EA201791669A3 - Новые терапевтические подходы в лечении смт и связанных с ней расстройств - Google Patents
Новые терапевтические подходы в лечении смт и связанных с ней расстройствInfo
- Publication number
- EA201791669A3 EA201791669A3 EA201791669A EA201791669A EA201791669A3 EA 201791669 A3 EA201791669 A3 EA 201791669A3 EA 201791669 A EA201791669 A EA 201791669A EA 201791669 A EA201791669 A EA 201791669A EA 201791669 A3 EA201791669 A3 EA 201791669A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- related disorders
- smt
- treatment
- new therapeutic
- therapeutic approaches
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 101001000631 Homo sapiens Peripheral myelin protein 22 Proteins 0.000 abstract 1
- 101001082860 Homo sapiens Peroxisomal membrane protein 2 Proteins 0.000 abstract 1
- 102100030564 Peroxisomal membrane protein 2 Human genes 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к композициям и способам для лечения болезни Шарко-Мари-Тусса и связанных с ней расстройств. Более конкретно, изобретение относится к комбинированной терапии для лечения указанного заболевания, воздействуя на экспрессию РМР22 у больного.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07301614A EP2065038A1 (en) | 2007-11-30 | 2007-11-30 | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
US99180007P | 2007-12-03 | 2007-12-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201791669A2 EA201791669A2 (ru) | 2017-12-29 |
EA201791669A3 true EA201791669A3 (ru) | 2018-03-30 |
EA035711B1 EA035711B1 (ru) | 2020-07-29 |
Family
ID=39264515
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000914A EA019402B1 (ru) | 2007-11-30 | 2008-11-28 | Композиции и способ лечения болезни шарко-мари-тусса |
EA201791669A EA035711B1 (ru) | 2007-11-30 | 2008-11-28 | Применение d-сорбита для лечения смт и связанных с ним расстройств |
EA201301078A EA032767B1 (ru) | 2007-11-30 | 2008-11-28 | Применение баклофена или его соли для лечения болезни шарко-мари-тусса (смт) и связанного с ней расстройства |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201000914A EA019402B1 (ru) | 2007-11-30 | 2008-11-28 | Композиции и способ лечения болезни шарко-мари-тусса |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201301078A EA032767B1 (ru) | 2007-11-30 | 2008-11-28 | Применение баклофена или его соли для лечения болезни шарко-мари-тусса (смт) и связанного с ней расстройства |
Country Status (24)
Country | Link |
---|---|
US (6) | US8992891B2 (ru) |
EP (4) | EP2065038A1 (ru) |
JP (4) | JP5953000B2 (ru) |
KR (1) | KR101546031B1 (ru) |
CN (2) | CN101883561B (ru) |
AU (1) | AU2008328745B2 (ru) |
BR (1) | BRPI0819678A2 (ru) |
CA (3) | CA3031490C (ru) |
CY (2) | CY1113980T1 (ru) |
DK (2) | DK2211846T3 (ru) |
EA (3) | EA019402B1 (ru) |
ES (3) | ES2831855T3 (ru) |
HR (2) | HRP20130345T1 (ru) |
HU (1) | HUE040596T2 (ru) |
IL (1) | IL205741A0 (ru) |
LT (1) | LT2609916T (ru) |
MX (1) | MX2010005709A (ru) |
NZ (1) | NZ585440A (ru) |
PL (2) | PL2211846T3 (ru) |
PT (2) | PT2211846E (ru) |
SI (2) | SI2609916T1 (ru) |
TR (1) | TR201819564T4 (ru) |
WO (1) | WO2009068668A1 (ru) |
ZA (1) | ZA201003610B (ru) |
Families Citing this family (32)
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EP2065038A1 (en) * | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
EP2135607A1 (en) * | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
US20110213193A1 (en) * | 2008-08-28 | 2011-09-01 | The Florida International University Board Of Trustees | Magnetic Nanodelivery of Therapeutic Agents Across the Blood Brain Barrier |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
EP2263665A1 (en) | 2009-06-02 | 2010-12-22 | Pharnext | New compositions for treating CMT and related disorders |
US9494605B2 (en) * | 2009-11-20 | 2016-11-15 | Pharnext | Diagnostic tools for charcot-marie-tooth disease |
EP2523661B1 (en) | 2010-01-15 | 2017-05-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nkcc inhibitors for the treatment of autism |
EP2624832B1 (en) * | 2010-10-08 | 2017-09-27 | Vib Vzw | Hdac inhibitors to treat charcot-marie-tooth disease |
CN102464610B (zh) * | 2010-11-16 | 2014-07-30 | 北大方正集团有限公司 | 一种美替拉酮的制备方法 |
EP3502236B1 (en) | 2011-02-18 | 2023-08-23 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
AU2012221704B2 (en) | 2011-02-23 | 2013-12-05 | Coeruleus Ltd. | Flumazenil complexes, compositions comprising same and uses thereof |
UA115968C2 (uk) | 2011-03-01 | 2018-01-25 | Фарнекст | Нові композиції для лікування неврологічних захворювань |
US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
EP2705842A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
CN102247324B (zh) * | 2011-07-14 | 2012-11-21 | 海南美兰史克制药有限公司 | 一种氟马西尼脂质体注射液 |
CN102887830B (zh) * | 2012-09-04 | 2013-11-27 | 苏州弘森药业有限公司 | 一种盐酸酚苄明的制备方法 |
WO2014063163A1 (en) | 2012-10-19 | 2014-04-24 | Block Jonathan D | Systems and methods for nerve mapping and monitoring |
EP2931267A1 (en) * | 2012-12-17 | 2015-10-21 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of x-linked charcot-marie-tooth |
WO2014195394A1 (en) | 2013-06-05 | 2014-12-11 | Pharnext | Stable oral solutions for combined api |
WO2015121218A1 (en) | 2014-02-11 | 2015-08-20 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
SG11201606485VA (en) * | 2014-02-24 | 2016-09-29 | Pharnext | New compositions for treating mechanical neuronal injuries |
WO2016187595A2 (en) * | 2015-05-20 | 2016-11-24 | Lupin Atlantis Holdings Sa | Oral pharmaceutical composition of methylergonovine |
AU2017229778A1 (en) | 2016-03-09 | 2018-08-16 | Ionis Pharmaceuticals, Inc. | Methods and compositions for inhibiting PMP22 expression |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
WO2018014007A1 (en) * | 2016-07-14 | 2018-01-18 | Sidewaystrategies Llc | System and methods for improving diagnostic evoked potential studies for functional assessments of nerves and nerve pathways |
CA3044691A1 (en) | 2016-10-26 | 2018-05-03 | Genea Biocells USA (Holdings), Inc. | Improved generation of muscle lineage cells and therapeutic uses thereof |
BR112020001755A2 (pt) | 2017-07-28 | 2020-07-21 | Applied Therapeutics Inc. | composições e métodos para o tratamento de galactosemia |
EP3966320A4 (en) * | 2019-05-07 | 2023-10-25 | University of Miami | TREATMENT AND DETECTION OF HEREDITARY NEUROPATHIES AND ASSOCIATED DISORDERS |
AU2021264454A1 (en) * | 2020-05-01 | 2022-12-08 | Applied Therapeutics, Inc. | Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency |
EP4019016A1 (en) * | 2020-12-24 | 2022-06-29 | Allaysis, LLC | Methods of administering intravenous baclofen |
US11523984B1 (en) * | 2021-11-12 | 2022-12-13 | Amneal Pharmaceuticals Llc | Compositions and methods of administering baclofen |
WO2023182288A1 (ja) * | 2022-03-22 | 2023-09-28 | 国立大学法人京都大学 | シャルコー・マリー・ツース病の治療または予防薬 |
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FR2842422B1 (fr) | 2002-07-16 | 2006-06-30 | Univ Aix Marseille Ii | Compositions destinees au traitement des neuropathies peripheriques, preparation et utilisations |
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EP2065038A1 (en) * | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
EP2263665A1 (en) | 2009-06-02 | 2010-12-22 | Pharnext | New compositions for treating CMT and related disorders |
EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
IT1400067B1 (it) | 2010-05-21 | 2013-05-17 | Molteni & C | Spray nasale liquido contenente naltrexone a bassi dosaggi. |
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US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
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2007
- 2007-11-30 EP EP07301614A patent/EP2065038A1/en not_active Withdrawn
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2008
- 2008-11-28 DK DK08854467.1T patent/DK2211846T3/da active
- 2008-11-28 ES ES18203488T patent/ES2831855T3/es active Active
- 2008-11-28 EP EP12196650.1A patent/EP2609916B1/en active Active
- 2008-11-28 NZ NZ585440A patent/NZ585440A/en unknown
- 2008-11-28 DK DK12196650.1T patent/DK2609916T3/en active
- 2008-11-28 CN CN200880118498.4A patent/CN101883561B/zh active Active
- 2008-11-28 US US12/744,962 patent/US8992891B2/en active Active
- 2008-11-28 EP EP08854467A patent/EP2211846B1/en active Active
- 2008-11-28 JP JP2010535399A patent/JP5953000B2/ja active Active
- 2008-11-28 CN CN201410322856.0A patent/CN104257657B/zh active Active
- 2008-11-28 SI SI200832028T patent/SI2609916T1/sl unknown
- 2008-11-28 ES ES12196650T patent/ES2703508T3/es active Active
- 2008-11-28 LT LTEP12196650.1T patent/LT2609916T/lt unknown
- 2008-11-28 HU HUE12196650A patent/HUE040596T2/hu unknown
- 2008-11-28 PL PL08854467T patent/PL2211846T3/pl unknown
- 2008-11-28 EA EA201000914A patent/EA019402B1/ru not_active IP Right Cessation
- 2008-11-28 AU AU2008328745A patent/AU2008328745B2/en active Active
- 2008-11-28 BR BRPI0819678A patent/BRPI0819678A2/pt not_active Application Discontinuation
- 2008-11-28 PT PT88544671T patent/PT2211846E/pt unknown
- 2008-11-28 CA CA3031490A patent/CA3031490C/en active Active
- 2008-11-28 PT PT12196650T patent/PT2609916T/pt unknown
- 2008-11-28 SI SI200830954T patent/SI2211846T1/sl unknown
- 2008-11-28 EA EA201791669A patent/EA035711B1/ru not_active IP Right Cessation
- 2008-11-28 KR KR1020107014240A patent/KR101546031B1/ko active IP Right Grant
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