ECSP055644A - Derivados de la quinolil-propil-piperidina y su utilización - Google Patents

Derivados de la quinolil-propil-piperidina y su utilización

Info

Publication number
ECSP055644A
ECSP055644A EC2005005644A ECSP055644A ECSP055644A EC SP055644 A ECSP055644 A EC SP055644A EC 2005005644 A EC2005005644 A EC 2005005644A EC SP055644 A ECSP055644 A EC SP055644A EC SP055644 A ECSP055644 A EC SP055644A
Authority
EC
Ecuador
Prior art keywords
alkyl
cooh
protected
protecting group
keto
Prior art date
Application number
EC2005005644A
Other languages
English (en)
Inventor
Erick Bacque
Antony Bigot
Ahmad Youssef El
Jean Luc Malleron
Baptiste Ronan
Michel Tabart
Fabrice Viviani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of ECSP055644A publication Critical patent/ECSP055644A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención concierne a derivados de piperidina quinolil de formula general (I) En donde R1 es hidrógeno, halógeno, hodroxi, amino, alquilamino, dialquilamino, hidroxiamino, alquiloxiamino o alquil alquiloxi-amino, y R1b es hidrógeno, o R1a y R1b forman un oxo. R2 es carboxi, carboximetil, o hodroximetil. R3 es alquil sustituido por cualquier feniltio opcionalmente sustituido por halógeno, alquil, alquiloxi, trifluorometil, trifluorometoxi, carboxi. alquiloxicarbonil, ciano o amino, o por cicloalquilitio (3 a 7 miembros) opcionalmente sustituidos por halogeno o trifluorometil, o por heroariltio (5 a 6 miembros) y de 1 a 4 heteroatomos seleccionados de N, O y S ), opcionalmente sustituidos por halogeno, hidroxi alquil, alquiloxi triflurometil, trifluometoxi, caboxi, alquiloxicarbonil, ciano o amino o R3 es propargil sustituido por fenil, o heteroaril rtal como se define arriba, R4 es alquil, alquenil-CH2- O alquinil- CH2-, cicloalquil o cicloalquil alquil, en sus varias formas isométricas separadas o mezcladas, así como sus sales. Dichos derivados novedosos son potentes agentes antibacteriales.
EC2005005644A 2002-09-11 2005-03-04 Derivados de la quinolil-propil-piperidina y su utilización ECSP055644A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211212A FR2844270B1 (fr) 2002-09-11 2002-09-11 Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent

Publications (1)

Publication Number Publication Date
ECSP055644A true ECSP055644A (es) 2005-07-06

Family

ID=31725983

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005644A ECSP055644A (es) 2002-09-11 2005-03-04 Derivados de la quinolil-propil-piperidina y su utilización

Country Status (10)

Country Link
US (1) US7232834B2 (es)
EP (1) EP1542988B1 (es)
AT (1) ATE323080T1 (es)
AU (1) AU2003278296A1 (es)
CA (1) CA2503732A1 (es)
DE (1) DE60304587T2 (es)
EC (1) ECSP055644A (es)
ES (1) ES2263036T3 (es)
FR (1) FR2844270B1 (es)
WO (1) WO2004024712A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AU2003239302A1 (en) * 2002-01-29 2003-09-02 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200406410A (en) * 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
WO2004041210A2 (en) 2002-11-05 2004-05-21 Smithkline Beecham Corporation Antibacterial agents
DE60331849D1 (de) 2002-11-05 2010-05-06 Glaxosmithkline Llc Antibakterielle wirkstoffe
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
US20070254872A1 (en) * 2004-07-08 2007-11-01 Glaxo Group Limited Antibacterial Agents
JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
US7605169B2 (en) 2005-01-25 2009-10-20 Glaxo Group Limited Antibacterial agents
EP1845995A4 (en) * 2005-01-25 2010-03-03 Glaxo Group Ltd ANTIBACTERIAL AGENTS
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
EP1846411A4 (en) * 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
CN101184487B (zh) 2005-03-31 2010-11-03 詹森药业有限公司 作为抗菌剂的二环吡唑化合物
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
BRPI0810064B8 (pt) * 2007-04-20 2021-05-25 Glaxo Group Ltd compostos contendo nitrogênio tricíclico como agentes antibacterianos, composições farmacêuticas que compreendem os ditos compostos e uso dos mesmos para o tratamento de infecções bacterianas em mamíferos
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
EP3182973B1 (en) 2014-08-22 2019-09-18 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH533123A (de) 1968-07-02 1973-01-31 Hoffmann La Roche Verfahren zur Herstellung von Chinolinderivaten
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
FR2844270B1 (fr) 2006-05-19
DE60304587D1 (de) 2006-05-24
CA2503732A1 (fr) 2004-03-25
AU2003278296A1 (en) 2004-04-30
WO2004024712A1 (fr) 2004-03-25
ES2263036T3 (es) 2006-12-01
US7232834B2 (en) 2007-06-19
ATE323080T1 (de) 2006-04-15
EP1542988A1 (fr) 2005-06-22
EP1542988B1 (fr) 2006-04-12
FR2844270A1 (fr) 2004-03-12
US20040087619A1 (en) 2004-05-06
DE60304587T2 (de) 2007-02-22

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