EA202092694A1 - Системы и способы количественного определения и модификации вязкости белков - Google Patents
Системы и способы количественного определения и модификации вязкости белковInfo
- Publication number
- EA202092694A1 EA202092694A1 EA202092694A EA202092694A EA202092694A1 EA 202092694 A1 EA202092694 A1 EA 202092694A1 EA 202092694 A EA202092694 A EA 202092694A EA 202092694 A EA202092694 A EA 202092694A EA 202092694 A1 EA202092694 A1 EA 202092694A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- systems
- modification
- quantitative determination
- viscosity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Abstract
В данном изобретении предлагаются системы и способы определения областей белков, которые вносят вклад в вязкость составов этих белков. Также предлагаются способы модификации вязкости концентрированных белковых составов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862669440P | 2018-05-10 | 2018-05-10 | |
PCT/US2019/031438 WO2019217626A1 (en) | 2018-05-10 | 2019-05-09 | Systems and methods for quantifying and modifying protein viscosity |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202092694A1 true EA202092694A1 (ru) | 2021-03-12 |
Family
ID=66794086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092694A EA202092694A1 (ru) | 2018-05-10 | 2019-05-09 | Системы и способы количественного определения и модификации вязкости белков |
Country Status (14)
Country | Link |
---|---|
US (1) | US20190345196A1 (ru) |
EP (1) | EP3791189A1 (ru) |
JP (1) | JP2021523349A (ru) |
KR (1) | KR20210007958A (ru) |
CN (1) | CN112136049A (ru) |
AR (1) | AR115383A1 (ru) |
AU (1) | AU2019266275A1 (ru) |
BR (1) | BR112020021140A2 (ru) |
CA (1) | CA3095190A1 (ru) |
EA (1) | EA202092694A1 (ru) |
MX (1) | MX2020012016A (ru) |
SG (1) | SG11202009372UA (ru) |
TW (1) | TW202016125A (ru) |
WO (1) | WO2019217626A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230150300A (ko) * | 2021-03-03 | 2023-10-30 | 리제너론 파마슈티칼스 인코포레이티드 | 단백질 점도를 정량화하고 변경시키기 위한 시스템 및 방법 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
CA2423227C (en) * | 2000-10-12 | 2011-11-29 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
DE60309238T2 (de) | 2002-03-08 | 2007-06-06 | Asml Netherlands B.V. | Lithographische Maske, lithographischer Apparat und Verfahren zur Herstellung einer Vorrichtung |
CN102585002A (zh) | 2006-06-02 | 2012-07-18 | 瑞泽恩制药公司 | 人il-6受体的高亲和力抗体 |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
CN101809037B (zh) | 2007-07-31 | 2014-01-15 | 瑞泽恩制药公司 | 人cd20的人抗体及其使用方法 |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
MX2011014008A (es) | 2009-06-26 | 2012-06-01 | Regeneron Pharma | Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original. |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
JOP20190250A1 (ar) | 2010-07-14 | 2017-06-16 | Regeneron Pharma | صيغ مستقرة تحتوي على الأجسام المضادة لمضاد عامل نمو الأعصاب |
AR083044A1 (es) | 2010-09-27 | 2013-01-30 | Regeneron Pharma | Anticuerpos anti-cd48 y usos de los mismos |
NZ609557A (en) | 2010-10-06 | 2014-12-24 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
JO3412B1 (ar) | 2011-06-17 | 2019-10-20 | Regeneron Pharma | أجسام مضادة ل angptl3 واستخداماتها |
CA2855822C (en) | 2011-11-14 | 2022-11-15 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
EP2807190B1 (en) | 2012-01-23 | 2018-12-26 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ang2 antibodies |
JO3820B1 (ar) | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
TW201843172A (zh) | 2012-06-25 | 2018-12-16 | 美商再生元醫藥公司 | 抗-egfr抗體及其用途 |
AU2013302925B2 (en) | 2012-08-13 | 2018-07-05 | Regeneron Pharmaceuticals, Inc. | Anti-PCSK9 antibodies with pH-dependent binding characteristics |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
JO3405B1 (ar) | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒f蛋白質的人類抗體及其使用方法 |
US9637535B2 (en) | 2013-03-15 | 2017-05-02 | Regeneron Pharmaceuticals, Inc. | IL-33 antagonists and uses thereof |
TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗-prlr抗體及其用途 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
CA2940685C (en) | 2014-03-11 | 2023-10-24 | Regeneron Pharmaceuticals, Inc. | Anti-egfrviii antibodies and uses thereof |
TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
ES2779070T3 (es) | 2014-05-05 | 2020-08-13 | Regeneron Pharma | Animales con C5 y C3 humanizadas |
JO3701B1 (ar) | 2014-05-23 | 2021-01-31 | Regeneron Pharma | مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي |
US9657099B2 (en) | 2014-09-16 | 2017-05-23 | Regeneron Pharmaceuticals, Inc. | Anti-glucagon antibodies |
WO2016054598A2 (en) * | 2014-10-03 | 2016-04-07 | Massachusetts Institute Of Technology | Antibodies that bind ebola glycoprotein and uses thereof |
EA201790946A8 (ru) * | 2014-12-01 | 2018-10-31 | Зе Скриппс Рисёрч Инститьют | Способы и композиции, связанные с функциональными полипептидами, встроенными в гетерологичные белковые каркасы |
TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
-
2019
- 2019-05-08 TW TW108115831A patent/TW202016125A/zh unknown
- 2019-05-09 EP EP19729401.0A patent/EP3791189A1/en active Pending
- 2019-05-09 KR KR1020207030233A patent/KR20210007958A/ko not_active Application Discontinuation
- 2019-05-09 WO PCT/US2019/031438 patent/WO2019217626A1/en active Application Filing
- 2019-05-09 CN CN201980030823.XA patent/CN112136049A/zh active Pending
- 2019-05-09 MX MX2020012016A patent/MX2020012016A/es unknown
- 2019-05-09 AU AU2019266275A patent/AU2019266275A1/en active Pending
- 2019-05-09 CA CA3095190A patent/CA3095190A1/en active Pending
- 2019-05-09 EA EA202092694A patent/EA202092694A1/ru unknown
- 2019-05-09 SG SG11202009372UA patent/SG11202009372UA/en unknown
- 2019-05-09 BR BR112020021140-0A patent/BR112020021140A2/pt unknown
- 2019-05-09 JP JP2020560157A patent/JP2021523349A/ja active Pending
- 2019-05-09 US US16/407,414 patent/US20190345196A1/en active Pending
- 2019-05-10 AR ARP190101253A patent/AR115383A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN112136049A (zh) | 2020-12-25 |
CA3095190A1 (en) | 2019-11-14 |
AU2019266275A1 (en) | 2020-11-05 |
JP2021523349A (ja) | 2021-09-02 |
WO2019217626A1 (en) | 2019-11-14 |
SG11202009372UA (en) | 2020-10-29 |
BR112020021140A2 (pt) | 2021-02-17 |
US20190345196A1 (en) | 2019-11-14 |
MX2020012016A (es) | 2021-01-29 |
AR115383A1 (es) | 2021-01-13 |
TW202016125A (zh) | 2020-05-01 |
EP3791189A1 (en) | 2021-03-17 |
KR20210007958A (ko) | 2021-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202090090A1 (ru) | Включение неприродных нуклеотидов и способы с ними | |
EA201890790A1 (ru) | Связывающие pd-1 белки и способы их применения | |
EA201892561A1 (ru) | Гибридные белки gdf15 и их применение | |
EA201892691A1 (ru) | Однодоменный белок, связывающий сывороточный альбумин | |
EA201890423A1 (ru) | Слитые белки фактора ix, способы их получения и применения | |
EA201991168A1 (ru) | Белок, связывающий простатический специфический мембранный антиген | |
EA201890247A1 (ru) | Ингибиторы дезоксиуридинтрифосфатазы, содержащие гидантоин | |
EA202190726A1 (ru) | Индольные ингибиторы арил-гидрокарбонового рецептора (ahr) и их применение | |
EA202190609A1 (ru) | Антитела против hla-g, композиции, содержащие антитела против hla-g, и способы применения антител против hla-g | |
EA202091130A1 (ru) | Лиофилизованный препарат моноклонального антитела к транстиретину | |
EA201991546A1 (ru) | Антигенсвязывающие белки против нейропилина и способы их применения | |
EA201991912A1 (ru) | Составы, содержащие pd-1-связывающие белки, и способы их получения | |
EA202092692A1 (ru) | Аналоги рапамицина и их применения | |
EA202191785A1 (ru) | Антитела к ctla4 и способы их применения | |
EA201892225A1 (ru) | АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ | |
EA202092508A1 (ru) | Составы на основе антител к pd-l1 человека | |
EA202192146A1 (ru) | Антитела к клаудину 6 и их применение | |
EA201792561A1 (ru) | Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения | |
EA202191656A1 (ru) | Анти-il-36 антитела и способы их применения | |
EA202090084A1 (ru) | Новый терапевтический ферментный слитый белок и его применение | |
EA202190810A1 (ru) | Способы и наборы для получения цельной крови с инактивированным патогеном | |
EA202192786A1 (ru) | Твердые формы (e)-3-[2-(2-тиенил)винил]-1h-пиразола | |
PH12020552270A1 (en) | Anti-steap1 antigen-binding protein | |
EA201890177A1 (ru) | Мультиспецифические связывающие белки | |
EA201991876A1 (ru) | Антитела против фактора d и их применения |