EA201492067A1 - Применение связывающих семафорин-4d молекул для промотирования нейрогенеза после инсульта - Google Patents

Применение связывающих семафорин-4d молекул для промотирования нейрогенеза после инсульта

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Publication number
EA201492067A1
EA201492067A1 EA201492067A EA201492067A EA201492067A1 EA 201492067 A1 EA201492067 A1 EA 201492067A1 EA 201492067 A EA201492067 A EA 201492067A EA 201492067 A EA201492067 A EA 201492067A EA 201492067 A1 EA201492067 A1 EA 201492067A1
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EA
Eurasian Patent Office
Prior art keywords
semaforin
stroke
molecules
binding
application
Prior art date
Application number
EA201492067A
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English (en)
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EA030796B1 (ru
Inventor
Эрнест С. Смит
Морис Заудерер
Original Assignee
Вэксинекс, Инк.
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Publication date
Application filed by Вэксинекс, Инк. filed Critical Вэксинекс, Инк.
Publication of EA201492067A1 publication Critical patent/EA201492067A1/ru
Publication of EA030796B1 publication Critical patent/EA030796B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Представлены способы промотирования нейрогенеза в нервной ткани пациента, имеющего по меньшей мере один из симптомов расстройства центральной нервной системы, включающие введение индивиду, нуждающемуся в этом, эффективного количества выделенной связывающей молекулы, которая специфически связывается с семафорином-4D (SEMA4D).
EA201492067A 2012-05-11 2013-05-10 Применение связывающих семафорин-4d молекул для промотирования нейрогенеза после инсульта EA030796B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261646119P 2012-05-11 2012-05-11
US13/842,523 US10494440B2 (en) 2012-05-11 2013-03-15 Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
PCT/US2013/040661 WO2013170221A1 (en) 2012-05-11 2013-05-10 Use of semaphorin-4d binding molecules to promote neurogenesis following stroke

Publications (2)

Publication Number Publication Date
EA201492067A1 true EA201492067A1 (ru) 2015-05-29
EA030796B1 EA030796B1 (ru) 2018-09-28

Family

ID=49548777

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492067A EA030796B1 (ru) 2012-05-11 2013-05-10 Применение связывающих семафорин-4d молекул для промотирования нейрогенеза после инсульта

Country Status (18)

Country Link
US (1) US10494440B2 (ru)
EP (1) EP2846831B1 (ru)
JP (1) JP6218810B2 (ru)
KR (1) KR102105436B1 (ru)
CN (2) CN110064054A (ru)
AU (1) AU2013259192B2 (ru)
BR (1) BR112014028160B1 (ru)
CA (1) CA2872928C (ru)
DK (1) DK2846831T3 (ru)
EA (1) EA030796B1 (ru)
ES (1) ES2882881T3 (ru)
IL (1) IL235603B (ru)
MX (1) MX358991B (ru)
NZ (1) NZ630864A (ru)
PT (1) PT2846831T (ru)
SG (1) SG11201407416XA (ru)
WO (1) WO2013170221A1 (ru)
ZA (1) ZA201501674B (ru)

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US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
JP6611709B2 (ja) 2013-06-25 2019-11-27 バクシネックス インコーポレーティッド 腫瘍成長および転移を阻害するための免疫調節療法との組み合わせでのセマフォリン−４ｄ阻害分子の使用
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US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
JP6611709B2 (ja) 2013-06-25 2019-11-27 バクシネックス インコーポレーティッド 腫瘍成長および転移を阻害するための免疫調節療法との組み合わせでのセマフォリン−４ｄ阻害分子の使用
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NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
BR112019017367A2 (pt) * 2017-02-22 2020-04-14 Vaccinex Inc detecção precoce de ativação de célula glial em doenças neurodegenerativas ou neuroinflamatórias

Also Published As

Publication number Publication date
US20130302320A1 (en) 2013-11-14
KR20150018555A (ko) 2015-02-23
IL235603B (en) 2020-01-30
DK2846831T3 (en) 2021-10-11
ES2882881T3 (es) 2021-12-03
BR112014028160B1 (pt) 2021-01-12
NZ630864A (en) 2017-03-31
ZA201501674B (en) 2021-06-30
EA030796B1 (ru) 2018-09-28
MX358991B (es) 2018-08-31
EP2846831B1 (en) 2021-07-07
PT2846831T (pt) 2021-08-19
EP2846831A4 (en) 2015-11-18
AU2013259192B2 (en) 2018-02-22
CN110064054A (zh) 2019-07-30
IL235603A0 (en) 2015-01-29
SG11201407416XA (en) 2015-03-30
JP6218810B2 (ja) 2017-10-25
CA2872928C (en) 2021-02-16
JP2015517502A (ja) 2015-06-22
EP2846831A1 (en) 2015-03-18
KR102105436B1 (ko) 2020-04-29
CA2872928A1 (en) 2013-11-14
US10494440B2 (en) 2019-12-03
AU2013259192A1 (en) 2014-11-27
MX2014013676A (es) 2015-02-05
WO2013170221A1 (en) 2013-11-14
CN104619341A (zh) 2015-05-13

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