EA201991105A1 - Методы оценки риска с использованием общей и специфической неклеточной днк - Google Patents

Методы оценки риска с использованием общей и специфической неклеточной днк

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Publication number
EA201991105A1
EA201991105A1 EA201991105A EA201991105A EA201991105A1 EA 201991105 A1 EA201991105 A1 EA 201991105A1 EA 201991105 A EA201991105 A EA 201991105A EA 201991105 A EA201991105 A EA 201991105A EA 201991105 A1 EA201991105 A1 EA 201991105A1
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EA
Eurasian Patent Office
Prior art keywords
total
specific non
risk assessment
cellular dna
assessment methods
Prior art date
Application number
EA201991105A
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English (en)
Inventor
Аой Томита Митчелл
Майкл Митчелл
Карл Стамм
Original Assignee
Дзе Медикал Колледж Оф Висконсин, Инк.
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Priority claimed from PCT/US2017/030293 external-priority patent/WO2017190106A1/en
Application filed by Дзе Медикал Колледж Оф Висконсин, Инк. filed Critical Дзе Медикал Колледж Оф Висконсин, Инк.
Publication of EA201991105A1 publication Critical patent/EA201991105A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2560/00—Nucleic acid detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к способам и композициям для оценки риска путем определения уровней общих и специфических неклеточных нуклеиновых кислот (таких как ДНК) у индивидуума. Описанные здесь способы и композиции могут быть применены для определения риска развития такого состояния, как отторжение трансплантата.
EA201991105A 2016-11-02 2017-11-02 Методы оценки риска с использованием общей и специфической неклеточной днк EA201991105A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662416689P 2016-11-02 2016-11-02
PCT/US2017/030293 WO2017190106A1 (en) 2016-04-29 2017-04-29 Multiplexed optimized mismatch amplification (moma)-target number
PCT/US2017/059808 WO2018085603A1 (en) 2016-11-02 2017-11-02 Methods for assessing risk using total and specific cell-free dna

Publications (1)

Publication Number Publication Date
EA201991105A1 true EA201991105A1 (ru) 2020-01-27

Family

ID=62076613

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991105A EA201991105A1 (ru) 2016-11-02 2017-11-02 Методы оценки риска с использованием общей и специфической неклеточной днк

Country Status (10)

Country Link
US (1) US20190367972A1 (ru)
EP (1) EP3535413A1 (ru)
JP (1) JP2019534016A (ru)
CN (1) CN110114477A (ru)
AU (1) AU2017355464A1 (ru)
CA (1) CA3042696A1 (ru)
EA (1) EA201991105A1 (ru)
IL (1) IL266382A (ru)
MX (1) MX2019005199A (ru)
WO (1) WO2018085603A1 (ru)

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US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
CA2798758C (en) 2010-05-18 2019-05-07 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
EP3294906B1 (en) 2015-05-11 2024-07-10 Natera, Inc. Methods for determining ploidy
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US20190360033A1 (en) * 2016-11-02 2019-11-28 The Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
JP2020524519A (ja) * 2017-06-20 2020-08-20 ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 全セルフリーｄｎａによる移植合併症リスクの評価
JP2021520816A (ja) 2018-04-14 2021-08-26 ナテラ， インコーポレイテッド 循環腫瘍ｄｎａの個別化された検出を用いる癌検出およびモニタリングの方法
WO2019217918A1 (en) * 2018-05-10 2019-11-14 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2021207244A1 (en) * 2020-04-06 2021-10-14 The Medical College Of Wisconsin, Inc. Methods for assessing the severity of, and for inhibiting, pro-inflammatory responses with total cell-free dna
WO2022182878A1 (en) * 2021-02-25 2022-09-01 Natera, Inc. Methods for detection of donor-derived cell-free dna in transplant recipients of multiple organs

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JP2013509883A (ja) * 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
JP5842811B2 (ja) * 2010-03-24 2016-01-13 凸版印刷株式会社 競合プライマーによる標的塩基配列の検出方法
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
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WO2014194113A2 (en) * 2013-05-29 2014-12-04 Chronix Biomedical Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients
DK3117012T3 (da) * 2014-03-14 2019-05-13 Caredx Inc Fremgangsmåder til overvågning af immunosuppressive terapier hos en transplantmodtager
CA2985134A1 (en) * 2014-05-09 2015-11-12 Sebastian Gromminger Detection of dna that originates from a specific cell-type and related methods
US10435750B2 (en) * 2014-07-03 2019-10-08 Multiplicom N.V. Methods for non-invasive detection of transplant health or rejection
US10704104B2 (en) * 2014-10-20 2020-07-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening a subject for a cancer
WO2016123698A1 (en) * 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs
AU2016255573A1 (en) * 2015-04-30 2017-12-21 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA
CN109661476A (zh) * 2016-04-29 2019-04-19 威斯康星州立大学医学院 用于评估胎儿健康的多重优化错配扩增(moma)实时pcr

Also Published As

Publication number Publication date
MX2019005199A (es) 2019-10-14
CN110114477A (zh) 2019-08-09
WO2018085603A1 (en) 2018-05-11
IL266382A (en) 2019-06-30
JP2019534016A (ja) 2019-11-28
EP3535413A1 (en) 2019-09-11
US20190367972A1 (en) 2019-12-05
AU2017355464A1 (en) 2019-05-30
CA3042696A1 (en) 2018-05-11

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