EP1336418A1 - Disposable syringe conditioning apparatus and related conditioning method - Google Patents
Disposable syringe conditioning apparatus and related conditioning method Download PDFInfo
- Publication number
- EP1336418A1 EP1336418A1 EP03425074A EP03425074A EP1336418A1 EP 1336418 A1 EP1336418 A1 EP 1336418A1 EP 03425074 A EP03425074 A EP 03425074A EP 03425074 A EP03425074 A EP 03425074A EP 1336418 A1 EP1336418 A1 EP 1336418A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- stopper
- inert gas
- truncated cone
- cone shaped
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2821—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
Definitions
- the present invention relates to an apparatus for conditioning disposable syringes.
- the present invention relates to a device for inserting the stopper into a syringe that has already been filled with a liquid product, normally a medicine or a pharmaceutical.
- containers such as ampoules, phials and syringes are filled in a substantially inert environment. This is because many medicinal substances tend to deteriorate in contact with air.
- the filling area is supplied with an inert gas such as nitrogen or carbon dioxide.
- inert gas means any gas that does not chemically react with the liquid substance contained in the syringe.
- Creating an inert environment is relatively simple for ampoules and phials which are filled using a cannula with a double lining, that is to say, having an inner duct for dosing the liquid product and an outer annular duct for discharging the inert gas.
- the inert gas discharged through the outer duct maintains the required inert environment during liquid filling operations and during subsequent sealing (of ampoules) and capping (of phials).
- the insertion of the stopper creates a movement of air which "blows" the inert gas away from the surface of the liquid.
- the aim of the present invention is to overcome the above mentioned drawbacks through an apparatus that creates an effective inert environment and that is, at the same time, functional, practical and economical to make.
- the present invention accordingly provides a disposable syringe conditioning apparatus comprising, within a defined working area, means for guiding and positioning a stopper inside a syringe, which is partly filled with a liquid substance, means for emitting an inert gas around the defined working area, the apparatus being characterised in that the emitting means comprise at least one outlet opening for introducing the inert gas into the guide and positioning means.
- the present invention also relates to a disposable syringe conditioning method.
- the present invention accordingly provides a disposable syringe conditioning method comprising the steps of placing a stopper inside respective guide and positioning means, pushing the stopper along a defined feed path through the guide and positioning means, inserting the stopper into the syringe, and introducing inert gas in the proximity of the syringe, the method being characterised in that the step of introducing the inert gas comprises the emission of the inert gas directly into the guide and positioning means.
- the numeral 1 denotes a portion of an apparatus for conditioning disposable syringes 2.
- the portion 1 forms a defined working area 3 of the conditioning apparatus.
- the apparatus 1 comprises a plunger 4 having a shaft 5 and, at the latter's lower end 5a, a tip 6 which engages with a stopper 7 designed to be inserted into the syringe 2, the latter being prefilled with a defined quantity of a liquid substance 8.
- the stopper 7 comprises a cylindrical body 9 and three elastic annular elements 10a, 10b, 10c, respectively, lower, central and upper elements, which are designed to come into sealed contact with an inside surface 11 of the syringe 2.
- the plunger 4 is reciprocatingly mobile in a straight direction D and is driven by customary drive means, for example, pneumatic or hydraulic, which are not illustrated.
- the plunger 4 engages with a bush 12 in such a way as to feed the stopper 7 along a defined feed path P that substantially coincides with the direction D.
- the bush 12 is mounted in a supporting block 13 and comprises a lower truncated cone shaped first portion 14 and an upper truncated cone shaped second portion 15.
- the truncated cone shaped first and second portions 14 and 15 have between them an interposed central cylindrical third portion 17 forming an annular band 18 whose centre is located on the feed path P of the stopper 7.
- the outlet openings 19 are connected, through a pneumatic conduit 21, to a source of the inert gas 20 under pressure, schematically represented as a block 22 in the drawings.
- the portion 1 also comprises a cylindrical tube 24 for guiding the stopper 7 and connected to the bush 12 at the lower end of the truncated cone shaped first portion 14.
- the outside diameter of the cylindrical guide tube 24 is smaller than the inside diameter of the syringe 2.
- the narrower end 15a of the truncated cone shaped second portion 15 has a rounded edge 15b that joins the second portion 15 to the cylindrical third portion 17 in such a way as not to damage the stopper 7 as the latter passes through the portions 15, 17.
- outlet openings 19 also have rounded edges 19a that do not damage the stopper 7 as it is pushed along the feed path P.
- the syringe 2 after being filled to a defined level with the liquid substance 8 at a customary dosing station which is not illustrated, is positioned under the mounting block 13 in a first, lowered position. Above the mounting block 13, the plunger 4 is at its raised end position.
- the stopper 7 is schematically represented as being suspended at an intermediate position between the plunger 4 and the mounting block 13 and is held in this position by customary supporting means which are not illustrated.
- Inert gas 20 is injected into the bush 12 through the pneumatic conduit 21 and outlet openings 19. The inert gas 20 spreads into the guide and positioning means 25 both above and below the outlet openings 19.
- the plunger 4 is lowered in the straight direction D by the aforementioned drive means (not illustrated) until its tip 6 engages with a cavity 26 formed in the cylindrical body 9 of the stopper 7.
- the plunger 4 As it moves down along the feed path P, pushes the stopper 7 into the upper truncated cone shaped second portion 15 of the bush 12. Owing to the narrowing cross section of the second portion 15, the stopper 7 is squeezed transversely, that is to say, its elastic annular seal elements 10a, 10b, 10c are deformed in such a way as to allow the stopper 7 to pass through the narrow end 15a of the second portion 15.
- the contact of at least one of the elastic annular elements 10a, 10b, 10c of the stopper 7 with the tapered inside surface of the truncated cone shaped second portion 15 stops the inert gas 20 from entering the second portion 15 and from spreading into the upper section of the guide means 25.
- Customary drive means which are not illustrated, now move the syringe 2 to a raised position in such a way that the stopper 7 guide tube 24 is inside the syringe 2, at a suitable distance from the surface 27 of the liquid substance 8 in the syringe 2.
- the inert gas 20 supplied to the lower section of the guide and positioning means 25 spreads over the surface 27 and, thanks to the clearance fit between the guide tube 24 and the inside surface 11 of the syringe 2, the inert gas 20 is free to flow out of the syringe 2. This prevents the pressure of the gas 20 from accumulating and causing turbulence in the liquid substance 8 in the syringe 2 or, worse still, pushing the liquid substance 8 out of the syringe 2 through the needle (not illustrated).
- the stopper 7 after going through the central cylindrical third portion 17 of the bush 12, is pushed by the plunger 4 into the lower truncated cone shaped first portion 14.
- the passage of the stopper 7 through the truncated cone shaped first portion 14 causes it to be transversely squeezed for a second time so that it can be inserted into the guide tube 24.
- the passage also allows the inert gas 20 to escape through aforementioned narrow end 15a of the upper truncated cone shaped second portion 15.
- the plunger 4 is lowered by the aforementioned drive means (not illustrated) in such way that it pushes the stopper 7 through the cylindrical guide tube 24 and positions it inside the syringe 2.
- the stopper 7 has moved into the guide tube 24 to reach its almost final position within the syringe 2.
- the instant the pushing action of the plunger 4 causes the lowermost portion of the stopper 7 to protrude from the guide tube 24 and to come into contact with the inside surface 11 of the syringe 2, the guide tube 24 and the syringe 2 are moved apart in such a way that the stopper 7 is left in its final, stable position without sliding against the inside surface 11 of the syringe 2.
- the aforementioned drive means (not illustrated) move the syringe 2 back to the lowered position and the plunger 4 withdraws in the straight direction D, as indicated by the arrow F.
- the aforementioned drive means (not illustrated) move the syringe 2 back to the lowered position and the plunger 4 withdraws in the straight direction D, as indicated by the arrow F.
- the emission of inert gas 20 at the cylindrical third portion 17 enables the inert gas 20 to accumulate in the annular sections 28 of the stopper 7, these annular sections 28 being axially delimited, as mentioned above, by the elastic annular seal elements 10a, 10b, 10c.
- the stopper 7 is squeezed into the truncated cone shaped first portion 14, a certain amount of inert gas 20 is trapped within the annular sections 28.
- the inert gas 20 trapped in the annular sections 28 augments the barrier effect created by the inert gas 20 between the surface 27 of the liquid substance 8 and the stopper 7, preventing contact between the liquid substance 8 and the outside atmosphere.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
- The present invention relates to an apparatus for conditioning disposable syringes.
- In particular, the present invention relates to a device for inserting the stopper into a syringe that has already been filled with a liquid product, normally a medicine or a pharmaceutical.
- In the liquid pharmaceutical packaging sector, it is known that containers such as ampoules, phials and syringes are filled in a substantially inert environment. This is because many medicinal substances tend to deteriorate in contact with air.
- To avoid contact with air, the filling area is supplied with an inert gas such as nitrogen or carbon dioxide.
- In the present specification, the term "inert gas" means any gas that does not chemically react with the liquid substance contained in the syringe.
- Creating an inert environment is relatively simple for ampoules and phials which are filled using a cannula with a double lining, that is to say, having an inner duct for dosing the liquid product and an outer annular duct for discharging the inert gas. The inert gas discharged through the outer duct maintains the required inert environment during liquid filling operations and during subsequent sealing (of ampoules) and capping (of phials).
- In the case of disposable syringes, on the other hand, the maintenance of a suitable inert environment during filling and subsequent insertion of the stopper presents several problems. In particular, it is extremely difficult to keep the required quantity of inert gas in contact with the surface of the liquid inside the syringe.
- In other words, the insertion of the stopper creates a movement of air which "blows" the inert gas away from the surface of the liquid.
- The aim of the present invention is to overcome the above mentioned drawbacks through an apparatus that creates an effective inert environment and that is, at the same time, functional, practical and economical to make.
- The present invention accordingly provides a disposable syringe conditioning apparatus comprising, within a defined working area, means for guiding and positioning a stopper inside a syringe, which is partly filled with a liquid substance, means for emitting an inert gas around the defined working area, the apparatus being characterised in that the emitting means comprise at least one outlet opening for introducing the inert gas into the guide and positioning means.
- The present invention also relates to a disposable syringe conditioning method.
- The present invention accordingly provides a disposable syringe conditioning method comprising the steps of placing a stopper inside respective guide and positioning means, pushing the stopper along a defined feed path through the guide and positioning means, inserting the stopper into the syringe, and introducing inert gas in the proximity of the syringe, the method being characterised in that the step of introducing the inert gas comprises the emission of the inert gas directly into the guide and positioning means.
- The technical characteristics of the invention, with reference to the above aims, are clearly described in the claims below and its advantages are apparent from the detailed description which follows, with reference to the accompanying drawings which illustrate a preferred embodiment of the invention provided merely by way of example without restricting the scope of the inventive concept, and in which:
- Figure 1 is a schematic side elevation view, with some parts in cross section and others cut away for clarity, of the disposable syringe conditioning apparatus according to the present invention in a first step of its process cycle;
- Figures 2 to 7 are schematic side elevation views, scaled down compared to Figure 1, showing six successive steps in the operation of the apparatus of Figure 1;
- Figure 8 is a schematic detail view, with some parts in cross section, showing a part of the apparatus illustrated in the other figures.
- With reference to the accompanying drawings, the
numeral 1 denotes a portion of an apparatus for conditioningdisposable syringes 2. - The
portion 1 forms a definedworking area 3 of the conditioning apparatus. - The
apparatus 1 comprises aplunger 4 having ashaft 5 and, at the latter'slower end 5a, atip 6 which engages with astopper 7 designed to be inserted into thesyringe 2, the latter being prefilled with a defined quantity of aliquid substance 8. - The
stopper 7 comprises acylindrical body 9 and three elasticannular elements inside surface 11 of thesyringe 2. - The
plunger 4 is reciprocatingly mobile in a straight direction D and is driven by customary drive means, for example, pneumatic or hydraulic, which are not illustrated. - As it moves in the direction D, the
plunger 4 engages with abush 12 in such a way as to feed thestopper 7 along a defined feed path P that substantially coincides with the direction D. - The
bush 12 is mounted in a supportingblock 13 and comprises a lower truncated cone shapedfirst portion 14 and an upper truncated cone shapedsecond portion 15. - The truncated cone shaped first and
second portions section 16 for elastically deforming the elasticannular elements - The truncated cone shaped first and
second portions third portion 17 forming anannular band 18 whose centre is located on the feed path P of thestopper 7. - At equal angular intervals around the
annular band 18 there is a plurality ofoutlet openings 19 for discharging aninert gas 20 into thebush 12. - The
outlet openings 19 are connected, through apneumatic conduit 21, to a source of theinert gas 20 under pressure, schematically represented as ablock 22 in the drawings. - The outlet openings 19, the
pneumatic conduit 21 and thesource 22 together constitute for theapparatus 1, means 23 for emitting theinert gas 20. - The
portion 1 also comprises acylindrical tube 24 for guiding thestopper 7 and connected to thebush 12 at the lower end of the truncated cone shapedfirst portion 14. The outside diameter of thecylindrical guide tube 24 is smaller than the inside diameter of thesyringe 2. - The
plunger 4, thebush 12 and thecylindrical tube 24 together constitute means 25 for guiding and positioning thestopper 7 in thesyringe 2. - As illustrated in more detail in Figure 8, the
narrower end 15a of the truncated cone shapedsecond portion 15 has arounded edge 15b that joins thesecond portion 15 to the cylindricalthird portion 17 in such a way as not to damage thestopper 7 as the latter passes through theportions - Similarly, the
outlet openings 19 also haverounded edges 19a that do not damage thestopper 7 as it is pushed along the feed path P. - With reference to use, the operation of the disposable
syringe conditioning apparatus 1 is illustrated in a succession of operating steps in Figures 1 to 7. - As shown in Figure 1, the
syringe 2, after being filled to a defined level with theliquid substance 8 at a customary dosing station which is not illustrated, is positioned under themounting block 13 in a first, lowered position. Above themounting block 13, theplunger 4 is at its raised end position. Thestopper 7 is schematically represented as being suspended at an intermediate position between theplunger 4 and themounting block 13 and is held in this position by customary supporting means which are not illustrated.Inert gas 20 is injected into thebush 12 through thepneumatic conduit 21 andoutlet openings 19. Theinert gas 20 spreads into the guide and positioning means 25 both above and below theoutlet openings 19. - With reference to Figure 2, the
plunger 4 is lowered in the straight direction D by the aforementioned drive means (not illustrated) until itstip 6 engages with acavity 26 formed in thecylindrical body 9 of thestopper 7. - As shown in Figure 3, the
plunger 4, as it moves down along the feed path P, pushes thestopper 7 into the upper truncated cone shapedsecond portion 15 of thebush 12. Owing to the narrowing cross section of thesecond portion 15, thestopper 7 is squeezed transversely, that is to say, its elasticannular seal elements stopper 7 to pass through thenarrow end 15a of thesecond portion 15. The contact of at least one of the elasticannular elements stopper 7 with the tapered inside surface of the truncated cone shapedsecond portion 15 stops theinert gas 20 from entering thesecond portion 15 and from spreading into the upper section of the guide means 25. Customary drive means, which are not illustrated, now move thesyringe 2 to a raised position in such a way that thestopper 7guide tube 24 is inside thesyringe 2, at a suitable distance from thesurface 27 of theliquid substance 8 in thesyringe 2. At this position, theinert gas 20 supplied to the lower section of the guide and positioning means 25 spreads over thesurface 27 and, thanks to the clearance fit between theguide tube 24 and theinside surface 11 of thesyringe 2, theinert gas 20 is free to flow out of thesyringe 2. This prevents the pressure of thegas 20 from accumulating and causing turbulence in theliquid substance 8 in thesyringe 2 or, worse still, pushing theliquid substance 8 out of thesyringe 2 through the needle (not illustrated). - As shown in Figure 4, the
stopper 7, after going through the central cylindricalthird portion 17 of thebush 12, is pushed by theplunger 4 into the lower truncated cone shapedfirst portion 14. The passage of thestopper 7 through the truncated cone shapedfirst portion 14 causes it to be transversely squeezed for a second time so that it can be inserted into theguide tube 24. The passage also allows theinert gas 20 to escape through aforementionednarrow end 15a of the upper truncated cone shapedsecond portion 15. - With reference to Figures 5 and 6, the
plunger 4 is lowered by the aforementioned drive means (not illustrated) in such way that it pushes thestopper 7 through thecylindrical guide tube 24 and positions it inside thesyringe 2. By this stage, therefore, thestopper 7 has moved into theguide tube 24 to reach its almost final position within thesyringe 2. The instant the pushing action of theplunger 4 causes the lowermost portion of thestopper 7 to protrude from theguide tube 24 and to come into contact with theinside surface 11 of thesyringe 2, theguide tube 24 and thesyringe 2 are moved apart in such a way that thestopper 7 is left in its final, stable position without sliding against theinside surface 11 of thesyringe 2. - More specifically, with reference to Figure 6, the aforementioned drive means (not illustrated) move the
syringe 2 back to the lowered position and theplunger 4 withdraws in the straight direction D, as indicated by the arrow F. During the steps of releasing thestopper 7 as just described, there is still a certain quantity ofinert gas 20 between thesurface 27 of theliquid substance 8 and thestopper 7 itself, and there is also someinert gas 20 inside theannular sections 28 delimited by the elasticannular seal elements - In Figure 7, the
plunger 4 is completely withdrawn from the guide and positioning means 24 and has returned to the initial retracted position shown in Figure 1, where it remains until another cycle like the one just described is started in order to insert thenext stopper 7 into thenext syringe 2. - Advantageously, with reference to the above description, the emission of
inert gas 20 at the cylindricalthird portion 17 enables theinert gas 20 to accumulate in theannular sections 28 of thestopper 7, theseannular sections 28 being axially delimited, as mentioned above, by the elasticannular seal elements stopper 7 is squeezed into the truncated cone shapedfirst portion 14, a certain amount ofinert gas 20 is trapped within theannular sections 28. When thestopper 7 is released in thesyringe 2, theinert gas 20 trapped in theannular sections 28 augments the barrier effect created by theinert gas 20 between thesurface 27 of theliquid substance 8 and thestopper 7, preventing contact between theliquid substance 8 and the outside atmosphere. - It will be understood that the invention can be subject to modifications and variations without thereby departing from the scope of the inventive concept. Moreover, all the details of the invention may be substituted by technically equivalent elements.
Claims (16)
- An apparatus for the conditioning of disposable syringes (2) comprising, within a defined working area (3):means (25) for guiding and positioning a stopper (7) in the syringe (2) that is partly filled with a liquid substance (8);means (23) for emitting an inert gas (20) around the defined working area (3);
- The apparatus according to claim 1, characterised in that the guide and positioning means (25) comprise a plunger (4) designed to push the stopper (7) into the syringe (2), along a defined feed path (P) through the guide and positioning means (25).
- The apparatus according to claims 1 and 2, where the stopper (7) is substantially cylindrical and has three elastic annular elements (10a, 10b, 10c) designed to engage with an inside surface (11) of the syringe (2), characterised in that the means (25) for guiding and positioning the stopper (7) comprise a section (16) designed to elastically deform at least the elastic annular elements (10a, 10b, 10c) so as to temporarily reduce the transversal dimension of the stopper (7).
- The apparatus according to claim 3, characterised in that the deforming section (16) comprises at least one first portion (14) which is substantially truncated cone shaped and through which the stopper (7) passes.
- The apparatus according to claim 4, characterised in that the deforming section (16) comprises at least one second portion (15), which is substantially truncated cone shaped and through which the stopper (7) passes, and which is located upstream of the first portion (14) relative to the feed path (P).
- The apparatus according to claim 5, characterised in that the outlet opening (19) for the inert gas (20) is located upstream of the truncated cone shaped first portion (14) along the defined feed path (P).
- The apparatus according to claims 4 and 5, characterised in that the outlet opening (19) is located between the truncated cone shaped first portion (14) and the truncated cone shaped second portion ((15).
- The apparatus according to any of the foregoing claims, characterised in that the emitting means (23) comprise a plurality of outlet openings (19) for the inert gas (20), these outlet openings (19) being distributed around an annular band (18) whose axis substantially coincides with the feed path (P) .
- The apparatus according to claim 8, characterised in that it comprises a substantially cylindrical third portion (17) located upstream of the truncated cone shaped first portion (14), the cylindrical third portion (17) constituting the annular band (18) around which the outlet openings (19) for the inert gas are distributed.
- The apparatus according to claim 9, characterised in that the substantially cylindrical third portion (17) is located between the truncated cone shaped first portion (14) and the truncated cone shaped second portion (15).
- The apparatus according to any of the foregoing claims from 2 to 10, characterised in that the outlet opening (19) for the inert gas (20) has a rounded edge (19a) so as not to damage the stopper (7) as it is pushed along the feed path (P).
- A method for the conditioning of disposable syringes (2) comprising the steps of:placing a stopper (7) inside respective guide and positioning means (25);pushing the stopper (7) along a defined feed path (P) through the guide and positioning means (25);pushing the stopper (7) into the syringe (2) that is at least partly filled with a liquid substance (8);introducing inert gas (20) in the proximity of the syringe (2);
- The method according to claim 12, where the stopper (7) is substantially cylindrical and has three elastic annular elements (10a, 10b, 10c) designed to engage with an inside surface (11) of the syringe (2), characterised in that the step of pushing the stopper (7) through the guide and positioning means (25) comprises a sub-step of elastically deforming at least the elastic annular elements (10a, 10b, 10c) so as to temporarily reduce their transversal dimensions.
- The method according to claim 13, characterised in that the sub-step of elastically deforming the elastic annular elements (10a, 10b, 10c) is carried out at a defined section (16) of the guide and positioning means (25), the section (16) having at least a truncated cone shaped first portion (14).
- The method according to claim 14, characterised in that the emission of inert gas (20) through at least one outlet opening (19) occurs upstream of the truncated cone shaped first portion (14) along the defined feed path (P).
- The method according to claims 14 and 15, characterised in that the emission of inert gas (20) through at least one outlet opening (19) occurs at a cylindrical third portion (17) of the defined section (16), the third portion (17) being located between the truncated cone shaped first portion (14) and a truncated cone shaped second portion (15) located upstream of the first portion (14).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITBO20020072 | 2002-02-14 | ||
IT2002BO000072A ITBO20020072A1 (en) | 2002-02-14 | 2002-02-14 | EQUIPMENT FOR THE CONDITIONING OF DISPOSABLE SYRINGES AND RELATED CONDITIONING METHOD |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1336418A1 true EP1336418A1 (en) | 2003-08-20 |
EP1336418B1 EP1336418B1 (en) | 2004-10-06 |
Family
ID=11439902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03425074A Expired - Lifetime EP1336418B1 (en) | 2002-02-14 | 2003-02-10 | Disposable syringe conditioning apparatus and related conditioning method |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1336418B1 (en) |
AT (1) | ATE278429T1 (en) |
DE (1) | DE60300066T2 (en) |
ES (1) | ES2229198T3 (en) |
IT (1) | ITBO20020072A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102019214071A1 (en) * | 2019-09-16 | 2021-03-18 | Rentschler Biopharma SE | Device and method for closing syringe bodies |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2896381A (en) * | 1954-05-27 | 1959-07-28 | Hodes Lange Corp | Method and apparatus for treating and filling ampoules |
GB1217421A (en) * | 1967-01-10 | 1970-12-31 | Helmut Sickel | Method and apparatus for filling and sealing ampoules |
US3670786A (en) * | 1970-06-02 | 1972-06-20 | American Home Prod | Container filling apparatus |
US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
-
2002
- 2002-02-14 IT IT2002BO000072A patent/ITBO20020072A1/en unknown
-
2003
- 2003-02-10 DE DE60300066T patent/DE60300066T2/en not_active Expired - Lifetime
- 2003-02-10 ES ES03425074T patent/ES2229198T3/en not_active Expired - Lifetime
- 2003-02-10 AT AT03425074T patent/ATE278429T1/en active
- 2003-02-10 EP EP03425074A patent/EP1336418B1/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2896381A (en) * | 1954-05-27 | 1959-07-28 | Hodes Lange Corp | Method and apparatus for treating and filling ampoules |
GB1217421A (en) * | 1967-01-10 | 1970-12-31 | Helmut Sickel | Method and apparatus for filling and sealing ampoules |
US3670786A (en) * | 1970-06-02 | 1972-06-20 | American Home Prod | Container filling apparatus |
US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
Also Published As
Publication number | Publication date |
---|---|
DE60300066T2 (en) | 2005-09-08 |
ITBO20020072A0 (en) | 2002-02-14 |
ITBO20020072A1 (en) | 2003-08-14 |
ATE278429T1 (en) | 2004-10-15 |
ES2229198T3 (en) | 2005-04-16 |
DE60300066D1 (en) | 2004-11-11 |
EP1336418B1 (en) | 2004-10-06 |
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