EP0000144A1 - Process for preparing 2-isocyanatoalkyl esters of unsaturated carboxylic acids - Google Patents
Process for preparing 2-isocyanatoalkyl esters of unsaturated carboxylic acids Download PDFInfo
- Publication number
- EP0000144A1 EP0000144A1 EP78100156A EP78100156A EP0000144A1 EP 0000144 A1 EP0000144 A1 EP 0000144A1 EP 78100156 A EP78100156 A EP 78100156A EP 78100156 A EP78100156 A EP 78100156A EP 0000144 A1 EP0000144 A1 EP 0000144A1
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- Prior art keywords
- oxazoline
- alkenyl
- water
- aqueous solution
- preparing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C263/00—Preparation of derivatives of isocyanic acid
- C07C263/08—Preparation of derivatives of isocyanic acid from or via heterocyclic compounds, e.g. pyrolysis of furoxans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
Definitions
- This invention is directed to a process for preparing a 2-isocyanatoalkyl ester of an unsaturated carboxylic acid by reacting a water-soluble 2-alkenyl--2-oxazoline with a solution of phosgene in a water--immiscible organic solvent in the presence of an aqueous solution of a hydrochloric acid acceptor characterized by the addition of the 2-alkenyl-2-oxazoline into the reaction lxture as an aqueous solution, the aqueous solution of the -alkenyl-2-oxazoline being prepared by (A) reacting a 2-alkyl-2-oxazoline with formaldehyde to form 2-(a-hydroxy- methylalkyl)-2-oxazoline, (B) dehydrating the 2-(a-hydroxy- methylalkyl)-2-oxazoline to form the 2-alkenyl-2-oxazoline, (C) separating a volatile composition comprising water and 2-alkenyl
- the present process is a substantial advance over tne closest known British Patent 1,252,099, which wequires that the 2-alkenyl-2-oxazoline be added to the eaction mixture as a solution in a water-immiscible solvent such as methylene chloride. It is now no longer necessary to prepare anhydrous 2-alkenyl-2-oxazolines to be dissolved in water-immiscible solvents. The total volume of water-immiscible solvents used in the process is substantially reduced over the process of the art, which results in further economy. There is also a significant advantage in terms of occupational safety.
- the 2-alkenyl-2-oxazolines are treated as a toxic class of compounds.
- the potential exposure by inhalation is reduced when aqueous solutions of 2-alkenyl--2-oxazolines are employed in comparison with employing solutions in water-immiscible solutions.
- the process of the present invention requires an aqueous solution of 2-alkenyl-2-oxazolines prepared by (A) reacting a 2-alkyl-2-oxazoline with formaldehyde to form a 2-(a-hydroxymethylalkyl)-2-oxazoline, (B) dehydrating the 2-(a-hydroxymethylalkyl)-2-oxazoline to form the 2-alkenyl--2-oxazoline, and (C) separating a volatile composition comprising water and 2-alkenyl-2-oxazoline which condenses to an aqueous solution of the 2- menyl-2-oxazoline.
- the preferred process for preparing the aqueous solution of the 2-alkenyl-2-oxazoline is described in patent applications corresponding to United States Patent Application Serial No. 699,091, filed June 23, 1976.
- Suitable 2-alkyl-2-oxazolines are those oxazolines in which the 2-alkyl group contains from 1 to 3 carbon atoms.
- the oxazoline ring may optionally contain inert substituents such as, for example, alkyl groups, in the 4- and/or 5-ring positions as long as the resultant 2-alkenyl-2-oxazolines are water-soluble.
- the most preferred 2-alkyl-2-oxazolines ' are 2-methyl-2-oxazoline and 2-ethyl-2-oxazoline.
- the yield of the desired 2-( ⁇ -hydroxymethylalkyl)--2-oxazoline is maximized when the molar ratio of oxazoline to formaldehyde is greater than 1:1. Normally, at least 1.5 moles of 2-alkyl-2-oxazoline per mole of formaldehyde is employed.
- the preferred ratio of reactants is from 2 to 10 moles of oxazoline per mole of formaldehyde. The most preferred ratio is 3 to 5 moles of oxazoline per mole of formaldehyde.
- Product yields of the 2-(a-hydroxymethylalkyl)-2-oxazoline are also maximized by conducting step A under ahydrous or substantially anhydrous conditions.
- the oxazoline reactant is preferably predried, employing such drying gents as, for example, molecular sieves or solid sodium- hydroxide.
- Paraformaldehyde having a 95 percent or greater formaldehyde content is the preferred formaldehyde source.
- Step A is onducted at any suitable temperature that promotes the r. setion and is below the decomposition lemperature of the desired product. Satisfactory reaction sates have been observed at temperatures of from 90°C to 115°C. Temperatures of from 95°C to 105°C are preferred. at those temperatures, reaction times of from 2 to 8 hours are conventional. Inert organic solvents such as, for example, benzene or toluene may be employed if desired. Preferably the process is conducted without employing a polvent.
- the 2-(a-hydroxymethylalkyl)-2-oxazoline is recovered from the reaction product of step A by conventional techniques. Fractional distillation under reduced pressure at a temperature below the decomposition temperature of the 2-(a-hydroxymethylalkyl)-2-oxazoline is preferred. The excess 2-alkyl-2-oxazoline and water co-distill first and are recovered.
- the 2-(a-hydroxymethylalkyl)-2-oxazolines are higher boiling. They are preferably further purified by such conventional techniques as, for example, distillation employing a falling film still.
- the 2-(a-hydroxymethylalkyl)-2-oxazolines are dehydrated to form the 2-a'lkenyl-2-oxazoline by contacting the reactant with an alkali or alkaline earth metal hydroxide.
- the dehydration reaction is conducted at a temperature of from 95°C to 200°C under reduced pressure such as, for example, 10 to 150 mm of mercury.
- the efficiency of the alkali or alkaline earth metal hydroxide as a dehydration catalyst tends to correlate with the solubility of the hydroxide in hot water.
- the more soluble hydroxides are the more efficient catalysts.
- the preferred catalysts are lithium hydroxide, sodium hydroxide, potassium hydroxide, and barium hydroxide. Most preferred is sodium hydroxide. 4
- the dehydration step may be conducted batchwise or continuously, the continuous process being preferred.
- the 2-( ⁇ -hydroxymethylalkyl)-2--oxazoline is added to the dehydration catalyst at the desired reaction temperature.
- the 2-alkenyl-2-oxazoline product is volatilized at the reaction temperature under reduced pressure and co-distills with water from the reaction vessel.
- the 2-(a-hydroxymethylalkyl)-2-oxazoline is metered into the reaction vessel at substantially the same rate at which the 2-alkenyl-2-oxazoline/water mixture is removed as overheads.
- the product When cooled to room temperature, the product is a solution of water and 2-alkenyl-2-oxazoline.
- Inert solvents which are liquid at the reaction temperature may be employed in the dehydration step.
- Lower alkyl monoethers of polyalkylene glycols are solvents for alkali and alkaline earth metal hydroxides and are preferred solvents for this step.
- Suitable compounds include, for example, the methyl, ethyl, propyl and butyl ethers of diethylene glycol and triethylene glycol.
- the preferred solvent is the monomethyl ether of triethylene glycol when sodium hydroxide is employed as the catalyst.
- the crude aqueous solution of 2-alkenyl-2-oxazolin ⁇ is surprisingly useful in the present process.
- the aqueous solution of the 2-alkenyl-2-oxazoline can be added per se into the reaction mixture or it can be further diluted with water before adding it to the reaction mixture. It is important that there be sufficient water present in the reaction mixture to create two phases with the water-immisci. ble solvent.
- the 2-alkenyl-2-oxazoline is an effective coupling agent. An insufficient amount of water in the reaction mixture would result in a single phase, which is not desirable.
- Preferably at least 15 moles of water per mole of oxazoline reactant is employed in the reaction mixture. Most preferably the proportion of water is at least 25 moles of water per mole of oxazoline reactant.
- Phosgene is employed as a solution in an inert water-immiscible organic solvent.
- suitable solvents include hydrocarbons such as hexane, cyclohexane, petroleum ether, benzene, toluene, xylene, and diisopropylbenzene; and chlorinated hydrocarbons such as methylene chloride, chloroform, chlorobenzene, and ortho-dichlorobenzene. Mixtures of such solvents may also be employed. Methylene chloride is the preferred solvent.
- Suitable hydrochloric acid acceptors include both inorganic and organic bases such as, for example, sodium and potassium hydroxides, sodium and potassium carbonates, sodium and potassium phosphates, triethylamine and pyridine.
- the inorganic water-soluble bases are pre.- ferred due to cost and ease of handling.
- Sodium hydroxide is the most preferred acid acceptor.
- the reaction step to produce the 2-isocyanatoalkyl ester is normally conducted at a temperature of from -30°C to 25°C, preferably from -10°C to 15°C, and more preferably from 0°C to 10°C.
- This reaction step is preferably conducted by simultaneously introducing a pre-cooled aqueous solution of the 2-alkenyl-2-oxaznline, a are-cooled organic solution of phosgene and a pre-cooled at Fous solution of the hydrochloric acid acceptor into a reaction vessel with vigorous stirring and cooling.
- the reaction is essentially instantaneous and is normally complete upon thorough mixing of the reactants. This step can be conducted batchwise or in a continuous fashion.
- the 2-isocyanatoalkyl ester of the unsaturated carboxylic acid is recovered from the organic phase of the reaction mixture by conventional techniques such as, for example, distillation.
- Product yields are maximized by recovering the product from the organic phase as soon as practical to minimize losses due to hydrolysis.
- 2-Ethyl-2-oxazoline (594 g; 6.0 moles) and 95 percent paraformaldehyde (63.2 g; 2.0 moles) were charged to a reaction vessel equipped with a mechanical stirrer and condenser. The reaction mixture was heated to 100°C with ctirring and maintained under these conditions for 4 hours. A sample of the reaction mixture was then analyzed by vapor phase chromatography with the following results: 60.7 weight percent 2-ethyl-2-oxazoline; 37.9 weight percent 2-(a-hydroxy- methylethyl)-2-oxazoline; and the remaining 1.4 weight percent vas not identified.
- the mixture contained 2.5 weight percent unreacted 2-ethyl-2-oxazoline; 11.7 weight percent water; and 85.8 weight percent 2-isopropenyl-2-oxazoline. This amounts to a 97.8 percent yield of 2-isopropenyl-2--oxazoline.
- a 3-liter jacketed reactor vessel was charged with 100 ml.of methylene chloride and cooled to approximately 0°C.
- a solution of 2-isopropenyl-2-oxazoline (100 g) in 177 ml of water, a solution of phosgene (131.5 g) in 400 ml of methylene chloride, and 250 ml of a solution of 35 weight percent sodium hydroxide in water were added simultaneously to the reaction vessel with stirring and cooling.
- the rates of addition were such that the three reagents were added over approximately a 50 minute time span with the temperature being maintained at 10° to 18°C. Stirring was continued for two minutes and the layers allowed to separate.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
- This invention is directed to a process for preparing a 2-isocyanatoalkyl ester of an unsaturated carboxylic acid by reacting a water-soluble 2-alkenyl--2-oxazoline with a solution of phosgene in a water--immiscible organic solvent in the presence of an aqueous solution of a hydrochloric acid acceptor characterized by the addition of the 2-alkenyl-2-oxazoline into the reaction lxture as an aqueous solution, the aqueous solution of the -alkenyl-2-oxazoline being prepared by (A) reacting a 2-alkyl-2-oxazoline with formaldehyde to form 2-(a-hydroxy- methylalkyl)-2-oxazoline, (B) dehydrating the 2-(a-hydroxy- methylalkyl)-2-oxazoline to form the 2-alkenyl-2-oxazoline, (C) separating a volatile composition comprising water and 2-alkenyl-2-oxazoline which condenses to an aqueous solution of the 2-alkenyl-2-oxazoline.
- The present process is a substantial advance over tne closest known British Patent 1,252,099, which wequires that the 2-alkenyl-2-oxazoline be added to the eaction mixture as a solution in a water-immiscible solvent such as methylene chloride. It is now no longer necessary to prepare anhydrous 2-alkenyl-2-oxazolines to be dissolved in water-immiscible solvents. The total volume of water-immiscible solvents used in the process is substantially reduced over the process of the art, which results in further economy. There is also a significant advantage in terms of occupational safety. The 2-alkenyl-2-oxazolines, particularly the lower molecular weight compounds such as 2--vinyl-2-oxazoline and 2-isopropenyl-2-oxazoline, are treated as a toxic class of compounds. The potential exposure by inhalation is reduced when aqueous solutions of 2-alkenyl--2-oxazolines are employed in comparison with employing solutions in water-immiscible solutions. These improvements of the present process result in economic and safety advantages over the prior art which are commercially significant.
- Prior art methods of preparing 2-isocyanatoalkyl esters of unsaturated carboxylic acids have utilized 2--alkenyl-2-oxazolines prepared from expensive reagents in multi-step processes. Product yields were often low. See Angew, Volume 78, pages 113 and following, published in 1966.
- The process of the present invention requires an aqueous solution of 2-alkenyl-2-oxazolines prepared by (A) reacting a 2-alkyl-2-oxazoline with formaldehyde to form a 2-(a-hydroxymethylalkyl)-2-oxazoline, (B) dehydrating the 2-(a-hydroxymethylalkyl)-2-oxazoline to form the 2-alkenyl--2-oxazoline, and (C) separating a volatile composition comprising water and 2-alkenyl-2-oxazoline which condenses to an aqueous solution of the 2- menyl-2-oxazoline. The preferred process for preparing the aqueous solution of the 2-alkenyl-2-oxazoline is described in patent applications corresponding to United States Patent Application Serial No. 699,091, filed June 23, 1976.
- Suitable 2-alkyl-2-oxazolines are those oxazolines in which the 2-alkyl group contains from 1 to 3 carbon atoms. The oxazoline ring may optionally contain inert substituents such as, for example, alkyl groups, in the 4- and/or 5-ring positions as long as the resultant 2-alkenyl-2-oxazolines are water-soluble. The most preferred 2-alkyl-2-oxazolines' are 2-methyl-2-oxazoline and 2-ethyl-2-oxazoline.
- The yield of the desired 2-(α-hydroxymethylalkyl)--2-oxazoline is maximized when the molar ratio of oxazoline to formaldehyde is greater than 1:1. Normally, at least 1.5 moles of 2-alkyl-2-oxazoline per mole of formaldehyde is employed. The preferred ratio of reactants is from 2 to 10 moles of oxazoline per mole of formaldehyde. The most preferred ratio is 3 to 5 moles of oxazoline per mole of formaldehyde.
- Product yields of the 2-(a-hydroxymethylalkyl)-2-oxazoline are also maximized by conducting step A under ahydrous or substantially anhydrous conditions. The oxazoline reactant is preferably predried, employing such drying gents as, for example, molecular sieves or solid sodium- hydroxide. Paraformaldehyde having a 95 percent or greater formaldehyde content is the preferred formaldehyde source.
- Step A is onducted at any suitable temperature that promotes the r. setion and is below the decomposition lemperature of the desired product. Satisfactory reaction sates have been observed at temperatures of from 90°C to 115°C. Temperatures of from 95°C to 105°C are preferred. at those temperatures, reaction times of from 2 to 8 hours are conventional. Inert organic solvents such as, for example, benzene or toluene may be employed if desired. Preferably the process is conducted without employing a polvent.
- The 2-(a-hydroxymethylalkyl)-2-oxazoline is recovered from the reaction product of step A by conventional techniques. Fractional distillation under reduced pressure at a temperature below the decomposition temperature of the 2-(a-hydroxymethylalkyl)-2-oxazoline is preferred. The excess 2-alkyl-2-oxazoline and water co-distill first and are recovered. The 2-(a-hydroxymethylalkyl)-2-oxazolines are higher boiling. They are preferably further purified by such conventional techniques as, for example, distillation employing a falling film still.
- The 2-(a-hydroxymethylalkyl)-2-oxazolines are dehydrated to form the 2-a'lkenyl-2-oxazoline by contacting the reactant with an alkali or alkaline earth metal hydroxide. The dehydration reaction is conducted at a temperature of from 95°C to 200°C under reduced pressure such as, for example, 10 to 150 mm of mercury.
- The efficiency of the alkali or alkaline earth metal hydroxide as a dehydration catalyst tends to correlate with the solubility of the hydroxide in hot water. The more soluble hydroxides are the more efficient catalysts. The preferred catalysts are lithium hydroxide, sodium hydroxide, potassium hydroxide, and barium hydroxide. Most preferred is sodium hydroxide. 4
- The dehydration step may be conducted batchwise or continuously, the continuous process being preferred. In the continuous process, the 2-(α-hydroxymethylalkyl)-2--oxazoline is added to the dehydration catalyst at the desired reaction temperature. The 2-alkenyl-2-oxazoline product is volatilized at the reaction temperature under reduced pressure and co-distills with water from the reaction vessel. Preferably, the 2-(a-hydroxymethylalkyl)-2-oxazoline is metered into the reaction vessel at substantially the same rate at which the 2-alkenyl-2-oxazoline/water mixture is removed as overheads. When cooled to room temperature, the product is a solution of water and 2-alkenyl-2-oxazoline.
- Inert solvents which are liquid at the reaction temperature may be employed in the dehydration step. Lower alkyl monoethers of polyalkylene glycols are solvents for alkali and alkaline earth metal hydroxides and are preferred solvents for this step. Suitable compounds include, for example, the methyl, ethyl, propyl and butyl ethers of diethylene glycol and triethylene glycol. The preferred solvent is the monomethyl ether of triethylene glycol when sodium hydroxide is employed as the catalyst.
- The crude aqueous solution of 2-alkenyl-2-oxazolinε is surprisingly useful in the present process. The aqueous solution of the 2-alkenyl-2-oxazoline can be added per se into the reaction mixture or it can be further diluted with water before adding it to the reaction mixture. It is important that there be sufficient water present in the reaction mixture to create two phases with the water-immisci. ble solvent. The 2-alkenyl-2-oxazoline is an effective coupling agent. An insufficient amount of water in the reaction mixture would result in a single phase, which is not desirable. Preferably at least 15 moles of water per mole of oxazoline reactant is employed in the reaction mixture. Most preferably the proportion of water is at least 25 moles of water per mole of oxazoline reactant.
- Phosgene is employed as a solution in an inert water-immiscible organic solvent. Examples of suitable solvents include hydrocarbons such as hexane, cyclohexane, petroleum ether, benzene, toluene, xylene, and diisopropylbenzene; and chlorinated hydrocarbons such as methylene chloride, chloroform, chlorobenzene, and ortho-dichlorobenzene. Mixtures of such solvents may also be employed. Methylene chloride is the preferred solvent.
- Suitable hydrochloric acid acceptors include both inorganic and organic bases such as, for example, sodium and potassium hydroxides, sodium and potassium carbonates, sodium and potassium phosphates, triethylamine and pyridine. The inorganic water-soluble bases are pre.- ferred due to cost and ease of handling. Sodium hydroxide is the most preferred acid acceptor.
- The reaction step to produce the 2-isocyanatoalkyl ester is normally conducted at a temperature of from -30°C to 25°C, preferably from -10°C to 15°C, and more preferably from 0°C to 10°C. This reaction step is preferably conducted by simultaneously introducing a pre-cooled aqueous solution of the 2-alkenyl-2-oxaznline, a are-cooled organic solution of phosgene and a pre-cooled at Fous solution of the hydrochloric acid acceptor into a reaction vessel with vigorous stirring and cooling. The reaction is essentially instantaneous and is normally complete upon thorough mixing of the reactants. This step can be conducted batchwise or in a continuous fashion.
- The 2-isocyanatoalkyl ester of the unsaturated carboxylic acid is recovered from the organic phase of the reaction mixture by conventional techniques such as, for example, distillation. Product yields are maximized by recovering the product from the organic phase as soon as practical to minimize losses due to hydrolysis.
- 2-Ethyl-2-oxazoline (594 g; 6.0 moles) and 95 percent paraformaldehyde (63.2 g; 2.0 moles) were charged to a reaction vessel equipped with a mechanical stirrer and condenser. The reaction mixture was heated to 100°C with ctirring and maintained under these conditions for 4 hours. A sample of the reaction mixture was then analyzed by vapor phase chromatography with the following results: 60.7 weight percent 2-ethyl-2-oxazoline; 37.9 weight percent 2-(a-hydroxy- methylethyl)-2-oxazoline; and the remaining 1.4 weight percent vas not identified. On this data, the conversion of 2-ethyl--2-oxazoline was 98.5 percent and the percent yield of 2--(α-hydroxymethylethyl)-2-oxazoline was 96.5 percent. The .xcess 2-ethyl-2-oxazoline was removed from the reaction- fixture by distillation under reduced pressure leaving the desired 2-(a-hydroxymethylethyl)-2-oxazoline as the still bottoms.
- Sodium hydroxide beads (60.0 g; 1.5 mole) were edded to a reaction vessel equipped with a mechanical stirrer, a dropping funnel and a distillation column packed with 1/4 inch (0.64 cm) glass beads. This material was heated to a pot temperature of approximately 175°C at a pressure of 150 mm Hg. To this heated system was added the 2-(a--hydroxymethylethyl)-2-oxazoline from the above (containing 100 ppm of a polymerization inhibitor) at a rate of approximately 1 g per minute. All volatiles passing through the distillation column were collected in a cold trap and analyzed by vapor phase chromatography using 1,2,4-trichlorobenzene as an internal standard. The mixture contained 2.5 weight percent unreacted 2-ethyl-2-oxazoline; 11.7 weight percent water; and 85.8 weight percent 2-isopropenyl-2-oxazoline. This amounts to a 97.8 percent yield of 2-isopropenyl-2--oxazoline.
- Similar high yields were obtained when the dehydration was conducted using sodium hydroxide dissolved in monomethyl ether of triethylene glycol and a minor amount of water. Data obtained on a series of such dehydrations indicate that the effective life of the sodium hydroxide catalyst was extended by using this material as a reaction medium.
- A 3-liter jacketed reactor vessel was charged with 100 ml.of methylene chloride and cooled to approximately 0°C. A solution of 2-isopropenyl-2-oxazoline (100 g) in 177 ml of water, a solution of phosgene (131.5 g) in 400 ml of methylene chloride, and 250 ml of a solution of 35 weight percent sodium hydroxide in water were added simultaneously to the reaction vessel with stirring and cooling. The rates of addition were such that the three reagents were added over approximately a 50 minute time span with the temperature being maintained at 10° to 18°C. Stirring was continued for two minutes and the layers allowed to separate. The organic layer was washed twice with 100 ml portions of a saturated aqueous sodium bicarbonate solution, dried over sodium sulfate and concentrated under reduced pressure. The colorless concentrate was inhibited with 0.1 g of pheno- thiazine and the desired product recovered therefrom as a colorless liquid (133.6 g) boiling at 46-47°C/0.4 mm Hg. Product yield 95.7 percent of theory.
Claims (2)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US806805 | 1977-06-15 | ||
US05/806,805 US4278809A (en) | 1977-06-15 | 1977-06-15 | Process for preparing 2-isocyanatoalkyl esters of organic carboxylic acids |
Publications (2)
Publication Number | Publication Date |
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EP0000144A1 true EP0000144A1 (en) | 1979-01-10 |
EP0000144B1 EP0000144B1 (en) | 1981-08-05 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP78100156A Expired EP0000144B1 (en) | 1977-06-15 | 1978-06-14 | Process for preparing 2-isocyanatoalkyl esters of unsaturated carboxylic acids |
Country Status (6)
Country | Link |
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US (1) | US4278809A (en) |
EP (1) | EP0000144B1 (en) |
JP (1) | JPS545921A (en) |
AU (1) | AU515393B2 (en) |
CA (1) | CA1099733A (en) |
DE (1) | DE2860892D1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3225247A1 (en) * | 1982-07-06 | 1984-01-12 | The Dow Chemical Co., 48640 Midland, Mich. | Process for the distillation of a 2-isocyanatoalkyl ester of an alpha , beta -ethylenically unsaturated carboxylic acid |
EP0141295A1 (en) * | 1983-10-20 | 1985-05-15 | Bayer Ag | Unsaturated ester isocyanates, process for their preparation and their utilization in the production of olefinically unsaturated oligourethanes |
US4692503A (en) * | 1980-12-29 | 1987-09-08 | Ppg Industries, Inc. | Coating compositions comprising free radical addition polymers with crosslinkable integral isocyanato groups |
US5512614A (en) * | 1992-08-13 | 1996-04-30 | Henkel Kommanditgesellschaft Auf Aktien | Binder mixtures for stoving lacquers |
EP2377847A1 (en) | 2010-04-14 | 2011-10-19 | 3M Innovative Properties Company | Process for producing isocyanates |
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JPS5780405A (en) * | 1980-11-10 | 1982-05-20 | Dow Chemical Co | Addition polymerizable polyethers having ethylenically unsaturated urethane branched group |
US4375546A (en) * | 1981-11-16 | 1983-03-01 | The Dow Chemical Company | Substituted pyridinyl esters of 2-(1-oxoalkyloxy)ethyl carbamic acid |
US4418198A (en) * | 1981-11-16 | 1983-11-29 | The Dow Chemical Company | Substituted pyridine carbonyl amino ethyl esters of 2-methyl-2-propenoic acid |
US4520074A (en) * | 1984-07-20 | 1985-05-28 | General Electric Company | Polymerizable 3-aroyloxyphenyl carbamates and methods for their preparation and use |
JPS61137964A (en) * | 1984-12-10 | 1986-06-25 | 株式会社ブリヂストン | Floor panel material |
AU584195B2 (en) | 1985-05-13 | 1989-05-18 | Nippon Paint Co., Ltd. | Isocyanate compounds and their production |
US4650889A (en) * | 1985-11-29 | 1987-03-17 | Dow Corning Corporation | Silane coupling agents |
WO2005012237A1 (en) | 2003-07-31 | 2005-02-10 | Showa Denko K.K. | Process for preparing high purity (meth)acryloyloxyalkyl isocyanate |
US20060229464A1 (en) * | 2003-07-31 | 2006-10-12 | Katsutoshi Morinaka | Stabilized (meth)acryloyloxyalkyl isocyanate a process for stabilization thereof and a process for preparation of the same |
JP5135564B2 (en) * | 2007-06-12 | 2013-02-06 | デクセリアルズ株式会社 | Adhesive composition |
CN102702028B (en) * | 2012-06-12 | 2013-11-06 | 江苏快达农化股份有限公司 | Method for synthesizing methacryloxyethyl isocyanate |
US9266824B2 (en) | 2014-01-13 | 2016-02-23 | Warsaw Orthopedic, Inc. | Methods and compositions for making an amino acid triisocyanate |
CN114929668A (en) | 2020-01-06 | 2022-08-19 | 昭和电工株式会社 | (meth) acrylate compound having isocyanate group and method for producing same |
Citations (3)
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US2821544A (en) * | 1954-04-26 | 1958-01-28 | Bayer Ag | Production of alkylisocyanate esters of 2-alkenoic acids |
FR1217276A (en) * | 1957-12-13 | 1960-05-03 | Bayer Ag | Process for the preparation of aromatic polyisocyanates containing ester groups |
DE1913273A1 (en) * | 1969-03-15 | 1970-09-24 | Bayer Ag | Process for the preparation of ester isocyanates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3535332A (en) * | 1968-03-11 | 1970-10-20 | Commercial Solvents Corp | Production of vinyl oxazoline esters |
-
1977
- 1977-06-15 US US05/806,805 patent/US4278809A/en not_active Expired - Lifetime
-
1978
- 1978-06-13 AU AU37059/78A patent/AU515393B2/en not_active Expired
- 1978-06-14 EP EP78100156A patent/EP0000144B1/en not_active Expired
- 1978-06-14 DE DE7878100156T patent/DE2860892D1/en not_active Expired
- 1978-06-14 CA CA305,468A patent/CA1099733A/en not_active Expired
- 1978-06-14 JP JP7200378A patent/JPS545921A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2821544A (en) * | 1954-04-26 | 1958-01-28 | Bayer Ag | Production of alkylisocyanate esters of 2-alkenoic acids |
FR1217276A (en) * | 1957-12-13 | 1960-05-03 | Bayer Ag | Process for the preparation of aromatic polyisocyanates containing ester groups |
DE1913273A1 (en) * | 1969-03-15 | 1970-09-24 | Bayer Ag | Process for the preparation of ester isocyanates |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692503A (en) * | 1980-12-29 | 1987-09-08 | Ppg Industries, Inc. | Coating compositions comprising free radical addition polymers with crosslinkable integral isocyanato groups |
DE3225247A1 (en) * | 1982-07-06 | 1984-01-12 | The Dow Chemical Co., 48640 Midland, Mich. | Process for the distillation of a 2-isocyanatoalkyl ester of an alpha , beta -ethylenically unsaturated carboxylic acid |
EP0141295A1 (en) * | 1983-10-20 | 1985-05-15 | Bayer Ag | Unsaturated ester isocyanates, process for their preparation and their utilization in the production of olefinically unsaturated oligourethanes |
US5512614A (en) * | 1992-08-13 | 1996-04-30 | Henkel Kommanditgesellschaft Auf Aktien | Binder mixtures for stoving lacquers |
EP2377847A1 (en) | 2010-04-14 | 2011-10-19 | 3M Innovative Properties Company | Process for producing isocyanates |
WO2011130032A1 (en) | 2010-04-14 | 2011-10-20 | 3M Innovative Properties Company | Process for producing isocyanates |
Also Published As
Publication number | Publication date |
---|---|
CA1099733A (en) | 1981-04-21 |
AU3705978A (en) | 1979-12-20 |
DE2860892D1 (en) | 1981-11-05 |
US4278809A (en) | 1981-07-14 |
JPS5757021B2 (en) | 1982-12-02 |
AU515393B2 (en) | 1981-04-02 |
EP0000144B1 (en) | 1981-08-05 |
JPS545921A (en) | 1979-01-17 |
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