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Priority claimed from PCT/US2019/021243external-prioritypatent/WO2019173653A1/en
Publication of EA202092110A1publicationCriticalpatent/EA202092110A1/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Данное изобретение относится к соединениям формулы (А) и формулы (I)или к их солям, где R1, R2, R10, R11, R12, R13, R14, R15, R16, q и р являются такими, как описано в данном документе. Соединения формулы (A), формулы (I) и их фармацевтические композиции являются ингибиторами интегрина v6, которые пригодны для лечения фиброза, такого как идиопатический фиброз легких (IPF) и неспецифическая интерстициальная пневмония (NSIP).This invention relates to compounds of formula (A) and formula (I) or salts thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. The compounds of formula (A), formula (I) and pharmaceutical compositions thereof are inhibitors of v6 integrin which are useful in the treatment of fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
EA202092110A2018-06-272019-03-07
AMINO ACID COMPOUNDS AND METHODS OF APPLICATION
EA202092110A1
(en)
Procedure for the preparation of (3s) -3- (4-chloro-3 - {[(2s, 3r) -2- (4-chlorophenyl) -4,4,4-trifluoro-3-methylbutanoyl] amino} phenyl) -3-cyclopropylpropanoic acid and its crystalline form for use as an active pharmaceutical ingredient.