EE05035B1 - 1-[fenüül-(8-kinolinüül)metüül]piperasiini derivaadid ning nende kasutamine meditsiinis - Google Patents
1-[fenüül-(8-kinolinüül)metüül]piperasiini derivaadid ning nende kasutamine meditsiinisInfo
- Publication number
- EE05035B1 EE05035B1 EEP200200334A EEP200200334A EE05035B1 EE 05035 B1 EE05035 B1 EE 05035B1 EE P200200334 A EEP200200334 A EE P200200334A EE P200200334 A EEP200200334 A EE P200200334A EE 05035 B1 EE05035 B1 EE 05035B1
- Authority
- EE
- Estonia
- Prior art keywords
- phenyl
- quinolinyl
- medicine
- methyl
- piperazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904673A SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Novel compounds |
| PCT/SE2000/002559 WO2001045637A2 (en) | 1999-12-20 | 2000-12-15 | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200200334A EE200200334A (et) | 2003-10-15 |
| EE05035B1 true EE05035B1 (et) | 2008-06-16 |
Family
ID=20418209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200334A EE05035B1 (et) | 1999-12-20 | 2000-12-15 | 1-[fenüül-(8-kinolinüül)metüül]piperasiini derivaadid ning nende kasutamine meditsiinis |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6784181B2 (et) |
| EP (1) | EP1242402B1 (et) |
| JP (1) | JP2003518022A (et) |
| KR (1) | KR100807515B1 (et) |
| CN (1) | CN1225465C (et) |
| AT (1) | ATE254120T1 (et) |
| AU (1) | AU780714B2 (et) |
| BG (1) | BG65456B1 (et) |
| BR (1) | BR0016578A (et) |
| CA (1) | CA2393568C (et) |
| CO (1) | CO5271646A1 (et) |
| CZ (1) | CZ20022122A3 (et) |
| DE (1) | DE60006583T2 (et) |
| DK (1) | DK1242402T3 (et) |
| EE (1) | EE05035B1 (et) |
| ES (1) | ES2210028T3 (et) |
| HK (1) | HK1048113B (et) |
| HU (1) | HUP0300298A2 (et) |
| IL (2) | IL150126A0 (et) |
| IS (1) | IS2194B (et) |
| MX (1) | MXPA02006062A (et) |
| MY (1) | MY125394A (et) |
| NO (1) | NO323402B1 (et) |
| NZ (1) | NZ519985A (et) |
| PL (1) | PL356797A1 (et) |
| PT (1) | PT1242402E (et) |
| RU (1) | RU2260006C2 (et) |
| SE (1) | SE9904673D0 (et) |
| SK (1) | SK285753B6 (et) |
| TR (1) | TR200400237T4 (et) |
| TW (1) | TWI238822B (et) |
| UA (1) | UA72945C2 (et) |
| WO (1) | WO2001045637A2 (et) |
| ZA (1) | ZA200204256B (et) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987736B2 (en) * | 2000-07-10 | 2015-03-24 | Amit Goyal | [100] or [110] aligned, semiconductor-based, large-area, flexible, electronic devices |
| SE0100764D0 (sv) | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
| WO2002094794A1 (en) * | 2001-05-18 | 2002-11-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| EP1450807B1 (en) * | 2001-10-29 | 2013-12-25 | Versi Group, LLC | Method of treating depression with delta receptor agonist compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| KR101234421B1 (ko) | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| EP2024364A1 (en) * | 2006-05-26 | 2009-02-18 | Neuromed Pharmaceuticals, Ltd. | Heterocyclic compounds as calcium channel blockers |
| MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
| BRPI0912756A2 (pt) * | 2008-05-20 | 2015-10-13 | Astrazeneca Ab | método para tratar transtorno depressivo maior ansioso em um animal de sangue quente, uso de um composto, composto, e, composição farmacêutica |
| JP7287628B2 (ja) * | 2017-12-12 | 2023-06-06 | 学校法人東京理科大学 | 活性エネルギー線硬化型組成物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585209A5 (et) | 1973-06-29 | 1977-02-28 | Cermol Sa | |
| DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
| SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| ATE102831T1 (de) | 1989-11-22 | 1994-04-15 | Janssen Pharmaceutica Nv | Verfahren zur verhuetung oder zur begrenzung einer reperfusionsschaedigung. |
| US5807858A (en) | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
| CA2168432C (en) | 1993-07-30 | 2004-03-23 | Kwen-Jen Chang | Piperazine compounds used in therapy |
| JP3352184B2 (ja) | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
-
1999
- 1999-12-20 SE SE9904673A patent/SE9904673D0/xx unknown
-
2000
- 2000-12-14 TW TW089126669A patent/TWI238822B/zh not_active IP Right Cessation
- 2000-12-15 TR TR2004/00237T patent/TR200400237T4/xx unknown
- 2000-12-15 DE DE60006583T patent/DE60006583T2/de not_active Expired - Fee Related
- 2000-12-15 AT AT00989096T patent/ATE254120T1/de not_active IP Right Cessation
- 2000-12-15 BR BR0016578-6A patent/BR0016578A/pt not_active Application Discontinuation
- 2000-12-15 CN CNB008189765A patent/CN1225465C/zh not_active Expired - Fee Related
- 2000-12-15 UA UA2002064508A patent/UA72945C2/uk unknown
- 2000-12-15 EE EEP200200334A patent/EE05035B1/et not_active IP Right Cessation
- 2000-12-15 US US10/149,911 patent/US6784181B2/en not_active Expired - Fee Related
- 2000-12-15 KR KR1020027007835A patent/KR100807515B1/ko not_active IP Right Cessation
- 2000-12-15 RU RU2002114345/04A patent/RU2260006C2/ru not_active IP Right Cessation
- 2000-12-15 PL PL00356797A patent/PL356797A1/xx not_active IP Right Cessation
- 2000-12-15 CA CA002393568A patent/CA2393568C/en not_active Expired - Fee Related
- 2000-12-15 DK DK00989096T patent/DK1242402T3/da active
- 2000-12-15 CZ CZ20022122A patent/CZ20022122A3/cs unknown
- 2000-12-15 HU HU0300298A patent/HUP0300298A2/hu unknown
- 2000-12-15 IL IL15012600A patent/IL150126A0/xx active IP Right Grant
- 2000-12-15 NZ NZ519985A patent/NZ519985A/en unknown
- 2000-12-15 EP EP00989096A patent/EP1242402B1/en not_active Expired - Lifetime
- 2000-12-15 PT PT00989096T patent/PT1242402E/pt unknown
- 2000-12-15 JP JP2001546378A patent/JP2003518022A/ja active Pending
- 2000-12-15 AU AU25643/01A patent/AU780714B2/en not_active Ceased
- 2000-12-15 MX MXPA02006062A patent/MXPA02006062A/es active IP Right Grant
- 2000-12-15 SK SK885-2002A patent/SK285753B6/sk not_active IP Right Cessation
- 2000-12-15 WO PCT/SE2000/002559 patent/WO2001045637A2/en active IP Right Grant
- 2000-12-15 ES ES00989096T patent/ES2210028T3/es not_active Expired - Lifetime
- 2000-12-18 MY MYPI20005939A patent/MY125394A/en unknown
- 2000-12-19 CO CO00096314A patent/CO5271646A1/es not_active Application Discontinuation
-
2002
- 2002-05-28 ZA ZA200204256A patent/ZA200204256B/en unknown
- 2002-06-10 BG BG106806A patent/BG65456B1/bg unknown
- 2002-06-10 IL IL150126A patent/IL150126A/en not_active IP Right Cessation
- 2002-06-14 IS IS6423A patent/IS2194B/is unknown
- 2002-06-18 NO NO20022918A patent/NO323402B1/no not_active IP Right Cessation
-
2003
- 2003-01-07 HK HK03100181.6A patent/HK1048113B/zh not_active IP Right Cessation
Also Published As
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| SE0001207D0 (sv) | Novel compounds | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20091215 |