EA201892095A1 - CYCLIC DYNUCLEOTIDE COMPOUNDS AND METHODS OF THEIR APPLICATION - Google Patents

CYCLIC DYNUCLEOTIDE COMPOUNDS AND METHODS OF THEIR APPLICATION

Info

Publication number
EA201892095A1
EA201892095A1 EA201892095A EA201892095A EA201892095A1 EA 201892095 A1 EA201892095 A1 EA 201892095A1 EA 201892095 A EA201892095 A EA 201892095A EA 201892095 A EA201892095 A EA 201892095A EA 201892095 A1 EA201892095 A1 EA 201892095A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
methods
cyclic
dynucleotide
application
Prior art date
Application number
EA201892095A
Other languages
Russian (ru)
Other versions
EA037513B1 (en
Inventor
Боюй Чжун
Лицзюнь Сунь
Ци Вэй
Юаньвэй Дай
Чо Чэнь
Чжицзянь Чэнь
Хэпин Ши
Original Assignee
ИММЬЮН СЕНСОР, ЭлЭлСи
Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ИММЬЮН СЕНСОР, ЭлЭлСи, Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем filed Critical ИММЬЮН СЕНСОР, ЭлЭлСи
Priority claimed from PCT/US2017/023093 external-priority patent/WO2017161349A1/en
Publication of EA201892095A1 publication Critical patent/EA201892095A1/en
Publication of EA037513B1 publication Critical patent/EA037513B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

Описанными являются циклические динуклеотидные аналоги цГАМФ, способы получения соединений, фармацевтические композиции, содержащие данные соединения, и применение соединений и композиций в медицинской терапии.The cyclic dinucleotide analogs of cGAMP, methods for preparing compounds, pharmaceutical compositions containing these compounds, and the use of compounds and compositions in medical therapy are described.

EA201892095A 2016-09-17 2017-03-17 Cyclic dinucleotide compounds and methods of use thereof EA037513B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662396140P 2016-09-17 2016-09-17
PCT/US2017/023093 WO2017161349A1 (en) 2016-03-18 2017-03-17 Cyclic di-nucleotide compounds and methods of use

Publications (2)

Publication Number Publication Date
EA201892095A1 true EA201892095A1 (en) 2019-03-29
EA037513B1 EA037513B1 (en) 2021-04-06

Family

ID=65949968

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892095A EA037513B1 (en) 2016-09-17 2017-03-17 Cyclic dinucleotide compounds and methods of use thereof

Country Status (1)

Country Link
EA (1) EA037513B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013185052A1 (en) * 2012-06-08 2013-12-12 Aduro Biotech Compostions and methods for cancer immunotherapy
ES2935257T3 (en) * 2013-03-15 2023-03-03 Univ Chicago Methods and Compositions Related to T Cell Activity
CN105377867B (en) * 2013-05-03 2019-11-12 加利福尼亚大学董事会 The cyclic annular dinucleotides of I type interferon induces

Also Published As

Publication number Publication date
EA037513B1 (en) 2021-04-06

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