EA201692359A1 - Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса - Google Patents

Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса

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Publication number
EA201692359A1
EA201692359A1 EA201692359A EA201692359A EA201692359A1 EA 201692359 A1 EA201692359 A1 EA 201692359A1 EA 201692359 A EA201692359 A EA 201692359A EA 201692359 A EA201692359 A EA 201692359A EA 201692359 A1 EA201692359 A1 EA 201692359A1
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EA
Eurasian Patent Office
Prior art keywords
virus
prrsv
seq
proteins
isolated
Prior art date
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EA201692359A
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English (en)
Other versions
EA038012B1 (ru
Inventor
Ким Бургард
Джереми Кролл
Сэра М. Лейтон
Фолькер Олингер
Франсуа-Ксавьер Орвейон
Штефан Пеш
Майкл Деннис Пёнтковский
Майкл Б. Руф
Филип Атли
Эрик Мартин Вон
Original Assignee
Бёрингер Ингельхайм Ветмедика Гмбх
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Publication of EA201692359A1 publication Critical patent/EA201692359A1/ru
Publication of EA038012B1 publication Critical patent/EA038012B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10064—Methods of inactivation or attenuation by serial passage
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10071—Demonstrated in vivo effect

Abstract

В заявке описана композиция, включающая новый штамм европейского PRRSV, или белки, по меньшей мере на 98% идентичные SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 и SEQ ID NO: 9, содержащий эту композицию продукт, представляющий собой вакцину, и их применение, а также выделенная нуклеиновая кислота и рекомбинантный экспрессионный вектор, предназначенные для получения белков, входящих в заявленную композицию.
EA201692359A 2011-02-17 2012-02-14 Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса EA038012B1 (ru)

Applications Claiming Priority (1)

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US201161444074P 2011-02-17 2011-02-17

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EA201692359A1 true EA201692359A1 (ru) 2017-04-28
EA038012B1 EA038012B1 (ru) 2021-06-23

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EA201300915A EA035624B1 (ru) 2011-02-17 2012-02-14 Вирулентный и ослабленный штаммы вируса репродуктивно-респираторного синдрома свиней (prrsv) европейского типа
EA201692359A EA038012B1 (ru) 2011-02-17 2012-02-14 Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса

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US (4) US8765142B2 (ru)
EP (2) EP2959916B1 (ru)
JP (1) JP5788027B2 (ru)
KR (2) KR102073075B1 (ru)
CN (2) CN103370078B (ru)
AR (2) AR085272A1 (ru)
AU (2) AU2012217169B2 (ru)
BR (2) BR112013021076B1 (ru)
CA (1) CA2826341C (ru)
CL (1) CL2013002379A1 (ru)
CO (1) CO6791570A2 (ru)
CY (1) CY1116835T1 (ru)
DK (2) DK2675475T3 (ru)
EA (2) EA035624B1 (ru)
ES (2) ES2550258T3 (ru)
HR (1) HRP20151031T1 (ru)
HU (1) HUE027731T2 (ru)
ME (1) ME02271B (ru)
MX (2) MX355058B (ru)
MY (2) MY186535A (ru)
PH (1) PH12017500962A1 (ru)
PL (2) PL2959916T3 (ru)
PT (2) PT2675475E (ru)
RS (1) RS54231B1 (ru)
SG (1) SG192820A1 (ru)
SI (1) SI2675475T1 (ru)
SM (1) SMT201500236B (ru)
TW (2) TWI673362B (ru)
UA (2) UA112768C2 (ru)
WO (1) WO2012110489A2 (ru)

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