CY1125047T1 - Διεργασιες για την παρασκευη ενωσεων τυπου οξαθειαζινης - Google Patents

Διεργασιες για την παρασκευη ενωσεων τυπου οξαθειαζινης

Info

Publication number
CY1125047T1
CY1125047T1 CY20221100186T CY221100186T CY1125047T1 CY 1125047 T1 CY1125047 T1 CY 1125047T1 CY 20221100186 T CY20221100186 T CY 20221100186T CY 221100186 T CY221100186 T CY 221100186T CY 1125047 T1 CY1125047 T1 CY 1125047T1
Authority
CY
Cyprus
Prior art keywords
oxathiazine
compounds
preparation
type
processes
Prior art date
Application number
CY20221100186T
Other languages
English (en)
Inventor
Rolf W. Pfirrmann
Original Assignee
Geistlich Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geistlich Pharma Ag filed Critical Geistlich Pharma Ag
Publication of CY1125047T1 publication Critical patent/CY1125047T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/12—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with thionylhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/79—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
    • C07C309/82—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/06—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/18—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by reaction of sulfides with compounds having functional groups with formation of sulfo or halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/10—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/12—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing esterified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Παρατίθενται ενώσεις τύπου οξαθειαζίνης, διεργασίες για την παρασκευή νέων ενώσεων τύπου οξαθειαζίνης, ενώσεις χρήσιμες στην παρασκευή ενώσεων τύπου οξαθειαζίνης, και οι χρήσεις τους. Επίσης παρατίθενται διαδικασίες περίθαλψης ασθενών που πάσχουν από καρκίνους, βακτηριακές μολύνσεις, μυκητιακές μολύνσεις ή/και ιογενείς μολύνσεις με τη χορήγηση ενώσεων τύπου οξαθειαζίνης. Αυτές οι ενώσεις διαπιστώθηκε ότι έχουν σημαντικά μεγαλύτερο χρόνο ημιζωής σε σύγκριση με την ταυρολιδίνη και την ταυρουλτάμη.
CY20221100186T 2014-12-19 2022-03-04 Διεργασιες για την παρασκευη ενωσεων τυπου οξαθειαζινης CY1125047T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462094580P 2014-12-19 2014-12-19
PCT/IB2015/059741 WO2016098054A1 (en) 2014-12-19 2015-12-17 Processes for preparing oxathiazin-like compounds

Publications (1)

Publication Number Publication Date
CY1125047T1 true CY1125047T1 (el) 2023-03-24

Family

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Country Status (21)

Country Link
US (2) US10392355B2 (el)
EP (2) EP4011871A3 (el)
JP (4) JP6746605B2 (el)
KR (1) KR102594322B1 (el)
CN (2) CN107257786B (el)
AU (2) AU2015365348B2 (el)
CA (1) CA2971570A1 (el)
CY (1) CY1125047T1 (el)
DK (1) DK3233813T3 (el)
ES (1) ES2907592T3 (el)
HR (1) HRP20220313T1 (el)
HU (1) HUE058257T2 (el)
IL (1) IL252912B (el)
LT (1) LT3233813T (el)
MX (2) MX369462B (el)
NZ (1) NZ733723A (el)
PL (1) PL3233813T3 (el)
PT (1) PT3233813T (el)
RS (1) RS62955B1 (el)
SI (1) SI3233813T1 (el)
WO (1) WO2016098054A1 (el)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11591302B2 (en) * 2014-12-19 2023-02-28 Geistlich Pharm A Ag Processes for preparing oxathiazin-like compounds
US10392355B2 (en) * 2014-12-19 2019-08-27 Geistlich Pharma Ag Processes for preparing oxathiazin-like compounds
ES2807558T3 (es) * 2016-04-07 2021-02-23 Geistlich Pharma Ag Procedimiento de preparación de compuestos de tipo oxatiazina
EP3960172B1 (en) * 2017-02-27 2023-11-08 Seed Research Institute Co., Ltd. Antifungal composition
CN109602744A (zh) * 2018-12-13 2019-04-12 中国人民解放军总医院 荜茇酰胺在制备抗菌消炎药物中的应用
WO2020234830A1 (en) * 2019-05-22 2020-11-26 Geistlich Pharma Ag Oxathiazin_dioxide for treating, preventing, inhibiting or reducing cytokine release
US20220323452A1 (en) * 2019-05-22 2022-10-13 Geistlich Pharma Ag Methods and compositions for inhibiting gapdh
EP3972608A1 (en) * 2019-05-22 2022-03-30 Geistlich Pharma AG Oxathiazin compounds for inhibiting gapdh
CN111671758A (zh) * 2020-07-06 2020-09-18 长春迈灵生物工程有限公司 牛磺罗定在制备抗hiv病毒药物中的应用
BR112023000308A2 (pt) * 2020-07-06 2023-03-28 Acad Of Military Medical Sciences Uso de taurolidina contra vírus
CN111617086A (zh) * 2020-07-06 2020-09-04 长春迈灵生物工程有限公司 牛磺罗定在制备抗hpv病毒药物中的应用

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Publication number Publication date
US20180370932A1 (en) 2018-12-27
WO2016098054A9 (en) 2016-12-22
IL252912A0 (en) 2017-08-31
JP7449913B2 (ja) 2024-03-14
ES2907592T3 (es) 2022-04-25
BR112017013188A2 (pt) 2018-04-10
KR102594322B1 (ko) 2023-10-26
JP2018502909A (ja) 2018-02-01
AU2015365348A1 (en) 2017-07-13
IL252912B (en) 2020-01-30
US10392355B2 (en) 2019-08-27
CN107257786B (zh) 2019-12-24
SI3233813T1 (sl) 2022-05-31
EP3233813B1 (en) 2022-02-02
PT3233813T (pt) 2022-03-14
MX2017008112A (es) 2018-02-09
HRP20220313T1 (hr) 2022-05-13
JP6746605B2 (ja) 2020-08-26
EP3233813A1 (en) 2017-10-25
PL3233813T3 (pl) 2022-05-30
LT3233813T (lt) 2022-04-11
MX2019013194A (es) 2020-01-13
CA2971570A1 (en) 2016-06-23
JP2022031717A (ja) 2022-02-22
AU2019261702A1 (en) 2019-11-28
HUE058257T2 (hu) 2022-07-28
KR20170113546A (ko) 2017-10-12
EP4011871A2 (en) 2022-06-15
AU2019261702B2 (en) 2021-03-25
US20190389819A1 (en) 2019-12-26
CN107257786A (zh) 2017-10-17
AU2015365348B2 (en) 2019-11-28
EP4011871A3 (en) 2022-08-24
JP2020040964A (ja) 2020-03-19
RS62955B1 (sr) 2022-03-31
JP7030093B2 (ja) 2022-03-04
JP2024028794A (ja) 2024-03-05
NZ733723A (en) 2024-03-22
CN110776479A (zh) 2020-02-11
WO2016098054A1 (en) 2016-06-23
US10968190B2 (en) 2021-04-06
MX369462B (es) 2019-11-08
DK3233813T3 (da) 2022-03-07

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