EP0855997A4 - Formyl derivatives as nonionic contrast media - Google Patents

Formyl derivatives as nonionic contrast media

Info

Publication number
EP0855997A4
EP0855997A4 EP96918506A EP96918506A EP0855997A4 EP 0855997 A4 EP0855997 A4 EP 0855997A4 EP 96918506 A EP96918506 A EP 96918506A EP 96918506 A EP96918506 A EP 96918506A EP 0855997 A4 EP0855997 A4 EP 0855997A4
Authority
EP
European Patent Office
Prior art keywords
contrast media
nonionic contrast
formyl derivatives
formyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96918506A
Other languages
German (de)
French (fr)
Other versions
EP0855997A1 (en
Inventor
Milos Sovak
Ronald C Terry
James Gordon Douglass Iii
Allen Seligson
Jason Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biophysica Foundation
Original Assignee
Biophysica Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophysica Foundation filed Critical Biophysica Foundation
Publication of EP0855997A1 publication Critical patent/EP0855997A1/en
Publication of EP0855997A4 publication Critical patent/EP0855997A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96918506A 1995-06-16 1996-06-13 Formyl derivatives as nonionic contrast media Withdrawn EP0855997A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49113595A 1995-06-16 1995-06-16
US491135 1995-06-16
PCT/US1996/010433 WO1997000240A1 (en) 1995-06-16 1996-06-13 Formyl derivatives as nonionic contrast media

Publications (2)

Publication Number Publication Date
EP0855997A1 EP0855997A1 (en) 1998-08-05
EP0855997A4 true EP0855997A4 (en) 1998-10-07

Family

ID=23950938

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96918506A Withdrawn EP0855997A4 (en) 1995-06-16 1996-06-13 Formyl derivatives as nonionic contrast media

Country Status (7)

Country Link
EP (1) EP0855997A4 (en)
JP (1) JPH11502231A (en)
KR (1) KR19990022943A (en)
AU (1) AU6114396A (en)
CA (1) CA2229664A1 (en)
NO (1) NO975880L (en)
WO (1) WO1997000240A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
NZ581765A (en) * 2007-07-12 2012-03-30 Ge Healthcare As Triiodinated compounds used in diagnostic compositions as contrast agents in diagnostic imaging
ES2413160T3 (en) 2007-10-12 2013-07-15 Ge Healthcare As Contrast agents
WO2009047315A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
EP2200656B1 (en) 2007-10-12 2012-12-05 GE Healthcare AS Contrast agents
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
JP2012514622A (en) * 2009-01-09 2012-06-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ Contrast preparation composition
BR112012033776A2 (en) 2010-07-12 2016-11-01 Ge Healthcare As composition and method of x-ray examination.
EP2655318B1 (en) 2010-12-21 2018-06-20 GE Healthcare AS Desalination of a composition comprising a contrast agent
CN103998349B (en) 2011-09-21 2020-01-14 通用电气医疗集团股份有限公司 Contrast media packaging
US9884808B2 (en) * 2012-09-27 2018-02-06 Ge Healthcare As Preparation of an intermediate compound of ioforminol
WO2016079330A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for local drug release
BR112018073493A2 (en) 2016-05-20 2019-03-26 Technical University Of Denmark palpable marker composition, method and part kit for identifying and / or locating a non-palpable tumor, a more precisely palpable tumor and / or target tissue, and use of a palpable marker composition.
US20220339285A1 (en) 2019-06-12 2022-10-27 Technical University Of Denmark Dissacharide formulations for controlled drug release

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001292A1 (en) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES
WO1994014478A1 (en) * 1992-12-24 1994-07-07 Bracco S.P.A. Aqueous injectable formulations useful for radio-diagnosis comprising iodinated aromatic compounds used as x-ray contrast media

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001292A1 (en) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES
WO1994014478A1 (en) * 1992-12-24 1994-07-07 Bracco S.P.A. Aqueous injectable formulations useful for radio-diagnosis comprising iodinated aromatic compounds used as x-ray contrast media

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9700240A1 *
Y. LIN ET AL.: "New nonionic Triiodated X-Ray Contrst Media ....", INVESTIGATIVE RADIOLOGY, vol. 29, - 1994, pages s275 - s277, XP002068744 *

Also Published As

Publication number Publication date
MX9710220A (en) 1998-10-31
WO1997000240A1 (en) 1997-01-03
AU6114396A (en) 1997-01-15
JPH11502231A (en) 1999-02-23
CA2229664A1 (en) 1997-01-03
KR19990022943A (en) 1999-03-25
EP0855997A1 (en) 1998-08-05
NO975880L (en) 1998-02-13

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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18W Application withdrawn

Withdrawal date: 20000817