EA201490859A1 - Алкилированные соединения пиперазина в качестве ингибиторов тирозинкиназы брутона - Google Patents
Алкилированные соединения пиперазина в качестве ингибиторов тирозинкиназы брутонаInfo
- Publication number
- EA201490859A1 EA201490859A1 EA201490859A EA201490859A EA201490859A1 EA 201490859 A1 EA201490859 A1 EA 201490859A1 EA 201490859 A EA201490859 A EA 201490859A EA 201490859 A EA201490859 A EA 201490859A EA 201490859 A1 EA201490859 A1 EA 201490859A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- thyrosinkinase
- bluton
- inhibitors
- piperazine compounds
- alkylated piperazine
- Prior art date
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
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Abstract
Предложены алкилированные соединения пиперазина формулы I, включая их стереоизомеры, таутомеры и фармацевтически приемлемые соли, используемые для ингибирования киназы Btk и для лечения иммунных расстройств, таких как воспаление, опосредованное киназой Btk. Раскрыты способы применения соединений формулы I для диагностики in vitro, in situи in vivoи для лечения таких расстройств в клетках млекопитающих или связанных с ними патологических состояний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201161555395P | 2011-11-03 | 2011-11-03 | |
PCT/US2012/063198 WO2013067277A1 (en) | 2011-11-03 | 2012-11-02 | Alkylated piperazine compounds as inhibitors of btk activity |
Publications (2)
Publication Number | Publication Date |
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EA201490859A1 true EA201490859A1 (ru) | 2014-09-30 |
EA027561B1 EA027561B1 (ru) | 2017-08-31 |
Family
ID=47146780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490859A EA027561B1 (ru) | 2011-11-03 | 2012-11-02 | Алкилированные соединения пиперазина в качестве ингибиторов тирозинкиназы брутона |
Country Status (22)
Country | Link |
---|---|
US (3) | US8729072B2 (ru) |
EP (1) | EP2773639B1 (ru) |
JP (2) | JP5976828B2 (ru) |
KR (1) | KR101716011B1 (ru) |
CN (1) | CN104024255B (ru) |
AR (1) | AR088642A1 (ru) |
AU (1) | AU2012332368A1 (ru) |
BR (1) | BR112014010439A2 (ru) |
CA (1) | CA2853970A1 (ru) |
CL (1) | CL2014001158A1 (ru) |
CO (1) | CO6950475A2 (ru) |
CR (1) | CR20140187A (ru) |
EA (1) | EA027561B1 (ru) |
IL (1) | IL232280A0 (ru) |
IN (1) | IN2014CN03265A (ru) |
MA (1) | MA35725B1 (ru) |
MX (1) | MX2014005289A (ru) |
PE (1) | PE20141686A1 (ru) |
SG (1) | SG11201401993RA (ru) |
TW (1) | TW201326171A (ru) |
WO (1) | WO2013067277A1 (ru) |
ZA (1) | ZA201403158B (ru) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
JP5976828B2 (ja) * | 2011-11-03 | 2016-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Btk活性阻害剤としてのアルキル化ピペラジン化合物 |
KR101815360B1 (ko) | 2013-07-03 | 2018-01-04 | 에프. 호프만-라 로슈 아게 | 헤테로아릴 피리돈 및 아자-피리돈 아마이드 화합물 |
EP3077384B1 (en) | 2013-12-05 | 2017-09-06 | F. Hoffmann-La Roche AG | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
JP6879740B2 (ja) | 2013-12-13 | 2021-06-02 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | リンパ形質細胞性リンパ腫を処置する方法 |
AU2014361800B2 (en) | 2013-12-13 | 2020-05-07 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
WO2015151006A1 (en) | 2014-03-29 | 2015-10-08 | Lupin Limited | Substituted purine compounds as btk inhibitors |
AU2015240465B2 (en) | 2014-04-04 | 2020-02-27 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
WO2015170266A1 (en) | 2014-05-07 | 2015-11-12 | Lupin Limited | Substituted pyrimidine compounds as btk inhibitors |
CN106922146B (zh) | 2014-10-02 | 2020-05-26 | 豪夫迈·罗氏有限公司 | 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物 |
WO2016065138A1 (en) | 2014-10-22 | 2016-04-28 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
JP6368043B2 (ja) | 2014-10-27 | 2018-08-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 三環式ラクタム化合物の製造法 |
CN105837576B (zh) | 2015-01-14 | 2019-03-26 | 湖北生物医药产业技术研究院有限公司 | Btk抑制剂 |
ES2907988T3 (es) * | 2015-03-10 | 2022-04-27 | Aurigene Discovery Tech Ltd | Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores |
EP4049660A1 (en) | 2016-02-29 | 2022-08-31 | F. Hoffmann-La Roche AG | Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase |
JP2020511462A (ja) | 2016-12-03 | 2020-04-16 | ジュノー セラピューティクス インコーポレイテッド | キナーゼ阻害剤との組み合わせで治療用t細胞を使用するための方法および組成物 |
TWI766176B (zh) * | 2016-12-15 | 2022-06-01 | 瑞士商赫孚孟拉羅股份公司 | 製備btk抑制劑之方法 |
CN107445981B (zh) * | 2017-08-25 | 2018-06-22 | 牡丹江医学院 | 一种用于防治***的活性化合物 |
CN113939292A (zh) | 2019-02-25 | 2022-01-14 | 广州麓鹏制药有限公司 | Btk及其突变体的抑制剂 |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
US20220363689A1 (en) | 2019-10-05 | 2022-11-17 | Newave Pharmaceutical Inc. | Inhibitor of btk and mutants thereof |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
EP4107154A4 (en) | 2020-02-20 | 2024-02-28 | Hutchison Medipharma Ltd | HETEROARYL HETEROCYCLIC COMPOUNDS AND THEIR USES |
CN115715291A (zh) * | 2020-06-18 | 2023-02-24 | 上海华汇拓医药科技有限公司 | 布鲁顿酪氨酸激酶抑制剂及其制备方法 |
IL301275A (en) | 2020-09-21 | 2023-05-01 | Hutchison Medipharma Ltd | Heterocyclic heteroaryl compounds and their uses |
US20230382900A1 (en) | 2020-10-30 | 2023-11-30 | Newave Pharmaceutical Inc. | Inhibitors of btk |
US20240058457A1 (en) | 2020-12-20 | 2024-02-22 | Newave Pharmaceutical Inc. | Btk degrader |
WO2023143491A1 (zh) * | 2022-01-28 | 2023-08-03 | 和记黄埔医药(上海)有限公司 | 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
CA2453113A1 (en) | 2001-07-12 | 2003-01-23 | Avecia Limited | Microencapsulated catalyst, methods of preparation and methods of use thereof |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
CA2587192A1 (en) | 2004-11-10 | 2006-05-18 | Cgi Pharmaceuticals, Inc. | Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity |
KR101357524B1 (ko) | 2005-03-10 | 2014-02-03 | 질레드 코네티컷 인코포레이티드 | 특정 치환된 아미드, 그의 제조 방법, 및 사용 방법 |
AU2006302415B2 (en) | 2005-10-07 | 2012-09-13 | Exelixis, Inc. | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
AR063946A1 (es) | 2006-09-11 | 2009-03-04 | Cgi Pharmaceuticals Inc | Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
PE20080839A1 (es) | 2006-09-11 | 2008-08-23 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas |
US7838523B2 (en) | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
US8426441B2 (en) | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
AU2009244291B2 (en) | 2008-05-06 | 2014-02-13 | Genentech, Inc. | Substituted amides, method of making, and use as Btk inhibitors |
EP2297142B1 (en) | 2008-06-24 | 2015-10-14 | F. Hoffmann-La Roche AG | Novel substituted pyridin-2-ones and pyridazin-3-ones |
RU2507202C2 (ru) * | 2008-07-02 | 2014-02-20 | Ф.Хоффманн-Ля Рош Аг | Новые фенилпиразиноны в качестве ингибиторов киназы |
JP5318952B2 (ja) | 2008-07-15 | 2013-10-16 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なフェニル−イミダゾピリジン類及びピリダジン類 |
US8598174B2 (en) | 2008-11-12 | 2013-12-03 | Genetech, Inc. | Pyridazinones, method of making, and method of use thereof |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
SG175287A1 (en) | 2009-04-24 | 2011-11-28 | Hoffmann La Roche | Inhibitors of bruton's tyrosine kinase |
WO2010126960A1 (en) * | 2009-04-29 | 2010-11-04 | Locus Pharmaceuticals, Inc. | Pyrrolotriazine compounds |
DK2473049T3 (en) * | 2009-09-04 | 2019-04-01 | Biogen Ma Inc | INHIBITORS OF BRUTON'S TYROSINKINASE |
CA3034600C (en) | 2010-05-07 | 2020-11-10 | Genentech, Inc. | Pyridone and aza-pyridone compounds and methods of use |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
US9249123B2 (en) | 2010-09-01 | 2016-02-02 | Genentech, Inc. | Pyridinones/pyrazinones, method of making, and method of use thereof |
JP5842004B2 (ja) | 2010-09-01 | 2016-01-13 | ジーアイリード コネチカット インコーポレーテッドGilead Connecticut,Inc. | ピリダジノン、その製造方法及びその使用方法 |
KR101585753B1 (ko) | 2011-05-17 | 2016-01-14 | 에프. 호프만-라 로슈 아게 | 브루톤 티로신 키나아제의 억제제 |
PE20140865A1 (es) | 2011-08-17 | 2014-07-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
JP5976828B2 (ja) * | 2011-11-03 | 2016-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Btk活性阻害剤としてのアルキル化ピペラジン化合物 |
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
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JP2014532763A (ja) | 2014-12-08 |
SG11201401993RA (en) | 2014-05-29 |
EA027561B1 (ru) | 2017-08-31 |
TW201326171A (zh) | 2013-07-01 |
MX2014005289A (es) | 2014-05-30 |
US20140221365A1 (en) | 2014-08-07 |
EP2773639A1 (en) | 2014-09-10 |
US8946213B2 (en) | 2015-02-03 |
US9115152B2 (en) | 2015-08-25 |
MA35725B1 (fr) | 2014-12-01 |
CA2853970A1 (en) | 2013-05-10 |
JP2016028045A (ja) | 2016-02-25 |
IN2014CN03265A (ru) | 2015-07-03 |
AR088642A1 (es) | 2014-06-25 |
KR20140090227A (ko) | 2014-07-16 |
US8729072B2 (en) | 2014-05-20 |
ZA201403158B (en) | 2017-09-27 |
CN104024255A (zh) | 2014-09-03 |
CL2014001158A1 (es) | 2014-09-12 |
PE20141686A1 (es) | 2014-11-08 |
IL232280A0 (en) | 2014-06-30 |
CO6950475A2 (es) | 2014-05-20 |
CN104024255B (zh) | 2017-01-18 |
JP5976828B2 (ja) | 2016-08-24 |
BR112014010439A2 (pt) | 2017-04-18 |
KR101716011B1 (ko) | 2017-03-13 |
AU2012332368A1 (en) | 2014-05-22 |
WO2013067277A1 (en) | 2013-05-10 |
US20150094302A1 (en) | 2015-04-02 |
US20130116245A1 (en) | 2013-05-09 |
EP2773639B1 (en) | 2017-04-26 |
CR20140187A (es) | 2014-06-20 |
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