EE200300134A - Uued tiadiasoolid ja oksadiasoolid ning nende kasutamine fosfodiesteraas-7 inhibiitoritena - Google Patents

Uued tiadiasoolid ja oksadiasoolid ning nende kasutamine fosfodiesteraas-7 inhibiitoritena

Info

Publication number: EE200300134A
Authority: EE; Estonia
Prior art keywords: oxadiazoles; phosphodiesterase; inhibitors; thiadiazoles; novel
Prior art date: 2000-10-02

Application number

EEP200300134A

Other languages

English (en)

Inventor

Vergne Fabrice

Ducrot Pierre

Andrianjara Charles

Bernardelli Patrick

Lorthiois Edwige

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-02

Filing date

2001-10-01

Publication date

2003-08-15

2001-10-01 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2003-08-15 Publication of EE200300134A publication Critical patent/EE200300134A/et

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

EEP200300134A 2000-10-02 2001-10-01 Uued tiadiasoolid ja oksadiasoolid ning nende kasutamine fosfodiesteraas-7 inhibiitoritena EE200300134A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00402710A EP1193261A1 (en)	2000-10-02	2000-10-02	New thiadiazoles and their use as phosphodiesterase-7 inhibitors
PCT/EP2001/011330 WO2002028847A1 (en)	2000-10-02	2001-10-01	New thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors

Publications (1)

Publication Number	Publication Date
EE200300134A true EE200300134A (et)	2003-08-15

Family

ID=8173891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300134A EE200300134A (et)	2000-10-02	2001-10-01	Uued tiadiasoolid ja oksadiasoolid ning nende kasutamine fosfodiesteraas-7 inhibiitoritena

Country Status (43)

Country	Link
US (1)	US7122565B2 (et)
EP (2)	EP1193261A1 (et)
JP (1)	JP4177098B2 (et)
KR (1)	KR100614158B1 (et)
CN (1)	CN1639141A (et)
AP (1)	AP1541A (et)
AR (1)	AR035347A1 (et)
AT (1)	ATE304003T1 (et)
AU (2)	AU2001289945B2 (et)
BG (1)	BG107654A (et)
BR (1)	BR0114391A (et)
CA (1)	CA2424279A1 (et)
CZ (1)	CZ2003857A3 (et)
DE (1)	DE60113283T2 (et)
DK (1)	DK1326853T3 (et)
DZ (1)	DZ3440A1 (et)
EA (1)	EA007179B1 (et)
EC (1)	ECSP034534A (et)
EE (1)	EE200300134A (et)
ES (1)	ES2247166T3 (et)
GE (1)	GEP20053459B (et)
GT (1)	GT200100196A (et)
HN (1)	HN2001000217A (et)
HR (1)	HRP20030247A2 (et)
HU (1)	HUP0301248A3 (et)
IL (1)	IL155122A0 (et)
IS (1)	IS6759A (et)
MA (1)	MA25916A1 (et)
MX (1)	MXPA03002839A (et)
NO (1)	NO20031482D0 (et)
NZ (1)	NZ524852A (et)
OA (1)	OA12518A (et)
PA (1)	PA8529501A1 (et)
PE (1)	PE20020419A1 (et)
PL (1)	PL366332A1 (et)
PT (1)	PT1326853E (et)
SI (1)	SI1326853T1 (et)
SK (1)	SK3812003A3 (et)
SV (1)	SV2003000633A (et)
TN (1)	TNSN01139A1 (et)
WO (1)	WO2002028847A1 (et)
YU (1)	YU24503A (et)
ZA (1)	ZA200302346B (et)

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WO2004044235A1 (en) *	2002-11-13	2004-05-27	Bayer Healthcare Ag	DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7A1 (PDE7a1)
ES2217956B1 (es) *	2003-01-23	2006-04-01	Almirall Prodesfarma, S.A.	Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
JP2006219374A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
JP2006219373A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
CN1976938B (zh)	2004-07-01	2012-08-15	第一三共株式会社	具有pde7抑制活性的噻吩并吡唑衍生物
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
US7998971B2 (en)	2006-09-08	2011-08-16	Braincells Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
ES2533206T3 (es) *	2007-03-27	2015-04-08	Omeros Corporation	Inhibidores de PDE7 para uso en el tratamiento de trastornos del movimiento
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
MD3995C2 (ro) *	2009-05-11	2010-07-31	Государственный Университет Молд0	Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
US8703768B2 (en)	2010-06-09	2014-04-22	Hoffmann-La Roche Inc.	Nitrogen containing heteroaryl compounds
CN103547267A (zh)	2010-11-08	2014-01-29	奥默罗斯公司	使用pde7抑制剂治疗成瘾和冲动控制障碍
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
CN102276625B (zh) *	2011-08-24	2013-07-17	天津药物研究院	噻二唑衍生物
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
CN103288777A (zh) *	2013-05-28	2013-09-11	浙江禾田化工有限公司	特丁噻草隆关键中间体2-甲基氨基-5-叔丁基-1,3,4-噻二唑的合成方法
US9416652B2 (en)	2013-08-08	2016-08-16	Vetco Gray Inc.	Sensing magnetized portions of a wellhead system to monitor fatigue loading
EP3307909A1 (en) *	2015-06-12	2018-04-18	Oryzon Genomics, S.A.	Biomarkers associated with lsd1 inhibitors and uses thereof
CN107674042B (zh) *	2017-09-28	2020-09-25	河南科技大学	一种超声波无溶剂合成噻二唑类化合物的方法
CN113480486B (zh) *	2021-07-30	2022-05-24	赣南师范大学	一种3-胺基-1,2,4-***类衍生物及其制备方法和应用
WO2024038090A1 (en)	2022-08-18	2024-02-22	Mitodicure Gmbh	Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

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DD251979A1 (de) *	1986-08-01	1987-12-02	Neubauer T Paedagog Hochschule	Verfahren zur herstellung von s-triazinylsubstituierten 2-imino-1,3,4-oxadiazolinen
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DE69909592T4 (de) *	1998-02-17	2005-03-24	Roche Diagnostics Gmbh	Verwendung von thiadiazolo[4,3-a]pyridine derivaten

2000
- 2000-10-02 EP EP00402710A patent/EP1193261A1/en not_active Withdrawn
2001
- 2001-09-19 SV SV2001000633A patent/SV2003000633A/es not_active Application Discontinuation
- 2001-09-26 TN TNTNSN01139A patent/TNSN01139A1/en unknown
- 2001-09-27 HN HN2001000217A patent/HN2001000217A/es unknown
- 2001-09-27 PA PA20018529501A patent/PA8529501A1/es unknown
- 2001-09-27 GT GT200100196A patent/GT200100196A/es unknown
- 2001-09-27 AR ARP010104558A patent/AR035347A1/es unknown
- 2001-09-27 PE PE2001000964A patent/PE20020419A1/es not_active Application Discontinuation
- 2001-10-01 IL IL15512201A patent/IL155122A0/xx unknown
- 2001-10-01 GE GE5120A patent/GEP20053459B/en unknown
- 2001-10-01 WO PCT/EP2001/011330 patent/WO2002028847A1/en active IP Right Grant
- 2001-10-01 MX MXPA03002839A patent/MXPA03002839A/es active IP Right Grant
- 2001-10-01 SK SK381-2003A patent/SK3812003A3/sk not_active Application Discontinuation
- 2001-10-01 US US09/968,371 patent/US7122565B2/en not_active Expired - Fee Related
- 2001-10-01 NZ NZ524852A patent/NZ524852A/en unknown
- 2001-10-01 CA CA002424279A patent/CA2424279A1/en not_active Abandoned
- 2001-10-01 SI SI200130423T patent/SI1326853T1/sl unknown
- 2001-10-01 AU AU2001289945A patent/AU2001289945B2/en not_active Ceased
- 2001-10-01 ES ES01969804T patent/ES2247166T3/es not_active Expired - Lifetime
- 2001-10-01 BR BR0114391-3A patent/BR0114391A/pt not_active IP Right Cessation
- 2001-10-01 DE DE60113283T patent/DE60113283T2/de not_active Expired - Fee Related
- 2001-10-01 EE EEP200300134A patent/EE200300134A/et unknown
- 2001-10-01 JP JP2002532432A patent/JP4177098B2/ja not_active Expired - Fee Related
- 2001-10-01 KR KR1020037004728A patent/KR100614158B1/ko not_active IP Right Cessation
- 2001-10-01 EP EP01969804A patent/EP1326853B1/en not_active Expired - Lifetime
- 2001-10-01 YU YU24503A patent/YU24503A/sh unknown
- 2001-10-01 DK DK01969804T patent/DK1326853T3/da active
- 2001-10-01 AU AU8994501A patent/AU8994501A/xx active Pending
- 2001-10-01 PL PL01366332A patent/PL366332A1/xx not_active Application Discontinuation
- 2001-10-01 DZ DZ013440A patent/DZ3440A1/fr active
- 2001-10-01 CN CNA018182070A patent/CN1639141A/zh active Pending
- 2001-10-01 OA OA1200300092A patent/OA12518A/en unknown
- 2001-10-01 AP APAP/P/2003/002764A patent/AP1541A/en active
- 2001-10-01 HU HU0301248A patent/HUP0301248A3/hu unknown
- 2001-10-01 PT PT01969804T patent/PT1326853E/pt unknown
- 2001-10-01 CZ CZ2003857A patent/CZ2003857A3/cs unknown
- 2001-10-01 AT AT01969804T patent/ATE304003T1/de not_active IP Right Cessation
- 2001-10-01 EA EA200300333A patent/EA007179B1/ru not_active IP Right Cessation
2003
- 2003-03-20 BG BG107654A patent/BG107654A/bg unknown
- 2003-03-26 ZA ZA200302346A patent/ZA200302346B/en unknown
- 2003-03-27 IS IS6759A patent/IS6759A/is unknown
- 2003-03-31 MA MA27082A patent/MA25916A1/fr unknown
- 2003-04-01 NO NO20031482A patent/NO20031482D0/no not_active Application Discontinuation
- 2003-04-01 HR HR20030247A patent/HRP20030247A2/hr not_active Application Discontinuation
- 2003-04-01 EC EC2003004534A patent/ECSP034534A/es unknown

Also Published As

Publication number	Publication date
BR0114391A (pt)	2003-06-24
NO20031482L (no)	2003-04-01
DE60113283T2 (de)	2006-06-08
HUP0301248A3 (en)	2005-06-28
GEP20053459B (en)	2005-02-25
HRP20030247A2 (en)	2005-04-30
BG107654A (bg)	2003-12-31
PA8529501A1 (es)	2003-06-30
HN2001000217A (es)	2002-06-13
CA2424279A1 (en)	2002-04-11
MXPA03002839A (es)	2004-09-10
US20030045557A1 (en)	2003-03-06
EA200300333A1 (ru)	2003-10-30
AR035347A1 (es)	2004-05-12
ZA200302346B (en)	2004-08-04
NZ524852A (en)	2004-09-24
KR100614158B1 (ko)	2006-08-21
SI1326853T1 (sl)	2005-12-31
ATE304003T1 (de)	2005-09-15
MA25916A1 (fr)	2003-10-01
GT200100196A (es)	2002-07-18
YU24503A (sh)	2006-03-03
AU2001289945B2 (en)	2005-12-22
CZ2003857A3 (cs)	2004-02-18
DK1326853T3 (da)	2005-12-12
EP1193261A1 (en)	2002-04-03
TNSN01139A1 (en)	2005-11-10
AP2003002764A0 (en)	2003-03-31
OA12518A (en)	2006-05-29
SV2003000633A (es)	2003-04-03
US7122565B2 (en)	2006-10-17
JP4177098B2 (ja)	2008-11-05
HUP0301248A2 (hu)	2003-10-28
CN1639141A (zh)	2005-07-13
PT1326853E (pt)	2005-11-30
IL155122A0 (en)	2003-10-31
AU8994501A (en)	2002-04-15
EA007179B1 (ru)	2006-08-25
ES2247166T3 (es)	2006-03-01
NO20031482D0 (no)	2003-04-01
EP1326853A1 (en)	2003-07-16
EP1326853B1 (en)	2005-09-07
SK3812003A3 (en)	2004-05-04
JP2004510769A (ja)	2004-04-08
AP1541A (en)	2006-01-11
IS6759A (is)	2003-03-27
DZ3440A1 (fr)	2002-04-11
DE60113283D1 (de)	2005-10-13
WO2002028847A1 (en)	2002-04-11
ECSP034534A (es)	2003-07-25
KR20030068542A (ko)	2003-08-21
PE20020419A1 (es)	2002-07-18
PL366332A1 (en)	2005-01-24

Publication	Publication Date	Title
EE200300134A (et)	2003-08-15	Uued tiadiasoolid ja oksadiasoolid ning nende kasutamine fosfodiesteraas-7 inhibiitoritena
EE200100373A (et)	2002-10-15	Bensoheterotsüklid ja nende kasutamine MEK inhibiitoritena
ID30590A (id)	2002-01-03	Celana sekali pakai jenis-celana pendek
CY2014017I2 (el)	2015-12-09	Νεες σουλφαμιδες και η χρηση τους σαν ανταγωνιστικων ληπτων ενδοθηλινης
DE60003148D1 (de)	2003-07-10	Bestimmung der Cachezeit
EE200200715A (et)	2004-08-16	Asendatud kinasoliini derivaadid ja nende kasutamine inhibiitoritena
EE200300459A (et)	2004-02-16	Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena
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