EP0538374A4 - Aspartic protease inhibitors - Google Patents

Aspartic protease inhibitors

Info

Publication number
EP0538374A4
EP0538374A4 EP19910913442 EP91913442A EP0538374A4 EP 0538374 A4 EP0538374 A4 EP 0538374A4 EP 19910913442 EP19910913442 EP 19910913442 EP 91913442 A EP91913442 A EP 91913442A EP 0538374 A4 EP0538374 A4 EP 0538374A4
Authority
EP
European Patent Office
Prior art keywords
protease inhibitors
aspartic protease
aspartic
inhibitors
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910913442
Other languages
English (en)
Other versions
EP0538374A1 (de
Inventor
Geoffrey Bainbridge Dreyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0538374A1 publication Critical patent/EP0538374A1/de
Publication of EP0538374A4 publication Critical patent/EP0538374A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3205Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211Esters of acyclic saturated acids which can have further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910913442 1990-07-06 1991-07-03 Aspartic protease inhibitors Withdrawn EP0538374A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54946090A 1990-07-06 1990-07-06
US549460 1990-07-06

Publications (2)

Publication Number Publication Date
EP0538374A1 EP0538374A1 (de) 1993-04-28
EP0538374A4 true EP0538374A4 (en) 1993-05-19

Family

ID=24193116

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910913442 Withdrawn EP0538374A4 (en) 1990-07-06 1991-07-03 Aspartic protease inhibitors

Country Status (4)

Country Link
EP (1) EP0538374A4 (de)
JP (1) JPH05508846A (de)
AU (1) AU8191091A (de)
WO (1) WO1992000954A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9306058A (pt) * 1992-03-11 1997-11-18 Narhex Ltd Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5321153A (en) * 1992-06-15 1994-06-14 Monsanto Company Process for making chiral alpha-amino phosphonates selected novel chiral alpha-amino phosphonates
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
DE4422911A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Phosphinsäure-Derivate, deren Herstellung sowie deren Verwendung
KR20230038457A (ko) 2020-06-10 2023-03-20 알리고스 테라퓨틱스 인코포레이티드 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435059A1 (de) * 1989-12-16 1991-07-03 Hoechst Aktiengesellschaft Inhibitoren retroviraler Proteasen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH627477A5 (de) * 1977-02-10 1982-01-15 Ciba Geigy Ag Verfahren zur herstellung einer neuen phosphinsaeure und ihrer salze.
CH634968A5 (de) * 1977-04-01 1983-03-15 Ciba Geigy Ag Herbizides und pflanzenwuchsregulierendes mittel enthaltend eine neue phosphinsaeure oder deren salze, ester, amide oder hydrazide sowie verwendung derselben.
EP0209848A3 (de) * 1985-07-24 1988-07-27 Merck & Co. Inc. Enzyminhibitoren

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435059A1 (de) * 1989-12-16 1991-07-03 Hoechst Aktiengesellschaft Inhibitoren retroviraler Proteasen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 106, no. 15, 25 July 1984, WASHINGTON, DC US pages 4282 - 4283 PAUL A. BARTLETT 'Phosphinic Acid Dipeptide Analogues: Potent, Slow-Binding Inhibitors of Aspartic Pepsidases' *
See also references of WO9200954A1 *

Also Published As

Publication number Publication date
WO1992000954A1 (en) 1992-01-23
EP0538374A1 (de) 1993-04-28
JPH05508846A (ja) 1993-12-09
AU8191091A (en) 1992-02-04

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Legal Events

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