EP0813472A1 - Vorrichtung zur herstellung von tabletten - Google Patents
Vorrichtung zur herstellung von tablettenInfo
- Publication number
- EP0813472A1 EP0813472A1 EP96943935A EP96943935A EP0813472A1 EP 0813472 A1 EP0813472 A1 EP 0813472A1 EP 96943935 A EP96943935 A EP 96943935A EP 96943935 A EP96943935 A EP 96943935A EP 0813472 A1 EP0813472 A1 EP 0813472A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- rotor
- filling
- pressing tools
- pressing
- die
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/025—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space whereby the material is transferred into the press chamber by relative movement between a ram and the press chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/12—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds on the circumference of a rotating drum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
- B30B15/302—Feeding material in particulate or plastic state to moulding presses
- B30B15/308—Feeding material in particulate or plastic state to moulding presses in a continuous manner, e.g. for roller presses, screw extrusion presses
Definitions
- the invention relates to a device for producing tablets or compacts according to the preamble of the claim
- Automatic devices for the production of tablets are based on the principle that a tablet is compressed into a tablet as a result of a pressing process.
- two movable punches serve as pressing tools.
- Known automatic devices for the production of tablets have a vertically aligned lower punch which runs in a die and an upper punch which is inserted into the die only for pressing.
- the upper punch slides into the die, pushes the powder together and presses the tablet.
- the thickness, strength and gloss of the tablet depend on him and his compression pressure.
- the depth of insertion and the pressure strength can be regulated.
- the lower stamp is located inside the die. It limits the filling space downwards. During the pressing process, it usually forms the counter bearing.
- the matrices are filled using a filling funnel, the bottom part of which is called a filling shoe.
- the filling principle (fixed filling shoe on rotating matrix table) has the consequence that relatively high material losses have to be accepted and through the sealing strips to be provided on the filling shoe, for example metal abrasion, reaches the product to be manufactured.
- the so-called black spots appear on the tablet surface.
- the object of the invention is therefore to provide a device for the production of tablets or compacts with which tablets or compacts can be produced without the so-called "black spots" on the tablet surface.
- the pressing tools are preferably arranged on a rotor which can be rotated.
- the filling device can be coupled to the rotor in such a way that it can be rotated together with it.
- the rotor and the filling device can be coupled to one another via the axis of rotation.
- the filling device can consist of a bulbous filling funnel, on which funnel-shaped tapering channels are attached, the tapered ends of which open into a filling opening of the respective die. This arrangement of the filling funnel enables the matrices to be filled with the tabletted material by means of centrifugal force. As a result, poorly flowing materials can also be processed well and dosing can be carried out more precisely.
- the pressing tools that are movable relative to one another are rotated by their respective associated movement curves moved in the horizontal direction.
- a correspondingly assigned work cycle can be carried out at certain angular positions.
- a pressure roller can be mounted eccentrically to the axis of rotation of the rotor and two further pressure rollers can be arranged at the edge of the rotating part of the device, so that the eccentric pressure roller and the two further pressure rollers arranged between them during the corresponding passage Pressing tools can be pressed against each other.
- These two further pressure rollers can be arranged at a different distance from the associated pressing tools in such a way that a different pressing pressure can be generated. In this way, pre-pressing can be ensured at a certain angular position by a first pressure roller, and complete pressing can be carried out by the second pressure roller at a second angular position.
- FIGS. 1 and 2 a plan view of a part of the device according to the invention according to FIGS. 1 and
- FIGS. 1 and 2 Detail representations which explain different working steps of the device according to the invention.
- the device shown in FIGS. 1 and 2 has a rotor 1 which is driven by a motor (not shown here in any more detail) and which can be set in rotation in the direction of rotation a according to FIG. 2.
- Two pressing tools 2, 4 arranged movably relative to one another are mounted horizontally on this rotor.
- the pressing tools 2, 4 are formed in the form of an inner punch 4 and an outer punch 2, which are immersed in a corresponding bore in a die 3.
- four pairs of press tools, which interact with the corresponding matrices, are arranged on the circumference of the rotor 1.
- a material filling funnel 5, which rotates together with the rotor 1, is additionally arranged on a central axis A of the rotor 1.
- the outer pressing tool 2, ie the outer punch is displaced in a horizontal plane relative to the rotor 1 via an outer guide curve 12 (cf. FIG. 2).
- the second press tool 4, ie the inner punch is displaced via a guide curve 11 during the rotation of the rotor 1 in the horizontal plane of the rotor.
- the pressing tools 2 and 4 are in a different position relative to one another depending on the angular position of the rotor 1 due to the respective guide curves. This becomes clear from the illustration according to FIG. 2.
- the pressure rollers 6, 7 and 8 are adjustable.
- the pressure roller 6 arranged in the central region of the rotor 1 is arranged eccentrically to the axis A of the rotor 1, its eccentricity being adjustable.
- the pressure rollers 7 and 8 are each adjustable in their distance from the rotor 1. This adjustability allows the pressing forces to form the tablet or compact to be varied.
- the pressure rollers 6, 7 and 8 serve, as previously stated, to generate the necessary pressing forces and to transmit them to the pressing tools.
- the contents of the die are compressed.
- the filling device 5 is designed as a bulging filling funnel, the funnel shape being obtained by a cone arranged inside the filling funnel. Channels 9 tapering in a funnel shape are formed between the filling funnel 5 and corresponding filling openings 10 in the matrices 3. Due to the centrifugal forces which act on the tabletting material particles located in the tapering ends as a result of the rotation of the filling funnel, safe delivery and thus filling of the dies 3 in position I is ensured. 3-5, different working positions of the pressing tools 2 and 4 are shown in relation to each other. In Fig. 3 the phase of the matrix filling is shown. This representation corresponds to position I in FIG. 2. The compression of the tableting material is shown in FIG.
- phase 2 corresponds to positions II and III according to FIG. 2.
- Phase III corresponds to position IV according to FIG. 2.
- the finished tablet T can fall down through a corresponding slot 13 due to gravity into a collecting container, not shown here.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Formation And Processing Of Food Products (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE29520473U DE29520473U1 (de) | 1995-12-22 | 1995-12-22 | Vorrichtung zur Herstellung von Tabletten |
DE29520473U | 1995-12-22 | ||
PCT/EP1996/005569 WO1997023347A1 (de) | 1995-12-22 | 1996-12-12 | Vorrichtung zur herstellung von tabletten |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0813472A1 true EP0813472A1 (de) | 1997-12-29 |
EP0813472B1 EP0813472B1 (de) | 2001-11-21 |
Family
ID=8017170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96943935A Expired - Lifetime EP0813472B1 (de) | 1995-12-22 | 1996-12-12 | Vorrichtung zur herstellung von tabletten |
Country Status (4)
Country | Link |
---|---|
US (1) | US5910324A (de) |
EP (1) | EP0813472B1 (de) |
DE (2) | DE29520473U1 (de) |
WO (1) | WO1997023347A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1292853B1 (it) * | 1997-04-08 | 1999-02-11 | Mg 2 Spa | Macchina comprimitrice per compresse multistrato. |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
CN1260057C (zh) | 2001-09-05 | 2006-06-21 | 库尔图瓦股份有限公司 | 压缩单元、清洁站、压片机及其清洁方法和压片制造方法 |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
WO2003057136A2 (en) * | 2001-12-24 | 2003-07-17 | Teva Pharmaceutical Industries Ltd. | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
AU2002251085A1 (en) * | 2002-03-27 | 2003-10-13 | Bostlan, S.A. | Method for the production of high-concentration manganese mini-tablets for alloying aluminum baths and device for implementing said method |
US20040026812A1 (en) * | 2002-08-12 | 2004-02-12 | Tiy Inc. | Apparatus for bench scale tablet-making |
WO2008102901A1 (ja) * | 2007-02-19 | 2008-08-28 | Teijin Pharma Limited | 転送盤 |
CN104309154B (zh) * | 2013-12-17 | 2017-06-16 | 深圳市华创精科生物技术有限公司 | 一种双冲回转式压片机 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR352070A (fr) * | 1905-03-06 | 1905-08-02 | John Treadwell | Presse pour la fabrication des briquettes |
US852457A (en) * | 1906-07-18 | 1907-05-07 | Robert Schorr | Briqueting-machine. |
US1448982A (en) * | 1921-09-13 | 1923-03-20 | Treadwell John | Briquette press |
GB1070587A (en) * | 1964-09-16 | 1967-06-01 | V Nauciino I I T Electromashin | Method and apparatus for compressing flowable powder materials |
FR2397227A1 (fr) * | 1977-07-13 | 1979-02-09 | Thierion Gabriel | Dispositif pour compacter des produits vegetaux, notamment du fourrage |
SU770836A1 (ru) * | 1978-11-30 | 1980-10-15 | Предприятие П/Я В-8906 | Автомат дл таблетировани порошка |
US4403935A (en) * | 1980-03-27 | 1983-09-13 | Manesty Machines Limited | Tabletting machines |
IT1221567B (it) * | 1987-12-30 | 1990-07-12 | Ima Spa | Macchina comprimitrice per la realizzazione di compresse |
NL9100383A (nl) * | 1991-03-01 | 1992-10-01 | Derckx Henricus A J M | Machine voor het vervaardigen van snoepgoed. |
-
1995
- 1995-12-22 DE DE29520473U patent/DE29520473U1/de not_active Expired - Lifetime
-
1996
- 1996-12-12 DE DE59608266T patent/DE59608266D1/de not_active Expired - Fee Related
- 1996-12-12 WO PCT/EP1996/005569 patent/WO1997023347A1/de active IP Right Grant
- 1996-12-12 EP EP96943935A patent/EP0813472B1/de not_active Expired - Lifetime
- 1996-12-12 US US08/894,541 patent/US5910324A/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO9723347A1 * |
Also Published As
Publication number | Publication date |
---|---|
DE59608266D1 (de) | 2002-01-03 |
DE29520473U1 (de) | 1996-03-28 |
US5910324A (en) | 1999-06-08 |
EP0813472B1 (de) | 2001-11-21 |
WO1997023347A1 (de) | 1997-07-03 |
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