ECSP088923A - Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatorias - Google Patents
Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatoriasInfo
- Publication number
- ECSP088923A ECSP088923A EC2008008923A ECSP088923A ECSP088923A EC SP088923 A ECSP088923 A EC SP088923A EC 2008008923 A EC2008008923 A EC 2008008923A EC SP088923 A ECSP088923 A EC SP088923A EC SP088923 A ECSP088923 A EC SP088923A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- treatment
- triazolopirazine
- degenerative
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen compuestos novedosos de [1.2.4]triazolo[1,5-a]pirazina que tienen una fórmula representada por la siguiente (fórmula I). Los compuestos se pueden preparar como composiciones farmacéuticas y se puede utilizar para la prevención y tratamiento de una diversidad de condiciones en mamíferos que incluyen humanos, que incluyen, a modo de ejemplo no limitante, artritis, inflamación y otros
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80355206P | 2006-05-31 | 2006-05-31 | |
US93184407P | 2007-05-25 | 2007-05-25 | |
US93176407P | 2007-05-25 | 2007-05-25 | |
US93176307P | 2007-05-25 | 2007-05-25 | |
US93210007P | 2007-05-29 | 2007-05-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088923A true ECSP088923A (es) | 2009-01-30 |
Family
ID=38618932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008923A ECSP088923A (es) | 2006-05-31 | 2008-11-28 | Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatorias |
Country Status (20)
Country | Link |
---|---|
US (3) | US7501411B2 (es) |
JP (1) | JP2009538877A (es) |
KR (1) | KR20090026288A (es) |
AT (1) | ATE465164T1 (es) |
AU (1) | AU2007267121A1 (es) |
BR (1) | BRPI0712531A2 (es) |
CA (1) | CA2653506A1 (es) |
CR (1) | CR10458A (es) |
DE (1) | DE602007006010D1 (es) |
DK (1) | DK2029602T3 (es) |
EA (1) | EA200870592A1 (es) |
EC (1) | ECSP088923A (es) |
HR (1) | HRP20100378T1 (es) |
IL (1) | IL195033A0 (es) |
MX (1) | MX2008015057A (es) |
NI (1) | NI200800299A (es) |
NO (1) | NO20084703L (es) |
NZ (1) | NZ573015A (es) |
PT (1) | PT2029602E (es) |
WO (1) | WO2007138072A2 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG163576A1 (en) | 2004-04-02 | 2010-08-30 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
CA2653506A1 (en) * | 2006-05-31 | 2007-12-06 | Galapagos Nv. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
ATE495743T1 (de) | 2006-12-01 | 2011-02-15 | Galapagos Nv | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
US8133895B2 (en) * | 2007-05-10 | 2012-03-13 | Janssen Pharmaceutica N.V. | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
WO2008138842A1 (en) | 2007-05-10 | 2008-11-20 | Galapagos N.V. | Imidazopyrazines and triazolopyrazine for the treatment of joint degenerative and inflammatory diseases |
DE102008035209A1 (de) | 2008-07-29 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
DE102007060172A1 (de) | 2007-12-13 | 2009-06-25 | Bayer Healthcare Ag | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
AR071619A1 (es) * | 2008-05-07 | 2010-06-30 | Galapagos Nv | Compuestos de pirazina fusionados utiles para el tratamiento de enfermedades degenerativas e inflamatorias y composiciones farmaceuticas que los contienen. |
DE102008023801A1 (de) | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基***并吡啶,其組合物及使用其之治療方法 |
WO2010123792A1 (en) | 2009-04-20 | 2010-10-28 | Osi Pharmaceuticals, Inc. | Preparation of c-pyrazine-methylamines |
EP2427192A1 (en) * | 2009-05-07 | 2012-03-14 | OSI Pharmaceuticals, LLC | Use of osi-906 for treating adrenocortical carcinoma |
TW201120043A (en) * | 2009-11-05 | 2011-06-16 | Galapagos Nv | Fused pyrazine compounds as their salts, useful for the treatment of degenerative and inflammatory diseases |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
CA2867061A1 (en) | 2012-03-14 | 2013-09-19 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
RS56034B1 (sr) | 2013-06-11 | 2017-09-29 | Bayer Pharma AG | Derivati prolekova supstituisanih triazolopiridina |
WO2014202458A1 (en) * | 2013-06-19 | 2014-12-24 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
KR20160104065A (ko) | 2014-01-03 | 2016-09-02 | 바이엘 애니멀 헬스 게엠베하 | 농약으로서의 신규 피라졸릴헤테로아릴아미드 |
WO2015166370A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
EP3323809A4 (en) | 2015-06-22 | 2019-01-02 | Sumitomo Dainippon Pharma Co., Ltd. | Bicyclic heterocyclic amide derivative |
PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
US10898469B2 (en) | 2016-02-26 | 2021-01-26 | Sumitomo Dainippon Pharma Co., Ltd. | Imidazolylamide derivative |
EP4302834A2 (en) | 2016-07-12 | 2024-01-10 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
EP3568135B1 (en) | 2017-01-11 | 2021-04-07 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
SG11201906412SA (en) | 2017-01-23 | 2019-08-27 | Revolution Medicines Inc | Pyridine compounds as allosteric shp2 inhibitors |
BR112019015075A2 (pt) * | 2017-01-23 | 2020-03-10 | Revolution Medicines, Inc. | Compostos bicíclicos como inibidores de shp2 alostéricos |
CN109206357A (zh) * | 2017-07-04 | 2019-01-15 | 浙江九洲药业股份有限公司 | 一种格列齐特中间体的通式化合物及其制备方法和应用 |
JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
SG11202002941WA (en) | 2017-10-12 | 2020-04-29 | Revolution Medicines Inc | Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors |
CA3084058A1 (en) | 2017-12-15 | 2019-06-20 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric shp2 inhibitors |
AU2019227607C1 (en) | 2018-02-27 | 2023-07-20 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors |
CN108379583B (zh) * | 2018-03-27 | 2021-08-17 | 北京大学 | 一种肿瘤转移药物治疗的靶标及其应用 |
JP7391046B2 (ja) | 2018-05-18 | 2023-12-04 | インサイト・コーポレイション | A2a/a2b阻害剤としての縮合ピリミジン誘導体 |
CN117304191A (zh) | 2018-07-05 | 2023-12-29 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003503354A (ja) * | 1999-06-30 | 2003-01-28 | メルク エンド カムパニー インコーポレーテッド | Srcキナーゼ阻害剤化合物 |
EP1218380B1 (de) * | 1999-10-08 | 2003-12-17 | Grünenthal GmbH | Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate |
ATE413403T1 (de) * | 1999-10-08 | 2008-11-15 | Gruenenthal Gmbh | Bicyclische imidazo-5-yl-aminderivate |
CA2382919C (en) * | 1999-10-08 | 2008-12-09 | Gruenenthal Gmbh | Bicyclic imidazo-3-yl-amine derivatives |
DE10019714A1 (de) * | 2000-04-20 | 2002-01-10 | Gruenenthal Gmbh | Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen |
NO311460B1 (no) | 2000-07-14 | 2001-11-26 | Zopa As | Fremgangsmåte og anordning for kjöling av produkter i et transportsystem |
DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
US20020132823A1 (en) | 2001-01-17 | 2002-09-19 | Jiahuai Han | Assay method |
CA2436487A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd. | Methods of inhibiting kinases |
US6919340B2 (en) * | 2002-04-19 | 2005-07-19 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof |
JP4799864B2 (ja) * | 2002-09-23 | 2011-10-26 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン |
WO2004037814A1 (en) | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
WO2004072081A1 (en) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
US7157460B2 (en) * | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US7186832B2 (en) * | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US7674791B2 (en) * | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
AU2004282219C1 (en) * | 2003-10-15 | 2009-12-17 | Osi Pharmaceuticals, Inc. | Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors |
WO2005085252A1 (en) | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
ATE424208T1 (de) | 2004-06-09 | 2009-03-15 | Oncalis Ag | Proteinkinaseinhibitoren |
WO2006049339A1 (ja) * | 2004-11-08 | 2006-05-11 | Banyu Pharmaceutical Co., Ltd. | 新規縮環イミダゾール誘導体 |
CA2587192A1 (en) * | 2004-11-10 | 2006-05-18 | Cgi Pharmaceuticals, Inc. | Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity |
US20060149535A1 (en) * | 2004-12-30 | 2006-07-06 | Lg Electronics Inc. | Method for controlling speed of audio signals |
WO2006086545A2 (en) | 2005-02-08 | 2006-08-17 | Robert W Desimone | Method to identify novel therapeutics |
MX2007011041A (es) * | 2005-03-10 | 2008-02-22 | Cgi Pharmaceuticals Inc | Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas. |
CA2620223A1 (en) * | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
CN101370811A (zh) * | 2005-11-10 | 2009-02-18 | 先灵公司 | 作为蛋白激酶抑制剂的咪唑并吡嗪化合物 |
JP2009515882A (ja) * | 2005-11-10 | 2009-04-16 | シェーリング コーポレイション | プロテインキナーゼを阻害するための方法 |
BRPI0619633A2 (pt) * | 2005-12-01 | 2011-10-04 | Elan Pharm Inc | 5-(arilsulfonil)-pirazolopiperidinas |
US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
CA2653506A1 (en) | 2006-05-31 | 2007-12-06 | Galapagos Nv. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
US20100160292A1 (en) | 2006-09-11 | 2010-06-24 | Cgi Pharmaceuticals, Inc | Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors |
-
2007
- 2007-05-30 CA CA002653506A patent/CA2653506A1/en not_active Abandoned
- 2007-05-30 US US11/809,294 patent/US7501411B2/en not_active Expired - Fee Related
- 2007-05-30 DK DK07729660.6T patent/DK2029602T3/da active
- 2007-05-30 EA EA200870592A patent/EA200870592A1/ru unknown
- 2007-05-30 NZ NZ573015A patent/NZ573015A/en not_active IP Right Cessation
- 2007-05-30 AT AT07729660T patent/ATE465164T1/de active
- 2007-05-30 BR BRPI0712531-3A patent/BRPI0712531A2/pt not_active IP Right Cessation
- 2007-05-30 DE DE602007006010T patent/DE602007006010D1/de active Active
- 2007-05-30 WO PCT/EP2007/055246 patent/WO2007138072A2/en active Application Filing
- 2007-05-30 MX MX2008015057A patent/MX2008015057A/es active IP Right Grant
- 2007-05-30 JP JP2009512585A patent/JP2009538877A/ja not_active Abandoned
- 2007-05-30 PT PT07729660T patent/PT2029602E/pt unknown
- 2007-05-30 AU AU2007267121A patent/AU2007267121A1/en not_active Abandoned
- 2007-05-30 KR KR1020087030751A patent/KR20090026288A/ko not_active Application Discontinuation
-
2008
- 2008-10-30 IL IL195033A patent/IL195033A0/en unknown
- 2008-11-10 NO NO20084703A patent/NO20084703L/no not_active Application Discontinuation
- 2008-11-20 NI NI200800299A patent/NI200800299A/es unknown
- 2008-11-25 CR CR10458A patent/CR10458A/es unknown
- 2008-11-28 EC EC2008008923A patent/ECSP088923A/es unknown
-
2009
- 2009-03-08 US US12/399,979 patent/US7915256B2/en not_active Expired - Fee Related
-
2010
- 2010-07-06 HR HR20100378T patent/HRP20100378T1/hr unknown
-
2011
- 2011-01-09 US US12/987,129 patent/US20110178067A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0712531A2 (pt) | 2012-12-25 |
CR10458A (es) | 2009-02-26 |
HRP20100378T1 (hr) | 2010-08-31 |
US7501411B2 (en) | 2009-03-10 |
AU2007267121A1 (en) | 2007-12-06 |
PT2029602E (pt) | 2010-07-08 |
DE602007006010D1 (de) | 2010-06-02 |
ATE465164T1 (de) | 2010-05-15 |
NZ573015A (en) | 2010-11-26 |
MX2008015057A (es) | 2008-12-10 |
NO20084703L (no) | 2009-02-19 |
EA200870592A1 (ru) | 2009-08-28 |
DK2029602T3 (da) | 2010-08-09 |
JP2009538877A (ja) | 2009-11-12 |
CA2653506A1 (en) | 2007-12-06 |
US20110178067A1 (en) | 2011-07-21 |
US20080090818A1 (en) | 2008-04-17 |
NI200800299A (es) | 2010-05-25 |
US20100298300A1 (en) | 2010-11-25 |
US7915256B2 (en) | 2011-03-29 |
WO2007138072A2 (en) | 2007-12-06 |
KR20090026288A (ko) | 2009-03-12 |
IL195033A0 (en) | 2009-08-03 |
WO2007138072A3 (en) | 2008-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP088923A (es) | Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatorias | |
EP2086540B8 (en) | Triazolopyridine compounds useful for the treatment of degenerative & inflammatory diseases | |
CR20110092A (es) | Nuevos compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatorias | |
WO2007133637A3 (en) | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | |
UA100007C2 (ru) | Гетероциклические ингибиторы мек, их применение и фармацевтическая композиция, которая их содержит | |
EA201101243A1 (ru) | 3h-имидазо[4,5-c]пиридин-6-карбоксамиды в качестве противовоспалительных средств | |
HK1133787A1 (en) | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof | |
WO2006093832A3 (en) | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | |
WO2007028022A3 (en) | Novel compounds as p2x7 modulators and uses thereof | |
ATE487720T1 (de) | 5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer | |
TNSN05197A1 (en) | Pharmaceutical compositions comprising a combination of rapamycin or its derivative and pimecrolimus for the treatment of inflammation -and immunologically- mediated diseases | |
WO2005105770A3 (en) | Arylphenylamino-, arylphenylamide-, and arylphenylether-sulfide derivatives | |
ATE522500T1 (de) | Amidderivate als ionenkanalliganden sowie pharmazeutische zusammensetzungen und verwendungsverfahren dafür | |
EA201071275A1 (ru) | Конденсированные соединения пиразина, которые можно использовать для лечения дегенеративных и воспалительных заболеваний | |
CL2008003027A1 (es) | Compuestos derivados de 5,6-diaril piridinas sustituidas en posiciones 2 y 3; compuestos intermediarios y su uso; composicion farmaceutica; y uso para tratar y/o prevenir trastornos psiaquiatricos, metabolicos, inflamatorios, para la prevencion del dolor, entre otras enfermedades. | |
WO2006099410A3 (en) | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | |
MA31630B1 (fr) | Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique | |
CL2008003933A1 (es) | Compuestos derivados de n-heterociclo-[1,2-a]-piridina-2-carboxamida; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras. | |
WO2005105766A3 (en) | Arylphenylamino-and arylphenylether-sulfide derivatives, useful for the treatment of inflammatory and immune diseases, and pharmaceutical compositions containing them | |
WO2012158197A3 (en) | Compounds useful as akt/pkb modulators and uses thereof | |
CL2008003928A1 (es) | Compuestos derivados de n-6-heterociclo-imidazo-[1,2-a]-piridin-2-carboxamida sustituidos; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras. | |
CL2008003931A1 (es) | Compuestos derivados de n-fenil-imidazo-[1,2-a]-piridin-2-carboxamida sustituido; compuestos intermediarios; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras. | |
UY33010A (es) | Compuestos de pirazina fusionados como sus sales, útiles para el tratamiento de enfermedades degenerativas e inflamatorias | |
TNSN07283A1 (en) | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | |
GB2452142A (en) | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |