EP1196191A4 - Death domain containing receptor 5 - Google Patents

Death domain containing receptor 5

Info

Publication number
EP1196191A4
EP1196191A4 EP00930329A EP00930329A EP1196191A4 EP 1196191 A4 EP1196191 A4 EP 1196191A4 EP 00930329 A EP00930329 A EP 00930329A EP 00930329 A EP00930329 A EP 00930329A EP 1196191 A4 EP1196191 A4 EP 1196191A4
Authority
EP
European Patent Office
Prior art keywords
domain containing
death domain
containing receptor
receptor
death
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00930329A
Other languages
German (de)
French (fr)
Other versions
EP1196191A1 (en
Inventor
Jian Ni
Reiner L Gentz
Guo-Liang Yu
Craig A Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP1196191A1 publication Critical patent/EP1196191A1/en
Publication of EP1196191A4 publication Critical patent/EP1196191A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP00930329A 1999-05-04 2000-05-04 Death domain containing receptor 5 Withdrawn EP1196191A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13249899P 1999-05-04 1999-05-04
US132498P 1999-05-04
US13323899P 1999-05-07 1999-05-07
US133238P 1999-05-07
US14893999P 1999-08-13 1999-08-13
US148939P 1999-08-13
PCT/US2000/012041 WO2000066156A1 (en) 1999-05-04 2000-05-04 Death domain containing receptor 5

Publications (2)

Publication Number Publication Date
EP1196191A1 EP1196191A1 (en) 2002-04-17
EP1196191A4 true EP1196191A4 (en) 2004-03-24

Family

ID=27384298

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00930329A Withdrawn EP1196191A4 (en) 1999-05-04 2000-05-04 Death domain containing receptor 5

Country Status (5)

Country Link
EP (1) EP1196191A4 (en)
JP (1) JP2002543151A (en)
AU (1) AU4817200A (en)
CA (1) CA2369371A1 (en)
WO (1) WO2000066156A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
CN100475848C (en) * 2001-05-18 2009-04-08 麒麟麦酒株式会社 Anti-TRAIL-R antibodies
CA2446723C (en) 2001-05-25 2014-01-21 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
JPWO2003038087A1 (en) 2001-10-04 2005-02-24 関西ティー・エル・オー株式会社 Promoter of DR5 gene and promoter of Siah-1 gene
ATE438662T1 (en) * 2003-03-26 2009-08-15 Apogenix Gmbh IMPROVED FC FUSION PROTEINS
AU2005227322A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
WO2005114187A2 (en) * 2004-04-23 2005-12-01 The United States Of America As Represented By Thesecretary, Department Of Health And Human Services Methods and compositions for diagnosing aids and other diseases and conditions involving immune system activation
JP5562521B2 (en) 2005-02-02 2014-07-30 ザ ユーエービー リサーチ ファンデーション Agents and methods relating to reducing resistance to apoptosis-inducing death receptor agonists
PE20071101A1 (en) 2005-08-31 2007-12-21 Amgen Inc POLYPEPTIDES AND ANTIBODIES
BR112012010698A2 (en) 2009-11-05 2016-11-29 Uab Research Foundation method for treating a subject with cancer, method for screening a breast cancer cell, and antibody
WO2011116344A2 (en) 2010-03-18 2011-09-22 The Uab Research Foundation Targeting cancer stem cells
EP2831116A1 (en) * 2012-03-28 2015-02-04 Amgen Inc. Dr5 receptor agonist combinations
SI2970473T1 (en) 2013-03-14 2017-10-30 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041629A2 (en) * 1997-03-17 1998-09-24 Human Genome Sciences, Inc. Death domain containing receptor 5
EP0870827A2 (en) * 1997-03-14 1998-10-14 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
EP1181319A1 (en) * 1999-05-28 2002-02-27 Genentech, Inc. Dr4 antibodies and uses thereof
EP1192185A2 (en) * 1999-06-09 2002-04-03 Genentech, Inc. Apo-2L RECEPTOR AGONIST AND CPT-11 SYNERGISM
EP1287035A1 (en) * 2000-05-02 2003-03-05 UAB Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870827A2 (en) * 1997-03-14 1998-10-14 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
WO1998041629A2 (en) * 1997-03-17 1998-09-24 Human Genome Sciences, Inc. Death domain containing receptor 5
EP1181319A1 (en) * 1999-05-28 2002-02-27 Genentech, Inc. Dr4 antibodies and uses thereof
EP1192185A2 (en) * 1999-06-09 2002-04-03 Genentech, Inc. Apo-2L RECEPTOR AGONIST AND CPT-11 SYNERGISM
EP1287035A1 (en) * 2000-05-02 2003-03-05 UAB Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CLERICI MARIO ET AL: "Type 1 and type 2 cytokines in HIV infection - A possible role in apoptosis and disease progression", ANNALS OF MEDICINE, vol. 29, no. 3, 1997, pages 185 - 188, XP009024281, ISSN: 0785-3890 *
FRANKFURT OSKAR S ET AL: "Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients", LEUKEMIA RESEARCH, vol. 21, no. 1, 1997, pages 9 - 16, XP001157166, ISSN: 0145-2126 *
GOOCH JENNIFER L ET AL: "Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells", CANCER RESEARCH, vol. 58, no. 18, 15 September 1998 (1998-09-15), pages 4199 - 4205, XP001157169, ISSN: 0008-5472 *
HILL MARK E ET AL: "Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British national lymphoma investigation study", BLOOD, vol. 88, no. 3, 1996, pages 1046 - 1051, XP002267563, ISSN: 0006-4971 *
HORIGOME ATSUSHI ET AL: "Tacrolimus-induced apoptosis and its prevention by interleukins in mitogen-activated human peripheral-blood mononuclear cells", IMMUNOPHARMACOLOGY, vol. 39, no. 1, March 1998 (1998-03-01), pages 21 - 30, XP002267562, ISSN: 0162-3109 *
LINDNER HEIDRUN ET AL: "Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair: Role of cytokines", BLOOD, vol. 89, no. 6, 1997, pages 1931 - 1938, XP002267561, ISSN: 0006-4971 *
LOTEM J ET AL: "Interferon-gamma inhibits apoptosis induced by wild-type p53, cytotoxic anti-cancer agents and viability factor deprivation in myeloid cells", LEUKEMIA (BASINGSTOKE), vol. 9, no. 4, 1995, pages 685 - 692, XP009024280, ISSN: 0887-6924 *
LOTEM JOSEPH ET AL: "Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor-beta-1 and cancer chemotherapy compounds in myeloid leukemic cells", BLOOD, vol. 80, no. 7, 1992, pages 1750 - 1757, XP001157168, ISSN: 0006-4971 *
ODAKA C ET AL: "Immunosuppressant deoxyspergualin induces apoptotic cell death in dividing cells", IMMUNOLOGY, vol. 95, no. 3, November 1998 (1998-11-01), pages 370 - 376, XP009024297, ISSN: 0019-2805 *
See also references of WO0066156A1 *
SIMONITSCH I ET AL: "Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha (TNF-alpha)", BRITISH JOURNAL OF CANCER, vol. 78, no. 7, October 1998 (1998-10-01), pages 862 - 870, XP009024301, ISSN: 0007-0920 *
ZOU WEIPING ET AL: "Administration of interleukin 13 to simian immunodeficiency virus-infected macaques: Induction of intestinal epithelial atrophy", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 14, no. 9, 10 June 1998 (1998-06-10), pages 775 - 783, XP009024312, ISSN: 0889-2229 *

Also Published As

Publication number Publication date
WO2000066156A1 (en) 2000-11-09
CA2369371A1 (en) 2000-11-09
EP1196191A1 (en) 2002-04-17
WO2000066156A8 (en) 2001-07-26
JP2002543151A (en) 2002-12-17
AU4817200A (en) 2000-11-17

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