EP1196760A4 - Integrierender breitbandwellenleitersensor - Google Patents

Integrierender breitbandwellenleitersensor

Info

Publication number
EP1196760A4
EP1196760A4 EP00919511A EP00919511A EP1196760A4 EP 1196760 A4 EP1196760 A4 EP 1196760A4 EP 00919511 A EP00919511 A EP 00919511A EP 00919511 A EP00919511 A EP 00919511A EP 1196760 A4 EP1196760 A4 EP 1196760A4
Authority
EP
European Patent Office
Prior art keywords
optical signals
waveguides
sensing
waveguide
length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00919511A
Other languages
English (en)
French (fr)
Other versions
EP1196760B1 (de
EP1196760A1 (de
Inventor
Mark J Feldstein
Brian D Maccraith
Frances S Ligler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Navy
Original Assignee
US Department of Navy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Navy filed Critical US Department of Navy
Publication of EP1196760A1 publication Critical patent/EP1196760A1/de
Publication of EP1196760A4 publication Critical patent/EP1196760A4/de
Application granted granted Critical
Publication of EP1196760B1 publication Critical patent/EP1196760B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Fluid Pressure (AREA)
  • Measurement Of Resistance Or Impedance (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
EP00919511A 1999-06-21 2000-03-22 Integrierender sensor mit mehreren wellenleitern Expired - Lifetime EP1196760B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/336,729 US6137117A (en) 1999-06-21 1999-06-21 Integrating multi-waveguide sensor
US336729 1999-06-21
PCT/US2000/007503 WO2000079240A1 (en) 1999-06-21 2000-03-22 Integrating multi-waveguide sensor

Publications (3)

Publication Number Publication Date
EP1196760A1 EP1196760A1 (de) 2002-04-17
EP1196760A4 true EP1196760A4 (de) 2005-03-02
EP1196760B1 EP1196760B1 (de) 2008-06-11

Family

ID=23317400

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00919511A Expired - Lifetime EP1196760B1 (de) 1999-06-21 2000-03-22 Integrierender sensor mit mehreren wellenleitern

Country Status (8)

Country Link
US (1) US6137117A (de)
EP (1) EP1196760B1 (de)
JP (1) JP2003502660A (de)
KR (1) KR100696237B1 (de)
AT (1) ATE398283T1 (de)
CA (1) CA2375425A1 (de)
DE (1) DE60039172D1 (de)
WO (1) WO2000079240A1 (de)

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US7399628B2 (en) * 2001-06-15 2008-07-15 Bayer Technology Services Gmbh Body for flow-through cells and the use thereof
US6873638B2 (en) * 2001-06-29 2005-03-29 3M Innovative Properties Company Laser diode chip with waveguide
US20030022394A1 (en) * 2001-07-27 2003-01-30 Dumas David P. Biochips and methods of making same
US6767733B1 (en) 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
US20040020993A1 (en) * 2001-12-28 2004-02-05 Green Larry R. Method for luminescent identification and calibration
US6850657B2 (en) * 2002-02-08 2005-02-01 The Research Foundation Of State University Of New York Capillary waveguide fluorescence sensor
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
JP2005537486A (ja) * 2002-09-03 2005-12-08 ツェプトゼンス　アクチエンゲゼルシャフト 分析対象物が試料中で固定化された特異的結合パートナーとして測定される分析プラットフォーム及び検出法
FR2846745B1 (fr) * 2002-10-30 2004-12-24 Genewave Dispositif de support d'elements chromophores.
US20060068412A1 (en) * 2004-03-05 2006-03-30 Cha-Mei Tang Integrated multistep bioprocessor and sensor
MXPA06014781A (es) 2004-07-02 2007-03-23 Bayer Healthcare Llc Sensor de prueba de guia de luz para uso en la determinacion de un analito en una muestra de fluido y metodos de manufactura del mismo.
US7496245B2 (en) * 2004-08-20 2009-02-24 Research International, Inc. Misalignment compensating optical sensor and method
US7291824B2 (en) * 2005-12-22 2007-11-06 Palo Alto Research Center Incorporated Photosensing throughout energy range and in subranges
US7522786B2 (en) 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
US7257279B2 (en) * 2004-09-20 2007-08-14 3M Innovative Properties Company Systems and methods for biosensing and microresonator sensors for same
US7547904B2 (en) * 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7315667B2 (en) * 2005-12-22 2008-01-01 Palo Alto Research Center Incorporated Propagating light to be sensed
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
GR20050100623A (el) * 2005-12-27 2007-07-23 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος" Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US7454102B2 (en) * 2006-04-26 2008-11-18 Honeywell International Inc. Optical coupling structure
EP1918693A1 (de) * 2006-10-31 2008-05-07 Honeywell International, Inc. Optische Wellenleitersensorvorrichtungen und Verfahren zu ihrer Herstellung und Verwendung
US20080101744A1 (en) * 2006-10-31 2008-05-01 Honeywell International Inc. Optical Waveguide Sensor Devices and Methods For Making and Using Them
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US8449833B2 (en) * 2007-10-29 2013-05-28 Koninklijke Philips Electronics N.V. Frustrated total internal reflection biosensor cartridge
US8320983B2 (en) 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US8373860B2 (en) 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8463083B2 (en) * 2009-01-30 2013-06-11 Claudio Oliveira Egalon Side illuminated multi point multi parameter optical fiber sensor
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
EP2425286B1 (de) 2009-04-29 2020-06-24 Ldip, Llc Auf wellenleitern basierendes detektionssystem mit abtastlichtquelle
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
CA2930836A1 (en) 2013-11-17 2015-05-21 Quantum-Si Incorporated Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
EP2916125A1 (de) * 2014-03-07 2015-09-09 One Drop Diagnostics Sàrl Fluoreszenz-Assays auf mikrofluidischen Chips
WO2016023010A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting, and analyzing molecules
MX2017001808A (es) 2014-08-08 2018-02-08 Quantum Si Inc Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas.
US9759658B2 (en) 2014-08-08 2017-09-12 Quantum-Si Incorporated Integrated device for temporal binning of received photons
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
WO2016162880A1 (en) * 2015-04-10 2016-10-13 Indian Institute Of Technology Madras A novel ultrasonic waveguide technique for distributed sensing and measurements of physical and chemical properties of surrounding media
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CA3012705A1 (en) 2016-02-17 2017-08-24 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
USD811196S1 (en) * 2017-02-15 2018-02-27 Bluewater Resources LLC Transport-container lock
USD811197S1 (en) * 2017-02-15 2018-02-27 Bluewater Resources LLC Transport-container lock
AU2019288394A1 (en) 2018-06-22 2021-01-07 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time

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US5809185A (en) * 1996-04-26 1998-09-15 Mitchell; Ralph Sensor for detecting microorganisms
US5841914A (en) * 1996-04-17 1998-11-24 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection

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CZ347196A3 (en) * 1994-05-27 1997-06-11 Ciba Geigy Ag Method of detecting evanescently excited luminescence
US5809184A (en) * 1996-10-15 1998-09-15 Doerr; Christopher Richard Polarization diversity waveguide grating receiver

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US5841914A (en) * 1996-04-17 1998-11-24 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US5809185A (en) * 1996-04-26 1998-09-15 Mitchell; Ralph Sensor for detecting microorganisms

Non-Patent Citations (1)

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Title
FELDSTEIN M J ET AL: "Array Biosensor: Optical and Fluidics Systems", JOURNAL OF BIOMEDICAL MICRODEVICES, vol. 1, no. 2, 1999, pages 139 - 153, XP002311997 *

Also Published As

Publication number Publication date
WO2000079240A1 (en) 2000-12-28
DE60039172D1 (de) 2008-07-24
EP1196760B1 (de) 2008-06-11
ATE398283T1 (de) 2008-07-15
US6137117A (en) 2000-10-24
CA2375425A1 (en) 2000-12-28
KR20020015993A (ko) 2002-03-02
KR100696237B1 (ko) 2007-03-20
EP1196760A1 (de) 2002-04-17
JP2003502660A (ja) 2003-01-21

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