EP0577725A4 - Targeted drug delivery via mixed phosphate derivatives - Google Patents
Targeted drug delivery via mixed phosphate derivativesInfo
- Publication number
- EP0577725A4 EP0577725A4 EP92909373A EP92909373A EP0577725A4 EP 0577725 A4 EP0577725 A4 EP 0577725A4 EP 92909373 A EP92909373 A EP 92909373A EP 92909373 A EP92909373 A EP 92909373A EP 0577725 A4 EP0577725 A4 EP 0577725A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- drug delivery
- targeted drug
- delivery via
- phosphate derivatives
- mixed phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000012377 drug delivery Methods 0.000 title 1
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/5532—Seven-(or more) membered rings
- C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/572—Five-membered rings
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- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
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- C—CHEMISTRY; METALLURGY
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- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
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- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
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- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
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- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67730491A | 1991-03-29 | 1991-03-29 | |
US677304 | 1991-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0577725A1 EP0577725A1 (en) | 1994-01-12 |
EP0577725A4 true EP0577725A4 (en) | 1996-04-17 |
Family
ID=24718156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92909373A Withdrawn EP0577725A4 (en) | 1991-03-29 | 1992-03-27 | Targeted drug delivery via mixed phosphate derivatives |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0577725A4 (ja) |
JP (1) | JPH06510020A (ja) |
CA (1) | CA2108041A1 (ja) |
WO (1) | WO1992017185A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL105244A (en) * | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
LT2574341T (lt) | 2004-03-29 | 2017-09-11 | University Of South Florida | Navikų ir vėžio efektyvus gydymas triciribino fosfatu |
US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
CA2575074C (en) | 2004-12-03 | 2009-09-01 | Green Arm Co., Ltd. | A method for continuous on-site recycling of an asphalt mixture layer of a pavement and a motor-driven vehicle system therefor |
EP3331895B1 (en) | 2015-08-06 | 2020-07-29 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
CN106365998A (zh) * | 2016-08-19 | 2017-02-01 | 陕西思尔生物科技有限公司 | 一种特戊酸碘甲酯的制备方法 |
WO2019060692A1 (en) | 2017-09-21 | 2019-03-28 | Chimerix, Inc. | MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0112130A1 (en) * | 1982-12-09 | 1984-06-27 | Teva Pharmaceutical Industries Limited | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use |
EP0202703A1 (en) * | 1985-05-15 | 1986-11-26 | N.V. Gantax Pharmaceutica | Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of them as prodrug functioning compounds and compounds obtained therein |
EP0271983A1 (en) * | 1986-10-31 | 1988-06-22 | Pfizer Inc. | Transdermal flux enhancing compositions |
EP0291873A2 (de) * | 1987-05-22 | 1988-11-23 | Hoechst Aktiengesellschaft | Verfahren zum Nachweis der antiaggregatorischen Wirkung von vasoaktiven Stoffen, speziell von Phosphodiesterase- und/oder Cyclooxygenase-Hemmern |
EP0331382A2 (en) * | 1988-02-29 | 1989-09-06 | Pfizer Inc. | Transdermal flux enhancing compositions |
EP0335164A2 (de) * | 1988-03-31 | 1989-10-04 | Merckle GmbH | Neopentylesterderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO1990008155A1 (en) * | 1989-01-23 | 1990-07-26 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
EP0407815A2 (en) * | 1989-07-10 | 1991-01-16 | Eisai Co., Ltd. | Polyprenyl compound composition for soft capsules |
EP0452908A2 (en) * | 1990-04-19 | 1991-10-23 | Abbott Laboratories | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
WO1992000988A1 (en) * | 1990-07-13 | 1992-01-23 | Bodor Nicholas S | Targeted drug delivery via phosphonate derivatives |
EP0481214A1 (en) * | 1990-09-14 | 1992-04-22 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Prodrugs of phosphonates |
EP0486046A2 (de) * | 1990-11-15 | 1992-05-20 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | Komplexe, enthaltend S(+)-Phenyl-alkansäuren und Aminozucker |
EP0486045A2 (de) * | 1990-11-15 | 1992-05-20 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | Komplexe, enthaltend S-(+)-Phenyl-alkansäuren und alpha-Aminosäuren |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816570A (en) * | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
CA1330794C (en) * | 1987-03-27 | 1994-07-19 | Phillip Frost | Anti-viral compounds, dosage forms and methods |
US4837311A (en) * | 1987-06-22 | 1989-06-06 | Hoffman-La Roche Inc. | Anti-retroviral compounds |
EP0375183A1 (en) * | 1988-12-05 | 1990-06-27 | Schering Corporation | Antiviral dimers and trimers |
-
1992
- 1992-03-27 WO PCT/US1992/002239 patent/WO1992017185A1/en not_active Application Discontinuation
- 1992-03-27 EP EP92909373A patent/EP0577725A4/en not_active Withdrawn
- 1992-03-27 JP JP4508920A patent/JPH06510020A/ja active Pending
- 1992-03-27 CA CA002108041A patent/CA2108041A1/en not_active Abandoned
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0112130A1 (en) * | 1982-12-09 | 1984-06-27 | Teva Pharmaceutical Industries Limited | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use |
EP0202703A1 (en) * | 1985-05-15 | 1986-11-26 | N.V. Gantax Pharmaceutica | Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of them as prodrug functioning compounds and compounds obtained therein |
EP0271983A1 (en) * | 1986-10-31 | 1988-06-22 | Pfizer Inc. | Transdermal flux enhancing compositions |
EP0291873A2 (de) * | 1987-05-22 | 1988-11-23 | Hoechst Aktiengesellschaft | Verfahren zum Nachweis der antiaggregatorischen Wirkung von vasoaktiven Stoffen, speziell von Phosphodiesterase- und/oder Cyclooxygenase-Hemmern |
EP0331382A2 (en) * | 1988-02-29 | 1989-09-06 | Pfizer Inc. | Transdermal flux enhancing compositions |
EP0335164A2 (de) * | 1988-03-31 | 1989-10-04 | Merckle GmbH | Neopentylesterderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO1990008155A1 (en) * | 1989-01-23 | 1990-07-26 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
EP0407815A2 (en) * | 1989-07-10 | 1991-01-16 | Eisai Co., Ltd. | Polyprenyl compound composition for soft capsules |
EP0452908A2 (en) * | 1990-04-19 | 1991-10-23 | Abbott Laboratories | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
WO1992000988A1 (en) * | 1990-07-13 | 1992-01-23 | Bodor Nicholas S | Targeted drug delivery via phosphonate derivatives |
EP0481214A1 (en) * | 1990-09-14 | 1992-04-22 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Prodrugs of phosphonates |
EP0486046A2 (de) * | 1990-11-15 | 1992-05-20 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | Komplexe, enthaltend S(+)-Phenyl-alkansäuren und Aminozucker |
EP0486045A2 (de) * | 1990-11-15 | 1992-05-20 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | Komplexe, enthaltend S-(+)-Phenyl-alkansäuren und alpha-Aminosäuren |
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BALDESSARINI R.J. ET AL: "Hydrolysis of diester prodrugs of apomorphine", BIOCHEM.PHARMACOL., 1977, VOL. 26, NO. 19, PAGE(S) 1749-1756 * |
BENNETT D.B. ET AL: "Biodegradable polymeric prodrugs of naltrexone", J. CONTROL. RELEASE, 1991, VOL. 16, NO. 1-2, PAGE(S) 43-52 * |
FARQUHAR D ET AL: "Biologically reversible phosphate-protective groups", J. PHARM. SCI., 1983, VOL. 72, NO. 3, PAGE(S) 324-5 * |
FREED, JEROME J. ET AL: "Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells", BIOCHEM. PHARMACOL., 1989, VOL.38, NO. 19, 3193-8 * |
LAZAR S. ET AL: "Synthesis and biological activity of the phosphate and sulfate esters of naloxone and naltrexone", EUR. J. MED. CHEM., 1994, VOL. 29, NO. 1, PAGE(S) 45-53, FR * |
SASTRY J K ET AL: "Membrane-permeable dideoxyuridine 5'-monophosphate analog inhibits human immunodeficiency virus infection", MOL. PHARMACOL. 1992, VOL. 41, NO. 3, PAGES 441-445 * |
See also references of WO9217185A1 * |
SRIVASTVA D N ET AL: "Mass spectral characterization of acyloxymethyl phosphates", J. CHEM. TECHNOL. BIOTECHNOL., 1990, VOL. 47, NO. 3, PAGE(S) 235-43 * |
SRIVASTVA, DEVENDRA N. ET AL: "Bioreversible phosphate protective groups: synthesis and stability of model acyloxymethyl phosphates", BIOORG. CHEM., vol. 12, no. 2, pages 118 - 129 * |
SRIVASTVA, DEVENDRA N. ET AL: "Mass spectral characterization of acyloxymethyl phosphates", J. CHEM. TECHNOL. BIOTECHNOL., 1990, VOL. 47, NO. 3, 235-43 * |
STARRETT, JOHN E., JR. ET AL: "Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine", ANTIVIRAL RES., 1992, VOL. 19, NO. 3, PAGES 267-73 * |
STELLA V.J. ET AL: "Prodrugs. Do they have advantages in clinical practice?", DRUGS, 1985, VOL. 29, NO. 5, PAGE(S) 455-473 * |
THOMSON W ET AL: "Synthesis and bioactivation of bis(aroyloxymethyl) and mono(aroyloxymethyl) esters of benzylphosphonate and phosphonoacetate", J. CHEM. SOC., PERKIN TRANS. 1, 1993, NO. 19, PAGE(S) 2303-8 * |
Also Published As
Publication number | Publication date |
---|---|
EP0577725A1 (en) | 1994-01-12 |
JPH06510020A (ja) | 1994-11-10 |
AU668506B2 (en) | 1996-05-09 |
AU1674892A (en) | 1992-11-02 |
CA2108041A1 (en) | 1992-09-30 |
WO1992017185A1 (en) | 1992-10-15 |
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