EP0833630A4 - Nouveaux composes de benzopyranne et leurs procedes d'utilisation - Google Patents

Nouveaux composes de benzopyranne et leurs procedes d'utilisation

Info

Publication number
EP0833630A4
EP0833630A4 EP96920608A EP96920608A EP0833630A4 EP 0833630 A4 EP0833630 A4 EP 0833630A4 EP 96920608 A EP96920608 A EP 96920608A EP 96920608 A EP96920608 A EP 96920608A EP 0833630 A4 EP0833630 A4 EP 0833630A4
Authority
EP
European Patent Office
Prior art keywords
methods
benzopyran compounds
novel benzopyran
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96920608A
Other languages
German (de)
English (en)
Other versions
EP0833630A1 (fr
Inventor
Peng Cho Tang
Gerald Mcmahon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Sugen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen LLC filed Critical Sugen LLC
Publication of EP0833630A1 publication Critical patent/EP0833630A1/fr
Publication of EP0833630A4 publication Critical patent/EP0833630A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
EP96920608A 1995-06-07 1996-06-03 Nouveaux composes de benzopyranne et leurs procedes d'utilisation Withdrawn EP0833630A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US479876 1995-06-07
US08/479,876 US5763470A (en) 1995-06-07 1995-06-07 Benzopyran compounds and methods for their use
PCT/US1996/008312 WO1996040110A1 (fr) 1995-06-07 1996-06-03 Nouveaux composes de benzopyranne et leurs procedes d'utilisation

Publications (2)

Publication Number Publication Date
EP0833630A1 EP0833630A1 (fr) 1998-04-08
EP0833630A4 true EP0833630A4 (fr) 1998-09-02

Family

ID=23905805

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96920608A Withdrawn EP0833630A4 (fr) 1995-06-07 1996-06-03 Nouveaux composes de benzopyranne et leurs procedes d'utilisation

Country Status (6)

Country Link
US (1) US5763470A (fr)
EP (1) EP0833630A4 (fr)
JP (1) JPH11507042A (fr)
AU (1) AU5886196A (fr)
CA (1) CA2224100A1 (fr)
WO (1) WO1996040110A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
CO4940469A1 (es) * 1997-03-05 2000-07-24 Sugen Inc Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
US6077850A (en) 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
AU753336B2 (en) 1997-11-10 2002-10-17 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6809083B1 (en) 1998-02-12 2004-10-26 Richard A. Mueller Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ATE321856T1 (de) * 1998-06-11 2006-04-15 Humane rezeptortyrosinkinase
EP1165080A2 (fr) 1999-02-12 2002-01-02 G.D. SEARLE & CO. Utilisation de composes substitues 1,5-dideoxy-1,5-imino-d-glucitol pour traiter les infections par le virus de l'hepatite
US6515028B1 (en) 1999-02-12 2003-02-04 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US7049410B2 (en) * 1999-05-14 2006-05-23 Majumdar Adhip P N Antibodies to a novel EGF-receptor related protein (ERRP)
AU5003200A (en) 1999-05-14 2000-12-05 United States Of America As Represented By The Department Of Veterans Affairs, The Isolation and characterization of epidermal growth factor related protein
AU2001261006A1 (en) * 2000-03-28 2001-10-08 Chugai Seiyaku Kabushiki Kaisha Benzopyranes useful as tnf alpha inhibitors
EP1275398A4 (fr) * 2000-04-06 2004-09-01 Kyowa Hakko Kogyo Kk Diagnostics et remedes contre la polyarthrite rhumatoide
EP1404707A4 (fr) * 2001-05-29 2005-02-02 Univ Michigan Systemes et procedes d'analyse de proteines
WO2003105842A1 (fr) * 2002-06-13 2003-12-24 Novuspharma S.P.A. Derives de chromen-2-one utilises comme inhibiteurs de la production des vegf dans les cellules mammaliennes
AU2003250701A1 (en) * 2002-07-31 2004-02-16 Wayne R. Danter Protein tyrosine kinase inhibitors
ES2298563T3 (es) * 2002-10-09 2008-05-16 Critical Outcome Technologies, Inc. Inhibidores de proteinas tirosina cinasas.
US20050187268A1 (en) * 2004-02-23 2005-08-25 Prolexys Pharmaceuticals Inc. Non-peptidyl agents with pHSP20-like activity, and uses thereof
KR101135574B1 (ko) 2004-12-31 2012-04-23 한국화학연구원 간섬유화 및 간경화 억제 활성을 나타내는ν-(2,2-이중치환-2η-크로멘-6-일)싸이오우레아 유도체
US8048912B2 (en) * 2004-12-31 2011-11-01 Sk Chemicals Co., Ltd. Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses
US8034815B2 (en) 2007-01-11 2011-10-11 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
ES2304112B1 (es) * 2007-02-23 2009-08-13 Universidad De Zaragoza Uso de compuestos como inhibidores de la flavodoxina de helicobacter.
ES2304221B1 (es) * 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas causadas por helicobacter.
ES2304220B1 (es) * 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas.
EP2225226B1 (fr) 2007-12-26 2016-08-17 Critical Outcome Technologies, Inc. Composés et leur utilisation dans un procédé pour le traitement du cancer
CA2730890C (fr) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Composes inhibiteurs et procedes de traitement du cancer
EP3235818A3 (fr) 2010-04-01 2018-03-14 Critical Outcome Technologies, Inc. Composés pour le traitement du vih
CN102643262B (zh) * 2012-04-28 2015-08-19 苏州大学 一种8-乙氧基-2-(对氟苯基)-3-硝基-2h-苯并吡喃的制备方法
EP2853530A1 (fr) * 2013-09-25 2015-04-01 Université de Rennes 1 Nouveaux inhibiteurs PI3K/AKT/mTOR et leurs utilisations pharmaceutiques
WO2016073470A1 (fr) 2014-11-04 2016-05-12 The University Of Kansas Activateurs de l'ampk de lkb1 pour une utilisation thérapeutique dans la polykystose rénale
US10682359B2 (en) * 2017-03-31 2020-06-16 University Of South Carolina Inhibitors of glucose kinases, along with methods of their formation and use
GB201901559D0 (en) * 2019-02-05 2019-03-27 Syngenta Crop Protection Ag Herbicidal compositions
US11059842B2 (en) 2019-04-29 2021-07-13 University Of South Carolina Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
US11555047B2 (en) 2019-10-31 2023-01-17 University Of South Carolina One-step synthesis of phosphate-based inhibitors and applications thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD286358A5 (de) * 1989-08-08 1991-01-24 Karl-Marx-Universitaet Leipzig,De Verfahren zur herstellung von substituierten 6-nitro-2h-thiochromonen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323293D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Substituted flavene and thioflavene derivatives
US4966849A (en) * 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
US5217999A (en) * 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
CA2078214C (fr) * 1990-04-02 1995-03-28 Robert Lee Dow Inhibiteur de tyrosine kinase a base d'acide phenylmethanephosphonique
US5302606A (en) * 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
KR920010763B1 (ko) * 1990-12-04 1992-12-17 일양약품공업 주식회사 항종양 면역증강효과가 있는 단백다당체(g 009)
DK0584222T3 (da) * 1991-05-10 1998-02-23 Rhone Poulenc Rorer Int Bis-mono- og bicycliske aryl- og heteroarylforbindelser, som inhiberer EGF- og/eller PDGF-receptor-tyrosinkinase
CA2108889A1 (fr) * 1991-05-29 1992-11-30 Robert Lee Dow Inhibiteurs tricycliques et polyhydroxyliques de la tyrosine kinase
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
RU2155187C2 (ru) * 1992-08-06 2000-08-27 Варнер-Ламберт Компани Производные индола, их таутомеры, смеси их изомеров или отдельные изомеры и фармацевтически приемлемые соли, фармацевтическая композиция с антиопухолевой или ингибирующей протеин-тирозинкиназу активностью и способ торможения зависящего от протеин-тирозинкиназы заболевания или борьбы с аберрантным ростом клеток млекопитающего или человека.
US5330992A (en) * 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD286358A5 (de) * 1989-08-08 1991-01-24 Karl-Marx-Universitaet Leipzig,De Verfahren zur herstellung von substituierten 6-nitro-2h-thiochromonen

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 115, no. 41, 1991, Columbus, Ohio, US; abstract no. 161210b, page 105; XP002068320 *
NOBORU ONO ET AL: "3-NITROCHROMENES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., vol. 23, 1993, LETCHWORTH GB, pages 1781 - 1782, XP002068319 *
See also references of WO9640110A1 *

Also Published As

Publication number Publication date
EP0833630A1 (fr) 1998-04-08
JPH11507042A (ja) 1999-06-22
WO1996040110A1 (fr) 1996-12-19
AU5886196A (en) 1996-12-30
US5763470A (en) 1998-06-09
CA2224100A1 (fr) 1996-12-19

Similar Documents

Publication Publication Date Title
EP0833630A4 (fr) Nouveaux composes de benzopyranne et leurs procedes d'utilisation
IL117177A0 (en) Benzopyran-containing compounds and method for their use
GB2298422B (en) Compounds and their use
EP0851759A4 (fr) Composes et procedes associes
EG21140A (en) Diaper
HU9601062D0 (en) Chromone derivatives
GB9504336D0 (en) Diaper
HK1010104A1 (en) Chromane derivatives
GB2308509B (en) Services-connections for trailer-vehicles
GB2308393B (en) Windshelter for sun-bathing
GB9722556D0 (en) Methods
HU9601518D0 (en) Retinoid-like compounds
GB9521912D0 (en) Diaper
ZA962391B (en) Chromene compounds
GB2298174B (en) Services-connections for trailer-vehicles
ZA951962B (en) Chromene derivatives
IL112338A0 (en) Tampons
IL118090A0 (en) Benzopyran derivatives
GB9523233D0 (en) Bandage
GB9505905D0 (en) Methods
GB9516970D0 (en) Methods
GB9510639D0 (en) Methods
GB9516940D0 (en) Methods
AUPN112895A0 (en) Method and novel compounds for use therein
HU9600004D0 (en) Novel dialkoxy-pyridinyl-benzimidazole derivatives

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980105

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): CH DE FR GB IT LI

A4 Supplementary search report drawn up and despatched

Effective date: 19980714

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): CH DE FR GB IT LI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SUGEN, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080101