EA201890635A1 - Пептиды и комбинации пептидов для применения в иммунотерапии мелкоклеточного рака легких и других видов рака - Google Patents

Пептиды и комбинации пептидов для применения в иммунотерапии мелкоклеточного рака легких и других видов рака

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EA201890635A1
EA201890635A1 EA201890635A EA201890635A EA201890635A1 EA 201890635 A1 EA201890635 A1 EA 201890635A1 EA 201890635 A EA201890635 A EA 201890635A EA 201890635 A EA201890635 A EA 201890635A EA 201890635 A1 EA201890635 A1 EA 201890635A1
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Prior art keywords
peptides
present
immunotherapy
lung
combinations
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EA201890635A
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English (en)
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Андреа Махр
Тони Вайншенк
Валентина Голдфингер
Оливер Шур
Дженс Фритше
Харприт Сингх
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Имматикс Байотекнолоджиз Гмбх
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Publication of EA201890635A1 publication Critical patent/EA201890635A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Настоящее изобретение относится к пептидам, белкам, нуклеиновым кислотам и клеткам для применения в иммунотерапевтических методах. В частности, настоящее изобретение относится к иммунотерапии рака. Настоящее изобретение относится далее к опухолеассоциированным пептидным эпитопам T-клеток, в отдельности или в комбинации с другими опухолеассоциированными пептидами, которые могут, например, служить в качестве активных фармацевтических ингредиентов вакцинных композиций, стимулирующих противоопухолевые иммунные ответы, или стимулировать T-клетки ex vivo с их перенесением в организм пациента. Пептиды, связанные с молекулами главного комплекса гистосовместимости (МНС), или пептиды в отдельности могут быть также мишенями антител, растворимых T-клеточных рецепторов и других связывающих молекул.
EA201890635A 2015-10-05 2016-09-30 Пептиды и комбинации пептидов для применения в иммунотерапии мелкоклеточного рака легких и других видов рака EA201890635A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562237091P 2015-10-05 2015-10-05
GBGB1517538.3A GB201517538D0 (en) 2015-10-05 2015-10-05 Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
PCT/EP2016/073416 WO2017060169A1 (en) 2015-10-05 2016-09-30 Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

Publications (1)

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EA201890635A1 true EA201890635A1 (ru) 2018-09-28

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EA201890635A EA201890635A1 (ru) 2015-10-05 2016-09-30 Пептиды и комбинации пептидов для применения в иммунотерапии мелкоклеточного рака легких и других видов рака

Country Status (18)

Country Link
US (5) US10253077B2 (ru)
EP (1) EP3359560A1 (ru)
JP (4) JP6868010B2 (ru)
KR (1) KR20180055826A (ru)
CN (1) CN108699119A (ru)
AU (3) AU2016335177B2 (ru)
CA (1) CA3001074A1 (ru)
CL (1) CL2018000780A1 (ru)
CO (1) CO2018003659A2 (ru)
CR (3) CR20200516A (ru)
EA (1) EA201890635A1 (ru)
GB (1) GB201517538D0 (ru)
MA (2) MA45424A (ru)
MX (1) MX2018004140A (ru)
PE (1) PE20181799A1 (ru)
SG (2) SG10202003124TA (ru)
TW (1) TWI776245B (ru)
WO (1) WO2017060169A1 (ru)

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