 2012-12-06 | Omnicare Inc. | Administration methods and packagings for oral medications |
JP6209971B2 (en) * | 2014-01-16 | 2017-10-11 | 大日本印刷株式会社 | Blister container |
US11229579B2 (en) * | 2014-11-11 | 2022-01-25 | Brian Dufour | Layered multiple single-dose medication systems and assemblies |
Family Cites Families (24)
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US3503493A (en) * | 1968-01-08 | 1970-03-31 | Hoffmann La Roche | Medicament packaging device |
US3743084A (en) * | 1970-11-09 | 1973-07-03 | Colgate Palmolive Co | Carrier-dispenser package |
DE2322055A1 (en) * | 1973-05-02 | 1975-01-30 | Bosch Gmbh Robert | CHILD RESISTANT TABLET PACK |
CA1097233A (en) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
DE2919713A1 (en) * | 1979-05-16 | 1980-11-20 | Helmut Zanker | Childproof blister pack - with safety foil forming detents around deep drawn pill cups |
US4398634A (en) * | 1981-11-12 | 1983-08-16 | Wrapade Machine Company, Inc. | Child-proof package system |
CH655913A5 (en) * | 1982-04-16 | 1986-05-30 | Ernst Ramseier | Packaging unit |
DE8902268U1 (en) * | 1989-02-25 | 1989-04-06 | Bayer Ag, 5090 Leverkusen | Device for dispensing solid dosage forms with electronic control and registration |
US4911304A (en) * | 1989-03-20 | 1990-03-27 | Merck & Co., Inc. | Sandwich blister package for tablets and similar articles |
US4955165A (en) * | 1989-05-04 | 1990-09-11 | Brooks Harvey L | Pipe tapering device |
US5046618A (en) * | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
EP0662918A1 (en) * | 1992-09-30 | 1995-07-19 | R.P. Scherer Corporation | Stepped-edge blister pack and use of steps |
US5325968A (en) * | 1993-07-14 | 1994-07-05 | Mcneil-Ppc, Inc. | Package for holding tablets |
US5620088A (en) | 1993-11-02 | 1997-04-15 | Johnson & Johnson Vision Products, Inc. | Packaging arrangement for contact lenses |
JP3892056B2 (en) * | 1994-06-10 | 2007-03-14 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | Contact lens packaging container and synthesized packaging means |
US5775505A (en) * | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
FR2760436B1 (en) | 1997-03-06 | 1999-04-16 | Oreal | MULTI-COMPARTMENT BAG |
JP4037464B2 (en) * | 1997-04-01 | 2008-01-23 | シーマ・ラブス・インコーポレイテッド | Blister package and package tablet |
US5899335A (en) * | 1997-07-07 | 1999-05-04 | Boyer; Mildred E. | Medication container and method of using |
DE19800682B4 (en) | 1998-01-10 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Process for producing a primary packaging for film or wafer-shaped administration forms |
US6036016A (en) * | 1998-04-20 | 2000-03-14 | Pinnacle Intellectual Property Services, Inc. | Blister package with easy tear blister |
FR2778893B1 (en) | 1998-05-19 | 2000-08-04 | Danisco Flexible France | MULTI-COMPARTMENT PACKAGING |
US6375956B1 (en) * | 1999-07-22 | 2002-04-23 | Drugtech Corporation | Strip pack |
DE10008165A1 (en) | 2000-02-23 | 2001-08-30 | Lohmann Therapie Syst Lts | Packaging of sheet-like objects with improved tear properties |
-
2001
- 2001-01-23 DE DE10102818A patent/DE10102818A1/en not_active Ceased
-
2002
- 2002-01-14 PT PT02702263T patent/PT1353857E/en unknown
- 2002-01-14 DE DE50200857T patent/DE50200857D1/en not_active Expired - Lifetime
- 2002-01-14 AT AT02702263T patent/ATE273869T1/en active
- 2002-01-14 KR KR1020037009742A patent/KR100808612B1/en active IP Right Grant
- 2002-01-14 WO PCT/EP2002/000287 patent/WO2002059012A1/en active IP Right Grant
- 2002-01-14 US US10/466,905 patent/US7293653B2/en not_active Expired - Lifetime
- 2002-01-14 EP EP02702263A patent/EP1353857B1/en not_active Expired - Lifetime
- 2002-01-14 ES ES02702263T patent/ES2227425T3/en not_active Expired - Lifetime
- 2002-01-14 DK DK02702263T patent/DK1353857T3/en active
- 2002-01-14 JP JP2002559320A patent/JP2004517011A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE50200857D1 (en) | 2004-09-23 |
US20040050749A1 (en) | 2004-03-18 |
JP2004517011A (en) | 2004-06-10 |
ATE273869T1 (en) | 2004-09-15 |
WO2002059012A1 (en) | 2002-08-01 |
DK1353857T3 (en) | 2004-12-27 |
US7293653B2 (en) | 2007-11-13 |
DE10102818A1 (en) | 2002-08-08 |
KR100808612B1 (en) | 2008-02-28 |
ES2227425T3 (en) | 2005-04-01 |
KR20030093201A (en) | 2003-12-06 |
PT1353857E (en) | 2004-12-31 |
EP1353857A1 (en) | 2003-10-22 |
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