EA201691208A1 - Фумаратредуктазы - Google Patents
ФумаратредуктазыInfo
- Publication number
- EA201691208A1 EA201691208A1 EA201691208A EA201691208A EA201691208A1 EA 201691208 A1 EA201691208 A1 EA 201691208A1 EA 201691208 A EA201691208 A EA 201691208A EA 201691208 A EA201691208 A EA 201691208A EA 201691208 A1 EA201691208 A1 EA 201691208A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dependent
- fumarate reductase
- reductase activity
- fumarateductases
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01006—Fumarate reductase (NADH) (1.3.1.6)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Настоящее изобретение относится к вариантному полипептиду, имеющему активность фумаратредуктазы, которая имеет модифицированную NADP(H)-зависимую и/или NAD(H)-зависимую активность по сравнению с эталонным полипептидом, имеющим активность фумаратредуктазы. Такой вариант может быть сверхэкспрессирован в клетке-хозяине для улучшения выработки дикарбоновой кислоты.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13196950 | 2013-12-12 | ||
PCT/EP2014/077638 WO2015086839A1 (en) | 2013-12-12 | 2014-12-12 | Fumarate reductases |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201691208A1 true EA201691208A1 (ru) | 2016-12-30 |
EA037088B1 EA037088B1 (ru) | 2021-02-04 |
Family
ID=49726663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691208A EA037088B1 (ru) | 2013-12-12 | 2014-12-12 | Фумаратредуктазы |
Country Status (8)
Country | Link |
---|---|
US (1) | US9944905B2 (ru) |
EP (1) | EP3080251B1 (ru) |
CN (2) | CN105814198A (ru) |
BR (1) | BR112016013526A2 (ru) |
CA (1) | CA2931591C (ru) |
EA (1) | EA037088B1 (ru) |
ES (1) | ES2790573T3 (ru) |
WO (1) | WO2015086839A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3485004B1 (en) * | 2016-07-13 | 2021-09-22 | DSM IP Assets B.V. | Malate dehyrogenases |
US20210207076A1 (en) * | 2018-05-25 | 2021-07-08 | Danisco Us Inc. | Overexpression of fumarate reductase results in an increased fermentation rate in yeast |
CN114806913B (zh) * | 2022-04-15 | 2023-11-28 | 盛虹控股集团有限公司 | 具有线粒体定位还原tca途径的高产琥珀酸酵母工程菌株及其构建方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2522622T3 (es) * | 2007-11-20 | 2014-11-17 | Dsm Ip Assets B.V. | Producción de ácido succínico en una célula eucariota |
EP2297297B1 (en) * | 2008-07-08 | 2017-02-08 | DSM IP Assets B.V. | Succinic acid production by fermentation at low ph |
WO2010111344A2 (en) * | 2009-03-24 | 2010-09-30 | Microbia, Inc. | Methods and microorganisms for production of c4-dicarboxylic acids |
WO2010118932A1 (en) * | 2009-04-15 | 2010-10-21 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
-
2014
- 2014-12-12 EP EP14833137.4A patent/EP3080251B1/en active Active
- 2014-12-12 ES ES14833137T patent/ES2790573T3/es active Active
- 2014-12-12 CA CA2931591A patent/CA2931591C/en active Active
- 2014-12-12 BR BR112016013526A patent/BR112016013526A2/pt not_active Application Discontinuation
- 2014-12-12 EA EA201691208A patent/EA037088B1/ru unknown
- 2014-12-12 WO PCT/EP2014/077638 patent/WO2015086839A1/en active Application Filing
- 2014-12-12 CN CN201480067432.2A patent/CN105814198A/zh active Pending
- 2014-12-12 US US15/103,237 patent/US9944905B2/en active Active
- 2014-12-12 CN CN202010993538.2A patent/CN112094826B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015086839A1 (en) | 2015-06-18 |
ES2790573T3 (es) | 2020-10-28 |
CN112094826A (zh) | 2020-12-18 |
CN105814198A (zh) | 2016-07-27 |
WO2015086839A9 (en) | 2016-09-09 |
US9944905B2 (en) | 2018-04-17 |
BR112016013526A2 (pt) | 2017-10-03 |
CA2931591C (en) | 2023-09-19 |
EA037088B1 (ru) | 2021-02-04 |
EP3080251A1 (en) | 2016-10-19 |
CN112094826B (zh) | 2023-12-19 |
US20160319245A1 (en) | 2016-11-03 |
CA2931591A1 (en) | 2015-06-18 |
EP3080251B1 (en) | 2020-03-04 |
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