EP0283629A1 - Packaging for extemporaneous preparations - Google Patents
Packaging for extemporaneous preparations Download PDFInfo
- Publication number
- EP0283629A1 EP0283629A1 EP19870440048 EP87440048A EP0283629A1 EP 0283629 A1 EP0283629 A1 EP 0283629A1 EP 19870440048 EP19870440048 EP 19870440048 EP 87440048 A EP87440048 A EP 87440048A EP 0283629 A1 EP0283629 A1 EP 0283629A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bottle
- neck
- membrane
- packaging according
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
- B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
Definitions
- the aforementioned bushing and crimping ring are made in a single piece molded in plastic material covering the neck of the first bottle, and by simple pushing, snap under said neck .
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Closures For Containers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Abstract
Description
La présente invention concerne des perfectionnements aux ensembles destinés à la préparation extemporanée de suspensions ou de solutions d'un produit actif, tels qu'ils sont décrits notamment au Brevet US 3 917 063.The present invention relates to improvements to assemblies intended for the extemporaneous preparation of suspensions or solutions of an active product, as described in particular in US Patent 3,917,063.
Un tel ensemble se compose d'une part de deux flacons hermétiques, le premier de ces flacons étant destiné à contenir ledit produit actif généralement sous forme de poudre sèche lyophilisée, et le second étant destiné à contenir le liquide dans lequel ledit produit doit être mis en solution ou en suspension au moment de son administration, et d'autre part de moyens de liaison permettant la mise en communication des deux flacons, en vue, dans un premier temps, d'introduire ledit liquide dans le premier flacon, puis, dans un second temps, d'aspirer, dans le second flacon, la solution ou la suspension ainsi formée.Such an assembly is composed on the one hand of two hermetic bottles, the first of these bottles being intended to contain said active product generally in the form of dry lyophilized powder, and the second being intended to contain the liquid in which said product must be put in solution or in suspension at the time of its administration, and on the other hand connecting means allowing the communication of the two bottles, with a view, firstly, to introducing said liquid into the first bottle, then, in a second step, to suck, in the second bottle, the solution or suspension thus formed.
A cet effet, le premier flacon est généralement en verre, et obturé par un bouchon élastique inséré dans son col, et présentant dans son axe un canal recouvert par une mince membrane d'étanchéité perforable, collée ou soudée sur une face, tandis que le second flacon,réalisé en matériau souple, est obturé par un stilligoutte dont l'extrémité a un diamètre légèrement inférieur à celui du canal précédent. Pour permettre l'assemblage et la mise en communication des deux flacons, l'embouchure du premier flacon est surmontée d'une douille, soit filetée intérieurement, soit lisse, alors que le flacon stilligoutte souple possède une partie cylindrique filetée pouvant se visser dans le manchon du premier flacon.For this purpose, the first bottle is generally made of glass, and closed by an elastic stopper inserted in its neck, and having in its axis a channel covered by a thin perforable sealing membrane, glued or welded on one side, while the second bottle, made of flexible material, is closed by a dropper whose end has a diameter slightly smaller than that of the previous channel. To allow the assembly and the communication of the two bottles, the mouth of the first bottle is surmounted by a socket, either internally threaded or smooth, while the flexible dropper bottle has a threaded cylindrical part which can be screwed into the sleeve of the first bottle.
L'utilisaton d'un tel ensemble consiste à visser le second flacon dans la douille du premier flacon, de telle manière que le stilligoutte vienne perforer la membrane en venant déboucher dans le premier flacon, tout en créant ainsi une étanchéité entre les deux flacons. En comprimant le second flacon, on provoque le passage du liquide dans le premier flacon ; en secouant l'ensemble, on crée la suspension ou solution, et en renversant l'ensemble en relachant la pression sur le second flacon, on fait retourner ladite solution en suspension dans ce second flacon où il est aisé de l'enfermer en plaçant un bouchon sur le stilligoutte.The use of such an assembly consists in screwing the second bottle into the socket of the first bottle, so that the dropper comes to perforate the membrane while coming to open in the first bottle, while thus creating a seal between the two bottles. By compressing the second bottle, it causes the passage of the liquid in the first bottle; by shaking the assembly, the suspension or solution is created, and by reversing the assembly by releasing the pressure on the second bottle, the said solution in suspension is returned to this second bottle where it is easy to enclose it by placing a cap on the stilligoutte.
Selon le mode de réalisation d'un tel ensemble décrit au Brevet US précité, la base de la douille filetée présente vers l'extérieur un rebord de même diamètre que la membrane d'étanchéisation, et cette douille est fixée sur le flacon au moyen d'une bague de sertissage métallique prenant appui, du côté supérieur sur ce rebord et du côté inférieur sur la collerette du premier flacon.According to the embodiment of such an assembly described in the aforementioned US Patent, the base of the threaded sleeve has outwardly a rim of the same diameter as the sealing membrane, and this sleeve is fixed to the bottle by means of '' a metal crimping ring supported on the upper side on this rim and on the lower side on the flange of the first bottle.
Un tel montage présente encore plusieurs inconvénients. En premier lieu pour la fixation de la douille sur le premier flacon, il exige deux pièces distinctes, la douille elle-même, généralement en matière plastique et la bague de sertissage, métallique. La douille reposant simplement sur le dessus du bouchon caoutchouc, exige un centrage délicat. Le sertissage lui-même de la bague représente une opération séparée, qui interdit le montage en série des différents éléments du flacon en continu sur une machine unique. Il en résulte un prix de revient des pièces et du temps de montage relativement élevé.Such an arrangement still has several drawbacks. First of all for fixing the socket on the first bottle, it requires two separate parts, the socket itself, generally made of plastic and the crimping ring, metallic. The socket simply resting on top of the rubber stopper requires delicate centering. The crimping of the ring itself represents a separate operation, which prohibits the serial mounting of the various elements of the bottle continuously on a single machine. This results in a relatively high cost price of the parts and assembly time.
L'invention vise un nouveau mode de réalisation d'un tel ensemble éliminant l'ensemble de ces inconvénients, grâce à une simplification des éléments précédents.The invention aims at a new embodiment of such an assembly eliminating all of these drawbacks, by simplifying the above elements.
A cet effet, selon la caractéristique essentielle de l'invention, la douille et la bague de sertissage précitées sont réalisées en une seule pièce moulée en matière plastique venant recouvrir le col du premier flacon, et par simple poussée, s'encliqueter sous ledit col.To this end, according to the essential characteristic of the invention, the aforementioned bushing and crimping ring are made in a single piece molded in plastic material covering the neck of the first bottle, and by simple pushing, snap under said neck .
Ladite pièce unique se met en place sans aucun problème de centrage, et s'immobilise sans nécessiter l'opération séparée de sertissage précitée.Said single piece is put in place without any centering problem, and stops without requiring the aforementioned separate crimping operation.
Le nombre de pièces et les opérations de montage se trouvent donc limité, ce qui représente une économie globale de matière et de temps.The number of parts and assembly operations are therefore limited, which represents an overall saving of material and time.
Pour empêcher la rotation de la douille au moment du vissage et du dévissage, il est prévu, selon l'invention, des nervures verticales sous la collerette d'encliquetage du flacon rigide.To prevent rotation of the sleeve during screwing and unscrewing, there are provided, according to the invention, vertical ribs under the flange of the rigid bottle.
Selon un premier mode de réalisation de cette invention, le moyen d'obturation du flacon contenant le produit solide demeure, comme dans le système classique, un bouchon en matériau élastomère, enfoncé dans le goulot du flacon, et traversé par un trou operculé par une membrane d'étanchéité perforable. Comme il sera exposé ciaprès, cette disposition assure l'étanchéité parfaite du système.According to a first embodiment of this invention, the means for closing the bottle containing the solid product remains, as in the conventional system, a stopper made of elastomeric material, pressed into the neck of the bottle, and traversed by a hole sealed by a perforable waterproofing membrane. As will be explained below, this arrangement ensures perfect sealing of the system.
Selon une seconde variante, l'obturation du flacon contenant le produit solide peut ne plus faire intervenir obligatoirement la présence d'un bouchon enfoncé dans le goulot de ce flacon, mais résulter uniquement de l'existence d'une membrane ou pellicule susceptible d'être perforée, rompue ou traversée par le stilligoutte au moment du vissage du second flacon sur la pièce de liaison.According to a second variant, the closure of the bottle containing the solid product may no longer necessarily involve the presence of a stopper pressed into the neck of this bottle, but result solely from the existence of a membrane or film capable of be punctured, ruptured or passed through by the dropper when the second bottle is screwed onto the connecting piece.
Cette membrane, qui, dans la variante précédente constituait un élément individuel placé sur le bouchon operculé, peut, selon cette seconde variante, venir d'une seule pièce de moulage avec la pièce de liaison, notamment dans la zone intermédiaire entre la portion supérieure filetée et la portion inférieure encliquetée. Elle peut également être collée sur la face supérieure du goulot du premier flacon.This membrane, which, in the previous variant constituted an individual element placed on the sealed cap, can, according to this second variant, come from a single molding piece with the connecting piece, in particular in the intermediate zone between the threaded upper portion and the bottom portion snapped. It can also be glued to the upper side of the neck of the first bottle.
Elle peut être simplement constituée d'un disque d'épaisseur constante, suffisamment mince pour être perforé par le stilligoutte. Elle peut également comporter une zone centrale de rupture, éventuellement renforcée par un croisillon.It can simply consist of a disc of constant thickness, thin enough to be punctured by the stilligoutte. It can also include a central rupture zone, possibly reinforced by a cross.
Elle peut également être réalisée en un matériau suffisamment élastique pour que, ayant été fabriquée dans un premier temps avec un passage perforé, elle puisse reprendre sa forme initiale, c'est-à-dire demeurer étanche.It can also be made of a sufficiently elastic material so that, having been manufactured initially with a perforated passage, it can return to its initial shape, that is to say remain waterproof.
Une telle variante présente donc sur la précédente l'avantage d'une simplification et d'une économie, puisqu'elle revient à supprimer complètement le bouchon en matériau élastomère et sa membrane d'étanchéité, ainsi que l'opération de montage de ce bouchon dans le second flacon avant mise en place de la pièce de liaison.Such a variant therefore has the advantage over the previous one of simplification and economy, since it amounts to completely eliminating the plug of elastomeric material and its sealing membrane, as well as the operation of mounting this plug. in the second bottle before fitting the connecting piece.
Par contre, un tel moyen d'obturation pouvant présenter le risque de n'être pas parfaitement étanche, il faut prévoir que l'étanchéité parfaite du système résultera de l'encliquetage aussi serré que possible de la pièce de liaison.On the other hand, since such a closure means may present the risk of not being perfectly sealed, provision must be made for the perfect sealing of the system to result from the snap-fitting as tight as possible of the connecting piece.
De toutes façons, la mise en oeuvre de cette variante est pratiquement identique à celle de la précédente, la communication entre les deux flacons étant simplement obtenue par perforation de l'opercule de la pièce de liaison au lieu de celle de la membrane du bouchon.In any case, the implementation of this variant is practically identical to that of the previous one, the communication between the two bottles being simply obtained by perforation of the lid of the connecting piece instead of that of the membrane of the plug.
L'invention va maintenant être décrite avec référence au dessin annexé sur lequel:
- - La figure 1 représente, en coupe axiale, un ensemble selon le premier mode de réalisation de l'invention,
- - La figure 2 représente, en vue éclatée, les éléments du premier flacon,
- - La figure 3 est une vue semblable à la figure 2 du second mode de réalisation de l'invention, et
- - la figure 4 est une vue de dessus de la pièce de liaison de la figure 3.
- FIG. 1 represents, in axial section, an assembly according to the first embodiment of the invention,
- - Figure 2 shows, in exploded view, the elements of the first bottle,
- FIG. 3 is a view similar to FIG. 2 of the second embodiment of the invention, and
- - Figure 4 is a top view of the connecting piece of Figure 3.
Si l'on se réfère d'abord aux figures 1 et 2, le second flacon B est retourné et vissé dans la douille 1 du premier flacon A. Cette douille 1 comprend une partie supérieure 2, présentant un filetage intérieur 4, et une partie inférieure 3 présentant un épaulement intérieur 5.If we refer first to Figures 1 and 2, the second bottle B is turned over and screwed into the
De la manière connue, le flacon B se termine par un stilligoutte 6, raccordé au corps 7 du flacon par un épaulemetn 8 fileté extérieurement. De même, le flacon A est obturé par un bouchon 9 en matériau élastomère, traversé par un trou 10 operculé par une membrane d'étanchéité 11 perforable par exemple complexe aluminium polyéthylène.In known manner, the bottle B ends in a dropper 6, connected to the body 7 of the bottle by a shoulder 8 externally threaded. Likewise, the bottle A is closed by a stopper 9 made of elastomeric material, crossed by a
Quand le flacon B est vissé sur le flacon A par coopération des filetages 4 et 8, le stilligoutte 6 vient perforer la membrane 11 et débouche dans le trou 10, mettant en communication les deux flacons.When the bottle B is screwed onto the bottle A by cooperation of the
Selon l'invention, la liaison entre lesdits deux flacons est réalisée au moyen de la pièce unique 1, cette pièce étant solidarisée avec le flacon A par encliquetage de l'épaulement 5 sur le col du flacon A.According to the invention, the connection between said two bottles is achieved by means of the
Pour faciliter le centrage et la préparation des éléments les uns par rapport aux autres, il est prévu, selon l'invention, de placer sous la collerette d'encliquetage 12, dite "carnette", des nervures verticales 13 autour du col du flacon A. Dans un premier temps l'encliquetage de 5 se fait de façon temporaire sur la carnette 12, puis par enfoncement de la douille sur le col, l'encliquetage définitif se fait sous la carnette 12, comme on le voit sur la figure 1. Le résultat de ces mesures est de faciliter le montage de la douille 1 sur le bouchon 9 et le flacon A et de le rendre moins coûteux.To facilitate centering and preparation of the elements with respect to one another, it is provided, according to the invention, to place under the snap-on
Bien entendu, il est possible de prévoir, dans cette variante, les diverses caractéristiques secondaires déjà illustrées au Brevet US précité, et notamment une bille emprisonnée dans le stilligoutte et la douille, évitant une perforation prématurée de la membrane d'étanchéité.Of course, it is possible to provide, in this variant, the various secondary characteristics already illustrated in the aforementioned US patent, and in particular a ball trapped in the dropper and the socket, preventing premature perforation of the waterproofing membrane.
Si l'on se réfère maintenant aux figures 3 et 4, en y retrouve le flacon A, destiné à contenir le produit solide à mettre en solution, et la pièce de liaison 1, destinée à permettre la mise en communication du flacon B contenant le produit liquide (non représenté ici), cette pièce 1 comportant une portion supérieure 2, présentant un filetage intérieur 4, et une portion inférieure 3, présenant un épaulement intérieur 5, destiné à s'encliqueter selon l'invention sur une collerette extérieure ou carnette 12 du goulot du flacon A.If we now refer to Figures 3 and 4, there is the bottle A, intended to contain the solid product to be dissolved, and the connecting
Selon la seconde variante illustrée ici, le bouchon operculé représenté en 8 -9-10 sur la figure 2 précédente est supprimé et l'obturation du flacon A est assurée, quand la pièce de liaison 1 est encliquetée en place sur le flacon A, par un opercule 14, interposé entre la portion supérieure 2 et la portion inférieure 3 de la pièce 1.According to the second variant illustrated here, the sealed cap shown at 8 -9-10 in the preceding figure 2 is removed and the closure of the bottle A is ensured, when the connecting
C'est cet opercule 14 qui est perforé par le stilligoutte du flacon B quand le goulot du flacon B est vissé dans le filetage 4. De préférence un croisillon 15 est prévu pour renforcer cet opercule.It is this
Il convient de remarquer que, dans le cas de la variante précédente, la pièce 1, quand elle est encliquetée sur le goulot du flacon A, exerce sur le bouchon operculé une pression, qui en assure l'étanchéité.It should be noted that, in the case of the previous variant, the
Au contraire, dans cette seconde variante, la communication entre les deux flacons A et B se fait directement par la pièce 1, ce qui implique que l'étanchéité soit assurée par la coopération étroite entre cette pièce et le flacon A, c'est-à-dire par un encliquetage aussi serré que possible.On the contrary, in this second variant, the communication between the two bottles A and B takes place directly through the
Selon une particularité constituant une variante préférée, il peut être prévu, entre les deux flacons préassemblés, une languette déchirable formant entretoise d'écartement. Cette entretoise interdit, au début du vissage, la descente du stilligoutte jusqu'à la membrane dont la fonction d'étanchéisation est ainsi garantie. Quand on déchire la languette, on peut poursuivre le vissage, et perforer la membrane avec le stilligoutte. Une telle languette est semblable à celle représentée en 13-14 sur le brevet US précité, mais intervient pour la première fois selon l'invention, en combinaison avec une pièce de liaison encliquetable.According to a feature constituting a preferred variant, there may be provided, between the two pre-assembled bottles, a tear-off tab forming a spacer. This spacer prohibits, at the start of screwing, the descent of the stilligoutte to the membrane, the sealing function of which is thus guaranteed. When you tear the tab, you can continue screwing, and puncture the membrane with the dropper. Such a tab is similar to that shown in 13-14 on the aforementioned US patent, but is used for the first time according to the invention, in combination with a snap-on connecting piece.
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT87440048T ATE70517T1 (en) | 1987-03-24 | 1987-07-30 | PACKAGING OF PREPARATIONS FOR PREPARATION ON THE SPOT. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8704195 | 1987-03-24 | ||
FR8704195A FR2612892B2 (en) | 1972-06-13 | 1987-03-24 | PACKAGING FOR EXTREMPORANEOUS PREPARATIONS |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0283629A1 true EP0283629A1 (en) | 1988-09-28 |
EP0283629B1 EP0283629B1 (en) | 1991-12-18 |
Family
ID=9349443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19870440048 Expired - Lifetime EP0283629B1 (en) | 1987-03-24 | 1987-07-30 | Packaging for extemporaneous preparations |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0283629B1 (en) |
AT (1) | ATE70517T1 (en) |
DE (1) | DE3775382D1 (en) |
ES (1) | ES2028122T3 (en) |
GR (1) | GR3004068T3 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2682088A1 (en) * | 1991-10-04 | 1993-04-09 | Emballages Conditionnement | Package for the extemporaneous preparation of medicinal products |
ES2078194A1 (en) * | 1994-06-03 | 1995-12-01 | Cusi Lab | Improvements to containers holding two-component products which have to be mixed in order to be administered |
WO1999009931A1 (en) * | 1997-08-27 | 1999-03-04 | Pentapharm Ag | Dual vial connecting system for lyophilized products |
WO2000002795A1 (en) * | 1998-07-10 | 2000-01-20 | Pentapharm Ag | Dual vial connecting system |
US20200369454A1 (en) * | 2017-12-08 | 2020-11-26 | Unipharma, Llc | Container and method for reconstitution of substances |
CN115998692A (en) * | 2023-02-15 | 2023-04-25 | 苏州欧康维视生物科技有限公司 | Atropine drug product and application thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105857890B (en) * | 2016-06-06 | 2018-03-23 | 洛阳海惠新材料股份有限公司 | A kind of packing container of antimony glycol |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1913926A1 (en) * | 1969-03-19 | 1970-09-24 | Hoechst Ag | Two-chamber syringe |
FR2160668A1 (en) * | 1971-11-20 | 1973-06-29 | Hoechst Ag | |
FR2427960A1 (en) * | 1978-06-06 | 1980-01-04 | Dehais Claude | Polypropylene adaptor for linking two bottles - with an integral diaphragm for sterile protection |
EP0138681A2 (en) * | 1983-09-26 | 1985-04-24 | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET | Assembly for preparing and dispensing a solution |
-
1987
- 1987-07-30 AT AT87440048T patent/ATE70517T1/en not_active IP Right Cessation
- 1987-07-30 EP EP19870440048 patent/EP0283629B1/en not_active Expired - Lifetime
- 1987-07-30 DE DE8787440048T patent/DE3775382D1/en not_active Expired - Lifetime
- 1987-07-30 ES ES87440048T patent/ES2028122T3/en not_active Expired - Lifetime
-
1992
- 1992-03-18 GR GR920400464T patent/GR3004068T3/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1913926A1 (en) * | 1969-03-19 | 1970-09-24 | Hoechst Ag | Two-chamber syringe |
FR2160668A1 (en) * | 1971-11-20 | 1973-06-29 | Hoechst Ag | |
FR2427960A1 (en) * | 1978-06-06 | 1980-01-04 | Dehais Claude | Polypropylene adaptor for linking two bottles - with an integral diaphragm for sterile protection |
EP0138681A2 (en) * | 1983-09-26 | 1985-04-24 | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET | Assembly for preparing and dispensing a solution |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2682088A1 (en) * | 1991-10-04 | 1993-04-09 | Emballages Conditionnement | Package for the extemporaneous preparation of medicinal products |
ES2036963A1 (en) * | 1991-10-04 | 1993-06-01 | Semco Emballage Conditionnemen | Packaging for the extemporaneous preparation of drug products |
ES2078194A1 (en) * | 1994-06-03 | 1995-12-01 | Cusi Lab | Improvements to containers holding two-component products which have to be mixed in order to be administered |
WO1999009931A1 (en) * | 1997-08-27 | 1999-03-04 | Pentapharm Ag | Dual vial connecting system for lyophilized products |
US6237649B1 (en) | 1997-08-27 | 2001-05-29 | Pentapharm Ag | Dual vial connecting system for lyophilized products |
WO2000002795A1 (en) * | 1998-07-10 | 2000-01-20 | Pentapharm Ag | Dual vial connecting system |
US20200369454A1 (en) * | 2017-12-08 | 2020-11-26 | Unipharma, Llc | Container and method for reconstitution of substances |
CN115998692A (en) * | 2023-02-15 | 2023-04-25 | 苏州欧康维视生物科技有限公司 | Atropine drug product and application thereof |
Also Published As
Publication number | Publication date |
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ES2028122T3 (en) | 1992-07-01 |
DE3775382D1 (en) | 1992-01-30 |
GR3004068T3 (en) | 1993-03-31 |
ATE70517T1 (en) | 1992-01-15 |
EP0283629B1 (en) | 1991-12-18 |
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