EP0783506A1 - Nouvelles imidazoloquinoxalinones heterocycliques substituees, leur preparation et leur utilisation - Google Patents

Nouvelles imidazoloquinoxalinones heterocycliques substituees, leur preparation et leur utilisation

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Publication number
EP0783506A1
EP0783506A1 EP95934074A EP95934074A EP0783506A1 EP 0783506 A1 EP0783506 A1 EP 0783506A1 EP 95934074 A EP95934074 A EP 95934074A EP 95934074 A EP95934074 A EP 95934074A EP 0783506 A1 EP0783506 A1 EP 0783506A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
group
trifluoromethyl
phenyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95934074A
Other languages
German (de)
English (en)
Inventor
Hans-Jörg Treiber
Wilfried Lubisch
Berthold Behl
Hans Peter Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19503825A external-priority patent/DE19503825A1/de
Application filed by BASF SE filed Critical BASF SE
Publication of EP0783506A1 publication Critical patent/EP0783506A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

  • the present invention relates to new heterocyclically substituted imidazoloquinoxalinones, processes for their preparation and their use for combating diseases.
  • excitatory amino acids especially glutamic acid
  • This excitatory amino acid acts as a transmitter substance for glutamate receptors, of which various subtypes are known.
  • a subtype is e.g. named after the specific agonist N-methyl-D-aspartate NMDA receptor.
  • This NMDA receptor has different binding sites for agonists or antagonists.
  • the amino acid glycine also binds to the NMDA receptor and modulates the action of the natural agonist glutamic acid. Antagonists at this glycine binding site can then show antagonistic effects on the NMDA receptor and inhibit "overexcitation" of this receptor.
  • AMPA 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
  • kainic acid Analogous to the NMDA receptor already mentioned, antagonists of these receptors could also inhibit "overexcitation”.
  • a number of neurodegenerative diseases or mental disorders have elevated glutamate levels, which can lead to states of overexcitation or toxic effects in the CNS.
  • Glutamate antagonists including in particular NMDA antagonists or their modulators (such as glycine antagonists) and the AMPA antagonists, are therefore suitable for therapeutic use as agents against neurodegenerative diseases (Huntington's disease and Parkinson's disease), neurotoxic disorders Hypoxia, anoxia or ischemia, as they occur after "Stroke”, or as antiepileptics, antidepressants and anxiolytics (cf. Medicinal Research 1990, 40, 511-514; TIPS, 1990, 11, 334-338 and Drugs of the Future 1989, 14 (11), 1059-1071.
  • a number of imidazoloquinoxalinones of the formula II are already known:
  • the compounds published as glutamate antagonists in the fused imidazole ring are only characterized by alkyl, trifluoromethyl or phenyl substituents.
  • the invention relates to new imidazolo-quinoxalinones of the formula I. wherein
  • R 1 is hydrogen, branched or rectilinear C 1-5 alkyl or a phenyl, pyridyl or thienyl group which is optionally substituted by one or two chlorine atoms, a trifluoromethyl, a nitro or methylenedioxy group,
  • R 2 is hydrogen, C 1-5 alkyl or C 3-8 dialkylaminoalkyl
  • R 3 is a chlorine or bromine atom, a trifluoromethyl, cyano or nitro group
  • A is a five-membered heterocycle, optionally substituted by R 4 and R 5, with 1-4 nitrogen atoms or with 1-2 nitrogen atoms and one oxygen or sulfur atom, each of the radicals R 4 and R 5 , which may be the same or different, being hydrogen, C 1-5 alkyl, C 1-5 hydroxyethyl, phenyl, phenyl substituted by a chlorine atom or a trifluoromethyl or nitro group, -COOH, -COO-C 1-5 alkyl,
  • B represents a bond or a C 1-5 alkylene chain
  • Preferred compounds of formula I are those in which R 1 represents a methyl, ethyl or phenyl group.
  • R 2 preferably represents a methyl or ethyl group or a hydrogen atom. If R 2 is hydrogen, these are
  • Acids capable of salt formation with alkali metal and alkaline earth metal hydroxides or organic nitrogen bases.
  • salt formation with, for example, sodium hydroxide or tris (hydroxymethyl) methylamine, the acids can, if desired, be converted into a water-soluble form.
  • Preferred Substituents for R 3 are electron-withdrawing groups such as the nitro or trifluoromethyl group in position 7.
  • Pyrrol and its derivatives are preferably mentioned as 5-ring heterocycles for A.
  • Preferred pyrrole derivatives are 3-formylpyrrole, acyl derivatives of 3-aminomethylpyrrole, such as the benzoyl or pyridoyl derivatives or those which have an arylurea group, substitution of the benzoyl group with a nitro or CF 3 group being particularly emphasized.
  • 5-ring heterocycles with 3 and 4 N atoms are, for example, 1,2,3-triazole, 1,2, 4-triazole and its derivatives, as well as the tetrazole system.
  • B preferably represents a bond.
  • the present heterocyclically substituted imidazole quinoxalinones surprisingly show advantages over known imidazole quinoxalinones, in particular higher effectiveness.
  • R 1 , R 3 and B have the meaning given above and R 2 represents an alkyl group, with 1,4-dicarbonyl compounds or amber dialdehyde derivatives, or cyclic or acyclic acetals derived therefrom, for example formula IV
  • Pyrrolyl compounds V according to the invention can be prepared by using appropriately substituted diketones or acetals of the formula IV.
  • substitution R 4 or R 5 can be changed in a suitable manner.
  • an aldehyde group can be converted into a hydroxyalkyl group or into an aminoalkyl group by reductive amination.
  • the reductive amination is in general at temperatures of 5 to 80 ° C, preferably 10 to 30 ° C, in the presence of reducing agents such as sodium cyanoborohydride or hydrogen in the presence of hydrogenation catalysts such as Pd / carbon, Pt / carbon or Raney-Nikkel, advantageously in polar organic solvents such as alcohols or dimethylformamide.
  • An aldehyde can by conventional methods, for. B. in RC Larock, "Comprehensive Organic Transformations", 1989, VCH Publisher, p. 838 f.
  • To the carboxylic acid according to the invention preferably the oxidation with potassium permanganate in solvents such as acetone is carried out at temperatures of 25 ° C.
  • the starting compounds of the formula VI, in which R 3 has the meaning given above but does not include the nitro group can be prepared analogously to a process according to EP 400 583 with subsequent nitration and reduction of the nitro group according to Scheme 1:
  • a double-activated carbonic acid derivative such as phosgene, diphenyl carbonate or, preferably, N, N'-carbonyldiimidazole in an inert aprotic solvent at an elevated temperature of 150-200 ° C.
  • the ring is closed to form imidazolo-quinoxalinone X.
  • Suitable solvents are decalin, tetralin, 1,2 -Dichlorobenzene or 1,3-dimethylethylene or propylene urea.
  • a process for the preparation of the nitro compounds XI is characterized in that compounds X (R 3 as above, but without affecting the nitro group) are nitrated with nitric acid, sulfuric acid, nitric acid or sulfuric acid potassium nitrate at temperatures between -10 ° and 20 °.
  • a further process for the preparation of the substances according to the invention is that, as described above, a nitrobenzene derivative XII, which has two interchangeable halogen atoms, is initially admixed with an imidazole derivative VII
  • R 1 -R 5 , A and B have the meaning given above.
  • Suitable heterocycles of the formula XIII are in particular
  • Suitable heterocycles can also contain another hetero atom, such as an oxygen or sulfur atom.
  • the process can optionally also be designed such that a corresponding nitrobenzene with two interchangeable halogen atoms and a protected amino group XV which is in the correct position for the final cyclization is first reacted with the desired heterocycle XIII, then with the desired imidazole derivative VII to XVI and after removal of the amino protecting group to XVII, the ring closure is carried out as described above:
  • the hydrolysis is preferably carried out under alkaline conditions, for example in the presence of an alkali metal hydroxide or of sodium hydrogen carbonate in a solvent such as water, a lower alcohol, tetrahydrofuran or mixtures thereof.
  • a solvent such as water, a lower alcohol, tetrahydrofuran or mixtures thereof.
  • the organic acids obtained in this way are optionally converted into a physiologically compatible amine or metal salt.
  • Tris (hydroxymethyl) aminomethane are antagonists of the excitatory amino acid glutamate, in particular antagonists of the glycine binding side of the NMDA receptor, the AMPA receptor and the kainate receptor. They are suitable as active pharmaceutical ingredients in human medicine and can be used to produce medicaments for the treatment of neurodegenerative diseases and neutoxic disorders of the central nervous system and for the production of antispasmodics, antiepileptics, anxiolytics and antidepressants.
  • the pharmacological activity of the compounds I was investigated on isolated membrane material from rat cerebrum. For this, the membranes were in the presence of the invention
  • 3H-2-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ( 3 H-AMPA), [ 3 H] -glycine and [ 3 H] -cainate, respectively, specifically on AMPA-, NMDA and kainate, respectively Bind receptors.
  • 3 H-AMPA 3H-2-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
  • [ 3 H] -glycine and [ 3 H] -cainate respectively, specifically on AMPA-, NMDA and kainate, respectively Bind receptors.
  • the extent of the binding of the radioactive receptor ligands mentioned to the membrane receptors was determined on the basis of the radioactivity which was measured by scintillation counting.
  • the concentration-dependent displacement of this bond by the
  • the compounds according to the invention could be used to calculate the affinity of the compounds according to the invention for the corresponding receptors.
  • the dissociation constant K l (as a measure of the affinity) was determined using an iterative nonlinear regression analysis with the Statistical Analysis System (SAS), similar to the program "Ligand” by PJ Munson and D. Rodbard (Analytical Biochem. 107, 220 (1980) , Ligand: Versatile Computerized Approach for Characterization of Ligand Binding Systems).
  • a buffer solution A consisting of 30 mM ⁇ , ⁇ , ⁇ -tris (hydroxymethyl) methylamine hydrochloride (TRIS-HCl) and 0.5 mM ethylenediaminetetraacetic acid (EDTA) - pH 7.4 - homogenized using an Ultra-Turrax ® stirrer.
  • the suspension was centrifuged at 48,000 g for 20 min. After separation of the supernatant liquid, the proteinaceous membrane material contained in the sediment was washed three times by suspending it in buffer solution A and then centrifuging at 48,000 g for 20 minutes each. The membrane material was then suspended in a 15-fold volume of buffer solution A and incubated at 37 ° C. for 30 min. The protein material was then washed twice by centrifugation and suspension and frozen at -70 ° C until used.
  • the protein material thawed at 37 ° C was centrifuged twice at 48,000 g (20 min) and then suspended in a buffer solution B of 50 mM TRIS-HCl, 0.1 M potassium thiocyanate and 2.5 mM calcium chloride - pH 7 , 1 - washed. Then 0.25 mg of membrane material, 0.1 ⁇ Ci 3 H-AMPA (60 Ci / mmol) and compound I dissolved in 1 ml of buffer solution B and incubated on ice for 60 min. The incubated solution was filtered through a CF / B filter (Whatman), which had previously been treated with a 0.5% aqueous solution of polyethyleneimine for at least 2 hours.
  • a buffer solution B 50 mM TRIS-HCl, 0.1 M potassium thiocyanate and 2.5 mM calcium chloride - pH 7 , 1 - washed. Then 0.25 mg of membrane material, 0.1 ⁇ Ci 3 H-AMPA (60 Ci / mmol)
  • the membrane residue was then washed with 5 ml of cold buffer solution B in order to separate bound and free 3H-AMPA from one another. After measuring the radioactivity of the bound 3 H-AMPA in the membrane material by scintillation counting, the K 1 value was determined by evaluating the displacement curves by means of regression analysis.
  • rat hippocampi were homogenized in a 10-fold volume of preparation buffer (50 mM Tris-HCl, 10 mM EDTA) using a Potter homogenizer. The homogenate was centrifuged at 48,000 xg for 20 min. The supernatant was discarded and the membranes obtained in the pellet were washed twice by resuspending and centrifuging at 48000 xg (20 min each). The resuspended membranes were frozen in liquid nitrogen and thawed again at 37 ° C. After a further washing step, the membrane suspension was incubated for 15 min at 37 ° C. in a shaking water bath.
  • preparation buffer 50 mM Tris-HCl, 10 mM EDTA
  • the membranes were frozen at -70 ° C. until further use.
  • the frozen membranes were thawed at 37 ° C. and washed twice by centrifugation at 48,000 ⁇ g (20 min) and then resuspending in binding buffer (50 mM Tris-HCl pH 7.4; 10 mM MgCl 2 ).
  • An incubation mixture contained 0.25 mg protein (membranes), 25 nM 3 H-glycine (16 Ci / mmol) and the substances to be tested in a total of 0.5 ml binding buffer. Non-specific binding was determined by adding 1 mM glycine.
  • the frozen membranes were thawed at 37 ° C, suspended in binding buffer (50 mM Tris-HCl pH 7.4) and centrifuged at 48,000 x g for 20 min. The membranes in the pellet were resuspended in binding buffer. An incubation batch contained 0.25 mg protein (membranes),
  • the pharmaceutical preparations according to the invention contain a therapeutically effective amount of the compounds I.
  • the active ingredients are present in an amount of 0.0001 to 1% by weight, preferably 0.001 to 0.1% by weight.
  • the preparations are administered in single doses. 0.1 to 100 mg per kg body weight are given in a single dose.
  • the preparations can be in a daily or several doses depending on the type and severity of the diseases.
  • the pharmaceutical preparations according to the invention contain, in addition to the active ingredient, the customary carriers and diluents.
  • pharmaceutical technical auxiliaries such as ethanol, isopropanol, ethoxylated castor oil, ethoxylated hydrogenated castor oil, polyacrylic acid, polyethylene glycol, polyethylene glycol stearate, ethoxylated fatty alcohols, paraffin oil, petroleum jelly and wool fat can be used.
  • z As milk sugar, propylene glycol, ethanol, starch, talc and polyvinyl pyrrolidone.
  • Antioxidants such as tocopherol and butylated hydroxyanisole and butylated hydroxytoluene, taste-improving additives, stabilizers, emulsifiers and lubricants can also be present.
  • the substances contained in the preparation in addition to the active substance and the substances used in the manufacture of the pharmaceutical preparation are toxicologically safe and compatible with the respective active substance.
  • the preparation of the pharmaceutical preparations is carried out in a conventional manner, e.g. B. by mixing the active ingredient with the other conventional carriers and diluents.
  • the pharmaceutical preparations can be administered in various modes of administration, such as orally, parenterally, subcutaneously, intraperitoneally and topically.
  • forms of preparation such as tablets, emulsions, infusion and injection solutions, pastes, ointments, gels, creams, lotions, powders and sprays are possible.
  • Example 1 4,5-Dihydro-1-methyl-8 (pyrrol-1-yl) -7-trifluoromethyl-4-oxo-imidazolo [1,2-a] quinoxaline-2-carboxylic acid ethyl ester a. 1- (2-nitro-4-trifluoromethylphenyl) -4-carbethoxy-5-methylimidazole
  • the cooled reaction mixture was mixed with 1000 ml of water, extracted with 250 ml of methylene chloride and the methylene chloride phase was dried with magnesium sulfate. The dried solution was evaporated and the residue was crystallized by trituration with ether.
  • Ethyl 4,5-dihydro-1-methyl-4-oxo-imidazolo- [1,2-a] quinoxaline-2-carboxylate was obtained by reacting 2-fluoronitrobenzene with 4 (5) -carbethoxy-5 (4) methylimidazole, followed by Hydrogenation and by subsequent ring closure with N, N'-carbonyldiimidazole.
  • the preceding compound d) was selectively hydrolyzed with hydrochloric acid, the compound first being heated to 70 ° C. and then slowly being cooled to room temperature.
  • the above compound was obtained by hydrolysis of the compound according to Example 27 with lithium hydroxide according to Example 10.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Des imidazoloquinoxalinones répondent à la formule (I), dans laquelle R1 désigne hydrogène, alkyle C¿1-5? à chaîne droite ou ramifiée, ou un groupe phényle, pyridyle ou thiényle substitué le cas échéant par un ou deux atomes de chlore ou par un groupe trifluorométhyle, nitrodioxy ou méthylènedioxy; R?2¿ désigne hydrogène, alkyle C¿1-5? ou dialkylaminoalkyle C3-8; R?3¿ désigne un atome de chlore ou de brome, un groupe trifluorométhyle, cyano ou nitro; A désigne un hétérocycle à cinq éléments substitué le cas échéant par R4 et R5, possédant 1 à 4 atomes d'azote ou 1 à 2 atomes d'azote et un atome d'oxygène ou de soufre, et les restes R4 et R5, qui peuvent être identiques ou différents, désignent hydrogène, alkyle C¿1-5?, hydroxyéthyle C1-5, phényle, phényle substitué par un atome de chlore, un groupe trifluorométhyle ou un groupe nitro, -CHO, -COOH, -COO-C1-5-alkyle, -CH2-NR?6R7 (où R6¿ désigne H, alkyle C¿1-5 et R?7 désigne H, alkyle C¿1-5?), -CH2-NH-CO=-R?8 (où R8¿ désigne alkyle-C¿1-5?, phényle, un groupe phényle ou un groupe hétéroaryle substitués le cas échéant par un atome de chlore d'un groupe nitro ou trifluorométhyle) ou -CH2-NHCONHR?8¿; et B désigne une liaison ou une chaîne alkylène C¿1-5?. L'invention concerne également les formes tautomères et isomères de ces composés ainsi que leurs sels physiologiquement compatibles. Ces nouvelles substances ont une action antagoniste vis-à-vis du glutamate et sont utiles pour combattre des maladies neurodégénératives.
EP95934074A 1994-09-30 1995-09-19 Nouvelles imidazoloquinoxalinones heterocycliques substituees, leur preparation et leur utilisation Withdrawn EP0783506A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4434941 1994-09-30
DE4434941 1994-09-30
DE19503825A DE19503825A1 (de) 1994-09-30 1995-02-06 Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung
DE19503825 1995-02-06
PCT/EP1995/003686 WO1996010572A1 (fr) 1994-09-30 1995-09-19 Nouvelles imidazoloquinoxalinones heterocycliques substituees, leur preparation et leur utilisation

Publications (1)

Publication Number Publication Date
EP0783506A1 true EP0783506A1 (fr) 1997-07-16

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EP95934074A Withdrawn EP0783506A1 (fr) 1994-09-30 1995-09-19 Nouvelles imidazoloquinoxalinones heterocycliques substituees, leur preparation et leur utilisation

Country Status (16)

Country Link
US (1) US6121265A (fr)
EP (1) EP0783506A1 (fr)
JP (1) JPH10513435A (fr)
CN (1) CN1046518C (fr)
AU (1) AU3650695A (fr)
BG (1) BG101328A (fr)
BR (1) BR9509055A (fr)
CA (1) CA2200358A1 (fr)
CZ (1) CZ94297A3 (fr)
FI (1) FI971317A0 (fr)
HU (1) HUT73969A (fr)
IL (1) IL115444A0 (fr)
NO (1) NO971424L (fr)
PL (1) PL319406A1 (fr)
SI (1) SI9520108A (fr)
WO (1) WO1996010572A1 (fr)

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DE19611476A1 (de) * 1996-03-22 1997-09-25 Basf Ag Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung
WO2000051590A2 (fr) * 1999-03-04 2000-09-08 The Board Of Trustees Of The University Of Illinois Traitement neuropharmacologique des troubles de respiration lies au sommeil
US7542773B2 (en) * 2002-03-29 2009-06-02 At&T Intellectual Property I, L.P. Customized alerts for incoming data messages
CN100386326C (zh) * 2003-10-22 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 1-羟甲基咪唑并[1，2-a]喹喔啉化合物及其应用
MX2008009475A (es) * 2006-01-23 2008-10-20 Amira Pharmaceuticals Inc Inhibidores triciclicos de 5-lipoxigenasa.
EP2666775A1 (fr) * 2012-05-21 2013-11-27 Domain Therapeutics Pyrazoloquinazolinones et pyrroloquinazolinones substitués en tant que modulateurs allostériques des récepteurs métabotropiques du glutamate du groupe II
FR3031105B1 (fr) * 2014-12-31 2018-04-06 Universite De Montpellier Nouveaux imidazo[1,2-a]quinoxalines et derives pour le traitement des cancers

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JPH09508632A (ja) * 1994-02-11 1997-09-02 ノボ ノルディスク アクティーゼルスカブ 複素環式化合物並びにそれらの製造及び使用
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Also Published As

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SI9520108A (en) 1997-10-31
BG101328A (en) 1997-08-29
NO971424D0 (no) 1997-03-25
CA2200358A1 (fr) 1996-04-11
PL319406A1 (en) 1997-08-04
JPH10513435A (ja) 1998-12-22
BR9509055A (pt) 1998-06-23
HU9502847D0 (en) 1995-11-28
AU3650695A (en) 1996-04-26
FI971317A (fi) 1997-03-27
WO1996010572A1 (fr) 1996-04-11
HUT73969A (en) 1996-10-28
IL115444A0 (en) 1995-12-31
US6121265A (en) 2000-09-19
NO971424L (no) 1997-05-22
CZ94297A3 (en) 1997-08-13
CN1159807A (zh) 1997-09-17
FI971317A0 (fi) 1997-03-27
CN1046518C (zh) 1999-11-17

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