EA201690731A1 - Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах - Google Patents
Анализ igfbp7, имеющий улучшенную характеристику в биологических образцахInfo
- Publication number
- EA201690731A1 EA201690731A1 EA201690731A EA201690731A EA201690731A1 EA 201690731 A1 EA201690731 A1 EA 201690731A1 EA 201690731 A EA201690731 A EA 201690731A EA 201690731 A EA201690731 A EA 201690731A EA 201690731 A1 EA201690731 A1 EA 201690731A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- analysis
- igfbp7
- improved characteristics
- biological specimens
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4745—Insulin-like growth factor binding protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
В настоящем изобретении предложены иммунологические анализы IGFBP7 с улучшенными клиническими характеристиками, в частности, при применении для оценки повреждений почек. Указанные иммунологические анализы основаны на выборе и применении антител и пар антител, демонстрирующих улучшенные аналитические характеристики при применении в сложных клинических образцах, таких как биологические жидкости, и, в частности, при применении в формате экспресс-анализа, например, в устройствах для анализа латерального растекания.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361900942P | 2013-11-06 | 2013-11-06 | |
US201462054324P | 2014-09-23 | 2014-09-23 | |
US201462064380P | 2014-10-15 | 2014-10-15 | |
PCT/US2014/064327 WO2015069880A1 (en) | 2013-11-06 | 2014-11-06 | Assays for igfbp7 having improved performance in biological samples |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201690731A1 true EA201690731A1 (ru) | 2016-10-31 |
Family
ID=53042071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690731A EA201690731A1 (ru) | 2013-11-06 | 2014-11-06 | Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах |
Country Status (12)
Country | Link |
---|---|
US (3) | US9822172B2 (ru) |
EP (2) | EP3556863A1 (ru) |
JP (4) | JP2017501211A (ru) |
KR (1) | KR102404285B1 (ru) |
CN (1) | CN105793439B (ru) |
AU (1) | AU2014346695B2 (ru) |
BR (1) | BR112016010106A2 (ru) |
CA (2) | CA2929547C (ru) |
EA (1) | EA201690731A1 (ru) |
HK (1) | HK1221490A1 (ru) |
MX (1) | MX2016005834A (ru) |
WO (1) | WO2015069880A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102246035B (zh) | 2008-10-21 | 2014-10-22 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
KR20120123056A (ko) | 2009-12-20 | 2012-11-07 | 아스튜트 메디컬 인코포레이티드 | 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물 |
EP3339860A1 (en) | 2010-06-23 | 2018-06-27 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US10935548B2 (en) | 2011-12-08 | 2021-03-02 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2 |
CN105074466B (zh) | 2013-01-17 | 2018-01-09 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
WO2015084939A1 (en) | 2013-12-03 | 2015-06-11 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
US11243202B2 (en) | 2015-04-09 | 2022-02-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP3359966B1 (en) * | 2015-10-08 | 2020-01-01 | Roche Diagnostics GmbH | Igfbp7 for prediction of risk of aki when measured prior to surgery |
AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
WO2018187453A1 (en) | 2017-04-05 | 2018-10-11 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
WO2019227055A1 (en) | 2018-05-24 | 2019-11-28 | Renibus Therapeutics, Inc. | Methods of treating patients at risk for renal injury and renal failure |
WO2020234482A1 (en) * | 2019-05-21 | 2020-11-26 | Universität Zürich | MAPKi RESISTANCE SIGNATURES |
KR102533791B1 (ko) * | 2022-09-15 | 2023-05-18 | 경북대학교 산학협력단 | 비색법 신호형질 복합체, 이를 이용하는 신장질환 진단용 키트 및 진단법 |
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-
2014
- 2014-11-06 EP EP19158290.7A patent/EP3556863A1/en active Pending
- 2014-11-06 JP JP2016552481A patent/JP2017501211A/ja active Pending
- 2014-11-06 KR KR1020167014700A patent/KR102404285B1/ko active IP Right Grant
- 2014-11-06 US US15/035,205 patent/US9822172B2/en active Active
- 2014-11-06 EP EP14860878.9A patent/EP3066221A4/en not_active Withdrawn
- 2014-11-06 CA CA2929547A patent/CA2929547C/en active Active
- 2014-11-06 AU AU2014346695A patent/AU2014346695B2/en active Active
- 2014-11-06 CN CN201480066318.8A patent/CN105793439B/zh active Active
- 2014-11-06 CA CA3185700A patent/CA3185700A1/en active Pending
- 2014-11-06 BR BR112016010106A patent/BR112016010106A2/pt not_active Application Discontinuation
- 2014-11-06 WO PCT/US2014/064327 patent/WO2015069880A1/en active Application Filing
- 2014-11-06 EA EA201690731A patent/EA201690731A1/ru unknown
- 2014-11-06 MX MX2016005834A patent/MX2016005834A/es active IP Right Grant
-
2016
- 2016-08-11 HK HK16109610.3A patent/HK1221490A1/zh unknown
-
2017
- 2017-11-20 US US15/818,669 patent/US10562961B2/en active Active
-
2019
- 2019-11-25 JP JP2019212462A patent/JP2020048569A/ja active Pending
-
2020
- 2020-01-17 US US16/745,781 patent/US20200247879A1/en not_active Abandoned
-
2022
- 2022-01-13 JP JP2022003920A patent/JP7277623B2/ja active Active
-
2023
- 2023-01-06 JP JP2023000938A patent/JP2023052239A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2929547A1 (en) | 2015-05-14 |
JP7277623B2 (ja) | 2023-05-19 |
AU2014346695B2 (en) | 2020-10-15 |
MX2016005834A (es) | 2016-11-17 |
KR20160068988A (ko) | 2016-06-15 |
KR102404285B1 (ko) | 2022-05-31 |
US20180066045A1 (en) | 2018-03-08 |
CA3185700A1 (en) | 2015-05-14 |
WO2015069880A1 (en) | 2015-05-14 |
JP2017501211A (ja) | 2017-01-12 |
US20200247879A1 (en) | 2020-08-06 |
US10562961B2 (en) | 2020-02-18 |
CN105793439A (zh) | 2016-07-20 |
BR112016010106A2 (pt) | 2017-12-05 |
JP2020048569A (ja) | 2020-04-02 |
AU2014346695A1 (en) | 2016-06-16 |
CN105793439B (zh) | 2020-09-04 |
CA2929547C (en) | 2023-02-28 |
EP3066221A4 (en) | 2017-09-20 |
US20160289308A1 (en) | 2016-10-06 |
US9822172B2 (en) | 2017-11-21 |
EP3066221A1 (en) | 2016-09-14 |
HK1221490A1 (zh) | 2017-06-02 |
JP2023052239A (ja) | 2023-04-11 |
JP2022068143A (ja) | 2022-05-09 |
EP3556863A1 (en) | 2019-10-23 |
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