Classifications

• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/26—Organic compounds containing nitrogen
  • C11D3/30—Amines; Substituted amines ; Quaternized amines
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/26—Organic compounds containing nitrogen
  • C11D3/33—Amino carboxylic acids
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/38—Products with no well-defined composition, e.g. natural products
  • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
  • C11D7/22—Organic compounds
  • C11D7/32—Organic compounds containing nitrogen
  • C11D7/3218—Alkanolamines or alkanolimines
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
  • C11D7/22—Organic compounds
  • C11D7/32—Organic compounds containing nitrogen
  • C11D7/3245—Aminoacids
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
  • C11D7/22—Organic compounds
  • C11D7/32—Organic compounds containing nitrogen
  • C11D7/3254—Esters or carbonates thereof

Definitions

• the invention relates to a detergent concentrate, the Use for cleaning and / or disinfecting medical Instruments and / or apparatus and corresponding cleaning processes.
• Surgical instruments and other medical devices are usually used in the hospital using alkaline Detergent cleaned by machine and then chemically or thermally disinfected.
• alkaline Detergent cleaned by machine and then chemically or thermally disinfected.
• Such strongly alkaline Agents can be aggressive to sensitive surfaces Act.
• Surgical instruments contaminated with blood often immediately after use, for example in an aldehyde-containing Disinfectant solution stored and remain in it initially until they are cleaned in the dishwasher become.
• the blood is coagulated by the disinfectant and the protein components contained in the blood denatured the aldehydic disinfectant.
• Such especially stubborn blood residues are often just through remove cleaning agents containing alkaline active chlorine.
• the oxidizing active chlorine component causes the decomposition of the denatured protein components.
• Other ingredients too of disinfectants such as iodine can be difficult form removing residues.
• the alkaline, active chlorine-containing cleaners have the disadvantages that they contain hazardous substances that require labeling, that special precautions when handling them are necessary to protect the operating personnel and that they represent an undesirable environmental impact in wastewater.
• EP-A-1 021 519 discloses an enzyme-free detergent concentrate for cleaning surgical instruments. As a disadvantage the enzymatic cleaner is called there that the enzyme activity can wear off after long storage.
• the invention has for its object a cleaning agent concentrate to create a good cleaning effect against mixed impurities occurring in the hospital area such as coagulated blood and disinfectant residues shows and the build-up of residual impurities such as protein or lime deposits on the cleaned instruments and the dishwasher used counteracts itself.
• the invention further relates to the use of such Concentrate for cleaning and / or disinfecting medical and / or surgical instruments and / or apparatus.
• the invention is based on the surprising finding that the combination of alkanolamine, complexing agent and enzyme storage-stable detergent concentrate results in the frame machine-dried, preheated or with, for example, aldehydic disinfectants denatured blood residues from surgical instruments can remove properly. Even disinfectants Frequently resulting iodine residues or their reaction products with blood components are removed.
• a special The advantage of the invention is that the structure of protein and / or alkaline earth salts or mixtures thereof on instruments and the interior of the dishwasher avoided becomes; Such deposits build up when using cleaning agent concentrates the state of the art frequently many rinse cycles and cannot or only afterwards difficult to remove.
• the cleaner concentrate according to the invention surprisingly avoids such deposit formation or removes existing deposits from cleaning processes the state of the art again.
• the enzymes contained in the concentrate according to the invention can in particular be amylases or proteases.
• proteolytic Enzymes are preferred.
• the amount of this proteolytic Enzyme is preferably between 0.005 and 0.1 Anson units per gram of concentrate.
• the alkanolamine content is preferably between 10 and 40% by weight, further 10 and 20% by weight, more preferably 10 and 15% by weight.
• Another preferred lower limit for the alkanolamine content is 11% by weight, the preferred ones Accordingly, ranges are 11 to 40, 11 to 20, and 11 up to 15% by weight.
• the alkanolamines used preferably have the following structure: wherein R 1 represents a hydroxyalkyl group having 1 to 6 carbon atoms and wherein R 2 and R 3 independently of one another represent the hydroxyalkyl group mentioned or hydrogen.
• Mono-, di- and / or triethanolamine are particularly preferred.
• the complexing agent content is preferably between 3 and 15% by weight, more preferably between 3 and 10% by weight, further preferably between 4 and 8% by weight, more preferably between 5 and 7% by weight.
• the complexing agents are used for water softening and can the cleaning effect by complexing alkaline earth ions improve over lime soaps.
• the complexing agents can it is homopolymers, copolymers or terpolymers based on Acrylic acid or its alkali salts are also phosphonic acids or their alkali salts, such as, for example, 1-hydroxyethane-1,1-diphosphonic acid, Aminotrismethylenephosphonic acid, ethylenediaminotetrakismethylenephosphonic acid, phosphonobutane; Tartaric acid, citric acid and gluconic acid; further Nitrilotriacetic acid or ethylenediaminotetraacetic acid or their salts.
• the use of chelating agents is preferred, in particular aminopolycarboxylic acids and their salts.
• the concentrate according to the invention can be nitrilotriacetic acid and / or a salt of this acid, particularly preferably its Trisodium salt.
• This addition of NTA surprisingly has the effect particularly good lime soap removal even with low pH values in the range 6 to 9.
• the addition of NTA is also advantageous if the concentrate with a high mineral content (hard) water to a ready-to-use solution should be applied.
• the detergent concentrate in ready-to-use diluted aqueous solution a pH of 9 to 11, preferably 9.5 to 10.5 on.
• Another embodiment of the invention is neutral to slightly alkaline and has a ready-to-use dilution aqueous solution has a pH of 6 to 9, preferably 7 to 9 on.
• a 0.5-100% aqueous solution of the detergent concentrate Roger that. If within the scope of the present application pH values of a dilute solution of the detergent concentrate are measured, is fully desalted as a solvent Water (demineralized water) used. If the concentrate with Common tap water prepared for a ready-to-use solution depending on the nature of this water slightly different pH values result.
• the pH is adjusted to the range mentioned preferably by adding acids and / or more suitable Buffer systems.
• Citric acid is special prefers.
• the acids are preferred to the concentrate in an amount of 0.5 to 15% by weight, more preferably 2 up to 10 wt .-% added. Some of these are organic Acids such as citric acid are simultaneous Complexing agents in the sense of the invention.
• the corrosive effect of complexing agents such as NTA on anodized aluminum surfaces and the like can be reduced or completely avoided by adding at least one mono- and / or diester of phosphoric acid with aliphatic alcohols of chain length C 1 to C 22 and / or aliphatic diols and / or aliphatic polyols of chain length C 2 to C 22 .
• a diester of phosphoric acid with butanol on the one hand and ethylene glycol on the other hand is particularly preferred.
• This ester is commercially available under the name Hordaphos® MDGB. According to the invention, a good cleaning action is obtained even when using hard water and a gentle action on exloxed aluminum surfaces.
• preservatives can be added to the concentrate are, for example p-hydroxybenzoic acid or its methyl ester, 5-bromo-5-nitro-1,3-dioxane, Salicylic acid, 2-naphthyl-m-N-dimethylthiocarbanilate, 5-chloro-5-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and mixtures of the latter two Links.
• a preferred preservative is p-hydroxybenzoic acid or its methyl ester. With help This preservative can be attacked by microbes and fungi avoid the detergent concentrate.
• assembly aids such as sodium cumene sulfonate, sodium toluenesulfonate, Sodium xylene sulfonate, urea, glycols, in particular polypropylene glycols and polyethylene glycols, methylacetamide and fatty alcohols such as or cetyl alcohol.
• wetting agents for example, wetting agents, emulsifiers, anti-foaming agents or the like can be added.
• the addition of N-acylglutamate is advantageous as a wetting agent.
• Usual ionic, nonionic or amphoteric Surfactants can also be added.
• this detergent concentrate for cleaning and / or medical and / or surgical disinfection Instruments and / or apparatus are preferably made by machine. Such machine cleaning is done without human To do during an automatic program run, in particular in a conventional instrument dishwasher.
• Characteristic "cleaning and / or disinfection" should be expressed brought that the concentrate according to the invention both when combining cleaning and disinfection in one single process step as well as used in program sequences can be a separate step in a cleaning step Disinfection step follows. In this case the concentrate according to the invention in both of these steps usable.
• the aqueous solution of the detergent concentrate is applied preferably by spraying, but can, for example. also done by immersion or watering.
• the concentrate can be in a very high concentration, possibly pure, as finer Mists are sprayed on and initially in this high concentration or act pure. Then, if necessary, additional Water is applied to the instruments to be cleaned and the diluted cleaning solution is circulated and again by spraying onto the instruments to be cleaned applied.
• the action defined in step b) can be after application the cleaning solution is left to act, i.e. without continuous application or spraying or mechanical Circulate or move the cleaning solution. So can for example, especially highly concentrated cleaning solution first be sprayed on, after spraying it will then let act.
• the exposure period can also be sections include in which the cleaning solution is continuous is again applied or sprayed onto the instruments and / or mechanically circulated or in any other way and way is moved.
• a combination is also advantageous of these two action cards, i.e. allow them to act first especially highly concentrated detergent solution at rest and then dilute the cleaner with water while running Circulation and spraying again.
• the aqueous solution of the detergent concentrate is advantageously as 0.5 to 20%, preferably as 0.5 to 10%, more preferably as 1 to 5% aqueous solution applied. During the exposure period the solution can of the concentrate further diluted with additional water a minimum concentration of 0.5% not fall below. It should be noted that all Percentages are percentages by weight.
• step b) is preferably done at Room temperature up to 55 ° C, more preferably at 35 - 50 ° C, particularly preferred at 40 - 50 ° C. Exposure temperatures of a little over 40 ° C has proven to be particularly advantageous, because it achieves a good cleaning effect and on the other hand the instruments to be cleaned be spared.
• the action time in step b) is advantageously 10 s to 10 min, preferably 30 s to 5 min.
• the list of process steps contained in claim 17 is not final. Additional advance or rinsing steps can be provided, or several Cleaning steps can be provided one after the other.
• Prefers is also an additional disinfection step, for example. can be done by chemical disinfectants. Especially thermal disinfection is preferred. This can be used as a downstream step, for example with fully desalinated Water at 85 ° C to 95 ° C, preferably 93 ° C. This Water can also be used for rinsing according to step c) be so that rinsing and thermal disinfection can be combined with each other. However, the Thermal disinfection step instead of using fresh water the cleaning solution heated to the appropriate temperature step b).
• the invention achieves a good cleaning effect, in particular even in difficult to access areas of surgical instruments, for example in the joint area of scissors.
• a cleaning agent concentrate according to the invention is prepared using the information in the table below.
• the amounts of the starting materials to be used are given in parts by weight.
• the instruments to be cleaned are in a one-tank dishwasher initially for 2 minutes at room temperature Cold water pre-rinsed. Then the dishwasher with cold water and the detergent concentrate according to Example 1 dosed in a concentration of 5 ml / l. The cleaning solution is heated to 50 ° C and 5 minutes kept at this temperature. During this time circulating the cleaning solution while rinsing the instruments.

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• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Wood Science & Technology (AREA)
• Organic Chemistry (AREA)
• Detergent Compositions (AREA)
• Apparatus For Disinfection Or Sterilisation (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)

Priority Applications (5)

Applications Claiming Priority (1)

Publications (2)

Family

ID=8185240

Family Applications (1)

Country Status (5)

Cited By (4)

Families Citing this family (1)

Citations (5)

• 2002
  • 2002-01-11 EP EP02000728A patent/EP1327674B1/fr not_active Expired - Lifetime
  • 2002-01-11 DE DE50212407T patent/DE50212407D1/de not_active Expired - Lifetime
  • 2002-01-11 AT AT02000728T patent/ATE399199T1/de active
  • 2002-01-11 ES ES02000728T patent/ES2307676T3/es not_active Expired - Lifetime
  • 2002-01-11 PT PT02000728T patent/PT1327674E/pt unknown

Patent Citations (5)

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