EE03783B1 - A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule - Google Patents

A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule

Info

Publication number: EE03783B1
Authority: EE; Estonia
Prior art keywords: antibody; epitheliomas; treatment; pharmaceutical composition; antibody molecule
Prior art date: 1995-12-06

Application number

EE9800164A

Other languages

Estonian (et)

Other versions

EE9800164A (en

Inventor

Heider Karl-Heinz

Adolf G�nther

Ostermann Elinborg

Patzelt Erik

Sproll Marlies

Original Assignee

Boehringer Ingelheim International Gmbh

Forschungszentrum Karlsruhe Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-06

Filing date

1996-12-05

Publication date

2002-06-17

1995-12-06 Priority claimed from DE19545472A external-priority patent/DE19545472A1/en

1996-12-05 Application filed by Boehringer Ingelheim International Gmbh, Forschungszentrum Karlsruhe Gmbh filed Critical Boehringer Ingelheim International Gmbh

1998-12-15 Publication of EE9800164A publication Critical patent/EE9800164A/en

2002-06-17 Publication of EE03783B1 publication Critical patent/EE03783B1/en

Links

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70585—CD44
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Optics & Photonics (AREA)
Zoology (AREA)
Toxicology (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EE9800164A 1995-12-06 1996-12-05 A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule EE03783B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19545472A DE19545472A1 (en)	1995-12-06	1995-12-06	Diagnosis of squamous epithelial cell carcinoma
DE19615074		1996-04-17
PCT/EP1996/005448 WO1997021104A1 (en)	1995-12-06	1996-12-05	Method of diagnosing and treating epithelioma

Publications (2)

Publication Number	Publication Date
EE9800164A EE9800164A (en)	1998-12-15
EE03783B1 true EE03783B1 (en)	2002-06-17

Family

ID=26020988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800164A EE03783B1 (en)	1995-12-06	1996-12-05	A pharmaceutical composition for the treatment of epitheliomas and the use of an antibody or antibody molecule

Country Status (26)

Country	Link
EP (1)	EP0865609B1 (en)
JP (1)	JP2000502067A (en)
KR (1)	KR100473824B1 (en)
CN (1)	CN1151377C (en)
AR (1)	AR004360A1 (en)
AT (1)	ATE235056T1 (en)
AU (1)	AU726704B2 (en)
BG (1)	BG62985B1 (en)
BR (1)	BR9611901A (en)
CA (1)	CA2239709A1 (en)
CO (1)	CO4520233A1 (en)
CZ (1)	CZ174198A3 (en)
DE (1)	DE59610248D1 (en)
DK (1)	DK0865609T3 (en)
EE (1)	EE03783B1 (en)
ES (1)	ES2190484T3 (en)
HK (1)	HK1011560A1 (en)
MX (1)	MX9804459A (en)
NO (1)	NO319903B1 (en)
NZ (1)	NZ324314A (en)
PL (1)	PL184521B1 (en)
PT (1)	PT865609E (en)
SK (1)	SK284378B6 (en)
TR (1)	TR199801027T2 (en)
UY (1)	UY24389A1 (en)
WO (1)	WO1997021104A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7189397B2 (en) *	1999-10-08	2007-03-13	Arius Research Inc.	Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) *	1999-10-08	2005-05-12	Young David S.	Cytotoxicity mediation of cells evidencing surface expression of CD44
US6972324B2 (en)	2001-05-18	2005-12-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Antibodies specific for CD44v6
EP1258255A1 (en) *	2001-05-18	2002-11-20	Boehringer Ingelheim International GmbH	Conjugates of an antibody to CD44 and a maytansinoid
US20030103985A1 (en)	2001-05-18	2003-06-05	Boehringer Ingelheim International Gmbh	Cytotoxic CD44 antibody immunoconjugates
WO2002094879A1 (en) *	2001-05-18	2002-11-28	Boehringer Ingelheim International Gmbh	Antibodies specific for cd44v6
EP1391213A1 (en) *	2002-08-21	2004-02-25	Boehringer Ingelheim International GmbH	Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) *	2002-11-08	2004-05-12	Boehringer Ingelheim International GmbH	Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
PL2531527T3 (en) *	2010-02-04	2014-08-29	Univ Miami	A monoclonal antibody to cd44 for use in the treatment of head and neck squamous cell carcinoma
US9218450B2 (en) *	2012-11-29	2015-12-22	Roche Molecular Systems, Inc.	Accurate and fast mapping of reads to genome
WO2019161528A1 (en) *	2018-02-22	2019-08-29	Abmart Shanghai Co., Ltd.	Therapeutic antibody and uses thereof
WO2023227644A2 (en)	2022-05-25	2023-11-30	Akiram Therapeutics Ab	Binding protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69406664T2 (en) *	1993-06-18	1998-06-04	Biotie Therapies Oy	COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6
EP0767378A1 (en) *	1993-06-22	1997-04-09	BOEHRINGER INGELHEIM INTERNATIONAL GmbH	Method for the diagnosis and analysis of stomach carcinoma
DE4326573A1 (en) *	1993-08-07	1995-02-23	Boehringer Ingelheim Int	Polypeptides encoded by exon v5 of the CD44 gene as targets for immunotherapy and immunoscintigraphy of tumors
UA58482C2 (en) *	1994-06-08	2003-08-15	Бьорінгер Інгельхайм Інтернаціональ Гмбх	MONOCLONAL ANTIBODY VFF-18 AGAINST CD44v6 AND ITS FRAGMENTS

1996
- 1996-12-03 UY UY24389A patent/UY24389A1/en not_active IP Right Cessation
- 1996-12-04 AR ARP960105480A patent/AR004360A1/en unknown
- 1996-12-05 AT AT96942362T patent/ATE235056T1/en not_active IP Right Cessation
- 1996-12-05 JP JP9520993A patent/JP2000502067A/en not_active Ceased
- 1996-12-05 EE EE9800164A patent/EE03783B1/en not_active IP Right Cessation
- 1996-12-05 BR BR9611901A patent/BR9611901A/en not_active Application Discontinuation
- 1996-12-05 WO PCT/EP1996/005448 patent/WO1997021104A1/en not_active Application Discontinuation
- 1996-12-05 EP EP96942362A patent/EP0865609B1/en not_active Expired - Lifetime
- 1996-12-05 NZ NZ324314A patent/NZ324314A/en unknown
- 1996-12-05 SK SK736-98A patent/SK284378B6/en unknown
- 1996-12-05 DK DK96942362T patent/DK0865609T3/en active
- 1996-12-05 PT PT96942362T patent/PT865609E/en unknown
- 1996-12-05 KR KR10-1998-0704242A patent/KR100473824B1/en not_active IP Right Cessation
- 1996-12-05 CZ CZ981741A patent/CZ174198A3/en unknown
- 1996-12-05 ES ES96942362T patent/ES2190484T3/en not_active Expired - Lifetime
- 1996-12-05 PL PL96327066A patent/PL184521B1/en not_active IP Right Cessation
- 1996-12-05 CA CA002239709A patent/CA2239709A1/en not_active Abandoned
- 1996-12-05 TR TR1998/01027T patent/TR199801027T2/en unknown
- 1996-12-05 AU AU11773/97A patent/AU726704B2/en not_active Ceased
- 1996-12-05 CO CO96063967A patent/CO4520233A1/en unknown
- 1996-12-05 CN CNB961992484A patent/CN1151377C/en not_active Expired - Fee Related
- 1996-12-05 DE DE59610248T patent/DE59610248D1/en not_active Expired - Fee Related
1998
- 1998-06-04 MX MX9804459A patent/MX9804459A/en not_active IP Right Cessation
- 1998-06-05 NO NO19982588A patent/NO319903B1/en unknown
- 1998-06-05 BG BG102513A patent/BG62985B1/en unknown
- 1998-12-07 HK HK98112910A patent/HK1011560A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0865609B1 (en)	2003-03-19
NO319903B1 (en)	2005-09-26
AU726704B2 (en)	2000-11-16
PT865609E (en)	2003-08-29
BR9611901A (en)	1999-03-02
AU1177397A (en)	1997-06-27
TR199801027T2 (en)	1998-10-21
UY24389A1 (en)	2001-10-25
CN1151377C (en)	2004-05-26
EP0865609A1 (en)	1998-09-23
CZ174198A3 (en)	1999-02-17
CO4520233A1 (en)	1997-10-15
MX9804459A (en)	1998-09-30
BG102513A (en)	1999-02-26
KR19990071952A (en)	1999-09-27
SK73698A3 (en)	1999-01-11
WO1997021104A1 (en)	1997-06-12
EE9800164A (en)	1998-12-15
BG62985B1 (en)	2000-12-29
NZ324314A (en)	2000-02-28
NO982588D0 (en)	1998-06-05
PL327066A1 (en)	1998-11-23
CN1207811A (en)	1999-02-10
SK284378B6 (en)	2005-02-04
KR100473824B1 (en)	2005-09-30
DK0865609T3 (en)	2003-06-23
JP2000502067A (en)	2000-02-22
HK1011560A1 (en)	1999-07-16
AR004360A1 (en)	1998-11-04
ES2190484T3 (en)	2003-08-01
DE59610248D1 (en)	2003-04-24
CA2239709A1 (en)	1997-06-12
PL184521B1 (en)	2002-11-29
ATE235056T1 (en)	2003-04-15
NO982588L (en)	1998-08-05

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2006-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20051205

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