EA201490911A1 - Способы лечения злокачественных опухолей с использованием пероральных составов аналогов цитидина - Google Patents

Способы лечения злокачественных опухолей с использованием пероральных составов аналогов цитидина

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Publication number
EA201490911A1
EA201490911A1 EA201490911A EA201490911A EA201490911A1 EA 201490911 A1 EA201490911 A1 EA 201490911A1 EA 201490911 A EA201490911 A EA 201490911A EA 201490911 A EA201490911 A EA 201490911A EA 201490911 A1 EA201490911 A1 EA 201490911A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
treatment
cytidine
disorders
malignant tumors
Prior art date
Application number
EA201490911A
Other languages
English (en)
Inventor
Кайл Дж. Макбет
Аарон Н. Нгуйен
Йорге Димартино
Original Assignee
Селджин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of EA201490911A1 publication Critical patent/EA201490911A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Abstract

В настоящем описании предоставлены способы лечения индивидуумов, страдающих злокачественной опухолью, такой как рецидивирующая или резистентная солидная опухоль, где способ включает введение индивидууму аналога цитидина. В определенных способах аналог цитидина вводят отдельно или в комбинации с одним или более противоопухолевых средств. Также раскрыты способы применения аналога цитидина для лечения заболеваний и нарушений, включая наряду с другими нарушения, связанные с аномальной клеточной пролиферацией, нарушения со стороны кроветворной системы и иммунные нарушения. В определенных способах аналог цитидина вводят в состав пероральной лекарственной формы и вводят перорально.
EA201490911A 2011-11-01 2012-10-31 Способы лечения злокачественных опухолей с использованием пероральных составов аналогов цитидина EA201490911A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161554344P 2011-11-01 2011-11-01
PCT/US2012/062845 WO2013067043A1 (en) 2011-11-01 2012-10-31 Methods for treating cancers using oral formulations of cytidine analogs

Publications (1)

Publication Number Publication Date
EA201490911A1 true EA201490911A1 (ru) 2014-09-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490911A EA201490911A1 (ru) 2011-11-01 2012-10-31 Способы лечения злокачественных опухолей с использованием пероральных составов аналогов цитидина

Country Status (16)

Country Link
US (2) US9125884B2 (ru)
EP (1) EP2773322A1 (ru)
JP (1) JP6162709B2 (ru)
KR (1) KR20140088603A (ru)
CN (1) CN104168884A (ru)
AU (1) AU2012318239B2 (ru)
BR (1) BR112014010417A2 (ru)
CA (1) CA2853949A1 (ru)
EA (1) EA201490911A1 (ru)
HK (1) HK1200716A1 (ru)
IL (1) IL232268A0 (ru)
MX (1) MX2014005314A (ru)
SG (1) SG11201401946QA (ru)
TW (2) TW201700103A (ru)
WO (1) WO2013067043A1 (ru)
ZA (2) ZA201403106B (ru)

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Also Published As

Publication number Publication date
SG11201401946QA (en) 2014-05-29
JP6162709B2 (ja) 2017-07-12
ZA201403106B (en) 2015-08-26
BR112014010417A2 (pt) 2014-11-18
TWI558401B (zh) 2016-11-21
EP2773322A1 (en) 2014-09-10
US20150216886A1 (en) 2015-08-06
KR20140088603A (ko) 2014-07-10
TW201700103A (zh) 2017-01-01
JP2014532704A (ja) 2014-12-08
ZA201502909B (en) 2016-11-30
WO2013067043A1 (en) 2013-05-10
NZ624323A (en) 2016-07-29
MX2014005314A (es) 2014-09-08
CN104168884A (zh) 2014-11-26
HK1200716A1 (en) 2015-08-14
IL232268A0 (en) 2014-06-30
TW201325598A (zh) 2013-07-01
US9693987B2 (en) 2017-07-04
US9125884B2 (en) 2015-09-08
US20130109644A1 (en) 2013-05-02
AU2012318239B2 (en) 2015-07-09
AU2012318239A1 (en) 2013-05-16
CA2853949A1 (en) 2013-05-10

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