EP1339404A2 - Zusammensetzung und verfahren - Google Patents
Zusammensetzung und verfahrenInfo
- Publication number
- EP1339404A2 EP1339404A2 EP01992146A EP01992146A EP1339404A2 EP 1339404 A2 EP1339404 A2 EP 1339404A2 EP 01992146 A EP01992146 A EP 01992146A EP 01992146 A EP01992146 A EP 01992146A EP 1339404 A2 EP1339404 A2 EP 1339404A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- day
- deterioration
- cognitive function
- composition
- accordance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Definitions
- This deterioration of cognitive function in older humans can now be prevented, inhibited or treated with specific components. These components can be administered in the diet or taken separately orally.
- composition comprising an antioxidant or mixture thereof quantities sufficient to a. prevent or b. inhibit, or r c. reverse deterioration of cognitive function
- a further aspect is a method of preventing, inhibiting or reversing deterioration of cognitive function through the administration of this composition.
- an antioxidant is a material that quenches a free radical.
- examples of such materials are beta-carotene, selenium, coenzyme Q10 (ubiquinone), lutein, tocotrienols, soy isoflavones, S-adenosylmethionine, glutathione, taurine, N-acetylcysteine, Vitamin E, Vitamin C, alpha-lipoic acid, 1- carnitine and the like.
- Vitamin E can be administered as a tocopherol or a mixture of tocopherols and various derivatives thereof such as esters like Vitamin E acetate, succinate, palmitate, and the like.
- the alpha form is preferable but beta, gamma and delta forms can be included.
- the d form is preferable but racemic mixtures are acceptable.
- the forms and derivatives will function in a Vitamin E like activity after ingestion.
- Vitamin C can be administered as ascorbic acid and its various derivatives thereof such as calcium phosphate salts, cholesteryl salt, 2-monophosphate, and the like which will function in a vitamin C like activity after ingesting by the human. They can be in any form such as liquid, semisolid, solid and heat stable form.
- Alpha-lipoic acid can be administered as alpha lipoic acid or as a lipoate derivative as in US Patent 5,621, 117, racemic mixtures, salts, esters or amides thereof.
- L-carnitine and various derivatives of carnitine such as the salts such as the hydrochloride, fumarate and succinate s, as well as acetylated carnitine, and the like can be used.
- the quantities administered to the human are calculated as the active material, per se, that is measured as specific material.
- the minimum amounts employed should not bring about toxicity.
- Vitamin E minimum is about 50 or 100 or 150 mg/day. Generally, no more than about 2,000 or desirably about 1,000 or about 750 mg/day can be employed.
- Vitamin C minimum quantities are generally about 150, about 200 or about 250 mg/day. Maximums generally do not exceed about 1,000 mg/day but can be lower, for example, about 900 or about 750 mg/day.
- Alpha lipoic acid can be administered up to about 10 or 20 mg/kg body weight/ day. Minimums are about .5 or 1 mg/kg body weight/ day.
- L-carnitine is administered in the same manner as alpha lipoic acid. Alpha lipoic acid and l-carnitine can be administered at much higher levels but there is no substantially different efficacy observed.
- Beta-carotene at least about 0.02 mg/kg body weight/ day 1-15 ppm can be employed.
- Lutein at least about 5 ppm mg/kg body weight/ day can be employed.
- Tocotrienols at least about 0.5 mg/kg body weight/ day can be employed.
- Coenzyme Q10 at least about 0.5 mg/kg body weight/ day can be employed.
- S-adenosylmethionine at least about 1.0 mg/kg body weight/ day can be employed.
- Taurine at least about 10 mg/kg body weight/ day can be employed.
- Soy isoflavones at least about 0.5 mg/kg body weight/ day can be used.
- N-acetylcysteine at least about 1.0 mg/kg/ body weight/ day can be used.
- Glutathione at least about 1.0 g/kg body weight/ day can be used.
- Ginkgo Biloba at least 1.0 mg/kg body weight/ day can be used.
- the quantities can be administered in a typical "one a day" dosage similar to a vitamin. It can be administered in tablet, capsule, caplet for example, or in a liquid carrier form all for ingestion by the human. Additionally, the daily dosage can be broken down into two, three, or four dosage unit forms for convenience or other reasons. Additionally, it can be administered in a food such as snack bars, cereals, and the like.
- Example 1
- a supplement or food providing 750 mg vitamin E, 250 mg/ vitamin C, 200 mg lipoic acid and 400 mg of l-carnitine is eaten by an adult human on a daily basis for 5 years starting at age 45.
- age of 50 no signs of mental deterioration such as disorientation, memory loss, learning impairment, or ability to cope independently with their environmental living situation, classified by objective (or nonobjective) tests such as Folstein's Mini-mental State Exam (MME), Logical Memory and Visual Reproduction tests from the Wechsler Memory Scale (WMS), Katz' scale of activities of daily living, Lawton's scale of instrumental activities of daily living, Pfeiffer's mental status questionnaire, or other pertinent tests as diagnosed by themselves, a care-giver, or health care provider, are observed.
- MME Folstein's Mini-mental State Exam
- WMS Wechsler Memory Scale
- Katz' scale of activities of daily living Lawton's scale of instrumental activities of daily living
- Pfeiffer's mental status questionnaire or other pertinent tests as
- MME Folstein's Mini-mental State Exam
- WMS Wechsler Memory Scale
- Katz' scale of activities of daily living Lawton's scale of instrumental activities of daily living
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US922633 | 1986-10-24 | ||
US24451100P | 2000-10-31 | 2000-10-31 | |
US244511P | 2000-10-31 | ||
US25344600P | 2000-11-28 | 2000-11-28 | |
US25344700P | 2000-11-28 | 2000-11-28 | |
US253446P | 2000-11-28 | ||
US253447P | 2000-11-28 | ||
US09/922,633 US20020052402A1 (en) | 2000-10-31 | 2001-08-06 | Composition and method |
PCT/US2001/048665 WO2002043666A2 (en) | 2000-10-31 | 2001-10-30 | Compositions containing an antioxidant such as alpha lipoic acid, carnitine, vitamin c or vitamin e for preventing or inhibiting loss of cognitive function |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1339404A2 true EP1339404A2 (de) | 2003-09-03 |
Family
ID=27500158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01992146A Withdrawn EP1339404A2 (de) | 2000-10-31 | 2001-10-30 | Zusammensetzung und verfahren |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1339404A2 (de) |
JP (1) | JP2004514686A (de) |
CN (1) | CN1477958A (de) |
AU (1) | AU2002232616A1 (de) |
CA (1) | CA2427470A1 (de) |
WO (1) | WO2002043666A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005185188A (ja) * | 2003-12-25 | 2005-07-14 | Nichirei Corp | アセロラ処理物およびl−カルニチン含有組成物 |
KR20060132667A (ko) * | 2004-01-28 | 2006-12-21 | 네스텍소시에테아노님 | 피부 상태 개선 및 피부 질환 예방을 위한 영양 조성물 |
EP1817058B1 (de) * | 2004-11-24 | 2015-09-02 | Hill's Pet Nutrition, Inc. | Zusammensetzung zur verwendung der verbesserung der beseitigung von xenobiotischen substanzen aus der leber bei einem tier |
RU2394561C2 (ru) * | 2004-11-24 | 2010-07-20 | Хилл`С Пет Ньютришн, Инк. | Способы увеличения иммунного ответа у животного |
US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
AU2006279429B2 (en) * | 2005-08-17 | 2010-02-25 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
CN1895671B (zh) * | 2005-12-08 | 2012-11-28 | 淮北辉克药业有限公司 | 治疗病毒型肝病的复方制剂 |
CN101045048B (zh) * | 2006-03-27 | 2011-05-18 | 中国科学院上海生命科学研究院 | 线粒体营养素组合物的应用 |
US20100076091A1 (en) * | 2007-02-14 | 2010-03-25 | Tohoku University | Composition and method for suppressing lipooxidation of erythrocyte |
EP2923582B1 (de) * | 2009-07-14 | 2018-03-21 | Hill's Pet Nutrition, Inc. | Haustierfutterzusammensetzung mit liponsäure mit verzögerter freisetzung |
EP2508179A1 (de) | 2011-04-05 | 2012-10-10 | Lonza Ltd. | Verwendung von L-Carnitin, Salzen und Derivaten davon zur Verringerung oder Vorbeugung von Ermüdung und zur Verbesserung der kognitiven Funktion |
CN103491954A (zh) | 2011-04-05 | 2014-01-01 | 隆萨有限公司 | L-肉碱、其盐及衍生物用于降低或预防疲劳和改善认知功能的用途 |
NL2024431B1 (en) * | 2019-12-11 | 2021-09-07 | Sulfateq Bv | Compounds for treatment of alzheimer’s disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06199690A (ja) * | 1992-03-06 | 1994-07-19 | Yunie:Kk | 脳代謝促進・脳機能改善剤 |
DE4343592C2 (de) * | 1993-12-21 | 1998-04-16 | Asta Medica Ag | Verwendung von R-(+)-alpha-Liponsäure und dessen Metaboliten in Form der freien Säure oder als Salze oder Ester oder Amide zur Behandlung von Glukosestoffwechselstörungen des zentralen Nervensystems |
FR2721516B1 (fr) * | 1994-06-27 | 1996-09-13 | Inst Rech Biolog Sa | Nouvelles utilisations d'un complexe à base de phospholipides cérébraux en thérapeutique et dans l'alimentation. |
US5977162A (en) * | 1996-09-16 | 1999-11-02 | Seidman; Michael D. | Therapeutic treatment for auditory function |
IT1302307B1 (it) * | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
AU3287200A (en) * | 1999-03-16 | 2000-10-04 | Merck Patent Gmbh | Composition comprising isoquercetin and ascorbic acid in a sustained release form |
AU3913800A (en) * | 1999-03-26 | 2000-10-16 | Lipogenics, Inc. | Novel antioxidant formulations and methods for using them |
DE19920316A1 (de) * | 1999-05-03 | 1999-12-09 | Heinz Kiefer | Arzneimittel als Antioxidans mit einer Vitamin-Spurenelement-Kombination zur Förderung der Funktionstüchtigkeit der Zellen |
US6646013B1 (en) * | 1999-06-15 | 2003-11-11 | Nutri-Logics | Nutrient formulations for disease reduction |
WO2001032168A1 (en) * | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
CA2399319A1 (en) * | 2000-01-25 | 2001-08-16 | Nathan D. Hamilton | Nutritional supplements for aged pets |
HU227182B1 (en) * | 2000-03-06 | 2010-09-28 | Andras Javor | Lecitin-ascorbic acid combination |
-
2001
- 2001-10-30 AU AU2002232616A patent/AU2002232616A1/en not_active Abandoned
- 2001-10-30 CN CNA018181880A patent/CN1477958A/zh active Pending
- 2001-10-30 JP JP2002545645A patent/JP2004514686A/ja active Pending
- 2001-10-30 WO PCT/US2001/048665 patent/WO2002043666A2/en not_active Application Discontinuation
- 2001-10-30 CA CA002427470A patent/CA2427470A1/en not_active Abandoned
- 2001-10-30 EP EP01992146A patent/EP1339404A2/de not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
M.H. BEERS, R. BERKOW: "The Merck Manual of Diagnosis and Therapy, Seventeenth Edition", 1999, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, N.J. * |
See also references of WO0243666A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002043666A2 (en) | 2002-06-06 |
CN1477958A (zh) | 2004-02-25 |
JP2004514686A (ja) | 2004-05-20 |
CA2427470A1 (en) | 2002-06-06 |
WO2002043666A3 (en) | 2003-01-30 |
AU2002232616A1 (en) | 2002-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030528 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
17Q | First examination report despatched |
Effective date: 20040430 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20061228 |