EP1341541A4 - COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE - Google Patents

COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE

Info

Publication number
EP1341541A4
EP1341541A4 EP00980450A EP00980450A EP1341541A4 EP 1341541 A4 EP1341541 A4 EP 1341541A4 EP 00980450 A EP00980450 A EP 00980450A EP 00980450 A EP00980450 A EP 00980450A EP 1341541 A4 EP1341541 A4 EP 1341541A4
Authority
EP
European Patent Office
Prior art keywords
lowering
combination therapy
intraocular pressure
controlling intraocular
controlling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00980450A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1341541A1 (en
Inventor
Abbot F Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Manufacturing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Manufacturing Ltd filed Critical Alcon Manufacturing Ltd
Publication of EP1341541A1 publication Critical patent/EP1341541A1/en
Publication of EP1341541A4 publication Critical patent/EP1341541A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP00980450A 2000-11-16 2000-11-16 COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE Ceased EP1341541A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/031557 WO2002040030A1 (en) 2000-11-16 2000-11-16 Combination therapy for lowering and controlling intraocular pressure

Publications (2)

Publication Number Publication Date
EP1341541A1 EP1341541A1 (en) 2003-09-10
EP1341541A4 true EP1341541A4 (en) 2004-11-17

Family

ID=21742004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00980450A Ceased EP1341541A4 (en) 2000-11-16 2000-11-16 COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE

Country Status (5)

Country Link
EP (1) EP1341541A4 (ja)
JP (1) JP2004522711A (ja)
AU (2) AU1770901A (ja)
CA (1) CA2428799A1 (ja)
WO (1) WO2002040030A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
ATE517908T1 (de) 2005-01-10 2011-08-15 Glaxo Group Ltd Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
EP3006453A1 (en) 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors
CN108066283B (zh) * 2017-12-28 2020-03-24 兆科（广州）眼科药物有限公司 一种盐酸左倍他洛尔滴眼液的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007141A1 (en) * 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Method for treating glaucoma
US5747061A (en) * 1993-10-25 1998-05-05 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4904649A (en) * 1986-05-23 1990-02-27 New England Medical Center Hospitals, Inc. Method and solution for treating glaucoma
US4876250A (en) * 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
US5371078A (en) * 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US5153192A (en) * 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5153193A (en) * 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
AU678961B2 (en) * 1991-11-22 1997-06-19 Alcon Laboratories, Inc. Angiostatic steroids
ATE245451T1 (de) * 1998-04-07 2003-08-15 Alcon Lab Inc Xanthangummi enthaltende gelbildende ophthalmische zusammensetzungen
JP2003517441A (ja) * 1998-09-25 2003-05-27 アルコン ラボラトリーズ， インコーポレイテッド 徐放性で快適な眼疾病用組成物および眼疾病の治療方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007141A1 (en) * 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Method for treating glaucoma
US5747061A (en) * 1993-10-25 1998-05-05 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CONRAD T J ET AL: "METHODS IN LABORATORY INVESTIGATION IN VIVO MEASUREMENT OF CORNEAL ANGIOGENESIS WITH VIDEO DATA ACQUISITION AND COMPUTERIZED IMAGE ANALYSIS", LABORATORY INVESTIGATION, UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, BALTIMORE,, US, vol. 70, no. 3, 1994, pages 426 - 434, XP008028154, ISSN: 0023-6837 *
EDELMAN JEFFREY L ET AL: "Quantitative image analysis of laser-induced choroidal neovascularization in rat", EXPERIMENTAL EYE RESEARCH, vol. 71, no. 5, November 2000 (2000-11-01), pages 523 - 533, XP002287544, ISSN: 0014-4835 *
ELLIS P P ET AL: "INFLUENCE OF OPHTHALMIC OINTMENTS ON THE PENETRATION OF PILOCARPINE DROPS", JOURNAL OF OCULAR PHARMACOLOGY, vol. 5, no. 2, 1989, pages 119 - 126, XP009027604, ISSN: 8756-3320 *
HARRIS M A ET AL: "DESENSITIZATION TO TOPICAL EPINEPHRINE IN THE RABBIT EYE ATTENUATION BY DEXAMETHASONE", INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE, vol. 27, no. 12, 1986, pages 1737 - 1740, XP009033350, ISSN: 0146-0404 *
KIM M A ET AL: "EFFECTS OF DEXAMETHASONE ACETAZOLAMIDE AND SODIUM ORTHOVANADATE ON INTRAOCULAR PRESSURE IN RABBITS", JOURNAL OF CATHOLIC MEDICAL COLLEGE, vol. 37, no. 4, 1984, pages 1103 - 1112, XP001182346, ISSN: 0368-7015 *
KODAMA T ET AL: "PHARMACOLOGICAL STUDY ON THE EFFECTS OF SOME OCULAR HYPOTENSIVE DRUGS ON AQUEOUS HUMOR FORMATION IN THE ARTERIALLY PERFUSED ENUCLEATED RABBIT EYE", OPHTHALMIC RESEARCH, vol. 17, no. 2, 1985, pages 120 - 124, XP002273534, ISSN: 0030-3747 *
KROHNE S G ET AL: "Inhibition of pilocarpine-induced aqueous humor flare, hypotony, and miosis by topical administration of anti-inflammatory and anesthetic drugs to dogs.", AMERICAN JOURNAL OF VETERINARY RESEARCH. UNITED STATES APR 1998, vol. 59, no. 4, April 1998 (1998-04-01), pages 482 - 488, XP009027614, ISSN: 0002-9645 *
NAUCK MARKUS ET AL: "Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 341, no. 2-3, 12 January 1998 (1998-01-12), pages 309 - 315, XP002287545, ISSN: 0014-2999 *
See also references of WO0240030A1 *
SOUTHEREN A L ET AL: "TREATMENT OF GLAUCOMA WITH 3ALPHA,5BETA-TETRAHYDROCORTISOL: A NEW THERAPEUTIC MODALITY", JOURNAL OF OCULAR PHARMACOLOGY, MARY ANN LIEBERT, INC. NEW YORK, NY, US, vol. 10, no. 1, 1994, pages 385 - 391, XP009027697, ISSN: 8756-3320 *
YOUSUFZAI S Y K ET AL: "PROSTAGLANDIN F2ALPHA AND ITS ANALOGS INDUCE RELEASE OF ENDOGENOUS PROSTAGLANDINS IN IRIS AND CILIARY MUSCLES ISOLATED FROM CAT AND OTHER MAMMALIAN SPECIES", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD., LONDON, GB, vol. 63, 1996, pages 305 - 310, XP002927490, ISSN: 0014-4835 *

Also Published As

Publication number Publication date
WO2002040030A8 (en) 2002-11-07
AU2001217709B2 (en) 2005-10-13
AU1770901A (en) 2002-05-27
EP1341541A1 (en) 2003-09-10
WO2002040030A1 (en) 2002-05-23
JP2004522711A (ja) 2004-07-29
CA2428799A1 (en) 2002-05-23

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