EA201992168A1 - Аналоги деутетрабеназина, их получение и применение - Google Patents
Аналоги деутетрабеназина, их получение и применениеInfo
- Publication number
- EA201992168A1 EA201992168A1 EA201992168A EA201992168A EA201992168A1 EA 201992168 A1 EA201992168 A1 EA 201992168A1 EA 201992168 A EA201992168 A EA 201992168A EA 201992168 A EA201992168 A EA 201992168A EA 201992168 A1 EA201992168 A1 EA 201992168A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- deutetrabenazine
- analogues
- production
- application
- compositions containing
- Prior art date
Links
- MKJIEFSOBYUXJB-VFJJUKLQSA-N (3r,11br)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one Chemical class C1CN2C[C@@H](CC(C)C)C(=O)C[C@@H]2C2=C1C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2 MKJIEFSOBYUXJB-VFJJUKLQSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 229950005031 deutetrabenazine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pens And Brushes (AREA)
- Machine Translation (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471484P | 2017-03-15 | 2017-03-15 | |
| PCT/US2018/022562 WO2018170214A1 (en) | 2017-03-15 | 2018-03-15 | Analogs of deutetrabenazine, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201992168A1 true EA201992168A1 (ru) | 2020-03-16 |
Family
ID=61873991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201992168A EA201992168A1 (ru) | 2017-03-15 | 2018-03-15 | Аналоги деутетрабеназина, их получение и применение |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11813232B2 (ja) |
| EP (1) | EP3596077A1 (ja) |
| JP (3) | JP2020510073A (ja) |
| KR (2) | KR20200003791A (ja) |
| CN (1) | CN110709398A (ja) |
| AR (1) | AR111182A1 (ja) |
| AU (2) | AU2018236336B2 (ja) |
| BR (1) | BR112019018966A2 (ja) |
| CA (1) | CA3056612A1 (ja) |
| CL (1) | CL2019002629A1 (ja) |
| CO (1) | CO2019011271A2 (ja) |
| EA (1) | EA201992168A1 (ja) |
| IL (1) | IL269132A (ja) |
| MX (1) | MX2019010913A (ja) |
| PE (1) | PE20191819A1 (ja) |
| SG (1) | SG11201908477QA (ja) |
| TW (1) | TWI772382B (ja) |
| UA (1) | UA127052C2 (ja) |
| WO (1) | WO2018170214A1 (ja) |
| ZA (1) | ZA201906326B (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021007063A (es) * | 2018-12-13 | 2021-12-10 | Auspex Pharmaceuticals Inc | Deutetrabenazina para el tratamiento de la discinesia en la paralisis cerebral. |
| WO2020165807A1 (en) * | 2019-02-14 | 2020-08-20 | Dr. Reddy's Laboratories Limited | Solid forms of deutetrabenazine and process for the preparation thereof |
| HUE065723T2 (hu) * | 2020-06-10 | 2024-06-28 | Auspex Pharmaceuticals Inc | Deutetrabenazint tartalmazó ozmotikus adagolási formák és eljárás ezek alkalmazására |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009004910A (es) | 2006-11-08 | 2009-07-24 | Neurocrine Biosciences Inc | Compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11-b- hexahidro-2h-pirido[2,1-a] isoquinolin-2-ol y métodos que se relacionan al mismo. |
| NO3061760T3 (ja) | 2008-09-18 | 2018-04-07 | ||
| JP2013527237A (ja) | 2010-06-01 | 2013-06-27 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | ベンゾキノロン系ｖｍａｔ２阻害剤 |
| WO2012081031A1 (en) * | 2010-12-15 | 2012-06-21 | Enaltec Labs Pvt. Ltd. | Process for preparing tetrabenazine |
| US9346800B2 (en) * | 2012-09-18 | 2016-05-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| US9550780B2 (en) * | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2930744A1 (en) * | 2013-12-03 | 2015-06-11 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| WO2016144901A1 (en) | 2015-03-06 | 2016-09-15 | Auspex Pharmaceuticals, Inc. | Methods for the treatment of abnormal involuntary movement disorders |
-
2018
- 2018-03-15 AR ARP180100611A patent/AR111182A1/es unknown
- 2018-03-15 UA UAA201910309A patent/UA127052C2/uk unknown
- 2018-03-15 BR BR112019018966A patent/BR112019018966A2/pt active Search and Examination
- 2018-03-15 SG SG11201908477Q patent/SG11201908477QA/en unknown
- 2018-03-15 AU AU2018236336A patent/AU2018236336B2/en active Active
- 2018-03-15 EA EA201992168A patent/EA201992168A1/ru unknown
- 2018-03-15 CN CN201880018609.8A patent/CN110709398A/zh active Pending
- 2018-03-15 CA CA3056612A patent/CA3056612A1/en active Pending
- 2018-03-15 TW TW107108832A patent/TWI772382B/zh active
- 2018-03-15 KR KR1020197030354A patent/KR20200003791A/ko not_active Application Discontinuation
- 2018-03-15 KR KR1020227043234A patent/KR20230003308A/ko not_active Application Discontinuation
- 2018-03-15 WO PCT/US2018/022562 patent/WO2018170214A1/en unknown
- 2018-03-15 EP EP18715393.7A patent/EP3596077A1/en active Pending
- 2018-03-15 US US15/922,329 patent/US11813232B2/en active Active
- 2018-03-15 JP JP2019550774A patent/JP2020510073A/ja active Pending
- 2018-03-15 MX MX2019010913A patent/MX2019010913A/es unknown
- 2018-03-15 PE PE2019001871A patent/PE20191819A1/es unknown
-
2019
- 2019-09-04 IL IL26913219A patent/IL269132A/en unknown
- 2019-09-13 CL CL2019002629A patent/CL2019002629A1/es unknown
- 2019-09-25 US US16/582,362 patent/US11179386B2/en active Active
- 2019-09-25 ZA ZA2019/06326A patent/ZA201906326B/en unknown
- 2019-10-10 CO CONC2019/0011271A patent/CO2019011271A2/es unknown
-
2021
- 2021-10-21 US US17/507,037 patent/US20220040170A1/en active Pending
- 2021-11-30 US US17/537,663 patent/US20220088006A1/en not_active Abandoned
-
2022
- 2022-05-18 AU AU2022203369A patent/AU2022203369B2/en active Active
- 2022-11-04 JP JP2022177578A patent/JP2023010754A/ja active Pending
-
2024
- 2024-01-30 JP JP2024011974A patent/JP2024050724A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CL2019002629A1 (es) | 2020-01-24 |
| AU2018236336A1 (en) | 2019-10-24 |
| US20180263972A1 (en) | 2018-09-20 |
| CO2019011271A2 (es) | 2020-02-28 |
| US20220040170A1 (en) | 2022-02-10 |
| KR20230003308A (ko) | 2023-01-05 |
| CA3056612A1 (en) | 2018-09-20 |
| MX2019010913A (es) | 2020-01-20 |
| AU2022203369A1 (en) | 2022-06-09 |
| KR20200003791A (ko) | 2020-01-10 |
| US20220088006A1 (en) | 2022-03-24 |
| UA127052C2 (uk) | 2023-03-29 |
| JP2024050724A (ja) | 2024-04-10 |
| CN110709398A (zh) | 2020-01-17 |
| TWI772382B (zh) | 2022-08-01 |
| AU2018236336B2 (en) | 2022-02-24 |
| US11179386B2 (en) | 2021-11-23 |
| PE20191819A1 (es) | 2019-12-27 |
| EP3596077A1 (en) | 2020-01-22 |
| JP2020510073A (ja) | 2020-04-02 |
| ZA201906326B (en) | 2022-12-21 |
| AR111182A1 (es) | 2019-06-12 |
| IL269132A (en) | 2019-11-28 |
| SG11201908477QA (en) | 2019-10-30 |
| US20200016148A1 (en) | 2020-01-16 |
| US11813232B2 (en) | 2023-11-14 |
| BR112019018966A2 (pt) | 2020-04-22 |
| TW201840317A (zh) | 2018-11-16 |
| WO2018170214A1 (en) | 2018-09-20 |
| JP2023010754A (ja) | 2023-01-20 |
| AU2022203369B2 (en) | 2024-04-04 |
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