ECSP20023535A - Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen

Info

Publication number
ECSP20023535A
ECSP20023535A ECSENADI202023535A ECDI202023535A ECSP20023535A EC SP20023535 A ECSP20023535 A EC SP20023535A EC SENADI202023535 A ECSENADI202023535 A EC SENADI202023535A EC DI202023535 A ECDI202023535 A EC DI202023535A EC SP20023535 A ECSP20023535 A EC SP20023535A
Authority
EC
Ecuador
Prior art keywords
contain
pharmaceutical compositions
preparation procedure
macrocyclic derivatives
new macrocyclic
Prior art date
Application number
ECSENADI202023535A
Other languages
English (en)
Inventor
Tiran Arnaud Le
Miklos Nyerges
Melinda Ligeti
Imre Fejes
Jerome-Benoit Starck
Jean-Claude Ortuno
I-Jen Chen
Didier Durand
Original Assignee
Vernalis R D Ltd
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis R D Ltd, Servier Lab filed Critical Vernalis R D Ltd
Publication of ECSP20023535A publication Critical patent/ECSP20023535A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuesto de fórmula (I): (VER FORMULA EN MEMORIA TECNICA) en la que A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y y G son tales como se han definido en la descripción, y su utilización en la fabricación de medicamentos.
ECSENADI202023535A 2017-10-25 2020-04-24 Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen ECSP20023535A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1760078A FR3072679B1 (fr) 2017-10-25 2017-10-25 Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2018/079113 WO2019081559A1 (fr) 2017-10-25 2018-10-24 Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ECSP20023535A true ECSP20023535A (es) 2020-05-29

Family

ID=61599283

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202023535A ECSP20023535A (es) 2017-10-25 2020-04-24 Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen

Country Status (26)

Country Link
US (1) US11833162B2 (es)
EP (1) EP3700911B1 (es)
JP (1) JP7253543B2 (es)
KR (1) KR102645096B1 (es)
CN (1) CN111511750B (es)
AR (1) AR113789A1 (es)
AU (1) AU2018355709B2 (es)
BR (1) BR112020007924A2 (es)
CA (1) CA3080116C (es)
CL (1) CL2020001073A1 (es)
CR (1) CR20200169A (es)
EA (1) EA202090978A1 (es)
EC (1) ECSP20023535A (es)
ES (1) ES2963996T3 (es)
FR (1) FR3072679B1 (es)
IL (1) IL274141A (es)
JO (1) JOP20200089A1 (es)
LT (1) LT3700911T (es)
MA (1) MA50450B1 (es)
MX (1) MX2020004345A (es)
NI (1) NI202000028A (es)
PE (1) PE20201498A1 (es)
PH (1) PH12020550448A1 (es)
SG (1) SG11202003550VA (es)
TW (1) TWI685498B (es)
WO (1) WO2019081559A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110256245A (zh) * 2019-06-06 2019-09-20 常州合全药业有限公司 一种4-氯-2-溴苯甲酸叔丁酯的合成方法
KR102589629B1 (ko) 2021-10-06 2023-10-13 한국생명공학연구원 파우시박터 아쿠아틸 유래 신규 화합물 및 이의 용도
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014022752A1 (en) * 2012-08-03 2014-02-06 Amgen Inc. Macrocycles as pim inhibitors
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
US10023613B2 (en) * 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Also Published As

Publication number Publication date
MA50450A (fr) 2020-09-02
AR113789A1 (es) 2020-06-10
EP3700911B1 (fr) 2023-09-06
NI202000028A (es) 2020-10-06
TWI685498B (zh) 2020-02-21
CA3080116C (fr) 2023-01-10
TW201922754A (zh) 2019-06-16
RU2020116154A3 (es) 2022-03-11
LT3700911T (lt) 2023-10-10
MX2020004345A (es) 2020-10-14
ES2963996T3 (es) 2024-04-03
KR102645096B1 (ko) 2024-03-06
JP7253543B2 (ja) 2023-04-06
FR3072679A1 (fr) 2019-04-26
JP2021500370A (ja) 2021-01-07
CN111511750A (zh) 2020-08-07
WO2019081559A1 (fr) 2019-05-02
AU2018355709A1 (en) 2020-05-07
BR112020007924A2 (pt) 2020-10-20
AU2018355709B2 (en) 2023-02-23
EA202090978A1 (ru) 2020-09-07
CL2020001073A1 (es) 2020-12-04
PE20201498A1 (es) 2020-12-29
CN111511750B (zh) 2023-06-13
RU2020116154A (ru) 2021-11-25
US11833162B2 (en) 2023-12-05
CR20200169A (es) 2020-06-14
EP3700911A1 (fr) 2020-09-02
CA3080116A1 (fr) 2019-05-02
KR20200077541A (ko) 2020-06-30
IL274141A (en) 2020-06-30
SG11202003550VA (en) 2020-05-28
FR3072679B1 (fr) 2020-10-30
US20200253993A1 (en) 2020-08-13
PH12020550448A1 (en) 2021-04-26
MA50450B1 (fr) 2023-10-31
JOP20200089A1 (ar) 2020-05-03

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