EP1087799A1 - Procede pour produire des surfaces biocompatibles - Google Patents
Procede pour produire des surfaces biocompatiblesInfo
- Publication number
- EP1087799A1 EP1087799A1 EP98963549A EP98963549A EP1087799A1 EP 1087799 A1 EP1087799 A1 EP 1087799A1 EP 98963549 A EP98963549 A EP 98963549A EP 98963549 A EP98963549 A EP 98963549A EP 1087799 A1 EP1087799 A1 EP 1087799A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- stent
- gas
- biomolecule
- loops
- diamond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Definitions
- the plasma polymerization takes place under a gas pressure in an interval of 0.02 to 1 Torr, preferably in an interval of 0.02 to 0.1 Torr and particularly preferably at 0.04 Torr.
- the radio frequency source emits radiation in an interval of 10 to 15 MHz, preferably radiation in an interval of 13 to 14 MHz and particularly preferably radiation of 13.46 MHz, the ultrasound source preferably emitting radiation in an interval of 5 to 100 kHz in an interval of 5 to 50 kHz and particularly preferably radiation in an interval of 5 to 25 kHz emitted; the ultrasound source very particularly preferably emits ultrasound waves with a frequency of 20 kHz.
- glycosaminoglycans - such as in particular heparin -, endostatin or angiostatin.
- suitable biomolecules are well known to those skilled in the art.
- stents are placed in a vertical position on the lower electrode.
- a Pt / Ir wire which is firmly connected to the lower electrode, makes electrical contact between the stent and the lower electrode.
- Example 2 The same conditions as in Example 1 are chosen.
- the plasma gas pressure is set to 0.1 Torr here.
- the average layer thickness on the stents is determined to be 75 nm.
- the stent now carries a lower layer made of PEI-TRIMID to which a layer of heparin is ionically bound.
- the stent is dried in UV for 15 min. exposed at a wavelength of 360 nm.
- a carbene is formed from the TRIMID covalently bound to the PEI, which on the one hand inserts covalently into the diamond-like layer and thus covalently binds the PEI via the TRIMID molecule.
- the TRIMID also inserts carbene into the heparin molecule and creates a chemical bond between heparin and PEI. The heparin molecule is thus covalently bound to the diamond-like surface via the TRIMID modified PEI linker molecule.
- FIG. 5 shows the heparin activity of covalently immobilized heparin on "stents" which were first provided with a "diamond-like" coating to which heparin was covalently bound according to the invention by the process according to the invention.
- FIG. 5 shows the activity of uncoated, HSA (Human Serum Albumin) coated and heparin coated "stents" in the diagram.
- the "stents” were coated according to the above procedure.
- the uncoated stent was not coated.
- the stent HSA was made with PEI-TRIMID and then coated with HSA.
- Stents 1, 2, 3 and 4 were coated according to the above procedure.
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98963549A EP1087799A1 (fr) | 1998-06-09 | 1998-12-09 | Procede pour produire des surfaces biocompatibles |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP9803465 | 1998-06-09 | ||
WOPCT/EP98/03465 | 1998-06-09 | ||
PCT/EP1998/008022 WO1999064085A1 (fr) | 1998-06-09 | 1998-12-09 | Procede pour produire des surfaces biocompatibles |
EP98963549A EP1087799A1 (fr) | 1998-06-09 | 1998-12-09 | Procede pour produire des surfaces biocompatibles |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1087799A1 true EP1087799A1 (fr) | 2001-04-04 |
Family
ID=26070317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98963549A Withdrawn EP1087799A1 (fr) | 1998-06-09 | 1998-12-09 | Procede pour produire des surfaces biocompatibles |
Country Status (1)
Country | Link |
---|---|
EP (1) | EP1087799A1 (fr) |
-
1998
- 1998-12-09 EP EP98963549A patent/EP1087799A1/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO9964085A1 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE4216878B4 (de) | Medizinische Vorrichtung mit erhöhter Biokompatibilität und Verfahren zum Erhöhen der Biokompatibilität von Polymeroberflächen einer medizinischen Vorrichtung mittels Radiofrequenzplasma | |
DE69909104T2 (de) | Neues verfahren zur herstellung von mitteln zur oberflächenbehandlung | |
DE60214513T2 (de) | Verfahren zur oberflächenmodifizierung | |
DE60027043T2 (de) | Verfahren zum imprägnieren eines porösen materials mit einer vernetzbaren zusammensetzung | |
DE69932034T2 (de) | Hydrophile beschichtung für eine intracorporale medizinische vorrichtung | |
DE69636351T3 (de) | Verfahren zur beschichtung von arzneimittel enthaltenden stents | |
DE69133445T2 (de) | Arzneistoffabgabesystem | |
DE69730475T2 (de) | Beschichteter Stent und Verfahren zur Wirkstoffabgabe | |
DE60026065T2 (de) | Elektropolymerisierbare monomere und polymerbeschichtungen auf implantierbaren geräten | |
DE69824648T2 (de) | Medizinische Wirkstoffe freisetzende Beschichtungen für medizinische Vorrichtungen | |
DE2139455C3 (de) | Verfahren zur Herstellung eines Im plantats | |
DE69912951T2 (de) | Biokompatible rissbeständige beschichtungszusammensetzungen enthaltend funktionelle silikonpolymere | |
DE60032912T2 (de) | Poröse prothese und verfahren zur abscheidung von substanzen in den poren | |
US8088158B2 (en) | Radiopaque ePTFE medical devices | |
DE2326863A1 (de) | Verfahren zur herstellung biokompatibler und biofunktioneller materialien | |
DE10212744A1 (de) | Prothese zur plastischen Wiederherstellung mit verbeserten Hydrophilieeigenschaften und Verfahren zu ihrer Gewinnung | |
DE19916315A1 (de) | Verfahren zum Bilden einer dünnen keramikartigen Schicht auf einem Bioimplantat | |
DE4336209C2 (de) | Verfahren zur Herstellung einer mit antithrombotischen Agenzien beschichteten Gefäßprothese | |
DE10106546A1 (de) | Verfahren zum Herstellen eines medizinischen Implantats | |
WO1999064085A1 (fr) | Procede pour produire des surfaces biocompatibles | |
DE102018110591A1 (de) | Medizinische Vorrichtung und Beschichtung mit Haftvermittler | |
DE10031199A1 (de) | Implantierbare Vorrichtung mit einem Bestandteil aus Poly-Aminosäure | |
WO2003086496A1 (fr) | Implant medical, de preference stent, et procede de fabrication dudit stent | |
EP1087799A1 (fr) | Procede pour produire des surfaces biocompatibles | |
DE10295443B4 (de) | Textiles Implantat mit Oberflächenmodifikation, und entsprechendes Verfahren zur Oberflächenmodifikation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010104 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20010521 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HERBST, FRANZ Owner name: KALATCHEV, ALEXEI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HERBST, FRANZ Inventor name: KALATCHEV, ALEXEI |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HERBST, FRANZ Owner name: KALATCHEV, ALEXEI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HERBST, FRANZ Inventor name: KALATCHEV, ALEXEI |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040825 |