EP0870596A1 - Maschine zum Pressen von mehrschichtigen Tabletten - Google Patents

Maschine zum Pressen von mehrschichtigen Tabletten Download PDF

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Publication number
EP0870596A1
EP0870596A1 EP98106369A EP98106369A EP0870596A1 EP 0870596 A1 EP0870596 A1 EP 0870596A1 EP 98106369 A EP98106369 A EP 98106369A EP 98106369 A EP98106369 A EP 98106369A EP 0870596 A1 EP0870596 A1 EP 0870596A1
Authority
EP
European Patent Office
Prior art keywords
product
container
chamber
machine according
towards
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98106369A
Other languages
English (en)
French (fr)
Inventor
Angelo Ansaloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MG 2 SpA
MG2 SpA
Original Assignee
MG 2 SpA
MG2 SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MG 2 SpA, MG2 SpA filed Critical MG 2 SpA
Publication of EP0870596A1 publication Critical patent/EP0870596A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/12—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds on the circumference of a rotating drum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/025—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space whereby the material is transferred into the press chamber by relative movement between a ram and the press chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0023—Drive arrangements for movable carriers, e.g. turntables
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
    • B30B15/304—Feeding material in particulate or plastic state to moulding presses by using feed frames or shoes with relative movement with regard to the mould or moulds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
    • B30B15/304—Feeding material in particulate or plastic state to moulding presses by using feed frames or shoes with relative movement with regard to the mould or moulds
    • B30B15/306—Feeding material in particulate or plastic state to moulding presses by using feed frames or shoes with relative movement with regard to the mould or moulds for multi-layer articles

Definitions

  • This invention relates to a tablet compressing machine for the production of multi-layer pharmaceutical tablets.
  • tablet compressing machines comprise:
  • the abovementioned pistons inside the corresponding hollow bodies move in a predetermined sequence firstly in order to create between them a chamber supplied with the pharmaceutical product and then to compact the product in order to obtain a tablet which, once formed, is ejected from the hollow body.
  • the tablet compressing machine described hereinabove has a few disadvantages.
  • a tablet made up of several layers where each layer can relate to a different pharmaceutical product cannot be obtained with this tablet compressing machine.
  • the pharmaceutical product passes between the container and the interior of the hollow body by means of a conduit with a substantially horizontal axis and therefore there is no guarantee of continuous and homogeneous feeding.
  • the pharmaceutical product may be deposits of the product along the internal walls of this conduit, obstructing the passage of the said product. Consequently, given that the dimensions of the chamber determine the quantity of product that is to be compacted, there is no guarantee that this chamber will be completely filled with the product and the actual quantity channelled into this chamber is therefore indeterminate.
  • the aim of this invention is to produce a multi-layer tablet compressing machine which does not have the aforesaid disadvantages and which therefore allows for the production of multi-layer tablets and also allows for correct and efficient channelling of the pharmaceutical product towards the compaction zone so as to determine with high precision the quantity of product to make up the layer of the tablet.
  • a multi-layer tablet compressing machine of the type adapted to compact one pharmaceutical product at a time in various stages in order to obtain one layer for each product and thereby to produce a multi-layer tablet is characterised in that it comprises:
  • the reference numeral 1 designates in its entirety a tablet compressing machine which compacts various pharmaceutical products 2 in order to obtain multi-layer tablets 3 ( Figure 8) in which each layer relates to one of the said pharmaceutical products 2.
  • the machine 1 comprises:
  • the machine 1 moreover comprises a plurality of first cams acting on the external piston 12 for the movement of the latter and a plurality of second cams acting on the internal piston 13 for the movement of the latter, the first cams being supported by an external ring gear 14 of the disc 5 and the second cams being supported by an internal ring gear 15 of the disc 5.
  • the disc 5 between the ring gears 14 and 15 is provided on its upper surface with an annular recess 16 inside which a lower portion 18 of the annular body 6 is housed by means of a bearing 17.
  • the said drive means comprise an electric motor 21 the casing of which is supported by the lower surface of the disc 5 inside the frame 4.
  • a drive shaft 23 with a vertical axis extends from the motor 21 into the recess 16 via a hole 22 formed in the disc 5, a gear wheel 24 being connected to the said drive shaft. Toothing 25 meshing with the gear wheel 24 is formed on the internal surface of the portion 18 of the body 6.
  • the annular body 6 has an upper annular portion 26 which extends towards the top outside the recess 16 and supports the said hollow bodies 7 with uniform distribution.
  • each hollow body 7 has a through hole 31 with an axis X inside which a cylinder 32 is housed in a substantially central position.
  • the cylinder 32 Coaxially with the axis X, the cylinder 32 has a through hole 33 in the interior of which the phase for preparing a chamber 34 ( Figure 4), the phase for feeding the pharmaceutical product 2 into the chamber 34 and the phase for compacting this product 2 in order to obtain one layer of the tablet 3 are carried out in succession for each feed unit, as will be seen more clearly hereinafter.
  • each hopper 11 is supported by a fixed column 11a coaxial with the corresponding axis Y'.
  • the column 11a is provided with an annular flange 11b which supports the corresponding container 8 rotating about the said axis Y'.
  • the column 11a supports a disc 10 rotating about the axis Y' by means of the bearings 9.
  • This disc 10 has a plurality of vertical through holes 19 along its external ring gear.
  • the machine 1 is provided with drive means for the disc 10 comprising an electric motor 29 to the drive shaft 30 of which a gear wheel 30a meshing with a toothed portion 10a of the disc 10 is connected.
  • the container 8 is defined by two annular walls and by a bottom wall from which the feeding elements extend towards the bottom, each of which is defined by a conduit 39 meshing with a corresponding hole 19 in the disc 10.
  • the rotation of the disc 10 therefore involves equal rotation of the container 8.
  • the circumference defined by all of the longitudinal axes of the holes 19 is tangential to the circumference defined by all of the longitudinal axes of a plurality of openings 36 each of which is formed in the upper part of each hollow body 7.
  • each conduit 39 communicates for a certain period of time with the chamber 34 of a hollow body 7 situated substantially therebelow via the said opening 36 and via a hole 37 formed in each cylinder 32.
  • An opening 38 is moreover formed in each hollow body 7 beside the cylinder 32, via which the tablet 3 drops towards the bottom ( Figure 7).
  • the pistons 12 and 13 have respective heads 41, central portions 42 and end portions 43 with a smaller diameter than that of the portions 42.
  • the end portions 43 of the two pistons 12 and 13 are adapted to slide relative to one another along the hole 33 in the cylinder 32.
  • the heads 41 of the pistons 12 and 13 are on opposite sides outside the hole 31 of the hollow body 7.
  • Each hollow body 7 supports an inverted L-shaped lever 44 on its upper surface in correspondence with the zone for housing the piston 13.
  • the lever 44 comprises a substantially horizontal portion 45 the free end of which is hinged on to a rib 46 extending towards the top from the hollow body 7 and a substantially vertical portion 47 extending towards the bottom.
  • each hollow body 7 supports a lever mechanism 48 of the type with an articulated quadrilateral acting on the opposite side to the lever 44.
  • the lever mechanism 48 comprises a fixed block 49 integral with the hollow body 7, a first lever 50 hinged via a first longitudinal end on to an upper section of a pin 52 and via a second longitudinal end on to the block 49, and a second lever 51 substantially parallel to the lever 50 hinged via a first longitudinal end on to the upper section of the pin 52 and via a central section on to the block 49, the said second lever 51 having a second longitudinal end which supports a roller 53.
  • the pin 52 is adapted to be outside the opening 36 during the feeding phase and during the phase for ejecting the multi-layer tablet 3 and is adapted to enter the opening 36 at a predetermined moment in time in order to help the product 2 fed in to drop towards the bottom via the opening 36.
  • the pin 52 then enters the interior of the hole 37 via the opening 36 in order to form a wall part of the chamber 34 via its shaped point 52a.
  • a series of cams 54 move the pin 52 as just described by means of contact with the roller 53.
  • the flange 11b supports a fixed wall 55 which extends from the top to the bottom inside the container 8.
  • This fixed wall 55 delimits an area of the container 8 in which there is no product 2 except in the conduit 39.
  • the product 2 is diverted, thereby leaving a zone of the container 8 below the wall 55 free of product 2.
  • the disc 10 for each hole 19 comprises a device 56 installed below the disc 10 and adapted to open or close the corresponding hole 19.
  • the device 56 comprises a block 57 having a flat part 57a and beside it a vertical through hole 57b.
  • the device 56 moreover comprises a horizontal pin 58 which supports the block 57 and which is movable by means of its vertical appendix 61 along a track 62 formed on the lower surface of the flange 11b from a position in which the flat part 57a closes the hole 19 and a position in which the hole 57b is coaxial with the hole 19 for a predetermined period of time.
  • the initial compaction and main compaction phases and therefore the phases for forming the layers are carried out in the section of the hole 33 situated between the chamber 34 and the opening 38.
  • the conduit 39 from which the product 2 is supposed to drop is situated in the space below the fixed wall 55 and therefore contains none of the product 2, the internal dimensions of the conduit 39 thereby defining the quantity of product 2 fed in.
  • the hole 57b is coaxial with the conduit 39 and the opening 36 so that the product 2 drops directly into the chamber 34.
  • the lever mechanism 48 comes into action, first performing the function of helping the product 2 to slide towards the chamber 34 by means of the pin 52 and then the function of delimiting the chamber 34 from above.
  • the piston 13 is moved towards the piston 12 before a reduced stroke in order to carry out the precompaction phase which allows the particles of the pharmaceutical product 2 present in the chamber 34 to be forced together and then a subsequent stroke in order to carry out the main compaction phase which determines the formation of the layer.
  • the phase for ejecting the tablet 3 takes place between the last and the first feed unit and, to this end, in this zone, the external ring gear 14 of the disc 5 supports a cam 65 which performs the function of raising the portion 47 of the lever 44 and moving the piston 12 towards the exterior and, in particular, bringing the free end of the portion 43 into correspondence with the opening 38.
  • the reference numeral 101 designates in its entirety a tablet compressing machine which differs from the machine 1 by only a few features, as a result of which those parts of the machine 101 also found in the machine 1 are designated by the same reference numerals.
  • the machine 101 is provided with feed units differing from those installed in the machine 1, for which reason the machine 101 does not have any lever mechanisms 48.
  • the feed unit of the machine 101 comprises a fixed hopper 102 and an annular container 103 rotating in the direction of the arrow R' about a vertical axis Y', the hopper 102 feeding the product 2 to the container 103 situated therebelow.
  • the feed unit of the machine 101 moreover comprises a plurality of feeding elements 104 each of which is carried by a corresponding hollow body 7.
  • Each feeding element 104 comprises a sleeve 105 with a vertical axis and a coaxial piston 106 installed within the sleeve 105.
  • Each hollow body 7 supports a block 108 by means of a vertical pin 107 with a longitudinal axis Y'', the said block carrying the upper end of the sleeve 105 and being movable along the axis Y''. In this manner, the sleeve 105 is movable along its longitudinal axis.
  • the block 108 in turn supports a second block 112 by means of a sprung vertical pin 111, the said block carrying the upper end of the piston 106 and being movable along the longitudinal axis of the pin 111.
  • the piston 106 is movable along its longitudinal axis independently of the sleeve 105.
  • the movement of the blocks 108 and 112 is controlled by two fixed cams 113.
  • the entire feeding element is lowered within the container 103 in order to remove a predetermined quantity of product 2 and immediately after this removal, it is raised so that the hollow body 7 can be discharged freely from the area of the container 103 described.
  • the phases for forming the layer are carried out in the same manner as that described for the machine 1, as illustrated in Figures 11 to 14.
  • the product 2 is removed from the container 103 by displacing the piston 106 towards the bottom to a predetermined level and by displacing the sleeve 105 towards the bottom to a level lower than that of the lower end of the piston 106 so as to create a chamber filled with product 2 inside the sleeve 105.
  • the piston 106 is then displaced towards the bottom over a reduced stroke so as to carry out reduced compaction of the product 2 inside the sleeve 105 in order to prevent the product 2 from being discharged from the sleeve 105 during the ascent of the feeding element 104.
  • the feeding element 104 is first displaced towards the bottom coaxially with the opening 36 and then only the piston 106 is displaced towards the bottom so as to discharge the product 2 from the sleeve 105 and press it towards the chamber 34.
  • the piston 106 is then displaced towards the bottom again in order to delimit the chamber 34 from above.
  • hollow bodies 7 can be grouped together in several sectors in order to facilitate assembly and disassembly thereof.
  • sectors can be produced in which several hollow bodies 7 are formed, wherein these sectors can be removed in a simple manner for correct and rapid maintenance of the machine 1, 101.
  • multi-layer tablets are produced using one pharmaceutical product for each layer.
  • the chambers 34 are moreover fed with a vertical stroke of reduced length, thereby resulting in correct and efficient feeding without the risk of deposits of the product 2 along the walls delimiting the said stroke.
  • the machine 1, 101 gives a better guarantee that the chamber 34 will be completely filled with the product 2 and that there will therefore be greater precision in the quantity of product 2 fed in from layer to layer.
  • the horizontal arrangement of the pistons 12 and 13 therefore allows for simplification of the construction and assembly of the cams controlling the stroke of the said pistons 12 and 13 and also makes it possible to produce tablets with a large number of layers.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
EP98106369A 1997-04-08 1998-04-07 Maschine zum Pressen von mehrschichtigen Tabletten Withdrawn EP0870596A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO970213 1997-04-08
IT97BO000213A IT1292853B1 (it) 1997-04-08 1997-04-08 Macchina comprimitrice per compresse multistrato.

Publications (1)

Publication Number Publication Date
EP0870596A1 true EP0870596A1 (de) 1998-10-14

Family

ID=11342189

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98106369A Withdrawn EP0870596A1 (de) 1997-04-08 1998-04-07 Maschine zum Pressen von mehrschichtigen Tabletten

Country Status (3)

Country Link
EP (1) EP0870596A1 (de)
JP (1) JPH115198A (de)
IT (1) IT1292853B1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015169756A3 (de) * 2014-05-05 2016-02-04 Gkn Sinter Metals Engineering Gmbh Pressenvorrichtung zur herstellung eines rohlings nebst verfahren hierzu und rohling

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114538933B (zh) * 2020-11-24 2022-11-22 娄底市安地亚斯电子陶瓷有限公司 一种行波管夹持杆的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1573565A (en) * 1924-07-21 1926-02-16 Paul C Mulligan Art of briquetting
FR1072611A (fr) * 1952-01-30 1954-09-14 John Holroyd & Company Ltd Machine pour produire ou enrober des pastilles, tablettes et objets analogues
DE1111340B (de) * 1960-02-15 1961-07-20 Kilian & Co G M B H Verfahren und Vorrichtung zum Herstellen von mehrschichtigen Tabletten
FR2397227A1 (fr) * 1977-07-13 1979-02-09 Thierion Gabriel Dispositif pour compacter des produits vegetaux, notamment du fourrage
EP0037689A1 (de) * 1980-03-27 1981-10-14 Manesty Machines Limited Tablettenpressmaschinen
DE29520473U1 (de) * 1995-12-22 1996-03-28 Koch, Rudolf, 83646 Bad Tölz Vorrichtung zur Herstellung von Tabletten
WO1996035566A1 (en) * 1995-05-09 1996-11-14 Fuisz Technologies, Ltd. Method and apparatus for forming compression dosage units within the product package
DE29619278U1 (de) * 1996-11-06 1996-12-12 Propharm Apotheker Koch GmbH, 83646 Bad Tölz Vorrichtung zur Herstellung von Tabletten

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1573565A (en) * 1924-07-21 1926-02-16 Paul C Mulligan Art of briquetting
FR1072611A (fr) * 1952-01-30 1954-09-14 John Holroyd & Company Ltd Machine pour produire ou enrober des pastilles, tablettes et objets analogues
DE1111340B (de) * 1960-02-15 1961-07-20 Kilian & Co G M B H Verfahren und Vorrichtung zum Herstellen von mehrschichtigen Tabletten
FR2397227A1 (fr) * 1977-07-13 1979-02-09 Thierion Gabriel Dispositif pour compacter des produits vegetaux, notamment du fourrage
EP0037689A1 (de) * 1980-03-27 1981-10-14 Manesty Machines Limited Tablettenpressmaschinen
WO1996035566A1 (en) * 1995-05-09 1996-11-14 Fuisz Technologies, Ltd. Method and apparatus for forming compression dosage units within the product package
DE29520473U1 (de) * 1995-12-22 1996-03-28 Koch, Rudolf, 83646 Bad Tölz Vorrichtung zur Herstellung von Tabletten
DE29619278U1 (de) * 1996-11-06 1996-12-12 Propharm Apotheker Koch GmbH, 83646 Bad Tölz Vorrichtung zur Herstellung von Tabletten

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015169756A3 (de) * 2014-05-05 2016-02-04 Gkn Sinter Metals Engineering Gmbh Pressenvorrichtung zur herstellung eines rohlings nebst verfahren hierzu und rohling
US10919250B2 (en) 2014-05-05 2021-02-16 Gkn Sinter Metals Engineering Gmbh Apparatus for producing a blank, also a method for this purpose and a blank

Also Published As

Publication number Publication date
ITBO970213A0 (it) 1997-04-08
ITBO970213A1 (it) 1998-10-08
IT1292853B1 (it) 1999-02-11
JPH115198A (ja) 1999-01-12

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