EP0434149A2 - Vorrichtung zum Übertragen von Flüssigkeiten - Google Patents
Vorrichtung zum Übertragen von Flüssigkeiten Download PDFInfo
- Publication number
- EP0434149A2 EP0434149A2 EP90203333A EP90203333A EP0434149A2 EP 0434149 A2 EP0434149 A2 EP 0434149A2 EP 90203333 A EP90203333 A EP 90203333A EP 90203333 A EP90203333 A EP 90203333A EP 0434149 A2 EP0434149 A2 EP 0434149A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- dispensing
- aperture
- passageway
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/28—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with stationary measuring chambers having constant volume during measurement
- G01F11/42—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with stationary measuring chambers having constant volume during measurement with supply or discharge valves of the rotary or oscillatory type
- G01F11/44—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with stationary measuring chambers having constant volume during measurement with supply or discharge valves of the rotary or oscillatory type for liquid or semiliquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1044—Using pneumatic means
Definitions
- This invention relates to liquid transfer apparatus and in particular, apparatus which allows any pipette to be used without careful control of manual positions, to accurately dispense small amounts of liquids for clinical analysis.
- the dispensing of aliquots of a body liquid such as blood serum onto a dried, slide-like test element is a key first step in the analysis of the liquid in an analyzer. Because of the peculiar properties of many body liquids, and the need for accurate and reproducible dispensing of a predetermined aliquot, great care has been taken in prior art devices to ensure that a) the proper tip is used by the dispensing apparatus to direct the flow properly, and/or b) the dispensing tip is properly presented and positioned at the test element at the time of dispensing. Examples of the technology which achieve feature a) above include tips of the type described in US-A-4347875.
- Examples of the technology used to achieve features b) above include dispensing means in analyzers of the type described in US-A-4340390; US-A-4452899 and US-A-4615360.
- the analyzer is constructed to carefully prepare the dispensing tip just prior to dispensing of the aliquot, for example, in its spacing from the test element and/or by blowing off any exterior liquid hanging on the outside of the tip.
- liquid transfer apparatus for transferring a predetermined amount of liquid from a pipette on to a test element
- the apparatus comprising:- an inlet aperture; a dispensing aperture for dispensing some of the liquid in droplet form; a first liquid flow path extending from the inlet aperture towards the dispensing aperture; an air vent; a second liquid flow path extending from the vent towards the first flow path; and valve means is interposed between the first and second liquid flow paths for allowing continuous liquid flow either from the inlet aperture to the dispensing aperture, or from the vent to the dispensing aperture with the inlet aperture blocked; characterized in that the apparatus further includes a support for supporting a test element, the test element having an upper surface which is to receive the dispensed liquid, and spacer means for accurately positioning the apparatus from the support at a predetermined distance such that an initial droplet from the dispensing aperture contacts the upper surface of the test element while still in contact with the dispensing aperture.
- a method of dispensing accurately a predetermined amount of liquid on to a test element comprising the steps of:-
- any pipette can be used manually, and without careful control, to dispense accurate aliquots of a body liquid in the proper way onto a test element for assaying.
- FIG. 1 is a fragmentary perspective view of a first embodiment of liquid transfer apparatus constructed in accordance with the present invention
- Figure 2 is a vertical sectioned view taken generally along the line II-II of Figure 1
- Figure 3 is a sectioned view similar to that shown in Figure 2, but illustrating the parts as they are positioned for the dispensing step
- Figure 4 is a plan view of another embodiment of liquid transfer apparatus constructed in accordance with the present invention
- Figures 5A and 5B are fragmentary sectioned views of the apparatus shown in Figure 4, showing valve means in the alternative liquid filling position and liquid dispensing position respectively.
- the invention is hereinafter described with respect to the preferred embodiments, which feature the use of particular kinds of valves to control the two flow paths to dispense preferably blood serum or a reference liquid. Additionally, the invention is useful regardless of the type of liquid being dispensed and with apparatus using other kinds of valves, so long as the valve is effective to allow either the one flow path or the other flow path to be effective.
- apparatus in accordance with the present invention features a pipette 10 and liquid transfer apparatus 20.
- the pipette 10 can be any pipette whatsoever, of any construction, conventional or otherwise, having a tip portion 12 with an outlet 14.
- Tip portion 12 can be fixed to or removable from the rest of the pipette 10. It is because of the interface provided by apparatus 20 that it does not matter what pipette is used.
- Apparatus 20 comprises a frame 22, which can be any shape, a rectangular slab being shown by way of example.
- Top surface 24 is constructed to engage the pipette and a source of ⁇ P air pressure (not shown).
- a bottom surface 26, shown more clearly in Figure 2 is provided to supply a dispensing aperture 28 and a proper spacing from a test element E, as shown in Figure 3, and will be described in more detail hereinafter.
- top surface 24 has an inlet aperture 30, shaped to receive tip portion 12 directly, or to receive liquid ejected therefrom.
- the pipette 10 is actually inserted, to seat on a surface 32 at the bottom of aperture 30, as shown in Figure 2.
- Aperture 30 fluidly connects with a fixed passageway 34, 35 which extends to an orifice 36 in surface 26.
- Valve 50 described hereinafter is disposed partway along passageway 34, 35.
- An appropriate dispensing tip 38 is mounted at orifice 36 to fluidly connect its aperture 28 with orifice 36.
- tip 38 Any kind of tip 38 can be used, provided it is shaped to discourage perfusion up outside surface 40 thereof, and instead directs flow, such as a drop D (shown in Figure 3) on to the element E.
- a useful example is a tip configured as described in US-A-4347875.
- a vent aperture 42 is provided, such as in top surface 24 ( Figure 2) and fluidly connects with a passageway 44 which extends towards passageway 34.
- passageway 44 has a width sufficiently large as to discourage capillary attraction of liquid out of passageway 56.
- valve 50 is interposed to allow, as alternatives, the completion of passageway 34-35 or the completion of passageway 44-35.
- a three-way stop cock valve here shown as cylindrically shaped, is useful.
- the valve 50 comprises a cylinder 52, disposed in a bore 53, having a diameter passageway 54, a radial passageway 56 extending from, and at an angle of 90° to passageway 54, and a handle means 58 exterior of frame 22 for rotating the valve 50 as shown in Figure 1.
- Appropriate seals, not shown, are included to prevent axial leakage along the cylinder 52.
- valve 50 In use, valve 50 is rotated to the position as shown in Figure 2. In this position, passageway 34 is connected to passageway 35 via passageway 54. As liquid is ejected from an inserted pipette 10, the liquid fills passageways 34, 35 until it reaches dispensing aperture 28.
- valve 50 has blocked off the inlet aperture 30.
- the application of pressure ⁇ P at aperture 42 will cause the dispensing of an aliquot of the liquid from passageway 35 and tip 38, onto element F.
- ⁇ P is generated from external air pressure delivered via means such as a hose (not shown) connected to aperture 42. (The hose is shaped to seal at aperture 42).
- surface 26 is positioned the proper height h above the support surface 70 of element E.
- Any suitable mechanism can be used to obtain such heights.
- a spacer block 72 can be utilized, which can be a separate element or can be an integral part of apparatus 20.
- apparatus 20 can be constructed to provide multiple transfer opportunities for a multiple number of pipettes 10, 10' containing each a different liquid, as is indicated in phantom in Figure 1.
- a plural number of passageways 34, 35 can be provided in parallel, each with an inlet aperture 30, to accommodate a ganged pipette 10, 10'.
- cylinder 52 can extend the full width of the entire device, so that handle means 58 is effective to rotate all the valves simultaneously.
- handle means 58 is effective to rotate all the valves simultaneously.
- Such a construction is useful to allow the dispensing of serum, from pipette 10 and a reference liquid from pipette 10' for example.
- the dispensing tips of which only the first one 38 is depicted ( Figure 2), preferably would be spaced apart a distance w, as shown in Figure 1, which would allow the simultaneous dispensing of serum and reference liquid onto a single ISE test element of the type described in US-A-4184936, for example.
- each of the separate passageways 34,35 can be valved separately from the others, in which case cylinder 52 would not extend across the entire unit. Instead, each passageway 34,35 would have its own cylinder and own operating handle means 58.
- an additional option is to provide a temporary seal (not shown) over aperture 30 after liquid is inserted via the pipette, to allow storage in apparatus 20 before the dispensing step.
- Tips 38 can be different in length, if plural units U are ganged together, as shown in Figure 1, and if a different height h' is needed at the adjacent apertures.
- liquid used for radial wash preferably is applied with a height which is less than h' used for serum dispensing.
- valve it is not essential that the valve be a rotating type as shown. Alternatively, for example, it can be a spool valve as shown in Figures 4, 5A and 5B. Parts similar to those previously described bear the same reference numeral, to which the distinguishing suffix A is appended.
- apparatus 20A comprises a frame 22A providing a top surface 24A in which an inlet aperture 30A and a vent aperture 42A are provided.
- a passageway 34A, 35A fluidly connects apertures 30A and 42A with a dispensing aperture 28A, via a valve 50A, also as in the previous embodiment.
- valve 50A is a spool valve comprising a cylinder 52A which slides, rather than rotates, within bore 53A.
- Outer diameter OD1 as shown in Figure 5A, seals within bore 53A, whereas a reduced inner diameter OD2 is provided at two locations 80, 82 spaced apart along axis 84 of cylinder 52A.
- the spacing of locations 80 and 82 is constructed to be less than the spacing x (shown in Figure 4) of passageway 34A from passageway 44A which extends from the vent aperture 42A.
- passageway 44A does not feed into the extension of passageway 34A, 35A which occurs within the valve, but rather joins passageway 35A downstream from valve 50A.
- valve 50A is moved, using handle 58A ( Figure 4) by sliding cylinder 50A sideways, in the direction of arrow 92 as shown in Figure 5B, so that outer diameter OD1 blocks any flow from passageway 34A to 35A, and at the same time OD1 at location 82 becomes aligned with the parts of passageway 44A.
- valve 50A When valve 50A is positioned as shown in Figure 5B, air pressure is applied continuously in an amount effective to accurately dispense a predetermined aliquot, for example 10 ⁇ l, of liquid out of the dispensing aperture.
- Passageway 35A can be serpentine in its construction, as shown in Figure 4, or it can be more linear in the manner of its construction shown in Figure 2.
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/455,548 US5010930A (en) | 1989-12-22 | 1989-12-22 | Pipette and liquid transfer apparatus for dispensing liquid for analysis |
US455548 | 1989-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0434149A2 true EP0434149A2 (de) | 1991-06-26 |
EP0434149A3 EP0434149A3 (en) | 1991-10-09 |
Family
ID=23809270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900203333 Withdrawn EP0434149A3 (en) | 1989-12-22 | 1990-12-13 | Liquid transfer apparatus |
Country Status (6)
Country | Link |
---|---|
US (1) | US5010930A (de) |
EP (1) | EP0434149A3 (de) |
JP (1) | JPH03291547A (de) |
KR (1) | KR910012714A (de) |
CA (1) | CA2017110A1 (de) |
IE (1) | IE904667A1 (de) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0526691A2 (de) * | 1991-08-07 | 1993-02-10 | WISSENSCHAFTLICHE GERÄTEBAU Dr.Ing.Herbert Knauer GMBH | Gerät zur Durchführung von chemischen Prozessen an einer Probe eines chemischen Materials |
WO1993017328A1 (en) * | 1992-02-20 | 1993-09-02 | Drew Scientific Limited | Liquid chromatography apparatus |
EP0646776A1 (de) * | 1993-10-01 | 1995-04-05 | Wilhelm A. Keller | Dosiervorrichtung für Flüssigkeiten |
US5850946A (en) * | 1994-10-03 | 1998-12-22 | Wilhelm A. Keller | Metering device |
WO1999036176A1 (en) * | 1998-01-17 | 1999-07-22 | Central Research Laboratories Limited | Apparatus for dispensing a predetermined volume of a liquid |
EP1058824A1 (de) * | 1998-02-18 | 2000-12-13 | Sarnoff Corporation | Gerät zur abgabe definierter volumina |
WO2001051208A1 (de) * | 2000-01-10 | 2001-07-19 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | Mikro-düsen-system |
WO2001074490A2 (en) * | 2000-04-03 | 2001-10-11 | Ecole Polytechnique Federale De Lausanne (Epfl) | A device for dispensing accurately-controlled small doses of liquid |
WO2001077640A2 (en) * | 2000-04-05 | 2001-10-18 | Alexion Pharmaceuticals, Inc. | Methods and devices for storing and dispensing liquids |
EP1150105A2 (de) * | 2000-04-28 | 2001-10-31 | Eppendorf Ag | Gaspolster-Mikrodosiersystem |
WO2002016652A2 (en) * | 2000-08-25 | 2002-02-28 | Genome Therapeutics Corporation | Device for rapid dna sample processing with integrated liquid handling, thermocycling, and purification |
US7427379B1 (en) | 1999-03-19 | 2008-09-23 | Biotage Ab | Liquid dispensing apparatus |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5344666A (en) * | 1992-03-12 | 1994-09-06 | Levine Marshall S | Liquid dispenser |
US5507323A (en) * | 1993-10-12 | 1996-04-16 | Fujitsu Limited | Method and dispenser for filling liquid crystal into LCD cell |
CA2108237C (en) * | 1993-10-12 | 1999-09-07 | Taizo Abe | Method and dispenser for filling liquid crystal into lcd cell |
CA2175001A1 (en) * | 1995-05-01 | 1996-11-02 | Andrew Shelley Foote | Method of avoiding decreased-size first drops when aspirating from immersed rest conditions |
WO2002102514A1 (en) * | 2001-06-19 | 2002-12-27 | B.C. Cancer Agency | Microvolume liquid dispenser suitable for microarrays and methods related thereto |
JP2005522679A (ja) * | 2002-04-12 | 2005-07-28 | インストゥルメンテイション ラボラトリー カンパニー | イムノアッセイプローブ |
US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
EP1898222A1 (de) * | 2005-06-24 | 2008-03-12 | Arkray, Inc. | Patrone |
JP4660662B2 (ja) * | 2005-09-06 | 2011-03-30 | アークレイ株式会社 | カートリッジ |
US8707559B1 (en) | 2007-02-20 | 2014-04-29 | Dl Technology, Llc | Material dispense tips and methods for manufacturing the same |
US8864055B2 (en) | 2009-05-01 | 2014-10-21 | Dl Technology, Llc | Material dispense tips and methods for forming the same |
US9725225B1 (en) * | 2012-02-24 | 2017-08-08 | Dl Technology, Llc | Micro-volume dispense pump systems and methods |
WO2017053105A1 (en) * | 2015-09-22 | 2017-03-30 | Dow Global Technologies Llc | Two-component spray polyurethane foam dispenser with continuous gas purging |
US11746656B1 (en) | 2019-05-13 | 2023-09-05 | DL Technology, LLC. | Micro-volume dispense pump systems and methods |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3757981A (en) * | 1969-11-24 | 1973-09-11 | Harris R | Valves and valve needle syringes |
US4052320A (en) * | 1975-08-29 | 1977-10-04 | Eastman Kodak Company | Telescoping serum separator and dispenser |
EP0023157A1 (de) * | 1979-07-23 | 1981-01-28 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Vorrichtung zum Befördern einer Flüssigkeit |
JPS5788340A (en) * | 1980-11-21 | 1982-06-02 | Esutetsuku:Kk | Constant volume dispenser for liquid |
US4452899A (en) * | 1982-06-10 | 1984-06-05 | Eastman Kodak Company | Method for metering biological fluids |
US4676274A (en) * | 1985-02-28 | 1987-06-30 | Brown James F | Capillary flow control |
EP0301743A2 (de) * | 1987-07-20 | 1989-02-01 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Analysator mit vom Inkubator separierter Waschstation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1528022A (en) * | 1920-01-02 | 1925-03-03 | Bircher Co Inc | Liquid-dispensing apparatus |
US1998531A (en) * | 1931-02-28 | 1935-04-23 | Edmund Rogers | Apparatus for filling metal containers |
US3272396A (en) * | 1964-12-23 | 1966-09-13 | Norton Co | Metering and discharging apparatus |
US3227312A (en) * | 1964-09-08 | 1966-01-04 | Nat Distillers Chem Corp | Shot injector |
SU438874A1 (ru) * | 1972-12-11 | 1974-08-05 | Предприятие П/Я Г-4035 | Дозатор жидкости |
NL7307629A (de) * | 1973-06-01 | 1974-12-03 | ||
US4033482A (en) * | 1974-08-30 | 1977-07-05 | Delta Scientific Corporation | Conical liquid metering device |
US4012325A (en) * | 1975-01-08 | 1977-03-15 | Eastman Kodak Company | Biological fluid dispenser and separator |
US4340390A (en) * | 1980-06-16 | 1982-07-20 | Eastman Kodak Company | Method and apparatus for metering biological fluids |
US4347875A (en) * | 1980-07-14 | 1982-09-07 | Eastman Kodak Company | Self-cleaning nozzle construction for aspirators |
US4615360A (en) * | 1985-09-05 | 1986-10-07 | Eastman Kodak Company | Means providing separation of exterior sheath of liquid on dispensing tip |
US4838855A (en) * | 1987-07-31 | 1989-06-13 | Lynn Lawrence A | Blood aspiration assembly and method |
-
1989
- 1989-12-22 US US07/455,548 patent/US5010930A/en not_active Expired - Fee Related
-
1990
- 1990-05-18 CA CA002017110A patent/CA2017110A1/en not_active Abandoned
- 1990-12-13 EP EP19900203333 patent/EP0434149A3/en not_active Withdrawn
- 1990-12-17 JP JP2402726A patent/JPH03291547A/ja active Pending
- 1990-12-21 KR KR1019900021381A patent/KR910012714A/ko not_active Application Discontinuation
- 1990-12-21 IE IE466790A patent/IE904667A1/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3757981A (en) * | 1969-11-24 | 1973-09-11 | Harris R | Valves and valve needle syringes |
US4052320A (en) * | 1975-08-29 | 1977-10-04 | Eastman Kodak Company | Telescoping serum separator and dispenser |
EP0023157A1 (de) * | 1979-07-23 | 1981-01-28 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Vorrichtung zum Befördern einer Flüssigkeit |
JPS5788340A (en) * | 1980-11-21 | 1982-06-02 | Esutetsuku:Kk | Constant volume dispenser for liquid |
US4452899A (en) * | 1982-06-10 | 1984-06-05 | Eastman Kodak Company | Method for metering biological fluids |
US4676274A (en) * | 1985-02-28 | 1987-06-30 | Brown James F | Capillary flow control |
EP0301743A2 (de) * | 1987-07-20 | 1989-02-01 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Analysator mit vom Inkubator separierter Waschstation |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN, vol. 6, no. 171 (P-140), 4th September 1982; & JP-A-57 088 340 (ESUTETSUKU K.K.) 02-06-1982 * |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0526691A3 (en) * | 1991-08-07 | 1993-04-28 | Herbert Knauer Wiss Geraetebau | Apparatus for carrying out chemical processes on a sample of chemical material |
EP0526691A2 (de) * | 1991-08-07 | 1993-02-10 | WISSENSCHAFTLICHE GERÄTEBAU Dr.Ing.Herbert Knauer GMBH | Gerät zur Durchführung von chemischen Prozessen an einer Probe eines chemischen Materials |
WO1993017328A1 (en) * | 1992-02-20 | 1993-09-02 | Drew Scientific Limited | Liquid chromatography apparatus |
EP0646776A1 (de) * | 1993-10-01 | 1995-04-05 | Wilhelm A. Keller | Dosiervorrichtung für Flüssigkeiten |
US5547110A (en) * | 1993-10-01 | 1996-08-20 | Wilhelm A. Keller | Metering device for fluids |
US5850946A (en) * | 1994-10-03 | 1998-12-22 | Wilhelm A. Keller | Metering device |
US6059148A (en) * | 1994-10-03 | 2000-05-09 | Wilhelm A. Keller | Metering device |
WO1999036176A1 (en) * | 1998-01-17 | 1999-07-22 | Central Research Laboratories Limited | Apparatus for dispensing a predetermined volume of a liquid |
EP1058824A4 (de) * | 1998-02-18 | 2005-12-07 | Orchid Biosciences Inc | Gerät zur abgabe definierter volumina |
EP1058824A1 (de) * | 1998-02-18 | 2000-12-13 | Sarnoff Corporation | Gerät zur abgabe definierter volumina |
US7427379B1 (en) | 1999-03-19 | 2008-09-23 | Biotage Ab | Liquid dispensing apparatus |
WO2001051208A1 (de) * | 2000-01-10 | 2001-07-19 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | Mikro-düsen-system |
WO2001074490A2 (en) * | 2000-04-03 | 2001-10-11 | Ecole Polytechnique Federale De Lausanne (Epfl) | A device for dispensing accurately-controlled small doses of liquid |
WO2001074490A3 (en) * | 2000-04-03 | 2002-04-11 | Ecole Polytech | A device for dispensing accurately-controlled small doses of liquid |
WO2001077640A3 (en) * | 2000-04-05 | 2002-03-28 | Alexion Pharma Inc | Methods and devices for storing and dispensing liquids |
US6905657B2 (en) | 2000-04-05 | 2005-06-14 | Bioprocessors Corp. | Methods and devices for storing and dispensing liquids |
WO2001077640A2 (en) * | 2000-04-05 | 2001-10-18 | Alexion Pharmaceuticals, Inc. | Methods and devices for storing and dispensing liquids |
EP1150105A3 (de) * | 2000-04-28 | 2002-08-07 | Eppendorf Ag | Gaspolster-Mikrodosiersystem |
EP1150105A2 (de) * | 2000-04-28 | 2001-10-31 | Eppendorf Ag | Gaspolster-Mikrodosiersystem |
WO2002016652A2 (en) * | 2000-08-25 | 2002-02-28 | Genome Therapeutics Corporation | Device for rapid dna sample processing with integrated liquid handling, thermocycling, and purification |
WO2002016652A3 (en) * | 2000-08-25 | 2003-07-10 | Genome Therapeutics Corp | Device for rapid dna sample processing with integrated liquid handling, thermocycling, and purification |
Also Published As
Publication number | Publication date |
---|---|
EP0434149A3 (en) | 1991-10-09 |
KR910012714A (ko) | 1991-08-08 |
IE904667A1 (en) | 1991-07-17 |
US5010930A (en) | 1991-04-30 |
CA2017110A1 (en) | 1991-06-22 |
JPH03291547A (ja) | 1991-12-20 |
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