DE69406664T2 - COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6 - Google Patents

COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6

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Publication number
DE69406664T2
DE69406664T2 DE69406664T DE69406664T DE69406664T2 DE 69406664 T2 DE69406664 T2 DE 69406664T2 DE 69406664 T DE69406664 T DE 69406664T DE 69406664 T DE69406664 T DE 69406664T DE 69406664 T2 DE69406664 T2 DE 69406664T2
Authority
DE
Germany
Prior art keywords
cell
epitope
cd44v6
cells
hermes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69406664T
Other languages
German (de)
Other versions
DE69406664D1 (en
Inventor
Sirpa Jalkanen
Marko Salmi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotie Therapies Corp
Original Assignee
Biotie Therapies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22141703&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69406664(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotie Therapies Corp filed Critical Biotie Therapies Corp
Application granted granted Critical
Publication of DE69406664D1 publication Critical patent/DE69406664D1/en
Publication of DE69406664T2 publication Critical patent/DE69406664T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

CD44 is a family of glycoproteins involved in cell-cell and cell-matrix interactions. In addition to the major 90 kD form present on most hematopoietic cells, larger forms are found on keratinocytes and carcinoma cell lines. These bigger isoforms of CD44 arise by alternative splicing that results in insertion of one or more of the "variant" exons into the extracellular part of the 90 kD constant form of the molecule. Antibodies were raised against a synthetic peptide containing a sequence encoded by the human exon 6A mAb thus obtained (designated Var3.1) strongly reacted with the plasma membranes of squamous cells in upper layers of skin and tonsil surface epithelia. Weaker staining was seen in germinal centers, vascular endothelia and enterocytes. CD44v6 was absent from tissue leukocytes and connective tissue components. In comparison, Hermes-3 epitope (on the constant part) containing forms of CD44 were preferentially localized in basal layers of epithelia, present on the surface of most leukocytes and connective tissue cells, and undetectable on the luminal surface of high endothelial venules. In benign neoplasms, epithelial cells stained with mAb Var3.1 like in normal tissues. In contrast, immunostaining of 30 squamous carcinoma specimens (both primary and metastatic lesions) revealed that malignant transformation resulted in down-regulation or disappearance of Var3.1 epitope, but in majority of cases, not in diminished expression of the Hermes-3 epitope. An examination of serum samples from normal individuals and from patients with inflammatory diseases indicated that CD44v6 was increased in samples from patients with rheumatoid arthritis or inflammatory bowel disease.
DE69406664T 1993-06-18 1994-06-16 COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6 Expired - Fee Related DE69406664T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7806393A 1993-06-18 1993-06-18
PCT/FI1994/000264 WO1995000658A1 (en) 1993-06-18 1994-06-16 COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6

Publications (2)

Publication Number Publication Date
DE69406664D1 DE69406664D1 (en) 1997-12-11
DE69406664T2 true DE69406664T2 (en) 1998-06-04

Family

ID=22141703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69406664T Expired - Fee Related DE69406664T2 (en) 1993-06-18 1994-06-16 COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6

Country Status (13)

Country Link
US (1) US5616468A (en)
EP (1) EP0703989B1 (en)
JP (1) JPH08511419A (en)
AT (1) ATE159953T1 (en)
AU (1) AU678487B2 (en)
CA (1) CA2165461A1 (en)
DE (1) DE69406664T2 (en)
DK (1) DK0703989T3 (en)
ES (1) ES2110764T3 (en)
GR (1) GR3025759T3 (en)
IL (1) IL110070A0 (en)
WO (1) WO1995000658A1 (en)
ZA (1) ZA944383B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134982A1 (en) * 1991-10-23 1993-04-29 Kernforschungsz Karlsruhe USE OF ANTIBODY-CONTAINING PREPARATIONS FOR IMMUNE SUPPRESSION
EP0656906B1 (en) * 1992-06-09 1999-09-08 Oy Biotie Therapies A novel endothelial cell molecule mediating lymphocyte binding in man
UA58482C2 (en) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх MONOCLONAL ANTIBODY VFF-18 AGAINST CD44v6 AND ITS FRAGMENTS
DE19540515C1 (en) * 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumor therapy through adoptive transfer of CD44v-specific cytotoxic T lymphocytes
DE19545472A1 (en) * 1995-12-06 1997-06-12 Boehringer Ingelheim Int Diagnosis of squamous epithelial cell carcinoma
UY24389A1 (en) * 1995-12-06 2001-10-25 Karlsruhe Forschzent PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF FLAT EPITHELIUM CARCINOMA
DE19653607A1 (en) 1996-12-20 1998-06-25 Boehringer Ingelheim Int Procedure for diagnosis and therapy of Hodgkin lymphoma
US7947496B2 (en) 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) * 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US6972324B2 (en) * 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
CN102504025B (en) * 2004-03-10 2015-10-21 克赖顿大学 Estrogen receptor and using method
WO2005095987A2 (en) * 2004-03-26 2005-10-13 University Of Miami Salivary soluble cd44: a molecular marker for head and neck cancer
EP2041299A4 (en) * 2006-07-14 2010-01-13 Aviva Biosciences Corp Methods and compositions for detecting rare cells from a biological sample
US20080057505A1 (en) * 2006-07-14 2008-03-06 Ping Lin Methods and compositions for detecting rare cells from a biological sample
WO2010058396A1 (en) 2008-11-19 2010-05-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A cd44vra antibody and diagnostic and therapeutic methods using same
MX2013010910A (en) * 2011-03-24 2014-03-27 Neurim Pharma 1991 Neuroprotective peptides.
RU2017104284A (en) 2014-07-15 2018-08-15 Йиссум Рисеч Девелопмент Компани Оф Зе Хебрю Юниверсити Оф Джерусалем Лтд. ISOLATED POLYPEPTIDES CD44 AND THEIR APPLICATION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4014510A1 (en) 1990-05-07 1991-11-14 Kernforschungsz Karlsruhe VARIANT CD44 SURFACE PROTEINS, THESE ENCODING C-DNA SEQUENCES, ANTIBODIES AGAINST THESE PROTEINS AND THEIR USE IN DIAGNOSTICS AND THERAPY
DE4134982A1 (en) 1991-10-23 1993-04-29 Kernforschungsz Karlsruhe USE OF ANTIBODY-CONTAINING PREPARATIONS FOR IMMUNE SUPPRESSION

Also Published As

Publication number Publication date
CA2165461A1 (en) 1995-01-05
US5616468A (en) 1997-04-01
WO1995000658A1 (en) 1995-01-05
DK0703989T3 (en) 1998-02-09
GR3025759T3 (en) 1998-03-31
IL110070A0 (en) 1994-10-07
ZA944383B (en) 1995-03-03
JPH08511419A (en) 1996-12-03
AU6972694A (en) 1995-01-17
ES2110764T3 (en) 1998-02-16
EP0703989B1 (en) 1997-11-05
EP0703989A1 (en) 1996-04-03
ATE159953T1 (en) 1997-11-15
DE69406664D1 (en) 1997-12-11
AU678487B2 (en) 1997-05-29

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee