EE200100371A - Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena - Google Patents

Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena

Info

Publication number
EE200100371A
EE200100371A EEP200100371A EEP200100371A EE200100371A EE 200100371 A EE200100371 A EE 200100371A EE P200100371 A EEP200100371 A EE P200100371A EE P200100371 A EEP200100371 A EE P200100371A EE 200100371 A EE200100371 A EE 200100371A
Authority
EE
Estonia
Prior art keywords
thrombin inhibitors
amidinobenzylamine
derivatives
amidinobenzylamine derivatives
thrombin
Prior art date
Application number
EEP200100371A
Other languages
English (en)
Inventor
Inghardt Tord
Nystr�m Jan-Erik
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9900071A external-priority patent/SE9900071D0/xx
Priority claimed from SE9904228A external-priority patent/SE9904228D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200100371A publication Critical patent/EE200100371A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
EEP200100371A 1999-01-13 2000-01-13 Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena EE200100371A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9900071A SE9900071D0 (sv) 1999-01-13 1999-01-13 New compounds
SE9904228A SE9904228D0 (sv) 1999-11-22 1999-11-22 New compounds
PCT/SE2000/000052 WO2000042059A1 (en) 1999-01-13 2000-01-13 New amidinobenzylamine derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
EE200100371A true EE200100371A (et) 2002-02-15

Family

ID=26663479

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100371A EE200100371A (et) 1999-01-13 2000-01-13 Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena

Country Status (22)

Country Link
US (1) US6599894B1 (et)
EP (1) EP1150996B1 (et)
JP (1) JP2002535250A (et)
KR (1) KR100639274B1 (et)
CN (1) CN1170842C (et)
AU (1) AU764121B2 (et)
BR (1) BR0007453A (et)
CA (1) CA2355792A1 (et)
CY (1) CY1107149T1 (et)
CZ (1) CZ20012529A3 (et)
DE (1) DE60037183T2 (et)
DK (1) DK1150996T3 (et)
EE (1) EE200100371A (et)
ES (1) ES2295004T3 (et)
IL (1) IL143987A (et)
IS (1) IS5990A (et)
NO (1) NO20013319L (et)
NZ (1) NZ512714A (et)
PL (1) PL349769A1 (et)
PT (1) PT1150996E (et)
TR (1) TR200102037T2 (et)
WO (1) WO2000042059A1 (et)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
IL154077A0 (en) * 2000-08-16 2003-07-31 Astrazeneca Ab New amidino derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
SE0102921D0 (sv) * 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
US7105559B2 (en) 2001-10-03 2006-09-12 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (et) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
DE69314478T2 (de) 1992-03-04 1999-02-11 Gyogyszerkutato Intezet Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
TW223629B (et) 1992-03-06 1994-05-11 Hoffmann La Roche
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
BR9607582A (pt) 1995-02-17 1998-07-07 Basf Ag Composto e peptídeo ou substância peptidomimética
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
JPH11503161A (ja) 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
WO1997033576A1 (en) 1996-03-12 1997-09-18 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
CA2258915A1 (en) 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
PL349769A1 (en) 2002-09-09
IL143987A0 (en) 2002-04-21
EP1150996B1 (en) 2007-11-21
NZ512714A (en) 2003-10-31
IS5990A (is) 2001-07-05
CA2355792A1 (en) 2000-07-20
CZ20012529A3 (cs) 2001-11-14
TR200102037T2 (tr) 2001-10-22
IL143987A (en) 2005-12-18
CN1170842C (zh) 2004-10-13
KR100639274B1 (ko) 2006-10-27
PT1150996E (pt) 2008-01-15
DK1150996T3 (da) 2008-02-11
AU2336200A (en) 2000-08-01
CN1343217A (zh) 2002-04-03
NO20013319D0 (no) 2001-07-04
ES2295004T3 (es) 2008-04-16
JP2002535250A (ja) 2002-10-22
DE60037183T2 (de) 2008-10-09
US6599894B1 (en) 2003-07-29
WO2000042059A1 (en) 2000-07-20
BR0007453A (pt) 2001-10-30
NO20013319L (no) 2001-09-12
KR20010101493A (ko) 2001-11-14
DE60037183D1 (de) 2008-01-03
AU764121B2 (en) 2003-08-07
EP1150996A1 (en) 2001-11-07
CY1107149T1 (el) 2012-10-24

Similar Documents

Publication Publication Date Title
EE200200715A (et) Asendatud kinasoliini derivaadid ja nende kasutamine inhibiitoritena
EE200200251A (et) Uued N-asabitsükloamiidi derivaadid ja nende kasutamine
EE200100373A (et) Bensoheterotsüklid ja nende kasutamine MEK inhibiitoritena
EE9900006A (et) Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
EE9900600A (et) Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
EE200300459A (et) Uued spirotritsüklilised derivaadid ja nende kasutamine fosfodiesteraas-7 inhibiitoritena
EE200300145A (et) Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon
DK1133477T3 (da) Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
CY2012026I1 (el) Παραγωγα κουιναζολινης ως αναστολεις vegf
EE200200341A (et) Asendatud oksasolidinoonid ja nende kasutamine
AR028575A1 (es) Derivados de pirrolopiridinona utiles como inhibidores de fosfodiesterasa
EE9800425A (et) Uued aminohappe derivaadid ja nende kasutamine trombiini inhibiitoritena
EE200100371A (et) Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena
AU2002230836A1 (en) Benzylamine derivatives and their use as thrombin inhibitors
PT1237856E (pt) Novos derivados fenilicos tri-substituidos e analogos
NO20014875L (no) Promedikamenter for trombin inhibitorer
NO20003814D0 (no) Trombininhibitorer
EE200100611A (et) NOS inhibiitorite uued farmatseutilised kombinatsioonid
AU5693101A (en) New thiochromane derivatives and their use as thrombin inhibitors
PT1189929E (pt) Inibidores do factor viia
DE60032898D1 (de) Arylthiazolidindion- und aryloxazolidinderivate
DE60117096D1 (de) Dihydroindol- und tetrahydrochinolinderivate
DK1200409T3 (da) Substituerede isoquinolinderivater og deres anvendelse som krampestillende midler
EE200000179A (et) 1-oxa, aza ja tianaftaleen-2-1 biseetrid fosfolambaani inhibiitoritena
SI1150996T1 (sl) Novi amidinobenzilaminski derivati in njihova uporaba kot trombinski inhibitorji