EA202191012A1 - T-клеточные рецепторы, специфичные к мезотелину, и их применение в иммунотерапии - Google Patents

T-клеточные рецепторы, специфичные к мезотелину, и их применение в иммунотерапии

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Publication number
EA202191012A1
EA202191012A1 EA202191012A EA202191012A EA202191012A1 EA 202191012 A1 EA202191012 A1 EA 202191012A1 EA 202191012 A EA202191012 A EA 202191012A EA 202191012 A EA202191012 A EA 202191012A EA 202191012 A1 EA202191012 A1 EA 202191012A1
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EA
Eurasian Patent Office
Prior art keywords
cancer
binding proteins
mesothelin
immunotherapy
cell receptors
Prior art date
Application number
EA202191012A
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English (en)
Inventor
Томас М. ШМИТТ
Од Дж. Шапюи
Филип Д. ГРИНБЕРГ
Original Assignee
Фред Хатчинсон Кэнсер Рисерч Сентер
Джуно Терапьютикс, Инк.
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Application filed by Фред Хатчинсон Кэнсер Рисерч Сентер, Джуно Терапьютикс, Инк. filed Critical Фред Хатчинсон Кэнсер Рисерч Сентер
Publication of EA202191012A1 publication Critical patent/EA202191012A1/ru

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K39/464468—Mesothelin [MSLN]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

В данном документе представлены связывающие белки, специфичные к пептидам Msln20-28 или Msln530-538. Также представлены полинуклеотиды, кодирующие связывающие белки, а также композиции и рекомбинантные клетки-хозяева, содержащие связывающие белки или полинуклеотиды. Композиции и рекомбинантные клетки-хозяева можно использовать для лечения субъекта, имеющего мезотелиому, рак поджелудочной железы, рак яичников, рак легких, рак, где пептид Msln20-28 экспрессируется на опухолевой клетке указанного злокачественного образования, или рак, где пептид Msln530-538 экспрессируется на опухолевой клетке указанного злокачественного образования.
EA202191012A 2018-11-09 2019-11-08 T-клеточные рецепторы, специфичные к мезотелину, и их применение в иммунотерапии EA202191012A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862758397P 2018-11-09 2018-11-09
PCT/US2019/060570 WO2020097530A2 (en) 2018-11-09 2019-11-08 Immunotherapy targeting mesothelin

Publications (1)

Publication Number Publication Date
EA202191012A1 true EA202191012A1 (ru) 2021-08-17

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EA202191012A EA202191012A1 (ru) 2018-11-09 2019-11-08 T-клеточные рецепторы, специфичные к мезотелину, и их применение в иммунотерапии

Country Status (13)

Country Link
US (1) US20220009992A1 (ru)
EP (1) EP3877404A2 (ru)
JP (1) JP2022506781A (ru)
KR (1) KR20210102231A (ru)
CN (1) CN113286815B (ru)
AU (1) AU2019377553A1 (ru)
BR (1) BR112021008973A8 (ru)
CA (1) CA3119188A1 (ru)
EA (1) EA202191012A1 (ru)
IL (1) IL282926A (ru)
MX (1) MX2021005308A (ru)
SG (1) SG11202104349QA (ru)
WO (1) WO2020097530A2 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022232599A1 (en) * 2021-04-30 2022-11-03 Regents Of The University Of Minnesota Mesothelin-specific t cell receptors and methods of using same

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WO2020097530A3 (en) 2020-07-23
BR112021008973A2 (pt) 2021-10-26
CN113286815B (zh) 2024-04-26
US20220009992A1 (en) 2022-01-13
MX2021005308A (es) 2021-09-08
JP2022506781A (ja) 2022-01-17
WO2020097530A2 (en) 2020-05-14
SG11202104349QA (en) 2021-05-28
AU2019377553A1 (en) 2021-05-27
CA3119188A1 (en) 2020-05-14
BR112021008973A8 (pt) 2023-05-02
CN113286815A (zh) 2021-08-20
KR20210102231A (ko) 2021-08-19
IL282926A (en) 2021-06-30
EP3877404A2 (en) 2021-09-15

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