EA201790881A1 - 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr - Google Patents

5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

Info

Publication number
EA201790881A1
EA201790881A1 EA201790881A EA201790881A EA201790881A1 EA 201790881 A1 EA201790881 A1 EA 201790881A1 EA 201790881 A EA201790881 A EA 201790881A EA 201790881 A EA201790881 A EA 201790881A EA 201790881 A1 EA201790881 A1 EA 201790881A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fxr
steroids
beta
hydroxy
alkyl
Prior art date
Application number
EA201790881A
Other languages
English (en)
Other versions
EA201790881A8 (ru
EA033445B1 (ru
Inventor
Александер Уэймаут-Уилсон
Зофиа Комста
Джеймс Бойдэлл
Лаура Уоллис
Натан Бартлетт
Монтсеррат Шелборн
Original Assignee
ЭнЗиПи Юкей ЛИМИТЕД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by ЭнЗиПи Юкей ЛИМИТЕД filed Critical ЭнЗиПи Юкей ЛИМИТЕД
Publication of EA201790881A1 publication Critical patent/EA201790881A1/ru
Publication of EA201790881A8 publication Critical patent/EA201790881A8/ru
Publication of EA033445B1 publication Critical patent/EA033445B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к соединениям формулы (I)где R, R, Y, Rи Rявляются такими, как определено в описании. Эти соединения являются промежуточными соединениями в синтезе синтетических желчных кислот.
EA201790881A 2014-11-19 2015-11-19 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr EA033445B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (3)

Publication Number Publication Date
EA201790881A1 true EA201790881A1 (ru) 2017-11-30
EA201790881A8 EA201790881A8 (ru) 2019-07-31
EA033445B1 EA033445B1 (ru) 2019-10-31

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790881A EA033445B1 (ru) 2014-11-19 2015-11-19 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

Country Status (14)

Country Link
US (1) US10131688B2 (ru)
EP (1) EP3221332B1 (ru)
JP (1) JP6724004B2 (ru)
KR (1) KR102526632B1 (ru)
CN (1) CN107108687B (ru)
CA (1) CA2968301C (ru)
DK (1) DK3221332T3 (ru)
EA (1) EA033445B1 (ru)
ES (1) ES2733643T3 (ru)
HK (1) HK1244285B (ru)
MX (1) MX2017006564A (ru)
PL (1) PL3221332T3 (ru)
TW (1) TWI686400B (ru)
WO (1) WO2016079518A1 (ru)

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Publication number Publication date
TW201629081A (zh) 2016-08-16
CA2968301C (en) 2023-05-16
TWI686400B (zh) 2020-03-01
HK1244285B (zh) 2020-06-05
KR20170099895A (ko) 2017-09-01
CA2968301A1 (en) 2016-05-26
EA201790881A8 (ru) 2019-07-31
EA033445B1 (ru) 2019-10-31
JP2017538691A (ja) 2017-12-28
CN107108687B (zh) 2019-10-29
PL3221332T3 (pl) 2019-10-31
CN107108687A (zh) 2017-08-29
KR102526632B1 (ko) 2023-04-27
US10131688B2 (en) 2018-11-20
US20170320907A1 (en) 2017-11-09
MX2017006564A (es) 2018-01-26
EP3221332A1 (en) 2017-09-27
EP3221332B1 (en) 2019-04-24
DK3221332T3 (da) 2019-07-29
JP6724004B2 (ja) 2020-07-15
ES2733643T3 (es) 2019-12-02
WO2016079518A1 (en) 2016-05-26

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