EE02950B1 - Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon - Google Patents

Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon

Info

Publication number: EE02950B1
Authority: EE; Estonia
Prior art keywords: pct; groups; group; independently; formula
Prior art date: 1990-12-20

Application number

EE9400299A

Other languages

English (en)

Inventor

Hanhij�rvi Hannu

Nupponen Heikki

Veps�l�inen Juoko

Pohjala Esko

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-20

Filing date

1994-11-14

Publication date

1996-12-16

1994-11-14 Application filed by Leiras Oy filed Critical Leiras Oy

1996-12-16 Publication of EE02950B1 publication Critical patent/EE02950B1/et

Links

MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
-1 methylenebisphosphonic acid ester amide Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Paints Or Removers (AREA)
Detergent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Luminescent Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EE9400299A 1990-12-20 1994-11-14 Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon EE02950B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI906296A FI89365C (fi)	1990-12-20	1990-12-20	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (1)

Publication Number	Publication Date
EE02950B1 true EE02950B1 (et)	1996-12-16

Family

ID=8531621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400299A EE02950B1 (et)	1990-12-20	1994-11-14	Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon

Country Status (25)

Country	Link
US (1)	US5442101A (et)
EP (1)	EP0570380B1 (et)
JP (1)	JPH06504770A (et)
KR (1)	KR930703336A (et)
CN (1)	CN1028866C (et)
AT (1)	ATE171182T1 (et)
AU (1)	AU663268B2 (et)
CA (1)	CA2098734A1 (et)
CZ (1)	CZ119593A3 (et)
DE (1)	DE69130231T2 (et)
DK (1)	DK0570380T3 (et)
EE (1)	EE02950B1 (et)
ES (1)	ES2121003T3 (et)
FI (1)	FI89365C (et)
HU (1)	HUT64547A (et)
IE (1)	IE914390A1 (et)
IL (1)	IL100336A (et)
NO (1)	NO303121B1 (et)
NZ (1)	NZ241039A (et)
PL (1)	PL169728B1 (et)
RU (1)	RU2100364C1 (et)
SK (1)	SK63093A3 (et)
TW (1)	TW203053B (et)
WO (1)	WO1992011268A1 (et)
ZA (1)	ZA9110007B (et)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1469003A3 (en) *	1996-10-09	2004-11-24	Pharmasset, Ltd.	Tetraphosphonate bicyclic trisanhydrides
ATE271058T1 (de)	1996-10-09	2004-07-15	Pharmasset Ltd	Mycophenol bisphosponatverbindungen
US20040181078A1 (en) *	1997-10-10	2004-09-16	Pharmasset, Ltd.	Tetraphosphonate bicyclic trisanhydrides
FI104901B (fi) *	1997-10-20	2000-04-28	Leiras Oy	Uudet metyleenibisfosfonihappojohdannaiset
US5998390A (en) *	1998-09-28	1999-12-07	The Research Foundation Of State University Of New York	Combination of bisphosphonate and tetracycline
WO2005090370A1 (en)	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US20070003608A1 (en) *	2005-04-08	2007-01-04	Almond Merrick R	Compounds, compositions and methods for the treatment of viral infections and other medical disorders
EP1868628B1 (en)	2005-04-08	2014-06-11	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
WO2009094190A2 (en) *	2008-01-25	2009-07-30	Chimerix, Inc.	Methods of treating viral infections
US8614200B2 (en)	2009-07-21	2013-12-24	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en)	2009-08-03	2011-02-10	Chimerix, Inc.	Composition and methods of treating viral infections and viral induced tumors
HUE032860T2 (en)	2010-02-12	2017-11-28	Chimerix Inc	A method for treating a virus infection
CN102190684A (zh) *	2010-03-15	2011-09-21	南通波锐生物医药有限公司	一种具有药物应用的含磷化合物及其制备和用途
WO2011139709A2 (en)	2010-04-26	2011-11-10	Chimerix, Inc.	Methods of treating retroviral infections and related dosage regimes
CN102453050B (zh) *	2010-11-03	2015-01-07	成都云克药业有限责任公司	一种二膦酸化合物及其制备方法
WO2018005659A1 (en) *	2016-06-28	2018-01-04	Aequor, Inc.	Antimicrobial compounds and methods of use
RU2630226C1 (ru) *	2016-12-20	2017-09-06	Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет"	Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4293505A (en) *	1967-04-06	1981-10-06	Randall David I	Preparation of β-haloethylphosphonic acids and half esters thereof
US3524846A (en) *	1967-06-02	1970-08-18	Syntex Corp	Process for the didealkylation of phosphonate esters
US3808265A (en) *	1971-03-26	1974-04-30	Gaf Corp	Preparation of 2-haloethylphosphonic acid
IT1187828B (it) *	1985-05-24	1987-12-23	Gentili Ist Spa	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US5212164A (en) *	1988-08-29	1993-05-18	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors
US5273969A (en) *	1988-08-29	1993-12-28	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors and method
EP0356866A3 (en) *	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphorus-containing squalene synthetase inhibitors and method
FI89366C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

1990
- 1990-12-20 FI FI906296A patent/FI89365C/fi not_active IP Right Cessation
1991
- 1991-12-11 IL IL10033691A patent/IL100336A/en not_active IP Right Cessation
- 1991-12-17 IE IE439091A patent/IE914390A1/en not_active Application Discontinuation
- 1991-12-18 HU HU9301780A patent/HUT64547A/hu unknown
- 1991-12-18 CA CA002098734A patent/CA2098734A1/en not_active Abandoned
- 1991-12-18 CZ CS931195A patent/CZ119593A3/cs unknown
- 1991-12-18 RU RU9393050805A patent/RU2100364C1/ru active
- 1991-12-18 WO PCT/FI1991/000396 patent/WO1992011268A1/en not_active Application Discontinuation
- 1991-12-18 DE DE69130231T patent/DE69130231T2/de not_active Expired - Fee Related
- 1991-12-18 AU AU90800/91A patent/AU663268B2/en not_active Ceased
- 1991-12-18 US US08/078,155 patent/US5442101A/en not_active Expired - Fee Related
- 1991-12-18 AT AT92901217T patent/ATE171182T1/de not_active IP Right Cessation
- 1991-12-18 JP JP4502098A patent/JPH06504770A/ja active Pending
- 1991-12-18 SK SK630-93A patent/SK63093A3/sk unknown
- 1991-12-18 NZ NZ241039A patent/NZ241039A/en unknown
- 1991-12-18 DK DK92901217T patent/DK0570380T3/da active
- 1991-12-18 KR KR1019930701879A patent/KR930703336A/ko active IP Right Grant
- 1991-12-18 PL PL91299980A patent/PL169728B1/pl unknown
- 1991-12-18 EP EP92901217A patent/EP0570380B1/en not_active Expired - Lifetime
- 1991-12-18 ES ES92901217T patent/ES2121003T3/es not_active Expired - Lifetime
- 1991-12-19 ZA ZA9110007A patent/ZA9110007B/xx unknown
- 1991-12-20 CN CN91111881A patent/CN1028866C/zh not_active Expired - Fee Related
- 1991-12-31 TW TW081100320A patent/TW203053B/zh active
1993
- 1993-06-18 NO NO932256A patent/NO303121B1/no unknown
1994
- 1994-11-14 EE EE9400299A patent/EE02950B1/et unknown

Also Published As

Publication number	Publication date
FI89365C (fi)	1993-09-27
KR930703336A (ko)	1993-11-29
CA2098734A1 (en)	1992-06-21
TW203053B (et)	1993-04-01
CN1028866C (zh)	1995-06-14
ZA9110007B (en)	1992-09-30
IL100336A (en)	1998-07-15
NZ241039A (en)	1993-05-26
CZ119593A3 (en)	1994-02-16
DE69130231D1 (de)	1998-10-22
IL100336A0 (en)	1992-09-06
DK0570380T3 (da)	1999-02-08
JPH06504770A (ja)	1994-06-02
CN1062533A (zh)	1992-07-08
NO932256L (no)	1993-08-20
SK63093A3 (en)	1993-12-08
ES2121003T3 (es)	1998-11-16
ATE171182T1 (de)	1998-10-15
RU2100364C1 (ru)	1997-12-27
US5442101A (en)	1995-08-15
WO1992011268A1 (en)	1992-07-09
FI906296A (fi)	1992-06-21
NO932256D0 (no)	1993-06-18
EP0570380A1 (en)	1993-11-24
HUT64547A (en)	1994-01-28
AU663268B2 (en)	1995-09-28
PL169728B1 (pl)	1996-08-30
AU9080091A (en)	1992-07-22
FI89365B (fi)	1993-06-15
HU9301780D0 (en)	1993-09-28
EP0570380B1 (en)	1998-09-16
FI906296A0 (fi)	1990-12-20
IE914390A1 (en)	1992-07-01
DE69130231T2 (de)	1999-03-25
NO303121B1 (no)	1998-06-02

Publication	Publication Date	Title
EE02950B1 (et)	1996-12-16	Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon
DK0618920T3 (da)	1996-12-30	Hidtil ukendte phosphonravsyrederivater, fremgangsmåde til fremstilling heraf samt lægemidler indeholdende disse forbindelser
HUT46024A (en)	1988-09-28	Process for producing diphosphonic acid derivatives and pharmaceutical compositions containing them as active components
DK151627C (da)	1988-06-20	Analogifremgangsmaade til fremstilling af terapeutisk virksomme 4-(fenylalkenyl)-imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf.
DE3869173D1 (de)	1992-04-23	Amino 5,6,7,8-tetrahydronaphtho(2,3b)furanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE61340T1 (de)	1991-03-15	Aminosaeurederivate und deren verfahren zur herstellung.
ATE150301T1 (de)	1997-04-15	Aminoalkanesulfonsäurederivate und pharmazeutische zusammensetzungen davon zur prävention oder behandlung von herzerkrankungen
ATE128139T1 (de)	1995-10-15	Neue methylenbisphosphonsäurederivate.
DE69909782D1 (de)	2003-08-28	Verwendung von benzofuroxanderivaten zur behandlung von angina pectoris
DK0823909T3 (da)	2003-01-20	Hidtil ukendte heterocykliske forbindelser
NZ219758A (en)	1989-04-26	Heterocyclic ester derivatives of 1,4 dihydropyridin-3,5-dicarboxylic acids intermediates and pharmaceutical compositions
ES2057116T3 (es)	1994-10-16	Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico.
DK0451626T3 (da)	1998-04-20	Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
ES2027492A6 (es)	1992-06-01	Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables.
ES2150149T3 (es)	2000-11-16	Derivados de 17-beta-(2-oxo-tetrahidrofuran-4-il)-tio-androstano (tioderivados de 17-beta-(lactona del acido gamma-butirico)) para el tratamiento de la inflamacion, composiciones farmaceuticas y un procedimiento para la produccion de los mismos.
ES8403123A1 (es)	1984-03-01	"procedimiento para la preparacion de esteres del acido alcoxivincaminico".
ES2005778A6 (es)	1989-03-16	Procedimiento para la obtencion de derivados de diisobutilxantina.