EP0904286A4 - Invasive spaltung von nukleinsäuren - Google Patents

Invasive spaltung von nukleinsäuren

Info

Publication number
EP0904286A4
EP0904286A4 EP97903931A EP97903931A EP0904286A4 EP 0904286 A4 EP0904286 A4 EP 0904286A4 EP 97903931 A EP97903931 A EP 97903931A EP 97903931 A EP97903931 A EP 97903931A EP 0904286 A4 EP0904286 A4 EP 0904286A4
Authority
EP
European Patent Office
Prior art keywords
nucleic acid
specific
present
acid sequences
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97903931A
Other languages
English (en)
French (fr)
Other versions
EP0904286A1 (de
Inventor
Jeff G Hall
Victor I Lyamichev
James R Prudent
Mary Ann D Brow
Michael W Kaiser
Natasha Lyamichev
David Michael Olive
James E Dahlberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Third Wave Technologies Inc
Original Assignee
Third Wave Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/599,491 external-priority patent/US5846717A/en
Priority claimed from US08/756,386 external-priority patent/US5985557A/en
Priority claimed from US08/758,314 external-priority patent/US6090606A/en
Application filed by Third Wave Technologies Inc filed Critical Third Wave Technologies Inc
Priority to EP10179329A priority Critical patent/EP2354252B1/de
Priority to EP05016686A priority patent/EP1634890B1/de
Priority to EP08020055A priority patent/EP2058407B1/de
Publication of EP0904286A1 publication Critical patent/EP0904286A1/de
Publication of EP0904286A4 publication Critical patent/EP0904286A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97903931A 1996-01-24 1997-01-22 Invasive spaltung von nukleinsäuren Withdrawn EP0904286A4 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10179329A EP2354252B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren
EP05016686A EP1634890B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren
EP08020055A EP2058407B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US08/599,491 US5846717A (en) 1996-01-24 1996-01-24 Detection of nucleic acid sequences by invader-directed cleavage
US599491 1996-01-24
US08/682,853 US6001567A (en) 1996-01-24 1996-07-12 Detection of nucleic acid sequences by invader-directed cleavage
US682853 1996-07-12
US08/756,386 US5985557A (en) 1996-01-24 1996-11-29 Invasive cleavage of nucleic acids
US756386 1996-11-29
US758314 1996-12-02
US759038 1996-12-02
US08/759,038 US6090543A (en) 1996-01-24 1996-12-02 Cleavage of nucleic acids
US08/758,314 US6090606A (en) 1996-01-24 1996-12-02 Cleavage agents
PCT/US1997/001072 WO1997027214A1 (en) 1996-01-24 1997-01-22 Invasive cleavage of nucleic acids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP05016686A Division EP1634890B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren

Publications (2)

Publication Number Publication Date
EP0904286A1 EP0904286A1 (de) 1999-03-31
EP0904286A4 true EP0904286A4 (de) 2004-01-14

Family

ID=27541970

Family Applications (2)

Application Number Title Priority Date Filing Date
EP05016686A Expired - Lifetime EP1634890B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren
EP97903931A Withdrawn EP0904286A4 (de) 1996-01-24 1997-01-22 Invasive spaltung von nukleinsäuren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP05016686A Expired - Lifetime EP1634890B1 (de) 1996-01-24 1997-01-22 Invasive Spaltung von Nukleinsäuren

Country Status (8)

Country Link
EP (2) EP1634890B1 (de)
JP (2) JP3665648B2 (de)
AT (1) ATE414793T1 (de)
AU (1) AU731062B2 (de)
CA (1) CA2243353C (de)
DK (1) DK1634890T3 (de)
ES (1) ES2317113T3 (de)
WO (1) WO1997027214A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759226B1 (en) 2000-05-24 2004-07-06 Third Wave Technologies, Inc. Enzymes for the detection of specific nucleic acid sequences
US7045289B2 (en) 1991-09-09 2006-05-16 Third Wave Technologies, Inc. Detection of RNA Sequences
US7150982B2 (en) 1991-09-09 2006-12-19 Third Wave Technologies, Inc. RNA detection assays
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US7432048B2 (en) 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US6913881B1 (en) 1996-01-24 2005-07-05 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US7527928B2 (en) 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
AU781188B2 (en) * 1996-01-24 2005-05-12 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
DK0966542T3 (da) * 1996-11-29 2009-03-23 Third Wave Tech Inc FEN-1 endonukleaser, blandinger og spaltningsmethoder
JP2001523111A (ja) 1997-05-05 2001-11-20 サード ウェーブ テクノロジーズ，インコーポレーテッド 構造体架橋オリゴヌクレオチドを使用した標的依存型反応
US6210880B1 (en) 1997-09-19 2001-04-03 Third Wave Technologies, Inc. Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides
US7101672B2 (en) 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6194149B1 (en) 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
EP1634966B1 (de) 1997-05-30 2010-11-03 TrovaGene, Inc. Verfahren zur Bestimmung von Nukleinsäuresequenzen in Urin
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US6528254B1 (en) * 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US7824859B2 (en) 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7838225B2 (en) 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
ATE296899T1 (de) 2000-03-27 2005-06-15 Applera Corp Verbesserter invasionsassay
EP1294863B1 (de) * 2000-05-24 2009-07-08 Third Wave Technologies, Inc. Nachweis von rna
US7060436B2 (en) 2000-06-17 2006-06-13 Third Wave Technologies, Inc. Nucleic acid accessible hybridization sites
JP2004507230A (ja) 2000-07-03 2004-03-11 アプレラ　コーポレイション ポリヌクレオチド配列アッセイ
CA2428798C (en) * 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
AU2002232177B2 (en) * 2001-02-15 2006-11-09 Takara Bio Inc. Method of detecting nucleotide polymorphism
US7485443B2 (en) 2001-07-17 2009-02-03 Northwestern University Solid-phase reactions
US7303869B2 (en) 2001-07-17 2007-12-04 Northwestern University Solid-phase reactions
US20040014067A1 (en) 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7312033B2 (en) 2002-11-14 2007-12-25 Third Wave Technologies, Inc. CFTR allele detection assays
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
AU2003297541A1 (en) 2002-12-18 2004-07-14 Third Wave Technologies, Inc. Detection of small nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7700750B2 (en) 2003-01-09 2010-04-20 Third Wave Technologies, Inc. Connexin allele detection assays
US20040161749A1 (en) 2003-01-24 2004-08-19 Hall Jeff G. 3' end tagged oligonucleotides
US7473773B2 (en) 2004-01-07 2009-01-06 Third Wave Technologies, Inc. Determination of hepatitis C virus genotype
US7462451B2 (en) 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US7939257B2 (en) 2005-05-12 2011-05-10 Third Wave Technologies, Inc. Polymorphic GHSR nucleic acids and uses thereof
EP1931806B1 (de) 2005-10-07 2011-10-05 California Institute Of Technology Pkr-aktivierung mittels hybridisierungskettenreaktion
US7482127B2 (en) 2005-11-03 2009-01-27 Third Wave Technologies, Inc. Nucleic acid detection assays employing blocker oligonucleotides
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
CN101541975B (zh) 2006-06-01 2013-04-03 第三次浪潮技术公司 核酸的检测
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
CA2665188C (en) 2006-10-04 2014-08-19 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
EP2155770B1 (de) * 2007-05-16 2013-10-16 California Institute of Technology Vielseitiges nukleinsäure-haarnadel-motiv zur programmierung biomolekularer selbstanordnungspfade
CN101970686B (zh) 2007-09-07 2013-03-27 第三次浪潮技术公司 靶标量化的方法和应用
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US20090253142A1 (en) 2008-03-15 2009-10-08 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
ES2532153T3 (es) 2008-07-18 2015-03-24 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
EP3269820A1 (de) 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit für die amplifizierung einer sequenz aus einer ribonukleinsäure
WO2013191197A1 (ja) * 2012-06-20 2013-12-27 東レ株式会社 核酸の検出方法および核酸検出キット
WO2014158628A1 (en) 2013-03-14 2014-10-02 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules
BR112015023527A2 (pt) 2013-03-15 2017-07-18 Trovagene Inc detecção de ácidos nucléicos na urina
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
US20180163259A1 (en) 2015-05-01 2018-06-14 Gen-Probe Incorporated Multiplex invasive cleavage assays
EP3481843B1 (de) 2016-07-05 2022-01-26 California Institute of Technology Hybridisierungskettenreaktion mit fraktioniertem initiator
EP3507296B1 (de) 2016-08-30 2022-10-12 California Institute of Technology Immunohistochemie mittels hybridisierungskettenreaktion
CA3156539A1 (en) 2017-07-10 2019-01-17 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
CA3072452A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated Compositions and methods for detecting staphylococcus aureus
US11662281B2 (en) 2017-12-13 2023-05-30 Gen-Probe Incorporated Compositions and methods for biological sample processing
EP3724354A1 (de) 2017-12-15 2020-10-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
EP3746225A1 (de) 2018-01-29 2020-12-09 Gen-Probe Incorporated Analytische systeme und verfahren
US20210317515A1 (en) 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
WO2020142347A2 (en) 2018-12-31 2020-07-09 Gen-Probe Incorporated Systems and methods for filling multi-well cartridges with solid reagents
JP2022518510A (ja) 2019-01-25 2022-03-15 ジェン－プローブ・インコーポレーテッド 薬物耐性ｍｙｃｏｐｌａｓｍａ ｇｅｎｉｔａｌｉｕｍの検出
CA3137749C (en) 2019-05-03 2023-12-05 Gen-Probe Incorporated Receptacle transport system for an analytical system
CN111172164B (zh) * 2020-03-09 2022-11-15 中国药科大学 一种用于任意核酸编辑的组合物及方法
EP4232379A2 (de) 2020-10-21 2023-08-30 Gen-Probe Incorporated Flüssigkeitsbehälterverwaltungssystem
EP4284925A1 (de) 2021-01-26 2023-12-06 California Institute of Technology Allosterische bedingte guide-rnas zur zellselektiven regulierung von crispr/cas
CN113774141B (zh) * 2021-09-30 2024-02-27 重庆大学 一种用于双位点顺反式突变检测的引物、探针组合物及其应用
WO2023200406A2 (en) * 2022-04-14 2023-10-19 National University Of Singapore Method of detecting a polynucleotide analyte
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

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WO1994029482A1 (en) * 1993-06-04 1994-12-22 Third Wave Technologies, Inc. 5' nucleases derived from thermostable dna polymerase

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CA1337639C (en) * 1989-08-01 1995-11-28 Joseph Eugene Celebuski Dna probe assay using neutrally charged probe strands
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
ATE217347T1 (de) * 1992-12-04 2002-05-15 Univ Yale Diagnose mittels signalverstärkung durch ein ribozym
US5422253A (en) * 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
EP0788557A4 (de) * 1994-11-09 2003-08-06 Third Wave Tech Inc Schneller nachweis und identifizierung von nukleinsäure varianten und pathogenen

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WO1994029482A1 (en) * 1993-06-04 1994-12-22 Third Wave Technologies, Inc. 5' nucleases derived from thermostable dna polymerase

Also Published As

Publication number Publication date
EP0904286A1 (de) 1999-03-31
EP1634890A1 (de) 2006-03-15
CA2243353A1 (en) 1997-07-31
AU731062B2 (en) 2001-03-22
CA2243353C (en) 2010-03-30
DK1634890T3 (da) 2009-03-09
ES2317113T3 (es) 2009-04-16
JP4295715B2 (ja) 2009-07-15
JP3665648B2 (ja) 2005-06-29
JP2005160481A (ja) 2005-06-23
ATE414793T1 (de) 2008-12-15
EP1634890B1 (de) 2008-11-19
JP2002515737A (ja) 2002-05-28
AU1836497A (en) 1997-08-20
WO1997027214A1 (en) 1997-07-31

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