EP1178786A4 - Agents a stabilisation proteinique actifs pharmacologiquement; procedes de fabrication et methodes d'utilisation - Google Patents
Agents a stabilisation proteinique actifs pharmacologiquement; procedes de fabrication et methodes d'utilisationInfo
- Publication number
- EP1178786A4 EP1178786A4 EP00932669A EP00932669A EP1178786A4 EP 1178786 A4 EP1178786 A4 EP 1178786A4 EP 00932669 A EP00932669 A EP 00932669A EP 00932669 A EP00932669 A EP 00932669A EP 1178786 A4 EP1178786 A4 EP 1178786A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- preparation
- active agents
- pharmacologically active
- protein stabilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US316642 | 1989-02-28 | ||
US09/316,642 US6749868B1 (en) | 1993-02-22 | 1999-05-21 | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
PCT/US2000/013954 WO2000071079A2 (fr) | 1999-05-21 | 2000-05-19 | Agents a stabilisation proteinique actifs pharmacologiquement; procedes de fabrication et methodes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1178786A1 EP1178786A1 (fr) | 2002-02-13 |
EP1178786A4 true EP1178786A4 (fr) | 2006-03-01 |
Family
ID=23229970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00932669A Ceased EP1178786A4 (fr) | 1999-05-21 | 2000-05-19 | Agents a stabilisation proteinique actifs pharmacologiquement; procedes de fabrication et methodes d'utilisation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1178786A4 (fr) |
AU (3) | AU784416B2 (fr) |
CA (2) | CA2371912C (fr) |
HK (1) | HK1045646A1 (fr) |
WO (1) | WO2000071079A2 (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
CA2389583A1 (fr) * | 1999-10-27 | 2001-05-03 | Baker Norton Pharmaceuticals, Inc. | Methode et compositions pour administration orale de taxanes a des patients humains |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
IL160927A0 (en) * | 2001-10-15 | 2004-08-31 | Crititech Inc | Compositions and methods for delivery of poorly water soluble drugs and method of treatment |
ITMI20020680A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento |
NZ518997A (en) * | 2002-05-16 | 2004-12-24 | Interag | Injection formulation for parenteral administration of biodegradable implant for sustained release of active agent |
SI21222A (sl) * | 2002-05-28 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek za pripravo nanodelcev |
GB0216700D0 (en) | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
JP2006524632A (ja) | 2002-12-09 | 2006-11-02 | アメリカン バイオサイエンス、インコーポレイテッド | 組成物及び薬物送達方法 |
GB0302673D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
IL160095A0 (en) * | 2004-01-28 | 2004-06-20 | Yissum Res Dev Co | Formulations for poorly soluble drugs |
WO2006073154A1 (fr) * | 2005-01-07 | 2006-07-13 | Eisai R&D Management Co., Ltd. | Préparation thérapeutique et procédé d'élaboration de ladite préparation |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
KR101914254B1 (ko) | 2005-02-18 | 2018-11-02 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 조합 및 투여 방식, 및 조합 요법 |
MX2007015183A (es) * | 2005-06-14 | 2008-02-19 | Baxter Int | Formulaciones farmaceuticas para minimizar las interacciones farmaco-farmaco. |
EP2404594B1 (fr) * | 2005-08-31 | 2017-12-20 | Abraxis BioScience, LLC | Compositions de docetaxel présentant une stabilité accrue |
US20100166872A1 (en) * | 2005-10-21 | 2010-07-01 | Amarjit Singh | Novel improved compositions for cancer therapy |
JP5301995B2 (ja) * | 2006-08-29 | 2013-09-25 | 富士フイルム株式会社 | 難水溶性化合物封入親水性マトリックスおよびその製法 |
US9675578B2 (en) | 2006-12-14 | 2017-06-13 | Abraxis Bioscience, Llc | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
DK2481402T3 (en) | 2007-03-07 | 2018-08-06 | Abraxis Bioscience Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
ES2435452T3 (es) | 2007-06-01 | 2013-12-19 | Abraxis Bioscience, Llc | Métodos y composiciones para tratar un cáncer recurrente |
FR2924024B1 (fr) * | 2007-11-27 | 2012-08-17 | Centre Nat Rech Scient | Nanoparticules d'actifs therapeutiques de faible solubilite aqueuse |
KR20100048751A (ko) * | 2008-10-31 | 2010-05-11 | 주식회사 동성바이오레인 | 스프레이 가능한 캡슐화된 기능성 미립자 조성물과 그 제조방법 |
AU2009319183B2 (en) * | 2008-11-27 | 2014-06-05 | B.R.A.I.N. Biotechnology Research And Information Network Ag | Hydrophobins as surface active proteins as excipients in solid pharmaceutical formulations |
JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
ME03596B (fr) | 2009-04-15 | 2020-07-20 | Abraxis Bioscience Llc | Compositions de nanoparticules exemptes de prion, et procédés afférents |
CA2776241A1 (fr) | 2009-10-30 | 2011-05-05 | Novozymes Biopharma Dk A/S | Variants d'albumine |
ES2675212T3 (es) | 2010-03-26 | 2018-07-09 | Abraxis Bioscience, Llc | Métodos de tratamiento de carcinoma hepatocelular |
MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
DK2552415T3 (en) | 2010-03-29 | 2016-11-28 | Abraxis Bioscience Llc | Methods for treating cancer |
CN103140225A (zh) | 2010-06-04 | 2013-06-05 | 阿布拉科斯生物科学有限公司 | 治疗胰腺癌的方法 |
DK2790675T3 (da) | 2011-12-14 | 2019-09-09 | Abraxis Bioscience Llc | Anvendelse af polymerexcipienser til frysetørring eller frysning af partikler |
EP3330283A3 (fr) | 2012-03-16 | 2018-07-11 | Albumedix A/S | Variants d'albumine |
EP2917233A1 (fr) | 2012-11-08 | 2015-09-16 | Novozymes Biopharma DK A/S | Variants d'albumine |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
PT106738B (pt) * | 2013-01-09 | 2015-06-08 | Hovione Farmaciencia Sa | Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
WO2014125082A1 (fr) | 2013-02-16 | 2014-08-21 | Novozymes Biopharma Dk A/S | Modèle pharmacocinétique animal |
JP6349381B2 (ja) | 2013-03-12 | 2018-06-27 | アブラクシス バイオサイエンス, エルエルシー | 肺がんを処置する方法 |
US9962373B2 (en) | 2013-03-14 | 2018-05-08 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
CN104548116A (zh) * | 2013-10-11 | 2015-04-29 | 程树海 | 一种稳定的蛋白质载药微粒***制备方法 |
CN104434808A (zh) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术(石家庄)有限公司 | 一种治疗性纳米粒子及其制备方法 |
US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
SG10202107198SA (en) | 2015-06-29 | 2021-08-30 | Abraxis Bioscience Llc | Methods of treating epithelioid cell tumors |
WO2017029407A1 (fr) | 2015-08-20 | 2017-02-23 | Albumedix A/S | Variants de l'albumine et leurs conjugués |
JP2020500306A (ja) | 2016-11-04 | 2020-01-09 | オーフス ウニベルシテット | 新生児Fc受容体の過剰発現により特徴づけられる腫瘍の同定と治療 |
DE102016125666A1 (de) * | 2016-12-23 | 2018-06-28 | Michael Denck | HSA-Galenik |
CN110753541A (zh) * | 2017-04-24 | 2020-02-04 | Zy治疗公司 | 用于体内递送的药物组合物、基本上不溶于水的药理学活性剂的制备方法 |
JP2021528362A (ja) | 2018-03-20 | 2021-10-21 | アブラクシス バイオサイエンス, エルエルシー | mTOR阻害剤およびアルブミンのナノ粒子の投与を介して中枢神経系障害を処置する方法 |
CN115003284A (zh) | 2019-10-28 | 2022-09-02 | 阿布拉科斯生物科学有限公司 | 白蛋白和雷帕霉素的药物组合物 |
US20230025865A1 (en) * | 2019-12-11 | 2023-01-26 | The Regents Of The University Of Michigan | COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998014174A1 (fr) * | 1996-10-01 | 1998-04-09 | Vivorx Pharmaceuticals, Inc. | Agents pharmaceutiquement actifs stabilises par proteine, procedes de preparation et procedes d'utilisation |
WO1999000113A1 (fr) * | 1997-06-27 | 1999-01-07 | Vivorx Pharmaceuticals, Inc. | Nouvelles formulations d'agents pharmacologiques, leurs procedes de preparation et d'utilisation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
-
2000
- 2000-05-19 CA CA2371912A patent/CA2371912C/fr not_active Expired - Lifetime
- 2000-05-19 WO PCT/US2000/013954 patent/WO2000071079A2/fr active IP Right Grant
- 2000-05-19 EP EP00932669A patent/EP1178786A4/fr not_active Ceased
- 2000-05-19 AU AU50359/00A patent/AU784416B2/en not_active Expired
- 2000-05-19 CA CA2684454A patent/CA2684454A1/fr not_active Abandoned
-
2002
- 2002-08-12 HK HK02105870.2A patent/HK1045646A1/zh unknown
-
2006
- 2006-06-30 AU AU2006202836A patent/AU2006202836B2/en not_active Expired
-
2009
- 2009-09-21 AU AU2009217409A patent/AU2009217409A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998014174A1 (fr) * | 1996-10-01 | 1998-04-09 | Vivorx Pharmaceuticals, Inc. | Agents pharmaceutiquement actifs stabilises par proteine, procedes de preparation et procedes d'utilisation |
WO1999000113A1 (fr) * | 1997-06-27 | 1999-01-07 | Vivorx Pharmaceuticals, Inc. | Nouvelles formulations d'agents pharmacologiques, leurs procedes de preparation et d'utilisation |
Non-Patent Citations (2)
Title |
---|
See also references of WO0071079A3 * |
SOON-SHIONG ET AL: "Biologic delivery systems: from discovery to clinical application", 1998, PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, PAGE(S) 103-104, ISSN: 1022-0178, XP002125685 * |
Also Published As
Publication number | Publication date |
---|---|
AU5035900A (en) | 2000-12-12 |
AU2006202836B2 (en) | 2009-10-08 |
AU2006202836A1 (en) | 2006-07-27 |
CA2371912C (fr) | 2010-02-16 |
AU784416B2 (en) | 2006-03-30 |
HK1045646A1 (zh) | 2002-12-06 |
CA2371912A1 (fr) | 2000-11-30 |
WO2000071079A2 (fr) | 2000-11-30 |
CA2684454A1 (fr) | 2000-11-18 |
EP1178786A1 (fr) | 2002-02-13 |
AU2009217409A1 (en) | 2009-10-08 |
WO2000071079A3 (fr) | 2008-03-27 |
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