EP0699230B1 - Bleichmethoden mit peroxysäurenaktivatoren zusammen mit enzymen - Google Patents

Bleichmethoden mit peroxysäurenaktivatoren zusammen mit enzymen Download PDF

Info

Publication number
EP0699230B1
EP0699230B1 EP94916771A EP94916771A EP0699230B1 EP 0699230 B1 EP0699230 B1 EP 0699230B1 EP 94916771 A EP94916771 A EP 94916771A EP 94916771 A EP94916771 A EP 94916771A EP 0699230 B1 EP0699230 B1 EP 0699230B1
Authority
EP
European Patent Office
Prior art keywords
alkyl
group
caprolactam
carbon atoms
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP94916771A
Other languages
English (en)
French (fr)
Other versions
EP0699230A1 (de
Inventor
Alan David Willey
Michael Eugene Burns
Richard Timothy Hartshorn
Chanchal Kumar Ghosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP0699230A1 publication Critical patent/EP0699230A1/de
Application granted granted Critical
Publication of EP0699230B1 publication Critical patent/EP0699230B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C11D3/3917—Nitrogen-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C11D3/3917—Nitrogen-containing compounds
    • C11D3/392—Heterocyclic compounds, e.g. cyclic imides or lactames

Definitions

  • the present invention relates to methods of laundering which employ one or more types of detersive enzymes and a bleaching system with one or more bleach activators.
  • peroxygen bleaches are effective for stain and/or soil removal from fabrics, but that such bleaches are temperature dependent. At a laundry liquor temperature of 60°C, peroxygen bleaches are only partially effective. As the laundry liquor temperature is lowered below 60°C, peroxygen bleaches become relatively ineffective. As a consequence, there has been a substantial amount of industrial research to develop bleaching systems which contain an activator that renders peroxygen bleaches effective at laundry liquor temperatures below 60°C.
  • TAED tetraacetyl ethylene diamine
  • NOBS nonanoyloxybenzenesulfonate
  • activators which generally comprise long chain alkyl moieties
  • Another problem in developing an all-around cleaning composition has been finding a cleaning agent that is effective under heavy soil load conditions.
  • the removal of heavy soil levels, especially nucleophilic and body soils, has proven especially difficult for conventional bleaching systems.
  • conventional activators such as NOBS appear to interact with, and be destroyed by, heavy soil loads before they can optimally provide their intended bleaching function.
  • Still another problem has been the stability of enzymes, especially lipases and proteases, in the presence of bleaches.
  • DAP diacylperoxide
  • the class of hydrophobic bleach activators derived from amido acids forms hydrophobic amido peracids upon perhydrolysis without the production of harmful, oily DAP's.
  • the DAP's produced by the perhydrolysis reaction of the amido acid-derived bleach activators used herein are insoluble crystalline solids. The solids do not form a coating film; therefore, the natural rubber parts are not exposed to the DAP's for extended periods of time and remain substantially undamaged.
  • the present invention solves the long-standing need for methods which provide efficient and effective performance over a wide range of cleaning needs by combining the cleaning actions of enzymes with the hydrophobic cleaning action of amido derived bleach activators or with the hydrophobic and hydrophilic cleaning action of N-acyl caprolactam bleach activators.
  • the invention also provides efficient and effective methods for washing machines which have parts made of natural rubber, such that the natural rubber is substantially undamaged by the bleaching system.
  • EP-A-0170386 and EP-A-0290292 describe amido-derived bleach activators and its corresponding peracids. Enzymes such as proteases or amylases may also be included within the bleaching compositions.
  • DE-A-3938526 discloses benzoxazin bleach activators in washing and cleaning compositions which may contain, among various auxiliaries, enzymes.
  • EP-A-0122763 discloses bleach activators such as N-acetyl caprolactam adsorbed onto perborate. Enzymes can optionally be included within the compositions.
  • WO-A-94/10284 discloses a granular detergent composition comprising an amido-derived bleach activator and a protease enzyme.
  • the invention herein provides methods which are safe for use in contact with natural rubber, and which provide not only bleach performance, but also good detersive enzyme stability and performance.
  • the present invention encompasses methods, which use compositions comprising an effective amount of one or more types of enzymes and a bleaching system comprising at least 0.1%, by weight, of a peroxygen bleaching compound and at least 0.1%, by weight, of one or more bleach activators, wherein said bleach activators are members selected from the group consisting of:
  • the molar ratio of hydrogen peroxide yielded by the peroxygen bleaching compound to bleach activator is greater than 1.0. Most preferably, the molar ratio of hydrogen peroxide to bleach activator is at least 1.5.
  • Preferred bleach activators of type a) are those wherein R 1 is an alkyl group containing from 6 to 12 carbon atoms, R 2 contains from 1 to 8 carbon atoms, and R 5 is H or methyl.
  • Particularly preferred bleach activators are those of the above general formulas wherein R 1 is an alkyl group containing from 7 to 10 carbon atoms and R 2 contains from 4 to 5 carbon atoms.
  • Preferred bleach activators of type b) are those wherein R 2 , R 3 , R 4 , and R 5 are H and R 1 is a phenyl group.
  • the preferred acyl moieties of said N-acyl caprolactam bleach activators of type c) have the formula R 6 -CO- wherein R 6 is H or an alkyl, aryl, alkoxyaryl, or alkaryl group containing from 1 to 12 carbons, preferably from 6 to 12 carbon atoms.
  • R 6 is a member selected from the group consisting of phenyl, heptyl, octyl, nonyl, 2,4,4-trimethylpentyl, decenyl and mixtures thereof.
  • compositions comprising bleach activators selected from the group consisting of:
  • the peroxygen bleaching compound can be any peroxide source, and is preferably a member selected from the group consisting of sodium perborate monohydrate, sodium perborate tetrahydrate, sodium pyrophosphate peroxyhydrate, urea peroxyhydrate, sodium percarbonate, sodium peroxide and mixtures thereof.
  • Preferred peroxygen bleaching compounds are selected from the group consisting of sodium perborate monohydrate, sodium percarbonate, sodium perborate tetrahydrate and mixtures thereof.
  • a highly preferred peroxygen bleaching compound is sodium percarbonate.
  • amido-derived and caprolactam bleach activators herein can also be used in combination with rubber-safe, enzyme-safe, hydrophilic activators such as TAED, typically at weight ratios of amido-derived or caprolactam activators:TAED in the range of 1:5 to 5:1, preferably about 1:1.
  • rubber-safe, enzyme-safe, hydrophilic activators such as TAED, typically at weight ratios of amido-derived or caprolactam activators:TAED in the range of 1:5 to 5:1, preferably about 1:1.
  • the methods herein are effective with all manner of detersive enzymes, e.g., members selected from the group consisting of proteases, amylases, lipases, cellulases, peroxidases and mixtures thereof.
  • lipase enzymes derived from the fungus Humicola lanuginosa , optionally as expressed in Aspergillus oryzae as host using art-disclosed genetic engineering techniques.
  • modified protease bacterial serine protease enzymes obtained from Bacillus subtilis, Bacillus lentus or Bacillus licheniformis. Said enzymes comprise at least 0.001%, preferably from 0.001% to 5%, of the detergent compositions.
  • the method can be carried out at temperatures below 60°C but, of course, is quite effective and is still safe to rubber parts at laundry temperatures up to the boil.
  • the aqueous laundry liquor comprises usually at least 300 ppm of conventional detergent ingredients, as well as at least 25 ppm of bleach activator and at least 25 ppm of bleaching compound.
  • said aqueous liquor comprises from 900 ppm to 20,000 ppm of the conventional detergent ingredients, from 100 ppm to 25,000 ppm of bleaching compound and from 100 ppm to 2,500 ppm of said bleach activator.
  • the conventional detergent ingredients employed in said method comprise generally from 1% to 99.8%, preferably from 5% to 80%, of a detersive surfactant.
  • detersive compositions can also comprise from 5% to 80% of a detergent builder.
  • Other optional detersive ingredients are also encompassed by the fully-formulated detergent/bleach compositions provided by this invention.
  • the detergent compositions employed in the present invention provide effective and efficient surface cleaning of fabrics which thereby removes stains and/or soils from the fabrics.
  • the bleaching systems in combination with one or more types of enzymes are particularly efficient at removing most types of soils from the fabrics, including protein and lipid soils, dingy soils, and heavy soil loads, especially from nucleophilic and body soils.
  • the superior bleaching/cleaning action of the present compositions is achieved with safety to natural rubber machine parts and other natural rubber articles, including fabrics containing natural rubber and natural rubber elastic materials.
  • the bleaching mechanism and, in particular, the surface bleaching mechanism are not completely understood. However, it is generally believed that the bleach activator undergoes nucleophilic attack by a perhydroxide anion, which is generated from the hydrogen peroxide evolved by the peroxygen bleach, to form a peroxycarboxylic acid. This reaction is commonly referred to as perhydrolysis.
  • the bleaching systems and activators herein afford additional advantages in that, unexpectedly, they are safer to fabrics and cause less color damage than other activators when used in the manner provided by this invention.
  • bleach activators within the invention can render peroxygen bleaches more efficient even at laundry liquor temperatures wherein bleach activators are not necessary to activate the bleach, i.e., above about 60°C. Therefore, with bleach systems of the invention, less peroxygen bleach is required to get the same level of surface bleaching performance as is obtained with the peroxygen bleach alone.
  • the bleaching systems wherein the bleach activator is used, also have as an essential component a peroxygen bleach capable of releasing hydrogen peroxide in aqueous solution.
  • Amido Derived Bleach Activators employed in the present invention are amide substituted compounds of the general formulas: or mixtures thereof, wherein R 1 , R 2 and R 5 are as defined above and L can be essentially any suitable leaving group.
  • a leaving group is any group that is displaced from the bleaching activator as a consequence of the nucleophilic attack on the bleach activator by the perhydroxide anion. This, the perhydrolysis reaction, results in the formation of the peroxycarboxylic acid.
  • a group to be a suitable leaving group it must exert an electron attracting effect. It should also form a stable entity so that the rate of the back reaction is negligible. This facilitates the nucleophilic attack by the perhydroxide anion.
  • the L group must be sufficiently reactive for the reaction to occur within the optimum time frame (e.g., a wash cycle). However, if L is too reactive, this activator will be difficult to stabilize for use in a bleaching composition.
  • pKa of the conjugate acid of the leaving group although exceptions to this convention are known. Ordinarily, leaving groups that exhibit such behavior are those in which their conjugate acid has a pKa in the range of from 4 to 13, preferably from about 6 to about 11 and most preferably from 8 to 11.
  • Preferred bleach activators are those of the above general formula wherein R 1 , R 2 and R 5 are as hereinabove defined and L is selected from the group consisting of: and mixtures thereof, wherein R 1 is an alkyl, aryl, or alkaryl group containing from 1 to 14 carbon atoms, R 3 is an alkyl chain containing from 1 to 8 carbon atoms, R 4 is H or R 3 , and Y is H or a solubilizing group.
  • the preferred solubilizing groups are -SO 3 - M + , -CO 2 - M + , -SO 4 - M + , -N + (R 3 ) 4 X - and O ⁇ --N(R 3 ) 3 and most preferably -SO 3 - M + and -CO 2 - M + wherein R 3 is an alkyl chain containing from 1 to 4 carbon atoms, M is a cation which provides solubility to the bleach activator and X is an anion which provides solubility to the bleach activator.
  • M is an alkali metal, ammonium or substituted ammonium cation, with sodium and potassium being most preferred, and X is a halide, hydroxide, methylsulfate or acetate anion.
  • bleach activators with a leaving group that does not contain a solubilizing groups should be well dispersed in the bleaching solution in order to assist in their dissolution.
  • Preferred bleach activators are those of the above general formula wherein L is selected from the group consisting of: wherein R 3 is as defined above and Y is -SO 3 - M + or -CO 2 - M + wherein M is as defined above.
  • bleach activators including those of type b) and type c), provide organic peracids as described herein by ring-opening as a consequence of the nucleophilic attack on the carbonyl carbon of the cyclic ring by the perhydroxide anion.
  • this ring-opening reaction in type c) activators involves attack at the caprolactam ring carbonyl by hydrogen peroxide or its anion. Since attack of an acyl caprolactam by hydrogen peroxide or its anion occurs preferably at the exocyclic carbonyl, obtaining a significant fraction of ring-opening may require a catalyst.
  • Another example of ring-opening bleach activators can be found in type b) activators, such as those disclosed in U.S. Patent 4,966,723, Hodge et al, issued Oct. 30, 1990.
  • Such activator compounds disclosed by Hodge include the activators of the benzoxazin-type, having the formula: including the substituted benzoxazins of the type wherein R 1 is H, alkyl, alkaryl, aryl, arylalkyl, and wherein R 2 , R 3 , R 4 , and R 5 may be the same or different substituents selected from H, halogen, alkyl, alkenyl, aryl, hydroxyl, alkoxyl, amino, alkyl amino, COOR 6 (wherein R 6 is H or an alkyl group) and carbonyl functions.
  • a preferred activator of the benzoxazin-type is:
  • washing solutions wherein the pH of such solution is between 8.5 and 10.5 and preferably between 9.5 and 10.5 in order to facilitate the perhydrolysis reaction.
  • pH can be obtained with substances commonly known as buffering agents, which are optional components of the bleaching systems herein.
  • the N-Acyl Caprolactam Bleach Activators employed in the present invention have the formula: wherein R 6 is H or an alkyl, aryl, alkoxyaryl, or alkaryl group containing from 1 to 12 carbons.
  • R 6 is H or an alkyl, aryl, alkoxyaryl, or alkaryl group containing from 1 to 12 carbons.
  • Caprolactam activators wherein the R 6 moiety contains at least 6, preferably from 6 to 12, carbon atoms provide hydrophobic bleaching which affords nucleophilic and body soil clean-up, as noted above.
  • Caprolactam activators wherein R 6 comprises from 1 to 6 carbon atoms provide hydrophilic bleaching species which are particularly efficient for bleaching beverage stains.
  • Mixtures of hydrophobic and hydrophilic caprolactams, typically at weight ratios of 1:5 to 5:1, preferably 1:1, can be used herein for mixed stain removal benefits.
  • N-acyl caprolactams are selected from the group consisting of benzoyl caprolactam, octanoyl caprolactam, nonanoyl caprolactam, 3,5,5trimethylhexanoyl caprolactam, decanoyl caprolactam, undecenoyl caprolactam, and mixtures thereof.
  • N-acyl caprolactams are well known in the art. Examples I and II, included below, illustrate preferred laboratory syntheses.
  • the bleach activator is preferably not absorbed onto the peroxygen bleaching compound. To do so in the presence of other organic detersive ingredients could cause safety problems.
  • the bleach activators of type a), b) or c) will comprise at least 0.1%, preferably from 0.1% to 50%, more preferably from 1% to 30%, most preferably from 3% to 25%, by weight of bleaching system or detergent composition.
  • washing solutions wherein the pH of such solution is between 8.5 and 10.5 and preferably between 9.5 and 10.5 in order to facilitate the perhydrolysis reaction.
  • pH can be obtained with substances commonly known as buffering agents, which are optional components of the bleaching systems herein.
  • the peroxygen bleaching systems useful herein are those capable of yielding hydrogen peroxide in an aqueous liquor. These compounds are well known in the art and include hydrogen peroxide and the alkali metal peroxides, organic peroxide bleaching compounds such as urea peroxide, and inorganic persalt bleaching compounds, such as the alkali metal perborates, percarbonates, perphosphates, and the like. Mixtures of two or more such bleaching compounds can also be used, if desired.
  • Preferred peroxygen bleaching compounds include sodium perborate, commercially available in the form of mono-, tri-, and tetra-hydrate, sodium pyrophosphate peroxyhydrate, urea peroxyhydrate, sodium percarbonate, and sodium peroxide. Particularly preferred are sodium perborate tetrahydrate, sodium perborate monohydrate and sodium percarbonate. Percarbonate is especially preferred because it is very stable during storage and yet still dissolves very quickly in the bleaching liquor. It is believed that such rapid dissolution results in the formation of higher levels of percarboxylic acid and, thus, enhanced surface bleaching performance.
  • Highly preferred percarbonate can be in uncoated or coated form.
  • the average particle size of uncoated percarbonate ranges from 400 to 1200 microns, most preferably from 400 to 600 microns.
  • the preferred coating materials include mixtures of carbonate and sulphate, silicate, borosilicate, or fatty carboxylic acids.
  • the peroxygen bleaching compound will comprise at least 0.1%, preferably from 1% to 75%, more preferably from 3% to 40%, most preferably from 3% to 25%, by weight of bleaching system or detergent composition.
  • the weight ratio of bleach activator to peroxygen bleaching compound in the bleaching system typically ranges from 2:1 to 1:5. Preferred ratios range from 1:1 to 1:3.
  • bleach activator/bleaching compound systems herein are useful per se as bleaches.
  • bleaching systems are especially useful compositions which can comprise various detersive adjuncts such as surfactants and, builders.
  • the detersive enzymes of the present invention are included for a wide variety of fabric laundering purposes, including removal of protein-based, carbohydrate-based, or triglyceride-based stains, for example, and for the prevention of fugitive dye transfer.
  • the enzymes to be incorporated include proteases, amylases, lipases, cellulases, and peroxidases, as well as mixtures thereof.
  • Other types of enzymes may also be included. They may be of any suitable origin, such as vegetable, animal, bacterial, fungal and yeast origin. However, their choice is governed by several factors such as pH-activity and/or stability optima, thermostability, stability versus active detergents, builders and so on. In this respect bacterial or fungal enzymes are preferred, such as bacterial amylases and proteases, and fungal cellulases.
  • Enzymes are normally incorporated at levels sufficient to provide up to 50 mg by weight, more typically 0.01 mg to 10 mg, of active enzyme per gram of detergent composition. Stated otherwise, an effective amount of the enzymes employed in the present invention will comprise at least 0.001%, preferably from 0.001% to 5%, more preferably from 0.001% to 1%, most preferably from 0.01% to 1%, by weight of detergent composition.
  • proteases are the subtilisins which are obtained from particular strains of B.subtilis, B.lentus and B.licheniforms.
  • Another suitable protease is a modified bacterial serine protease enzyme obtained from Bacillus subtilis or Bacillus licheniformis , having maximum activity throughout the pH range of 8-12, developed and sold by Novo Industries A/S under the registered trade name ESPERASE. The preparation of this enzyme and analogous enzymes is described in British Patent Specification No. 1,243,784 of Novo.
  • Proteolytic enzymes suitable for removing protein-based stains include those sold under the tradenames ALCALASE and SAVINASE by Novo Industries A/S (Denmark) and MAXATASE by International Bio-Synthetics, Inc. (The Netherlands).
  • Other proteases include Protease A (see European Patent Application 130,756, published January 9, 1985) and Protease B (see European Patent Application Serial No. 87303761.8, filed April 28, 1987, and European Patent Application 130,756, Bott et al, published January 9, 1985).
  • Protease C is a variant of an alkaline serine protease from Bacillus , particularly Bacillus lentus , in which arginine replaced lysine at position 27, tyrosine replaced valine at position 104, serine replaced asparagine at position 123, and alanine replaced threonine at position 274.
  • Protease C is described in EP 90915958.4, U.S. Patent No. 5,185,250 and U.S. Patent No. 5,204,015. Genetically modified variants, particularly of Protease C, are also included herein.
  • Amylases include, for example, a-amylases described in British Patent Specification No. 1,296,839 (Novo), RAPIDASE, International Bio-Synthetics, Inc. and TERMAMYL, Novo Industries.
  • the cellulases usable in the present invention include both bacterial or fungal cellulase. Preferably, they will have a pH optimum of between 5 and 9.5. Suitable cellulases are disclosed in U.S. Patent 4,435,307, Barbesgoard et al, issued March 6, 1984, which discloses fungal cellulase produced from Humicola insolens and Humicola strain DSM1800 or a cellulase 212-producing fungus belonging to the genus Aeromonas, and cellulase extracted from the hepatopancreas of a marine mollusk (Dolabella Auricula Solander). Suitable cellulases are also disclosed in GB-A-2.075.028; GB-A-2.095.275 and DE-OS-2.247.832.
  • Suitable lipase enzymes for detergent usage include those produced by microorganisms of the Pseudomonas group, such as Pseudomonas stutzeri ATCC 19.154, as disclosed in British Patent 1,372,034. See also lipases in Japanese Patent Application 53-20487, laid open to public inspection on February 24, 1978. This lipase is available from Amano Pharmaceutical Co. Ltd., Nagoya, Japan, under the trade name Lipase P "Amano,” hereinafter referred to as "Amano-P.” Other commercial lipases include Amano-CES, lipases ex Chromobacter viscosum, e.g. Chromobacter viscosum var.
  • lipolyticum NRRLB 3673 commercially available from Toyo Jozo Co., Tagata, Japan; and further Chromobacter viscosum lipases from U.S. Biochemical Corp., U.S.A. and Disoynth Co., The Netherlands, and lipases ex Pseudomonas gladioli.
  • the LIPOLASE enzyme derived from the fungus Humicola lanuginosa and expressed in Aspergillus oryzae as host and commercially available from Novo (see also E.P. Patent 341,947) is a preferred lipase for use herein.
  • Peroxidase enzymes are used in combination with oxygen sources, e.g., percarbonate, perborate, persulfate, hydrogen peroxide, etc. They are used for "solution bleaching," i.e. to prevent transfer of dyes or pigments removed from substrates during wash operations to other substrates in the wash solution.
  • Peroxidase enzymes are known in the art, and include, for example, horseradish peroxidase, ligninase, and haloperoxidase such as chloro- and bromo-peroxidase.
  • Peroxidase-containing detergent compositions are disclosed, for example, in PCT International Application WO 89/099813, published October 19, 1989, by O. Kirk, assigned to Novo Industries A/S.
  • Enzyme stabilization systems are also described, for example, in U.S. Patents 4,261,868, 3,600,319, and 3,519,570.
  • Enzyme Stabilizers The enzymes employed herein are stabilized by the presence of water-soluble sources of calcium ions in the finished compositions which provide calcium ions to the enzymes. Additional stability can be provided by the presence of various other art-disclosed stabilizers, especially borate species: see Severson, U.S. 4,537,706, cited above.
  • Typical detergents, especially liquids will comprise from 1 to 30, preferably from 2 to 20, more preferably from 5 to 15, and most preferably from 8 to 12, millimoles of calcium ion per liter of finished composition. This can vary somewhat, depending on the amount of enzyme present and its response to the calcium ions.
  • the level of calcium ion should be selected so that there is always some minimum level available for the enzyme, after allowing for complexation with builders, fatty acids, etc., in the composition.
  • Any water-soluble calcium salt can be used as the source of calcium ion, including, but not limited to, calcium chloride, calcium sulfate, calcium malate, calcium hydroxide, calcium formate, and calcium acetate.
  • a small amount of calcium ion generally from 0.05 to 0.4 millimoles per liter, is often also present in the composition due to calcium in the enzyme slurry and formula water.
  • the formulation may include a sufficient quantity of a water-soluble calcium ion source to provide such amounts in the laundry liquor. In the alternative, natural water hardness may suffice.
  • compositions herein may also optionally, but preferably, contain various additional stabilizers including silicate coatings and, especially borate-type stabilizers.
  • additional stabilizers including silicate coatings and, especially borate-type stabilizers.
  • such stabilizers will be used at levels in the compositions from 0.25% to 10%, preferably from 0.5% to 5%, more preferably from 0.75% to 3%, by weight of boric acid or other borate compound capable of forming boric acid in the composition (calculated on the basis of boric acid).
  • Boric acid is preferred, although other compounds such as boric oxide, borax and other alkali metal borates (e.g., sodium ortho-, meta- and pyroborate, and sodium pentaborate) are suitable.
  • Substituted boric acids e.g., phenylboronic acid, butane boronic acid, and p-bromo phenylboronic acid
  • the amount of detersive surfactant included in the fully-formulated detergent compositions used according to the present invention can vary from 1% to 99.8% depending upon the particular surfactants used and the effects desired.
  • the detersive surfactants comprise from 5% to 80% by weight of the detergent ingredients.
  • the detersive surfactant can be nonionic, anionic, ampholytic, zwitterionic, or cationic. Mixtures of these surfactants can also be used.
  • Preferred detergent compositions comprise anionic detersive surfactants or mixtures of anionic surfactants with other surfactants, especially nonionic surfactants.
  • Nonlimiting examples of surfactants useful herein include the conventional C 11- C 18 alkyl benzene sulfonates and primary, secondary, and random alkyl sulfates, the C 10 -C 18 alkyl alkoxy sulfates, the C 10 -C 18 alkyl polyglycosides and their corresponding sulfated polyglycosides, C 12 -C 18 alpha-sulfonated fatty acid esters, C 12 -C 18 alkyl and alkyl phenol alkoxylates (especially ethoxylates and mixed ethoxy/propoxy), C 12 -C 18 betaines and sulfobetaines ("sultaines”), C 10 -C 18 amine oxides, and the like.
  • Other conventional useful surfactants are listed in standard texts.
  • adjunct nonionic surfactants especially useful herein comprises the polyhydroxy fatty acid amides of the formula: wherein: R 1 is H, C 1 -C 8 hydrocarbyl, 2-hydroxyethyl, 2-hydroxypropyl, or a mixture thereof, preferably C 1 -C 4 alkyl, more preferably C 1 or C 2 alkyl, most preferably C 1 alkyl (i.e., methyl); and R 2 is a C 5 -C 32 hydrocarbyl moiety, preferably straight chain C 7 -C 19 alkyl or alkenyl, more preferably straight chain C 9 -C 17 alkyl or alkenyl, most preferably straight chain C 11 -C 19 alkyl or alkenyl, or mixture thereof; and Z is a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain with at least 2 (in the case of glyceraldehyde) or at least 3 hydroxyls (in the case of other reducing sugars) directly connected to the
  • Z preferably will be derived from a reducing sugar in a reductive amination reaction; more preferably Z is a glycityl moiety.
  • Suitable reducing sugars include glucose, fructose, maltose, lactose, galactose, mannose, and xylose, as well as glyceraldehyde.
  • high dextrose corn syrup, high fructose corn syrup, and high maltose corn syrup can be utilized as well as the individual sugars listed above. These corn syrups may yield a mix of sugar components for Z. It should be understood that it is by no means intended to exclude other suitable raw materials.
  • Z preferably will be selected from the group consisting of -CH 2 -(CHOH) n -CH 2 OH,CH(CH 2 OH)-(CHOH) n-1 - -CH 2 OH,-CH 2- -(CHOH) 2 (CHOR')(CHOH)-CH 2 ,OH, where n is an integer from 1 to 5, inclusive, and R' is H or a cyclic mono- or poly- saccharide, and alkoxylated derivatives thereof. Most preferred are glycityls wherein n is 4, particularly -CH 2 -(CHOH) 4 CH 2 OH.
  • R 1 can be, for example, N-methyl, N-ethyl, N-propyl, Nisopropyl, N-butyl, N-isobutyl, N-2-hydroxy ethyl, or N-2-hydroxy propyl.
  • R 1 is preferably methyl or hydroxyalkyl.
  • R 1 is preferably C 2- C 8 alkyl, especially n-propyl, iso-propyl, n-butyl, iso-butyl, pentyl, hexyl and 2-ethyl hexyl.
  • R 2 -CO-N ⁇ can be, for example, cocamide, stearamide, oleamide, lauramide, myristamide, capricamide, palmitamide, tallowamide, etc.
  • Optional detergent ingredients employed in the present invention contain inorganic and/or organic detersive builders to assist in mineral hardness control. If used, these builders comprise from 5% to 80% by weight of the detergent compositions.
  • Inorganic detersive builders include, but are not limited to, the alkali metal, ammonium and alkanolammonium salts of polyphosphates (exemplified by the tripolyphosphates, pyrophosphates, and glassy polymeric meta-phosphates), phosphonates, phytic acid, silicates, carbonates (including bicarbonates and sesquicarbonates), sulphates, and aluminosilicates.
  • polyphosphates exemplified by the tripolyphosphates, pyrophosphates, and glassy polymeric meta-phosphates
  • phosphonates phosphonates
  • phytic acid e.g., silicates
  • carbonates including bicarbonates and sesquicarbonates
  • sulphates sulphates
  • aluminosilicates aluminosilicates
  • silicate builders are the alkali metal silicates, particularly those having a SiO 2 :Na 2 O ratio in the range 1.6:1 to 3.2:1 and layered silicates, such as the layered sodium silicates described in U.S. Patent 4,664,839, issued May 12, 1987 to H. P. Rieck, available from Hoechst under the trademark "SKS"; SKS-6 is an especially preferred layered silicate builder.
  • Carbonate builders especially a finely ground calcium carbonate with surface area greater than 10 m 2 /g, are preferred builders that can be used in granular compositions.
  • the density of such alkali metal carbonate built detergents can be in the range of 450-850 g/l with the moisture content preferably below 4%.
  • carbonate builders are the alkaline earth and alkali metal carbonates as disclosed in German Patent Application No. 2,321,001 published on November 15, 1973.
  • Aluminosilicate builders are especially useful in the present invention.
  • Preferred aluminosilicates are zeolite builders which have the formula: Na z [(AlO 2 ) z (SiO 2 ) y ] . xH 2 O wherein z and y are integers of at least 6, the molar ratio of z to y is in the range from 1.0 to 0.5, and x is an integer from 15 to 264.
  • aluminosilicate ion exchange materials are commercially available. These aluminosilicates can be crystalline or amorphous in structure and can be naturally-occurring aluminosilicates or synthetically derived. Methods for producing aluminosilicate ion exchange materials are disclosed in U.S. Patent 3,985,669, Krummel, et al, issued October 12, 1976, and U.S. Patent 4,605,509, Corkill, et al, issued Aug. 12, 1986. Preferred synthetic crystalline aluminosilicate ion exchange materials useful herein are available under the designations Zeolite A, Zeolite P (B) (including those disclosed in EPO 384,070), and Zeolite X. Preferably, the aluminosilicate has a particle size of about 0.1-10 microns in diameter.
  • Organic detersive builders suitable for the purposes of the present invention include, but are not restricted to, a wide variety of polycarboxylate compounds, such as ether polycarboxylates, including oxydisuccinate, as disclosed in Berg, U.S. Patent 3,128,287, issued April 7, 1964, and Lamberti et al, U.S. Patent 3,635,830, issued January 18, 1972. See also "TMS/TDS" builders of U.S. Patent 4,663,071, issued to Bush et al, on May 5, 1987.
  • Suitable ether polycarboxylates also include cyclic compounds, particularly alicyclic compounds, such as those described in U.S. Patents 3,923,679; 3,835,163; 4,158,635; 4,120,874 and 4,102,903.
  • ether hydroxy-polycarboxylates copolymers of maleic anhydride with ethylene or vinyl methyl ether, 1, 3, 5trihydroxy benzene-2, 4, 6-trisulphonic acid, and carboxymethyl-oxysuccinic acid
  • various alkali metal, ammonium and substituted ammonium salts of polyacetic acids such as ethylenediamine tetraacetic acid and nitrilotriacetic acid
  • polycarboxylates such as mellitic acid, succinic acid, oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic acid, carboxymethyloxysuccinic acid, and soluble salts thereof.
  • Citrate builders e.g., citric acid and soluble salts thereof (particularly sodium salt), are preferred polycarboxylate builders that can also be used in granular compositions, especially in combination with zeolite and/or layered silicate builders.
  • detergent compositions of the present invention are the 3,3-dicarboxy-4-oxa-1,6-hexanedioates and the related compounds disclosed in U.S. Patent 4,566,984, Bush, issued January 28, 1986.
  • the various alkali metal phosphates such as the well-known sodium tripolyphosphates, sodium pyrophosphate and sodium orthophosphate can be used.
  • Phosphonate builders such as ethane-1hydroxy-1,1-diphosphonate and other known phosphonates (see, for example, U.S. Patents 3,159,581; 3,213,030; 3,422,021; 3,400,148 and 3,422,137) can also be used.
  • the conventional detergent ingredients employed herein can be selected from typical detergent composition components such as detersive surfactants and detersive builders.
  • the detergent ingredients can include one or more other detersive adjuncts or other materials for assisting or enhancing cleaning performance, treatment of the substrate to be cleaned, or to modify the aesthetics of the detergent composition.
  • Usual detersive adjuncts of detergent compositions include the ingredients set forth in U.S. Pat. No. 3,936,537, Baskerville et al, are incorporated herein by reference.
  • adjuncts which can be included in detergent compositions employed in the present invention, in their conventional art-established levels for use (generally from 0% to 20% of the detergent ingredients, preferably from 0.5% to 10%), include color speckles, suds boosters, suds suppressors, antitarnish and/or anticorrosion agents, soil-suspending agents, soil release agents, dyes, fillers, optical brighteners, germicides, alkalinity sources, hydrotropes, antioxidants, perfumes, solvents, solubilizing agents, clay soil removal/anti-redeposition agents, polymeric dispersing agents, processing aids, fabric softening components and static control agents.
  • Bleach systems optionally, but preferably, will also comprise a chelant which not only enhances bleach stability by scavenging heavy metal ions which tend to decompose bleaches, but also assists in the removal of polyphenolic stains such as tea stains, and the like.
  • a chelant including the aminophosphonates, available as DEQUEST from Monsanto, the nitrilotriacetates, the hydroxyethyl-ethylenediamine triacetates, and the like, are known for such use.
  • Preferred biodegradable, non-phosphorus chelants include ethylene-diamine disuccinate ("EDDS"; see U.S.
  • EDDG ethylenediamine-N,N'-diglutamate
  • HPDDS 2-hydroxypropylenediamine-N,N'-disuccinate
  • Such chelants can be used in their alkali or alkaline earth metal salts, typically at levels from 0.1% to 10% of the present compositions.
  • the detergent compositions employed herein can comprise, in addition to the bleaching system of the present invention, one or more other conventional bleaching agents, activators, or stabilizers which do not react with or otherwise harm natural rubber.
  • the formulator will ensure that the bleach compounds used are compatible with the detergent formulation.
  • Conventional tests such as tests of bleach activity on storage in the presence of the separate or fully-formulated ingredients, can be used for this purpose.
  • a specific example of an optional bleaching agent for incorporation in this invention is tetraacetyl ethylene diamine (TAED)
  • TAED tetraacetyl ethylene diamine
  • Such bleaching compounds and agents can be optionally included in detergent compositions in their conventional art-established levels of use, generally from 0% to 15%, by weight of detergent composition.
  • Bleaching activators of the invention are especially useful in conventional laundry detergent compositions such as those typically found in granular detergents or laundry bars.
  • reaction mixture is then cooled, filtered, and the solvent removed by rotary evaporation to yield 121.7g of the product as an oil which crystallizes on standing.
  • This crude product is then redissolved in toluene and precipitated with hexane, yielding 103g (79% theoretical yield) of a white solid which which is shown by NMR to be over 95% pure, with the remaining material being benzoic acid.
  • NACA-Cl Acid Chloride
  • the reaction is carried out in a 5L, 3-necked flask equipped with an addition funnel, mechanical stirrer and argon sweep.
  • To a suspension of 542g (2.0 moles) of NACA in 2L of toluene is added (in a slow stream over 30 minutes) 476g (4.0 moles) of thionyl chloride.
  • This mixture is stirred at room temperature for four hours during which time the solids dissolve.
  • the solution is partially evaporated (30°C, 10 mm) to remove any excess thionyl chloride leaving 905g of NACA-Cl/toluene solution (contains approximately 2 moles of NACA-Cl).
  • An IR spectrum confirms conversion of COOH to COCI.
  • NACA-OBS (6-nonanamidocaproyl)oxybenzenesulfonate (NACA-OBS) -
  • the reactor is a 12L, 3-necked flask equipped with a condenser, mechanical stirrer and static argon supply.
  • To the reactor are added 647g of the above NACA-Cl/toluene solution (1.43 moles), 6L of toluene and 310.8g (1.43 moles) of disodium p-phenolsulfonate (disodium p-phenolsulfonate is previously prepared and dried in a vacuum oven before use (110°C, 0.1mm hg, 18 hours). This mixture is refluxed for 18 hours.
  • a granular detergent composition comprising the following ingredients.
  • Aqueous crutcher mixes of heat and alkali stable components of the detergent compositions are prepared and spray-dried and the other ingredients are admixed so that they contain the ingredients tabulated at the levels shown.
  • the detergent granules with bleach activator are added together with 5 lb. (2.3 kg) of previously laundered fabrics including natural rubber articles such as elastic materials, to an automatic washing machine equipped with a natural rubber sump hose. Actual weights of detergent and bleach activator are taken to provide a 950 ppm concentration of the former and 50 ppm concentration of the latter in the 17 gallon (65 l) water-fill machine.
  • the water used has 119,8 mg/liter (7 grains/gallon) hardness and a pH of 7 to 7.5 prior to (about 9 to about 10.5 after) addition of the detergent and bleaching system.
  • the fabrics are laundered at 35°C (95°F) for a full cycle (12 min.) and rinsed at 21°C (70°F).
  • the laundering method is repeated for 2,000 wash cycles without rupture of, or significant damage to, the natural rubber parts or without damage to the natural rubber contained in the fabrics and with good enzyme performance.
  • a granular detergent composition comprising the following ingredients.
  • Nonionic surfactant 5 Zeolite (0.1-10 micron) 10
  • Trisodium citrate 2 SKS-6 silicate builder 10 Acrylate maleate polymer 4
  • Nonanoyl caprolactam 5 Sodium percarbonate 15 Sodium carbonate 5
  • Ethylenediamine disuccinate chelant (EDDS) 0.4 Suds suppressor 2 Protease (as SAVINASE) 0.3 Lipase (as LIPOLASE) 0.3 Soil release agent 0.2 Minors, filler and water Balance to 100%
  • Aqueous crutcher mixes of heat and alkali stable components of the detergent composition are prepared and spray-dried, and the other ingredients are admixed so that they contain the ingredients tabulated at the levels shown.
  • the detergent granules with bleach activator are added via the dispensing drawer together with 5 lb. (2.3 kg) of previously laundered fabrics to an automatic washing machine equipped with a natural rubber sump hose. Actual weights of detergent and bleach activator are taken to provide a 8,000 ppm concentration of the former and 400 ppm concentration of the latter in the 17 1 water-fill machine.
  • the water used has 10 grains/gallon hardness and a pH of 7 to 7.5 prior to (about 9 to about 10.5 after) addition of the detergent and bleaching system.
  • the fabrics are laundered at 40°C (104°F) for a full cycle (40 min.) and rinsed at 21°C (70°F).
  • the laundering method is repeated for 2,000 wash cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example V, with the single exception that an equivalent amount of benzoyloxybenzene sulfonate is substituted for the nonanoyl caprolactam.
  • the laundering method of Example V is repeated for about 1200 cycles at which time the natural rubber parts ruptures.
  • a detergent composition is prepared by a procedure identical to that of Example V, with the single exception that an equivalent amount of (6-nonanamidocaproyl)-oxybenzenesulfonate as prepared in Example III is substituted for the nonanoyl caprolactam.
  • the laundering method of Example V is repeated for 2000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example V, with the exceptions that 15% of a 1:1:1 mixture of benzoyl caprolactam, nonanoyl caprolactam and (6-nonanamidocaproyl)oxybenzene-sulfonate as prepared following Example III is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example IV, with the exceptions that 20% of a 1:1 mixture of benzoyl caprolactam and (6-nonanamidocaproyl)oxybenzenesulfonate as prepared following Example III is substituted for the nonanoyl caprolactam, the amount of sodium percarbonate is 20%, and the amount of phosphate is 0%.
  • the laundering method of Example IV is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example V, with the single exception that an equivalent amount of a benzoxazin-type activator is substituted for the nonanoyl caprolactam.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example V, with the exceptions that 10% of a 1:1 mixture of a benzoxazin-type activator and tetraacetyl ethylene diamine is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 25%.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a laundry bar suitable for hand-washing soiled fabrics is prepared by standard extrusion processes and comprises the following: Component Weight % C 12 linear alkyl benzene sulfonate 30 Phosphate (as sodium tripolyphosphate) 7 Sodium carbonate 25 Sodium pyrophosphate 7 Coconut monoethanolamide 2 Zeolite A (0.1-10 micron) 5 Carboxymethylcellulose 0.2 Polyacrylate (m.w. 1400) 0.2 (6-nonanamidocaproyl)oxybenzenesulfonate 5 Sodium percarbonate 5 Brightener, perfume 0.2 Protease (as Protease C) 0.3 Lipase (as LIPOLASE) 0.3 CaSO 4 1 MgSO 4 1 Water 4 Filler Balance to 100%
  • the detergent laundry bars are processed in conventional soap or detergent bar making equipment as commonly used in the art. Testing is conducted following the procedures and methods in Example V. The laundering method, is repeated for 2,000 wash cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XII, with the single exception that an equivalent amount of benzoyl caprolactam is substituted for the (6-nonanamidocaproyl)oxybenzenesulfonate.
  • the laundering method of Example XII is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XII, with the single exception that an equivalent amount of nonanoyl caprolactam is substituted for the (6-nonanamidocaproyl)oxybenzenesulfonate.
  • the laundering method of Example XII is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a granular detergent composition comprising the following ingredients.
  • Nonionic surfactant 5 Zeolite (0.1-10 micron) 10
  • Trisodium citrate 2 SKS-6 silicate builder 10 Acrylate maleate polymer 4
  • Nonanoyl caprolactam 5 Sodium percarbonate 15 Sodium carbonate 5
  • Ethylenediamine disuccinate chelant (EDDS) 0.4 Suds suppressor 2 Protease (as Protease C) 0.5 Soil release agent 0.2 Minors, filler and water Balance to 100%
  • Aqueous crutcher mixes of heat and alkali stable components of the detergent composition are prepared and spray-dried, and the other ingredients are admixed so that they contain the ingredients tabulated at the levels shown.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the single exception that an equivalent amount of benzoyl caprolactam is substituted for the nonanoyl caprolactam.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the exceptions that 15%, by weight, of (6-nonanamidocaproyl)oxybenzenesulfonate is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the exceptions that 15%, by weight, of a 1:1 mixture of (6nonanamidocaproyl)oxybenzenesulfonate and (6-decanamidocaproyl)oxybenzenesulfonate activator is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the exceptions that 15%, by weight, of a 1:1 mixture of (6octanamidocaproyl)oxybenzenesulfonate and (6-decanamidocaproyl)oxybenzenesulfonate activator is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the exceptions that 15%, by weight, of (6-octanamidocaproyl)oxybenzenesulfonate is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant damage to, the natural rubber parts and with good enzyme stability and performance.
  • a detergent composition is prepared by a procedure identical to that of Example XV, with the exceptions that 15%, by weight, of (6-decanamidocaproyl)oxybenzenesulfonate activator is substituted for the nonanoyl caprolactam and the amount of sodium percarbonate is 30%.
  • Example V Testing is conducted following the procedures and methods in Example V.
  • the laundering method of Example V is repeated for 2,000 cycles without rupture of, or significant to, the natural rubber parts and with good enzyme stability and performance.
  • the bleach activators may be processed with a range of organic and inorganic substances to achieve a rapid dispersion in the bleaching liquor and to insure good stability in the detergent composition.
  • the bleach activators are preferably employed in particulate form.
  • caprolactam bleach activator particles is an agglomerate of 65%, by weight, benzoyl caprolactam; 7% of a builder, such as aluminium silicate; 15% sodium carbonate; 9% dispersant, such as a polyacrylate polymer; and 4% of a solubilizing agent, such as a linear alkyl sulfonate.
  • a preferred caprolactam bleach activator particle is an agglomerate of 80% to 85%, by weight, benzoyl caprolactam and 15% to 20% of a binder, such as tallow alcohol ethoxylate, preferably TAE25.
  • An example of a preferred amido-derived bleach activator particle comprises a 1:1:1 mixture of (6-octanamidocaproyl)oxybenzenesulfonate, (6decanamidocaproyl)-oxybenzenesulfonate, and citric acid powder.
  • the mixture is intimately mixed in a food mixer for 5-10 minutes.
  • To the resultant mixture is added tallow alcohol ethoxylate (TAE25) nonionic surfactant at 50° C until granules are formed.
  • TAE25 tallow alcohol ethoxylate
  • successful granulations are achieved with a ratio of bleach activator/citric acid solid mixtures:nonionic binding agent of 3.5:1.
  • the resultant granules, ellipsodial and spherical in shape, are white and free flowing.
  • a typical particle composition is 40% to 60%, preferably 55%, by weight, of the bleach activator or mixture of bleach activators; 20% to 40%, preferably 25%, by weight, of citric acid; and 15% to about 30%, preferably 20%, by weight, TAE25 binding agent.
  • a 2:1 mixture of (6-decanamidocaproyl)oxybenzenesulfonate and citric acid powder may be used.
  • the composition on the granule is 55% bleach activator, 25% citric acid, and 20% TAE25 binding agent.
  • Other preferred organic binding agents include anionic surfactants (C 12 linear alkyl benzene sulfonates), polyethylene glycols, and TAE50.
  • a preferred amido-derived bleach activator particle comprises a 1:1:1 mixture of (6-octanamidocaproyl)oxybenzenesulfonate, (6-decanamidocaproyl)oxybenzenesulfonate, and sodium hydrogen sulfate.
  • an anionic surfactant alkyl sulfate is particularly perferred.
  • the components are mixed into a paste with water, typically 30-50% by weight of water being added, and introduced into an air flow such that droplets are formed.
  • This techinque is commonly known as spray drying. This may be achieved using, for example a Nyro atomiser, or a spray gun.
  • Hot air typically 150-300 degree Celisius
  • the resulting particles formed are collected at the bottom of the column and classified into desired size.
  • a typical particle composition is 40-60%, preferably 55%, by weight of the bleach activator or mixture of activators, 20-40%, preferably 25%, of sodium hydrogen sulfate, and 15-25%, preferably about 20%, of anionic surfactant.
  • a 2:1 mixture of (6decanamidocaproyl)oxybenzenesulfonate and sodium hydrogen sulfate may be used.
  • Citric acid or boric acid may also be used in place of sodium hydrogen sulfate in the above examples.
  • the particle size of the resulting granules may be varied according to the desired performance/stability. Fine particles ( ⁇ 250 um) show improved solubility; though coarse particles (>1180 um) are more stable in high temperatures/moist environments. A typical, preferred particle size range is 250-1180 um; particles conforming to this specification show excellent stability and solubility.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Claims (10)

  1. Verfahren zum Reinigen von Textilien in einer automatischen Waschmaschine, welche Teile aufweist, die aus natürlichem Kautschuk hergestellt sind, welcher gegenüber oxidativem Abbbau anfällig ist, wobei das Verfahren das Bewegen der Textilien in der Maschine in einer wäßrigen Flotte umfaßt, welche eine Waschmittelzusammensetzung enthält, umfassend eine wirksame Menge eines oder mehrerer Typen von Enzymen und ein Bleichmittelsystem, umfassend mindestens 0,1 Gew.-% einer Persauerstoff-Bleichmittelverbindung, die in der Lage ist, Wasserstoffperoxid in einer wäßrigen Flotte zu erzielen und mindestens 0,1 Gew. -% eines oder mehrerer Bleichaktivatoren, wobei die Bleichaktivatoren Vertreter sind, gewählt aus der Gruppe, bestehend aus:
    a) einem Bleichaktivator der allgemeinen Formel:
    Figure 00420001
    oder Mischungen hiervon, worin R1 eine Alkyl-, Aryl- oder Alkarylgruppe mit 1 bis 14 Kohlenstoffatomen ist, R2 eine Alkylen-, Arylen- oder Alkarylengruppe mit 1 bis 14 Kohlenstoffatomen ist, R5 H oder eine Alkyl-, Aryl- oder Alkarylgruppe mit 1 bis 10 Kohlenstoffatomen ist, und L eine Abgangsgruppe ist;
    b) einem Bleichaktivator vom Benzoxazin-Typ der Formel:
    Figure 00420002
    worin R1 H, Alkyl, Alkaryl, Aryl, Arylalkyl ist und worin R2, R3, R4 und R5 gleiche oder verschiedene Substituenten sein können, gewählt aus H, Halogen, Alkyl, Alkenyl, Aryl, Hydroxyl, Alkoxyl, Amino, Alkylamino, -COOR6, worin R6 H oder eine Alkylgruppe ist, und Carbonylfunktionen;
    c) einem N-Acylcaprolactam-Beichaktivator der Formel:
    Figure 00430001
    worin R6 H oder eine Alkyl-, Aryl-, Alkoxyaryl- oder Alkarylgruppe mit 1 bis 12 Kohlenstoffatomen ist; und
    d) Mischungen von a), b) und c).
  2. Verfahren nach Anspruch 1, wobei die Enzyme mindestens 0,001 Gew.-% der Waschmittelzusammensetzung umfassen und aus der Gruppe gewählt sind, bestehend aus Proteasen, Amylasen, Lipasen, Cellulasen, Peroxidasen und Mischungen hiervon.
  3. Verfahren nach Anspruch 2, wobei das Enzym Lipase ist, abgeleitet von dem Pilz Humicola lanuginosa oder eine modifizierte bakterielle Serinprotease, abgeleitet von Bacillus subtilis, Bacillus lentus oder Bacillus licheniformis.
  4. Verfahren nach mindestens einem der vorangehenden Ansprüche, wobei der Bleichaktivator aus der Gruppe gewählt ist, bestehend aus:
    a) einem Bleichaktivator der Formel:
    Figure 00430002
    oder Mischungen hiervon, worin R1 eine Alkyl-, Aryl- oder Alkarylgruppe mit 1 bis 14 Kohlenstoffatomen ist, R2 eine Alkylen-, Arylen- oder Alkarylengruppe mit 1 bis 14 Kohlenstoffatomen ist, R5 H oder eine Alkyl-, Aryl- oder Alkarylgruppe mit 1 bis 10 Kohlenstoffatomen ist, und L eine Abgangsgruppe ist;
    b) einem N-Acylcaprolactam-Bleichaktivator der Formel:
    Figure 00440001
    worin R6 H oder eine Alkyl-, Aryl-, Alkoxyaryl- oder Alkarylgruppe mit 1 bis 12 Kohlenstoffatomen ist; und
    c) Mischungen von a) und b);
    und wobei das Enzym aus der SAVINASE, Protease C und Mischungen hiervon umfassenden Gruppe gewählt ist.
  5. Verfahren nach mindestens einem der vorangehenden Ansprüche, wobei der Bleichaktivator aus der Gruppe gewählt ist, bestehend aus Benzoylcaprolactam, Nonaylcaprolactam, Octanoylcaprolactam, 3,5,5-Trimethylhexanoylcaprolactam, Decanoylcaprolactam, Undecenoylcaprolactam, (6-Octanamidocaproyl)oxybenzolsulfonat, (6-Nonanamidocaproyl)oxybenzolsulfonat, (6-Decanamidocaproyl)oxybenzolsulfonat und Mischungen hiervon; das Enzym Protease C ist; und die Persauerstoff-Bleichmittelverbindung aus der Gruppe gewählt ist, bestehend aus Natriumperboratmonohydrat, Natriumperborattetrahydrat, Natriumpyrophosphatperoxyhydrat, Harstoffperoxyhydrat, Natriumpercarbonat, Natriumperoxid und Mischungen hiervon.
  6. Verfahren nach mindestens einem der vorangehenden Ansprüche, wobei das Molverhältnis von Wasserstoffperoxid zu Bleichaktivator größer als 1,0 ist.
  7. Verfahren nach den Ansprüchen 1 bis 4, wobei R1 eine Alkylgruppe mit 6 bis 12, vorzugsweise 7 bis 10 Kohlenstoffatomen ist; R2 1 bis 8, vorzugsweise 4 bis 5 Kohlenstoffatome enthält; R5 H oder Methyl ist; und L aus der Gruppe gewählt ist, bestehend aus:
    Figure 00440002
    Figure 00450001
    Figure 00450002
    Figure 00450003
    Figure 00450004
    und Mischungen hiervon, worin R1 wie in Anspruch 1 definiert ist, R3 eine Alkylkette mit 1 bis 8 Kohlenstoffatomen ist, R4 H oder R3 ist, und Y H oder eine solubilisierende Gruppe ist.
  8. Verfahren nach Anspruch 7, wobei L aus der Gruppe gewählt ist, bestehend aus:
    Figure 00450005
    worin R3 eine Alkylkette mit 1 bis 8 Kohlenstoffatomen ist, Y -SO3 -M+ oder CO2 -M+ ist, worin M Natrium oder Kalium ist.
  9. Zusammensetzung nach Anspruch 1, wobei der Bleichaktivator vom Benzoxazin-Typ der Formel entspricht:
    Figure 00460001
  10. Verfahren nach mindestens einem der vorangehenden Ansprüche, wobei die Zusammensetzung weiterhin 5 bis 80 Gew.-% eines Waschtensids: 5 bis 80 Gew.-% eines Waschmittelbuilders; und 0 bis 20 Gew. -% herkömmliche Waschmittelzusatzstoffe umfaßt.
EP94916771A 1993-05-20 1994-05-12 Bleichmethoden mit peroxysäurenaktivatoren zusammen mit enzymen Expired - Lifetime EP0699230B1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US151316 1988-02-01
US6456393A 1993-05-20 1993-05-20
US64563 1993-05-20
US13369193A 1993-10-07 1993-10-07
US15131693A 1993-11-12 1993-11-12
US19632294A 1994-02-15 1994-02-15
US196322 1994-02-15
PCT/US1994/005372 WO1994028106A1 (en) 1993-05-20 1994-05-12 Bleaching compounds comprising peroxyacid activators used with enzymes
US133691 1998-08-13

Publications (2)

Publication Number Publication Date
EP0699230A1 EP0699230A1 (de) 1996-03-06
EP0699230B1 true EP0699230B1 (de) 1998-09-02

Family

ID=27490432

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94916771A Expired - Lifetime EP0699230B1 (de) 1993-05-20 1994-05-12 Bleichmethoden mit peroxysäurenaktivatoren zusammen mit enzymen

Country Status (14)

Country Link
EP (1) EP0699230B1 (de)
JP (1) JPH08510780A (de)
CN (1) CN1086734C (de)
AT (1) ATE170552T1 (de)
AU (1) AU6833594A (de)
BR (1) BR9406531A (de)
CA (1) CA2161212A1 (de)
CZ (1) CZ305995A3 (de)
DE (1) DE69413028T2 (de)
ES (1) ES2120047T3 (de)
HU (1) HUT73731A (de)
MA (1) MA23200A1 (de)
PE (1) PE56994A1 (de)
WO (1) WO1994028106A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803604B2 (en) 2000-07-28 2010-09-28 Henkel Ag & Co. Kgaa Amylolytic enzyme extracted from Bacillus sp. A 7-7 (DSM 12368) and washing and cleaning agents containing this novel amylolytic enzyme

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5755992A (en) * 1994-04-13 1998-05-26 The Procter & Gamble Company Detergents containing a surfactant and a delayed release peroxyacid bleach system
US5686015A (en) * 1994-08-31 1997-11-11 The Procter & Gamble Company Quaternary substituted bleach activators
US5584888A (en) * 1994-08-31 1996-12-17 Miracle; Gregory S. Perhydrolysis-selective bleach activators
US5460747A (en) * 1994-08-31 1995-10-24 The Procter & Gamble Co. Multiple-substituted bleach activators
CA2205412A1 (en) * 1994-11-18 1996-05-30 Alan David Willey Bleaching compositions and bleach-additives comprising bleach activators effective at low perhydroxyl concentrations
US5523434A (en) * 1995-03-15 1996-06-04 The Procter & Gamble Company Synthesis of bleach activators
DE19609953A1 (de) * 1996-03-14 1997-09-18 Basf Ag Feste Zusammensetzung aus heterocyclischen Verbindungen und/oder Oximestern und inerten porösen Trägermaterialien und ihre Verwendung als stabile Bleichaktivator-Komponente in Wasch-, Bleich- und Reinigungsmitteln
US6100080A (en) * 1996-12-18 2000-08-08 Novo Nordisk A/S Method for enzymatic treatment of biofilm
JP2001515062A (ja) * 1997-08-20 2001-09-18 ザ、プロクター、エンド、ギャンブル、カンパニー アミド酸フェニルエステルスルホネートの調製方法および／または精製方法
EP1093512A2 (de) * 1998-07-08 2001-04-25 The Procter & Gamble Company Verfahren zur verminderung oder vorbeugung von gummizersetzung während des bleichvorgangs
DE19900939C2 (de) * 1999-01-13 2001-06-07 Clariant Gmbh Verfahren zur Herstellung von Amidosäurephenylestern
BR0108127A (pt) * 2000-02-15 2003-01-28 Procter & Gamble Método para aplicação de acabamentos de vincos duráveis para componentes têxteis, através do uso de uma preparação alvejante hidrofóbica
US6830591B1 (en) 2000-02-15 2004-12-14 The Procter & Gamble Company Method for the use of hydrophobic bleaching systems in textile preparation
WO2001060960A2 (en) * 2000-02-15 2001-08-23 The Procter & Gamble Company Method for the use of hydrophobic bleaching systems in textile preparation
US6743761B2 (en) 2000-02-15 2004-06-01 The Procter & Gamble Company Method for the one step preparation of textiles
US6527690B2 (en) 2000-06-02 2003-03-04 Bhaskar Krishna Arumugam Purification of phenyl ester salts
US6500973B2 (en) 2000-06-02 2002-12-31 Eastman Chemical Company Extractive solution crystallization of chemical compounds
US6569209B2 (en) * 2001-02-27 2003-05-27 The Procter & Gamble Company Method for the use of hydrophobic bleaching systems in cold batch textile preparation
DE102006036889A1 (de) * 2006-08-04 2008-02-07 Clariant International Limited Verwendung von Aminoacetonen und deren Salzen als Bleichkraftverstärker für Persauerstoffverbindungen
US9228158B2 (en) 2012-02-01 2016-01-05 Gurtler Industries, Inc. Composition and method for removing stains derived from chlorhexidine gluconate
CN105907483B (zh) * 2016-05-08 2019-01-15 浙江艾卡医学科技有限公司 一种含氧的多功能洗涤剂组合物
US11525106B2 (en) * 2018-04-16 2022-12-13 Dow Global Technologies Llc Tetraacetyldiamine and triacetyldiamine derivatives useful as bleach activators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122763A2 (de) * 1983-04-14 1984-10-24 Interox Chemicals Limited Bleichmittelzusammensetzungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415909D0 (en) * 1984-06-21 1984-07-25 Procter & Gamble Ltd Peracid compounds
US4852989A (en) * 1987-05-08 1989-08-01 The Procter & Gamble Company Bleaching compounds and compositions comprising fatty peroxyacids salts thereof and precursors therefor having amide moieties in the fatty chain
JPH0696720B2 (ja) * 1989-06-14 1994-11-30 花王株式会社 漂白剤及び漂白洗浄剤組成物
DE3938526A1 (de) * 1989-11-21 1991-05-23 Basf Ag Verwendung von heterocyclischen verbindungen als bleichaktivatoren oder optische aufheller in wasch- und reinigungsmitteln
HU217918B (hu) * 1992-10-23 2000-05-28 The Procter & Gamble Co. Granulált mosószerek proteáz enzimmel és fehérítővel

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122763A2 (de) * 1983-04-14 1984-10-24 Interox Chemicals Limited Bleichmittelzusammensetzungen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803604B2 (en) 2000-07-28 2010-09-28 Henkel Ag & Co. Kgaa Amylolytic enzyme extracted from Bacillus sp. A 7-7 (DSM 12368) and washing and cleaning agents containing this novel amylolytic enzyme

Also Published As

Publication number Publication date
HUT73731A (en) 1996-09-30
PE56994A1 (es) 1995-02-01
MA23200A1 (fr) 1994-12-31
JPH08510780A (ja) 1996-11-12
CA2161212A1 (en) 1994-12-08
HU9503301D0 (en) 1996-01-29
CZ305995A3 (en) 1996-05-15
BR9406531A (pt) 1996-01-02
DE69413028T2 (de) 1999-05-06
CN1124036A (zh) 1996-06-05
CN1086734C (zh) 2002-06-26
EP0699230A1 (de) 1996-03-06
ES2120047T3 (es) 1998-10-16
DE69413028D1 (de) 1998-10-08
ATE170552T1 (de) 1998-09-15
AU6833594A (en) 1994-12-20
WO1994028106A1 (en) 1994-12-08

Similar Documents

Publication Publication Date Title
US5998350A (en) Bleaching compounds comprising N-acyl caprolactam and/or peroxy acid activators
EP0699230B1 (de) Bleichmethoden mit peroxysäurenaktivatoren zusammen mit enzymen
EP0699232B1 (de) Bleichmittelzusammensetzungen enthaltend n-acylcaprolactam aktivatoren
EP0778881B1 (de) Selektiv wirksame perhydrolysebleichaktivatoren
CA2197443C (en) Quarternary substituted bleach activators
US5405412A (en) Bleaching compounds comprising N-acyl caprolactam and alkanoyloxybenzene sulfonate bleach activators
US5560862A (en) Multiple-substituted bleach activators
US5686401A (en) Bleaching compounds comprising N-acyl caprolactam for use in hand-wash or other low-water cleaning systems
EP0699233B1 (de) Bleichverfahren mit peroxosäurenaktivatoren mit amidbindungen enthaltenden zusammensetzungen
CA2205574C (en) Use of bleach activators for low perhydroxyl concentrations
EP0755430A1 (de) Enzym- und chelathaltige waschmittel mit verringerten bleichmittelanteilen
EP0723006A2 (de) Reinigungsverfahren und -produkte, die eine aufeinander abgestimmte, stufenweise Freisetzung eines Bleichmittels, gefolgt von Enzymen, bewirken
CA2208701C (en) Detergent compositions comprising stabilised polyamino acid compounds
CA2162362C (en) Bleaching compounds comprising n-acyl caprolactam and alkanoyloxybenzene sulfonate bleach activators
US5902782A (en) Detergent compositions comprising stabilised polyamino acid compounds
EP1032631B1 (de) O-substitutierte n,n-diacylhydroxylamine als bleichaktivatoren und diese enthaltende zusammensetzungen
EP0792345A1 (de) Bleichmittel-zusammensetzungen und bleich-additive, bestehend aus bleich-aktivatoren, die bei niederen peroxydkonzentrationen wirksam sind

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950929

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 19960607

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19980902

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19980902

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19980902

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19980902

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19980902

REF Corresponds to:

Ref document number: 170552

Country of ref document: AT

Date of ref document: 19980915

Kind code of ref document: T

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 69413028

Country of ref document: DE

Date of ref document: 19981008

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2120047

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19981202

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19981202

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 19981207

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990512

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990512

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20030401

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20030403

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20030505

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20030522

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20030530

Year of fee payment: 10

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040513

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20041201

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20041201

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20040512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050131

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20041201

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050512

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20040513