EA201992877A1 - SUBSTITUTED NITROGEN CONTAINING COMPOUNDS - Google Patents
SUBSTITUTED NITROGEN CONTAINING COMPOUNDSInfo
- Publication number
- EA201992877A1 EA201992877A1 EA201992877A EA201992877A EA201992877A1 EA 201992877 A1 EA201992877 A1 EA 201992877A1 EA 201992877 A EA201992877 A EA 201992877A EA 201992877 A EA201992877 A EA 201992877A EA 201992877 A1 EA201992877 A1 EA 201992877A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- containing compounds
- nitrogen containing
- substituted nitrogen
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Раскрыты соединения с формулой (I)или их соль, где Rпредставляет собойкаждый W независимо представляет собой NRили O; Z представляет собой связь или CHR; и R, R, R, R, R, L, B, V, Y и n имеют определения, приведенные в настоящем документе. Также раскрыты способы применения таких соединений в качестве ингибиторов ROMK и фармацевтические композиции, содержащие такие соединения. Эти соединения полезны при лечении сердечно-сосудистых заболеваний.Compounds of formula (I) or a salt thereof are disclosed wherein R is each W independently represents N R or O; Z represents a bond or CHR; and R, R, R, R, R, L, B, V, Y and n are as defined herein. Methods of using such compounds as ROMK inhibitors and pharmaceutical compositions containing such compounds are also disclosed. These compounds are useful in the treatment of cardiovascular diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201811004486 | 2018-02-06 | ||
| PCT/US2018/035270 WO2018222795A1 (en) | 2017-06-01 | 2018-05-31 | Substituted nitrogen containing compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201992877A1 true EA201992877A1 (en) | 2020-06-15 |
Family
ID=71138792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201992877A EA201992877A1 (en) | 2018-02-06 | 2018-05-31 | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA201992877A1 (en) |
-
2018
- 2018-05-31 EA EA201992877A patent/EA201992877A1/en unknown
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