EP1061921A4 - Vitronectin receptor antagonists - Google Patents
Vitronectin receptor antagonistsInfo
- Publication number
- EP1061921A4 EP1061921A4 EP99909952A EP99909952A EP1061921A4 EP 1061921 A4 EP1061921 A4 EP 1061921A4 EP 99909952 A EP99909952 A EP 99909952A EP 99909952 A EP99909952 A EP 99909952A EP 1061921 A4 EP1061921 A4 EP 1061921A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- vitronectin receptor
- vitronectin
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7761098P | 1998-03-10 | 1998-03-10 | |
| US77610P | 1998-03-10 | ||
| US9606398P | 1998-08-11 | 1998-08-11 | |
| US96063P | 1998-08-11 | ||
| PCT/US1999/005232 WO1999045927A1 (en) | 1998-03-10 | 1999-03-10 | Vitronectin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1061921A1 EP1061921A1 (en) | 2000-12-27 |
| EP1061921A4 true EP1061921A4 (en) | 2005-03-30 |
Family
ID=26759473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99909952A Withdrawn EP1061921A4 (en) | 1998-03-10 | 1999-03-10 | Vitronectin receptor antagonists |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1061921A4 (en) |
| JP (1) | JP2002506033A (en) |
| KR (1) | KR20010041812A (en) |
| CN (1) | CN1299282A (en) |
| AP (1) | AP2000001898A0 (en) |
| AR (1) | AR015241A1 (en) |
| AU (1) | AU758498B2 (en) |
| BG (1) | BG104824A (en) |
| BR (1) | BR9908636A (en) |
| CA (1) | CA2323208A1 (en) |
| CO (1) | CO5080762A1 (en) |
| DZ (1) | DZ2741A1 (en) |
| EA (1) | EA200000921A1 (en) |
| HU (1) | HUP0101143A3 (en) |
| ID (1) | ID26223A (en) |
| IL (1) | IL138245A0 (en) |
| NO (1) | NO20004503L (en) |
| OA (1) | OA12189A (en) |
| PE (1) | PE20000323A1 (en) |
| PL (1) | PL342881A1 (en) |
| SK (1) | SK13292000A3 (en) |
| TR (1) | TR200002625T2 (en) |
| UY (2) | UY25421A1 (en) |
| WO (1) | WO1999045927A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19939980A1 (en) | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitors of the integrin alphavbeta¶3¶ |
| DE19939981A1 (en) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | New inhibitors of the integrin alphavß3 |
| EG24179A (en) * | 1999-09-07 | 2008-09-28 | Smithkline Beecham Corp | Vitronectin receptor antagonists |
| US6881736B1 (en) | 1999-09-07 | 2005-04-19 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
| US6448278B2 (en) | 1999-12-23 | 2002-09-10 | Pfizer Inc. | Procollagen C-proteinase inhibitors |
| FR2808798A1 (en) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | New N-heterocyclyl-aminoacid derivatives and analogs, are vitronectin analogs useful e.g. for treating osteoporosis, tumor growth or metastasis, inflammation or cardiovascular disease |
| PE20020665A1 (en) | 2000-06-15 | 2002-08-14 | Pharmacia Corp | CYCLOALKYL PHENYL ALCANOIC ACID AS ANTAGONIST OF INTEGRINS OVß3 |
| US6531494B1 (en) | 2001-08-29 | 2003-03-11 | Pharmacia Corporation | Gem-substituted αvβ3 antagonists |
| US6645993B2 (en) | 2001-03-30 | 2003-11-11 | Warner-Lambert Company | 3-heterocyclylpropanohydroxamic acid PCP inhibitors |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| WO2005049589A2 (en) * | 2003-10-14 | 2005-06-02 | Cadila Healthcare Limited | Heterocyclic compounds for the treatment of hyperlipidemia, diabetes, obesity and similar diseases |
| WO2005085241A1 (en) * | 2004-03-05 | 2005-09-15 | Taisho Pharmaceutical Co., Ltd. | Thiazole derivative |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| JP2008536918A (en) | 2005-04-20 | 2008-09-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Fluorine-substituted pyridine N-oxide thrombin modulator and method for N-oxidation of nitrogen-containing heteroaryl |
| WO2015030189A1 (en) * | 2013-08-29 | 2015-03-05 | 京都薬品工業株式会社 | Novel aromatic compound and use thereof |
| HUE063437T2 (en) | 2013-09-24 | 2024-01-28 | Fujifilm Corp | Pharmaceutical composition of a nitrogen-containing compound or salt thereof, or metal complex thereof |
| KR20160147007A (en) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | Carbonitrile derivatives as selective androgen receptor modulators |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024124A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| WO1997024122A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
-
1999
- 1999-03-10 EP EP99909952A patent/EP1061921A4/en not_active Withdrawn
- 1999-03-10 AU AU29033/99A patent/AU758498B2/en not_active Ceased
- 1999-03-10 CN CN99805833A patent/CN1299282A/en active Pending
- 1999-03-10 PE PE1999000188A patent/PE20000323A1/en not_active Application Discontinuation
- 1999-03-10 OA OA00000248A patent/OA12189A/en unknown
- 1999-03-10 AR ARP990101019A patent/AR015241A1/en not_active Application Discontinuation
- 1999-03-10 IL IL13824599A patent/IL138245A0/en unknown
- 1999-03-10 EA EA200000921A patent/EA200000921A1/en unknown
- 1999-03-10 KR KR1020007010091A patent/KR20010041812A/en not_active Application Discontinuation
- 1999-03-10 AP APAP/P/2000/001898A patent/AP2000001898A0/en unknown
- 1999-03-10 PL PL99342881A patent/PL342881A1/en unknown
- 1999-03-10 SK SK1329-2000A patent/SK13292000A3/en unknown
- 1999-03-10 WO PCT/US1999/005232 patent/WO1999045927A1/en not_active Application Discontinuation
- 1999-03-10 HU HU0101143A patent/HUP0101143A3/en unknown
- 1999-03-10 CO CO99014712A patent/CO5080762A1/en unknown
- 1999-03-10 ID IDW20001737A patent/ID26223A/en unknown
- 1999-03-10 JP JP2000535342A patent/JP2002506033A/en not_active Withdrawn
- 1999-03-10 DZ DZ990042A patent/DZ2741A1/en active
- 1999-03-10 TR TR2000/02625T patent/TR200002625T2/en unknown
- 1999-03-10 CA CA002323208A patent/CA2323208A1/en not_active Abandoned
- 1999-03-10 BR BR9908636-0A patent/BR9908636A/en not_active Application Discontinuation
- 1999-03-10 UY UY25421A patent/UY25421A1/en unknown
- 1999-05-19 UY UY25519A patent/UY25519A1/en unknown
-
2000
- 2000-09-08 NO NO20004503A patent/NO20004503L/en unknown
- 2000-10-03 BG BG104824A patent/BG104824A/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024124A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| WO1997024122A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO9945927A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL342881A1 (en) | 2001-07-16 |
| UY25519A1 (en) | 1999-12-13 |
| NO20004503L (en) | 2000-10-10 |
| EP1061921A1 (en) | 2000-12-27 |
| CO5080762A1 (en) | 2001-09-25 |
| KR20010041812A (en) | 2001-05-25 |
| CN1299282A (en) | 2001-06-13 |
| WO1999045927A1 (en) | 1999-09-16 |
| TR200002625T2 (en) | 2000-12-21 |
| OA12189A (en) | 2006-05-09 |
| SK13292000A3 (en) | 2001-06-11 |
| DZ2741A1 (en) | 2003-09-08 |
| JP2002506033A (en) | 2002-02-26 |
| CA2323208A1 (en) | 1999-09-16 |
| BR9908636A (en) | 2002-01-08 |
| NO20004503D0 (en) | 2000-09-08 |
| IL138245A0 (en) | 2001-10-31 |
| PE20000323A1 (en) | 2000-05-24 |
| AP2000001898A0 (en) | 2000-09-30 |
| ID26223A (en) | 2000-12-07 |
| EA200000921A1 (en) | 2001-04-23 |
| AU758498B2 (en) | 2003-03-20 |
| BG104824A (en) | 2001-05-31 |
| HUP0101143A2 (en) | 2001-08-28 |
| AR015241A1 (en) | 2001-04-18 |
| AU2903399A (en) | 1999-09-27 |
| HUP0101143A3 (en) | 2002-12-28 |
| UY25421A1 (en) | 2001-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20001009 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| AX | Request for extension of the european patent |
Free format text: RO PAYMENT 20001009;SI PAYMENT 20001009 |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20050216 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20050512 |
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| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1035319 Country of ref document: HK |