EP1087799A1 - Procede pour produire des surfaces biocompatibles - Google Patents

Procede pour produire des surfaces biocompatibles

Info

Publication number
EP1087799A1
EP1087799A1 EP98963549A EP98963549A EP1087799A1 EP 1087799 A1 EP1087799 A1 EP 1087799A1 EP 98963549 A EP98963549 A EP 98963549A EP 98963549 A EP98963549 A EP 98963549A EP 1087799 A1 EP1087799 A1 EP 1087799A1
Authority
EP
European Patent Office
Prior art keywords
stent
gas
biomolecule
loops
diamond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98963549A
Other languages
German (de)
English (en)
Inventor
Franz Herbst
Alexei Kalatchev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Herbst Franz
Kalatchev Alexei
Original Assignee
Herbst Franz
Kalatchev Alexei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbst Franz, Kalatchev Alexei filed Critical Herbst Franz
Priority to EP98963549A priority Critical patent/EP1087799A1/fr
Priority claimed from PCT/EP1998/008022 external-priority patent/WO1999064085A1/fr
Publication of EP1087799A1 publication Critical patent/EP1087799A1/fr
Withdrawn legal-status Critical Current

Links

Definitions

  • the plasma polymerization takes place under a gas pressure in an interval of 0.02 to 1 Torr, preferably in an interval of 0.02 to 0.1 Torr and particularly preferably at 0.04 Torr.
  • the radio frequency source emits radiation in an interval of 10 to 15 MHz, preferably radiation in an interval of 13 to 14 MHz and particularly preferably radiation of 13.46 MHz, the ultrasound source preferably emitting radiation in an interval of 5 to 100 kHz in an interval of 5 to 50 kHz and particularly preferably radiation in an interval of 5 to 25 kHz emitted; the ultrasound source very particularly preferably emits ultrasound waves with a frequency of 20 kHz.
  • glycosaminoglycans - such as in particular heparin -, endostatin or angiostatin.
  • suitable biomolecules are well known to those skilled in the art.
  • stents are placed in a vertical position on the lower electrode.
  • a Pt / Ir wire which is firmly connected to the lower electrode, makes electrical contact between the stent and the lower electrode.
  • Example 2 The same conditions as in Example 1 are chosen.
  • the plasma gas pressure is set to 0.1 Torr here.
  • the average layer thickness on the stents is determined to be 75 nm.
  • the stent now carries a lower layer made of PEI-TRIMID to which a layer of heparin is ionically bound.
  • the stent is dried in UV for 15 min. exposed at a wavelength of 360 nm.
  • a carbene is formed from the TRIMID covalently bound to the PEI, which on the one hand inserts covalently into the diamond-like layer and thus covalently binds the PEI via the TRIMID molecule.
  • the TRIMID also inserts carbene into the heparin molecule and creates a chemical bond between heparin and PEI. The heparin molecule is thus covalently bound to the diamond-like surface via the TRIMID modified PEI linker molecule.
  • FIG. 5 shows the heparin activity of covalently immobilized heparin on "stents" which were first provided with a "diamond-like" coating to which heparin was covalently bound according to the invention by the process according to the invention.
  • FIG. 5 shows the activity of uncoated, HSA (Human Serum Albumin) coated and heparin coated "stents" in the diagram.
  • the "stents” were coated according to the above procedure.
  • the uncoated stent was not coated.
  • the stent HSA was made with PEI-TRIMID and then coated with HSA.
  • Stents 1, 2, 3 and 4 were coated according to the above procedure.

Landscapes

  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un nouveau procédé optimisé pour produire des surfaces biocompatibles, notamment des surfaces d'objets médicaux tels que des implants. L'invention concerne en outre des extenseurs présentant des propriétés optimisées.
EP98963549A 1998-06-09 1998-12-09 Procede pour produire des surfaces biocompatibles Withdrawn EP1087799A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98963549A EP1087799A1 (fr) 1998-06-09 1998-12-09 Procede pour produire des surfaces biocompatibles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP9803465 1998-06-09
WOPCT/EP98/03465 1998-06-09
PCT/EP1998/008022 WO1999064085A1 (fr) 1998-06-09 1998-12-09 Procede pour produire des surfaces biocompatibles
EP98963549A EP1087799A1 (fr) 1998-06-09 1998-12-09 Procede pour produire des surfaces biocompatibles

Publications (1)

Publication Number Publication Date
EP1087799A1 true EP1087799A1 (fr) 2001-04-04

Family

ID=26070317

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98963549A Withdrawn EP1087799A1 (fr) 1998-06-09 1998-12-09 Procede pour produire des surfaces biocompatibles

Country Status (1)

Country Link
EP (1) EP1087799A1 (fr)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9964085A1 *

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