EE05125B1 - 6-(4-klorofenl)-2,2-dimetl-7-fenl-2,3-dihdro-1H-prrolisiin-5-l„„dikhappe valmistamismeetod - Google Patents

6-(4-klorofenl)-2,2-dimetl-7-fenl-2,3-dihdro-1H-prrolisiin-5-l„„dikhappe valmistamismeetod

Info

Publication number
EE05125B1
EE05125B1 EEP200200417A EEP200200417A EE05125B1 EE 05125 B1 EE05125 B1 EE 05125B1 EE P200200417 A EEP200200417 A EE P200200417A EE P200200417 A EEP200200417 A EE P200200417A EE 05125 B1 EE05125 B1 EE 05125B1
Authority
EE
Estonia
Prior art keywords
compound
preparation
formula
pyrrolizine
chlorophenyl
Prior art date
Application number
EEP200200417A
Other languages
English (en)
Estonian (et)
Inventor
Kammermeier Thomas
Laufer Stefan
Merckle Philipp
Striegel Hans-G�nter
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/001047A external-priority patent/MXPA00001047A/xx
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of EE200200417A publication Critical patent/EE200200417A/xx
Publication of EE05125B1 publication Critical patent/EE05125B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200200417A 2000-01-28 2001-01-26 6-(4-klorofenl)-2,2-dimetl-7-fenl-2,3-dihdro-1H-prrolisiin-5-l„„dikhappe valmistamismeetod EE05125B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXPA/A/2000/001047A MXPA00001047A (en) 2000-01-28 Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid
PCT/EP2001/000852 WO2001055149A1 (de) 2000-01-28 2001-01-26 Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure

Publications (2)

Publication Number Publication Date
EE200200417A EE200200417A (et) 2003-12-15
EE05125B1 true EE05125B1 (et) 2009-02-16

Family

ID=32589023

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200417A EE05125B1 (et) 2000-01-28 2001-01-26 6-(4-klorofenl)-2,2-dimetl-7-fenl-2,3-dihdro-1H-prrolisiin-5-l„„dikhappe valmistamismeetod

Country Status (31)

Country Link
US (1) US6417371B1 (xx)
EP (1) EP1252164B1 (xx)
JP (1) JP5143326B2 (xx)
KR (1) KR100749222B1 (xx)
CN (1) CN1160357C (xx)
AT (1) ATE262529T1 (xx)
AU (1) AU779616B2 (xx)
BG (1) BG65567B1 (xx)
BR (1) BR0107898A (xx)
CA (1) CA2397767C (xx)
CU (1) CU23193A3 (xx)
DE (1) DE50101761D1 (xx)
DK (1) DK1252164T3 (xx)
EA (1) EA004938B1 (xx)
EE (1) EE05125B1 (xx)
ES (1) ES2218382T3 (xx)
GE (1) GEP20043408B (xx)
HK (1) HK1047590A1 (xx)
HR (1) HRP20020707B1 (xx)
HU (1) HUP0300604A3 (xx)
IS (1) IS2404B (xx)
NZ (1) NZ520429A (xx)
PL (1) PL208027B1 (xx)
PT (1) PT1252164E (xx)
RS (1) RS50374B (xx)
SK (1) SK286608B6 (xx)
TR (1) TR200400691T4 (xx)
TW (1) TWI289561B (xx)
UA (1) UA72580C2 (xx)
WO (1) WO2001055149A1 (xx)
ZA (1) ZA200206832B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141285A1 (de) * 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
DE102005012971A1 (de) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
WO2007108006A1 (en) * 2006-03-23 2007-09-27 Unichem Laboratories Limited Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates
EP2350082B1 (en) * 2008-10-31 2015-01-14 c-a-i-r biosciences GmbH Choline and tromethamine salt of licofelone
EP3324959B1 (en) * 2015-07-17 2023-07-12 The Board Of Regents Of The University Of Oklahoma Licofelone derivatives and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4419247A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419246A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie

Also Published As

Publication number Publication date
JP5143326B2 (ja) 2013-02-13
EP1252164B1 (de) 2004-03-24
CA2397767C (en) 2008-05-06
GEP20043408B (en) 2004-06-10
HK1047590A1 (en) 2003-02-28
KR100749222B1 (ko) 2007-08-13
PL208027B1 (pl) 2011-03-31
ATE262529T1 (de) 2004-04-15
TR200400691T4 (tr) 2004-11-22
KR20020075895A (ko) 2002-10-07
US20020028953A1 (en) 2002-03-07
EP1252164A1 (de) 2002-10-30
BG106951A (en) 2003-07-31
EA200200740A1 (ru) 2002-12-26
PL356774A1 (en) 2004-07-12
PT1252164E (pt) 2004-08-31
CN1160357C (zh) 2004-08-04
TWI289561B (en) 2007-11-11
AU3371101A (en) 2001-08-07
HRP20020707B1 (en) 2006-05-31
DK1252164T3 (da) 2004-07-05
RS50374B (sr) 2009-11-10
UA72580C2 (en) 2005-03-15
SK286608B6 (sk) 2009-02-05
SK10432002A3 (sk) 2003-02-04
DE50101761D1 (de) 2004-04-29
JP2004517799A (ja) 2004-06-17
HUP0300604A2 (hu) 2003-07-28
IS6475A (is) 2002-07-19
CN1396922A (zh) 2003-02-12
CU23193A3 (es) 2007-03-23
BR0107898A (pt) 2002-11-05
EE200200417A (et) 2003-12-15
IS2404B (is) 2008-09-15
HUP0300604A3 (en) 2003-10-28
US6417371B1 (en) 2002-07-09
WO2001055149A1 (de) 2001-08-02
HRP20020707A2 (en) 2004-12-31
YU56502A (sh) 2005-06-10
EA004938B1 (ru) 2004-10-28
BG65567B1 (bg) 2008-12-30
AU779616B2 (en) 2005-02-03
ZA200206832B (en) 2003-10-07
ES2218382T3 (es) 2004-11-16
CA2397767A1 (en) 2001-08-02
NZ520429A (en) 2003-08-29

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20130126