EP1267898A4 - Bile acid containing prodrugs with enhanced bioavailability - Google Patents

Bile acid containing prodrugs with enhanced bioavailability

Info

Publication number
EP1267898A4
EP1267898A4 EP01926709A EP01926709A EP1267898A4 EP 1267898 A4 EP1267898 A4 EP 1267898A4 EP 01926709 A EP01926709 A EP 01926709A EP 01926709 A EP01926709 A EP 01926709A EP 1267898 A4 EP1267898 A4 EP 1267898A4
Authority
EP
European Patent Office
Prior art keywords
acid containing
bile acid
containing prodrugs
enhanced bioavailability
bioavailability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01926709A
Other languages
German (de)
French (fr)
Other versions
EP1267898A2 (en
Inventor
James E Polli
Andrew Coop
Dean Y Maeda
Kimberley A Lentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland at Baltimore
Original Assignee
University of Maryland at Baltimore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland at Baltimore filed Critical University of Maryland at Baltimore
Publication of EP1267898A2 publication Critical patent/EP1267898A2/en
Publication of EP1267898A4 publication Critical patent/EP1267898A4/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP01926709A 2000-04-07 2001-04-06 Bile acid containing prodrugs with enhanced bioavailability Ceased EP1267898A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19585400P 2000-04-07 2000-04-07
US195854P 2000-04-07
US26990601P 2001-02-21 2001-02-21
US269906P 2001-02-21
PCT/US2001/011327 WO2001076531A2 (en) 2000-04-07 2001-04-06 Bile acid containing prodrugs with enhanced bioavailability

Publications (2)

Publication Number Publication Date
EP1267898A2 EP1267898A2 (en) 2003-01-02
EP1267898A4 true EP1267898A4 (en) 2006-02-01

Family

ID=26891401

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01926709A Ceased EP1267898A4 (en) 2000-04-07 2001-04-06 Bile acid containing prodrugs with enhanced bioavailability

Country Status (5)

Country Link
EP (1) EP1267898A4 (en)
JP (1) JP2003530329A (en)
AU (3) AU5322601A (en)
CA (1) CA2405151A1 (en)
WO (1) WO2001076531A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002032376A2 (en) 2000-10-06 2002-04-25 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
WO2002028881A1 (en) * 2000-10-06 2002-04-11 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
US7144877B2 (en) 2000-10-06 2006-12-05 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
AU2003303714B2 (en) 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
WO2006012725A1 (en) * 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds
AU2007230991A1 (en) * 2006-03-22 2007-10-04 Syndexa Pharmaceuticals Corporation Compounds and methods for treatment of disorders associated with ER stress
JP5201546B2 (en) * 2008-01-18 2013-06-05 学校法人近畿大学 N-acetylcysteine-conjugated bile acid, pharmaceutical composition containing the same and method for producing the same
WO2016070082A1 (en) 2014-10-31 2016-05-06 University Of Utah Research Foundation Compositions and methods for bile acid particles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012927A1 (en) * 1997-09-11 1999-03-18 Commonwealth Scientific And Industrial Research Organisation Purine acyclonucleosides as antiviral agents
WO2000058337A1 (en) * 1999-03-27 2000-10-05 Karo Bio Ab Liver specific bile acid derivatives of the glucocorticoid antagonist ru486
WO2001020331A1 (en) * 1999-09-14 2001-03-22 Xenoport, Inc. Substrates and screening methods for transport proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012927A1 (en) * 1997-09-11 1999-03-18 Commonwealth Scientific And Industrial Research Organisation Purine acyclonucleosides as antiviral agents
WO2000058337A1 (en) * 1999-03-27 2000-10-05 Karo Bio Ab Liver specific bile acid derivatives of the glucocorticoid antagonist ru486
WO2001020331A1 (en) * 1999-09-14 2001-03-22 Xenoport, Inc. Substrates and screening methods for transport proteins

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
KRAMER ET AL (ED PAUMGARTNER ET AL): "Bile Acids and the Hepatobiliary System (ISBN 0792388291)", 1993, KLUWER, DORDRECHT, NETHERLANDS, XP008056225 *
KRAMER W ET AL: "Bile acid derived HMG-CoA reductase inhibitors", BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR BASIS OF DISEASE 1994 NETHERLANDS, vol. 1227, no. 3, 1994, pages 137 - 154, XP002355916, ISSN: 0925-4439 *
KRAMER W ET AL: "LIVER-SPECIFIC DRUG TARGETING BY COUPLING TO BILE ACIDS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 267, no. 26, 15 September 1992 (1992-09-15), pages 18598 - 18604, XP000453577, ISSN: 0021-9258 *
KRAMER W ET AL: "Modified bile acids as carriers for peptides and drugs", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 1-2, 5 May 1997 (1997-05-05), pages 17 - 30, XP004096309, ISSN: 0168-3659 *
MILLS C O ET AL: "BILIARY EXCRETION OF CHENODEOXYCHOLYLLYSYLRHODAMINE IN WISTAR RATS A POSSIBLE ROLE OF A BILE ACID AS A CARRIER FOR DRUGS", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1126, no. 1, 1992, pages 35 - 40, XP002355917, ISSN: 0006-3002 *
See also references of WO0176531A3 *
STEPHAN Z F ET AL: "REDUCTION OF CARDIOVASCULAR AND THYROXINE-SUPPRESSING ACTIVITIES OFL-T3 BY LIVER TARGETING WITH CHOLIC ACID", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 43, no. 9, 8 May 1992 (1992-05-08), pages 1969 - 1974, XP000982833, ISSN: 0006-2952 *
SWAAN P W ET AL: "Enhanced transepithelial transport of peptides by conjugation to cholic acid", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 8, no. 4, 1997, pages 520 - 525, XP002158726, ISSN: 1043-1802 *

Also Published As

Publication number Publication date
AU2001253226B2 (en) 2006-06-08
CA2405151A1 (en) 2001-10-18
WO2001076531A2 (en) 2001-10-18
AU5322601A (en) 2001-10-23
WO2001076531A3 (en) 2002-02-14
AU2006202213A1 (en) 2006-06-15
JP2003530329A (en) 2003-10-14
EP1267898A2 (en) 2003-01-02

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